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91. 发明授权

US08704172B2 Excitation of ions in an ICR-cell with structured trapping electrodes 有权
标题翻译：在具有结构化捕获电极的ICR电池中激发离子
公开(公告)号：US08704172B2
公开(公告)日：2014-04-22
申请号：US11970125
申请日：2008-01-07
申请人： Gökhan Baykut
发明人： Gökhan Baykut
IPC分类号： G01N24/14
CPC分类号： H01J49/38 , H01J49/0031 , H01J49/025
摘要： In an ion cyclotron resonance cell, which is enclosed at its ends by electrode structure elements with DC voltages of alternating polarity, longitudinal electrodes are divided so that the ICR measurement cell between the electrode structure elements consists of at least three sections. An excitation of ion cyclotron motions can be performed by applying additional trapping voltages to longitudinal electrodes located closest to the electrode structure elements and introducing ions into the center set of longitudinal electrodes. The ions are then excited into cyclotron orbits by applying radiofrequency excitation pulses to at least two rows of longitudinal electrodes to produce orbiting ion clouds. Subsequently, the additional trapping voltages are removed and an ion-attracting DC voltage is superimposed on the DC voltages. Ions excited to circular orbits can be detected using detection electrodes in the outer ICR cell sections.
摘要翻译：在离子回旋共振电池中，其电极结构元件由具有交替极性的直流电压的端部封闭，纵向电极被分割，使得电极结构元件之间的ICR测量单元由至少三个部分组成。可以通过向最靠近电极结构元件的纵向电极施加附加的俘获电压并将离子引入纵向电极的中心集合中来执行离子回旋加速器运动的激发。然后通过向至少两排纵向电极施加射频激发脉冲将离子激发到回旋加速器轨道中以产生轨道离子云。随后，去除附加的捕获电压，并且在DC电压上叠加离子吸引的DC电压。可以使用外部ICR细胞部分中的检测电极检测到圆周轨道激发的离子。

92. 发明授权

US08642945B2 Arrangement for a removable ion-optical assembly in a mass spectrometer 有权
标题翻译：在质谱仪中可拆卸离子光学组件的布置
公开(公告)号：US08642945B2
公开(公告)日：2014-02-04
申请号：US13567213
申请日：2012-08-06
申请人： Ewgenij Kern , Jens Rebettge
发明人： Ewgenij Kern , Jens Rebettge
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/02 , H01J49/068
摘要： A device for use in a mass spectrometer allows an ion-optical assembly to be removed, cleaned and reinserted with relatively high positioning accuracy. In particular, the device obviates the need for complex adjustments requiring special knowledge after the reinsertion. The objective is achieved by an arrangement comprising a receptacle and a mount for a removable ion-optical assembly in a mass spectrometer. Favorable implementations provide a mount and a receptacle with three pairs of complementary support elements, the three support elements on the receptacle form a support plane, and, when the mount is inserted into the receptacle, at least two pairs of support elements are engaged and the mount is aligned with respect to the support plane with the aid of the third pair of support elements.
摘要翻译：用于质谱仪的装置允许以相对高的定位精度去除，清洁和重新插入离子光学组件。特别地，该装置避免了在重新插入之后需要特殊知识的复杂调整的需要。该目的通过一种装置实现，该装置包括在质谱仪中用于可移除离子光学组件的插座和安装件。有利的实施方案提供了具有三对互补支撑元件的安装座和容器，容器上的三个支撑元件形成支撑平面，并且当座架插入插座时，至少两对支撑元件被接合，并且借助于第三对支撑元件，支座相对于支撑平面对齐。

