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1. 发明申请

US20100237230A1 CALIBRATION SUBSTANCES FOR ATMOSPHERIC PRESSURE ION SOURCES 有权
标题翻译：用于大气压源的校准物质
公开(公告)号：US20100237230A1
公开(公告)日：2010-09-23
申请号：US12727829
申请日：2010-03-19
申请人： Thomas Zey , Jan Willmann
发明人： Thomas Zey , Jan Willmann
IPC分类号： G12B13/00 , G01N31/00 , H01J49/26
CPC分类号： H01J49/0009 , Y10T436/10 , Y10T436/104165 , Y10T436/24
摘要： A Mixture of substances is provided for precise calibration of the mass scale of mass spectrometers equipped with ion sources that operate at atmospheric pressure (AP) with ionization of the analyte molecules, for example by APCI (chemical ionization), or by APPI (photoionization), often at high temperatures of up to 470° C. Out of physical reasons, the mass scale of any time-of-flight mass spectrometer deviates in the lower mass range from the theoretical relation between charge-related mass m/z and flight time t. A closely spaced arrangement of low mass calibration reference points is necessary if high mass accuracy is to be achieved for substances of low molecular weight. APCI and APPI sources are increasingly used in time-of-flight mass spectrometers with orthogonal ion injection (OTOF MS) for the detection of non-polar and weakly polar compounds, in particular, for analyte molecules with relatively low molecular weights. Calibration substances in solutions that are easily handled, nontoxic, stable at the high temperatures involved, will accept both positive and negative ionization, and supply enough reference points for calibration in the mass range up to 500 daltons. Mixtures of saturated fatty acids dissolved in toluene may be used. For photoionization, also mixtures of phenyl and naphthyl fatty acids.
摘要翻译：提供物质混合物，用于精确校准装备有大气压力（AP）的离子源的质谱仪的质谱仪，分析物分子例如通过APCI（化学电离）或APPI（光电离）离子化，，通常在高达470°C的高温下。由于物理原因，任何飞行时间质谱仪的质量尺度在电荷相关质量m / z和飞行时间之间的理论关系的较低质量范围内偏差 t。如果要实现低分子量物质的高质量精度，则需要紧密排列的低质量校准参考点。 APCI和APPI来源越来越多地用于具有正交离子注入（OTOF MS）的飞行时间质谱仪中，用于检测非极性和弱极性化合物，特别是具有相对较低分子量的分析物分子。易于处理，无毒，在高温下稳定的溶液中的校准物质将接受正电离和负电离，并在质量范围达500道尔顿范围内提供足够的参考点进行校准。可以使用溶解在甲苯中的饱和脂肪酸的混合物。对于光电离，也可以是苯基和萘基脂肪酸的混合物。

2. 发明授权

US08563315B2 Calibration substances for atmospheric pressure ion sources 有权
标题翻译：大气压离子源的校准物质
公开(公告)号：US08563315B2
公开(公告)日：2013-10-22
申请号：US12727829
申请日：2010-03-19
申请人： Thomas Zey , Jan Willmann
发明人： Thomas Zey , Jan Willmann
IPC分类号： B01D59/44 , H01J49/00 , G01N33/92
CPC分类号： H01J49/0009 , Y10T436/10 , Y10T436/104165 , Y10T436/24
摘要： A Mixture of substances is provided for precise calibration of the mass scale of mass spectrometers equipped with ion sources that operate at atmospheric pressure (AP) with ionization of the analyte molecules, for example by APCI (chemical ionization), or by APPI (photoionization), often at high temperatures of up to 470° C. Out of physical reasons, the mass scale of any time-of-flight mass spectrometer deviates in the lower mass range from the theoretical relation between charge-related mass m/z and flight time t. A closely spaced arrangement of low mass calibration reference points is necessary if high mass accuracy is to be achieved for substances of low molecular weight. APCI and APPI sources are increasingly used in time-of-flight mass spectrometers with orthogonal ion injection (OTOF MS) for the detection of non-polar and weakly polar compounds, in particular, for analyte molecules with relatively low molecular weights. Calibration substances in solutions that are easily handled, nontoxic, stable at the high temperatures involved, will accept both positive and negative ionization, and supply enough reference points for calibration in the mass range up to 500 daltons. Mixtures of saturated fatty acids dissolved in toluene may be used. For photoionization, also mixtures of phenyl and naphthyl fatty acids.
摘要翻译：提供物质混合物，用于精确校准装备有大气压力（AP）的离子源的质谱仪的质谱仪，分析物分子例如通过APCI（化学电离）或APPI（光电离）离子化，，通常在高达470°C的高温下。由于物理原因，任何飞行时间质谱仪的质量尺度在电荷相关质量m / z和飞行时间之间的理论关系的较低质量范围内偏差 t。如果要实现低分子量物质的高质量精度，则需要紧密排列的低质量校准参考点。 APCI和APPI来源越来越多地用于具有正交离子注入（OTOF MS）的飞行时间质谱仪中，用于检测非极性和弱极性化合物，特别是具有相对较低分子量的分析物分子。易于处理，无毒，在高温下稳定的溶液中的校准物质将接受正电离和负电离，并在质量范围达500道尔顿范围内提供足够的参考点进行校准。可以使用溶解在甲苯中的饱和脂肪酸的混合物。对于光电离，也可以是苯基和萘基脂肪酸的混合物。

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