93. 发明授权

US08563315B2 Calibration substances for atmospheric pressure ion sources 有权
标题翻译：大气压离子源的校准物质
公开(公告)号：US08563315B2
公开(公告)日：2013-10-22
申请号：US12727829
申请日：2010-03-19
申请人： Thomas Zey , Jan Willmann
发明人： Thomas Zey , Jan Willmann
IPC分类号： B01D59/44 , H01J49/00 , G01N33/92
CPC分类号： H01J49/0009 , Y10T436/10 , Y10T436/104165 , Y10T436/24
摘要： A Mixture of substances is provided for precise calibration of the mass scale of mass spectrometers equipped with ion sources that operate at atmospheric pressure (AP) with ionization of the analyte molecules, for example by APCI (chemical ionization), or by APPI (photoionization), often at high temperatures of up to 470° C. Out of physical reasons, the mass scale of any time-of-flight mass spectrometer deviates in the lower mass range from the theoretical relation between charge-related mass m/z and flight time t. A closely spaced arrangement of low mass calibration reference points is necessary if high mass accuracy is to be achieved for substances of low molecular weight. APCI and APPI sources are increasingly used in time-of-flight mass spectrometers with orthogonal ion injection (OTOF MS) for the detection of non-polar and weakly polar compounds, in particular, for analyte molecules with relatively low molecular weights. Calibration substances in solutions that are easily handled, nontoxic, stable at the high temperatures involved, will accept both positive and negative ionization, and supply enough reference points for calibration in the mass range up to 500 daltons. Mixtures of saturated fatty acids dissolved in toluene may be used. For photoionization, also mixtures of phenyl and naphthyl fatty acids.
摘要翻译：提供物质混合物，用于精确校准装备有大气压力（AP）的离子源的质谱仪的质谱仪，分析物分子例如通过APCI（化学电离）或APPI（光电离）离子化，，通常在高达470°C的高温下。由于物理原因，任何飞行时间质谱仪的质量尺度在电荷相关质量m / z和飞行时间之间的理论关系的较低质量范围内偏差 t。如果要实现低分子量物质的高质量精度，则需要紧密排列的低质量校准参考点。 APCI和APPI来源越来越多地用于具有正交离子注入（OTOF MS）的飞行时间质谱仪中，用于检测非极性和弱极性化合物，特别是具有相对较低分子量的分析物分子。易于处理，无毒，在高温下稳定的溶液中的校准物质将接受正电离和负电离，并在质量范围达500道尔顿范围内提供足够的参考点进行校准。可以使用溶解在甲苯中的饱和脂肪酸的混合物。对于光电离，也可以是苯基和萘基脂肪酸的混合物。

94. 发明申请

US20130164174A1 RADICAL IONS FOR ELECTRON TRANSFER DISSOCIATION 有权
标题翻译：用于电子转移分离的放射性离子
公开(公告)号：US20130164174A1
公开(公告)日：2013-06-27
申请号：US13772701
申请日：2013-02-21
申请人： Ralf Hartmer
发明人： Ralf Hartmer
IPC分类号： G01N33/68
CPC分类号： G01N33/6848 , H01J49/0072
摘要： Radical anions for use in the fragmentation of positively charged biopolymer ions by means of electron transfer are produced from substances previously unknown for use as ETD production substances. The inventive substances produce radical anions that lead to electron transfer dissociations with a high yield of fragment ions. The substances have high volatility that allows them to be kept in unheated containers outside the vacuum system and transported into the vacuum system to an in vacuum electron attachment ion source via unheated lines and low molecular weights that allow the measurement of even very light fragment ions. In one embodiment, a suitable substance is 1-3-5-7-cyclooctatetraene.
摘要翻译：用于通过电子转移使带正电荷的生物聚合物离子分解的自由基阴离子由以前未知的用作ETD生产物质的物质产生。本发明的物质产生导致电子转移离解的自由基阴离子，具有高产率的碎片离子。这些物质具有高挥发性，使其能够保持在真空系统外部的未加热的容器中，并通过未加热的管线和低分子量输送到真空电子附着离子源，允许测量甚至非常轻的碎片离子。在一个实施方案中，合适的物质是1-3-5-7-环辛四烯。

95. 发明申请

US20130146761A1 INTRODUCTION OF IONS INTO KINGDON ION TRAPS 有权
标题翻译：引入离子进入金属离子
公开(公告)号：US20130146761A1
公开(公告)日：2013-06-13
申请号：US13706807
申请日：2012-12-06
申请人： Bruker Daltonik GmbH
发明人： Claus KÖSTER , Jochen FRANZEN
IPC分类号： H01J49/02 , H01J49/26
CPC分类号： H01J49/02 , H01J49/26 , H01J49/425
摘要： The geometry of a Kingdon ion trap, in which harmonic ion oscillation in a potential well in a longitudinal direction is completely decoupled from ion oscillation in a direction transverse to the longitudinal direction, is arranged so that the oscillating ions introduced through the entrance tube cannot return to the entrance tube until they have performed several longitudinal oscillations during which time heavier ions can be introduced into the trap. In one embodiment, ions enter the trap via an entrance tube extending through, but electrically insulated from, one of the Kingdon trap housing electrodes and located outside the minimum of the potential well in the longitudinal direction.
摘要翻译： Kingdon离子阱的几何形状，其中在纵向方向上的势阱中的谐波离子振荡在垂直于纵向方向的方向上与离子振荡完全解耦，使得通过入口管引入的振荡离子不能返回直到进入管，直到它们进行了几个纵向振荡，在此期间较重的离子可以被引入陷阱。在一个实施例中，离子通过入口管进入陷阱，该入口管延伸穿过Kingdon陷阱壳体电极之一但电绝缘，并位于纵向方向上位于势阱最小值之外。

96. 发明授权

US08450081B2 Identification of pathogens in body fluids 有权
标题翻译：体液中病原体的鉴定
公开(公告)号：US08450081B2
公开(公告)日：2013-05-28
申请号：US12734719
申请日：2008-11-20
申请人： Ulrich Weller
发明人： Ulrich Weller
IPC分类号： C12Q1/02 , C12N11/02
CPC分类号： C12Q1/04 , G01N33/569 , G01N33/6851
摘要： Identification of infectious pathogens, particularly viruses, bacteria and other microorganisms is effected with a method whereby pathogens of acute infections can be identified, without first culturing them in external nutrient media, by mass spectrometric measurement of their protein profiles obtained from pathogens directly precipitated from body fluid into pellets by centrifuging. With this method, pathogens which cause acute infections can be identified in less than one hour.
摘要翻译：感染性病原体，特别是病毒，细菌和其他微生物的鉴定是通过以下方法进行的：通过质谱法测定从身体直接沉淀的病原体获得的蛋白质图谱，可以鉴定出急性感染病原体，而无需先将其培养在外部营养培养基中通过离心将液体转化成颗粒。通过这种方法，可以在不到一小时的时间内鉴定引起急性感染的病原体。

97. 发明授权

US08435757B2 Mass spectrometric endopeptidase assay 有权
标题翻译：质谱内肽酶测定
公开(公告)号：US08435757B2
公开(公告)日：2013-05-07
申请号：US12785909
申请日：2010-05-24
申请人： Peter Findeisen , Michael Neumaier
发明人： Peter Findeisen , Michael Neumaier
IPC分类号： C12Q1/37
CPC分类号： C12Q1/37 , G01N33/6851
摘要： The activity of a selected endopeptidase in a body fluid is determined by the mass spectrometric measurement of the reaction products of reporter substrate molecules added to the body fluid. Each reporter substrate molecule includes a peptide with the cleavage motif of the endopeptidase, an anchor group A1 on one side of the cleavage site and a different anchor group A2 on the other side of the cleavage site. One anchor is used to extract the reporter substrate molecules from the body fluid and the other anchor is used to extract digest fragments of the reporter molecules from the body fluid. Mass markers allow several reporter substrates to be used simultaneously in the same body fluid sample to measure the activity of different types of endopeptidase.
摘要翻译：选择的内肽酶在体液中的活性通过加入到体液中的报告基质分子的反应产物的质谱测量来确定。每个报道底物分子包括具有内肽酶切割基序的肽，在切割位点一侧的锚定基团A1和切割位点另一侧的不同锚定基团A2。一个锚被用于从体液中提取报告基质分子，另一个锚用于从体液中提取报道分子的消化片段。质量标记允许在同一体液样品中同时使用几个报道底物来测量不同类型的内肽酶的活性。

98. 发明授权

US08410429B2 Ion manipulation cell with tailored potential profiles 有权
标题翻译：具有定制潜力分布的离子手术细胞
公开(公告)号：US08410429B2
公开(公告)日：2013-04-02
申请号：US13017803
申请日：2011-01-31
申请人： Jochen Franzen , Gökhan Baykut , Oliver Räther , Carsten Stoermer , Evgenij Nikolaev
发明人： Jochen Franzen , Gökhan Baykut , Oliver Räther , Carsten Stoermer , Evgenij Nikolaev
IPC分类号： H01J49/06 , H01J49/36
CPC分类号： H01J49/4205 , H01J49/062
摘要： An ion cell having an axis includes a sheath of individual electrodes that extends along the axis and defines an internal volume. Adjacent individual electrodes are electrically insulated from each other. The individual electrodes each receive a DC potential and RF voltage. At least some of the individual electrodes have a width that varies in the axial direction such that an electrical effect on an axis potential varies along the axis of the ion cell.
摘要翻译：具有轴的离子电池包括沿着轴线延伸并且限定内部体积的各个电极的护套。相邻的单个电极彼此电绝缘。各个电极各自接收DC电位和RF电压。单个电极中的至少一些具有在轴向上变化的宽度，使得轴电位上的电效应沿离子电池的轴线变化。

99. 发明授权

US08368012B2 Guiding charged droplets and ions in an electrospray ion source 有权
标题翻译：在电喷雾离子源中引导带电的液滴和离子
公开(公告)号：US08368012B2
公开(公告)日：2013-02-05
申请号：US12699550
申请日：2010-02-03
申请人： Evgenij Nikolaev , Jochen Franzen
发明人： Evgenij Nikolaev , Jochen Franzen
IPC分类号： H01J49/10 , H01J27/02 , H01J3/14
CPC分类号： H01J37/248 , H01J49/062 , H01J49/165 , H01J2237/03
摘要： Charged spray droplets are guided in a pseudopotential distribution generated by audio frequency voltages at electrodes of a guiding device, focusing the spray droplets toward the axis. An axial electric field profile and an axial flow profile of a drying gas in the guiding device allow the drift of different-sized droplets to be controlled in the longitudinal direction of the guiding device, so that the droplets are roughly equal in size when they leave the guiding device and finally dry up shortly after leaving. As a result, the ions are formed in a relatively small spatial region. Electrostatic potentials guide the analyte ions from this small spatial region to the entrance aperture of the inlet capillary; during this process, very light ions, especially protons and water-proton complexes, can be filtered out by a mobility filter.
摘要翻译：带电喷雾液滴由引导装置的电极处的音频电压产生的赝势分布引导，将喷雾液滴聚焦到轴上。引导装置中的干燥气体的轴向电场分布和轴向流动分布允许不同尺寸的液滴在引导装置的纵向方向上的漂移被控制，使得当它们离开时液滴大小相当大小引导装置，最后在离开后立即干燥。结果，离子形成在较小的空间区域。静电势将分析离子从该小空间区域引导到入口毛细管的入口孔; 在此过程中，非常轻的离子，特别是质子和水 - 质子复合物可以通过迁移率过滤器过滤掉。

100. 发明授权

US08314384B2 Mixed radio frequency multipole rod system as ion reactor 有权
标题翻译：混合射频多极杆系统作为离子反应器
公开(公告)号：US08314384B2
公开(公告)日：2012-11-20
申请号：US13112593
申请日：2011-05-20
申请人： Carsten Stoermer , Karsten Michelmann , Michael Schubert
发明人： Carsten Stoermer , Karsten Michelmann , Michael Schubert
IPC分类号： H01J49/42 , B01D59/44
CPC分类号： H01J49/0072 , H01J49/063
摘要： The invention relates to a linear multipole ion storage device which is suitable for reactions between positive and negative ions, and for fragmentation reactions by electron transfer dissociation (ETD) in particular. The invention uses a linear RF ion trap with at least three pairs of rods with a new type of electronic power supply. The two phases of a first RF voltage are applied to the pole rods alternately around the circumference and confine positive as well as negative ions in the radial direction. A second RF voltage is either applied single-phase to some of the pole rods, but not to all of them, or two-phase to unequal numbers of pole rods so that the axis potential oscillates with the frequency of this second RF voltage and generates a pseudopotential barrier which acts axially on ions of both polarities at the ends of the ion storage device. In the interior, the second RF produces a complex superposition field resulting in an increased fragmentation yield for ETD.
摘要翻译：本发明涉及一种线性多极离子存储装置，其适用于正离子和负离子之间的反应，特别涉及电子转移离解（ETD）的断裂反应。本发明使用具有新型电子电源的至少三对杆的线性RF离子阱。第一RF电压的两相交替地围绕圆周施加到极棒，并且在径向方向上限制正极以及负离子。第二RF电压或者单相施加到一些极棒，但不是施加到一些极棒，而是施加到所有的极点，或者两相到不相等的极棒，使得轴电位以该第二RF电压的频率振荡并产生在离子存储装置的端部轴向地作用于两个极性的离子的赝势垒。在内部，第二RF产生复杂的叠加场，导致ETD的碎裂产率增加。

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