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91. 发明申请

US20070232546A1 Linear Natriuretic Peptide Constructs 有权
标题翻译：线性利钠肽构建体
公开(公告)号：US20070232546A1
公开(公告)日：2007-10-04
申请号：US11694358
申请日：2007-03-30
申请人： Shubh D. Sharma , Margarita Bastos , Wei Yang , Hui-Zhi Cai
发明人： Shubh D. Sharma , Margarita Bastos , Wei Yang , Hui-Zhi Cai
IPC分类号： A61K38/16 , A61K38/10 , C07K7/08
CPC分类号： C07D241/08 , A61K38/00 , A61K47/60 , C07K14/58
摘要： Linear constructs with an N-terminus and a C-terminus which bind to a natriuretic peptide receptor and include a plurality of amino acid residues and at least one amino acid surrogate of formula I: where R, R′, Q, Y, W, Z, J, x and n are as defined in the specification, and optionally at least one prosthetic group covalently bound to a reactive group of at least one of the amino acid residues or surrogates, pharmaceutical compositions including such linear constructs, and methods of treating congestive heart failure or other conditions, syndromes or diseases for which induction of anti-hypertensive, cardiovascular, renal or endocrine effects are desired.
摘要翻译：具有与利尿钠肽受体结合的N末端和C末端并且包括多个氨基酸残基和至少一个式I的氨基酸替代物的线性构建体：其中R，R'，Q，Y，W， Z，J，x和n如说明书中所定义，以及任选地至少一个与至少一个氨基酸残基或替代物的反应性基团共价结合的假基团，包括这种线型构建体的药物组合物，以及治疗方法充血性心力衰竭或其它需要诱导抗高血压，心血管，肾或内分泌作用的综合征或疾病。

92. 发明授权

US07239573B2 Method of storing data in blocks per operation 有权
标题翻译：每个操作以块的形式存储数据的方法
公开(公告)号：US07239573B2
公开(公告)日：2007-07-03
申请号：US11111729
申请日：2005-04-22
申请人： David Ho , Wei Yang
发明人： David Ho , Wei Yang
IPC分类号： G11C8/00
CPC分类号： G06F3/0656 , G06F3/0613 , G06F3/0679 , G11C5/04
摘要： The present invention is to provide a method of storing data for driving an MMC or SD under an operating system (e.g., Linux), which comprises the steps of collecting data in a plurality of discreet blocks of a high-speed buffer for each writing request made by a device driver under the OS; temporarily storing data in a plurality of continuous blocks of another buffer; and writing data from the continuous blocks of another buffer into a continuous block of the MMC or the SD in one operation in the form of multiple blocks in due time. By utilizing this method, data writing speed is significantly increased.
摘要翻译：本发明提供一种在操作系统（例如Linux）下存储用于驱动MMC或SD的数据的方法，其包括以下步骤：在每个写入请求的高速缓冲器的多个离散块中收集数据由操作系统下的设备驱动程序制作; 将数据临时存储在另一缓冲器的多个连续块中; 并且在一段时间内以多个块的形式将数据从另一缓冲器的连续块写入到MMC或SD的连续块中。通过利用该方法，数据写入速度显着增加。

93. 发明申请

US20060240481A1 Melanocortin Metallopeptode Combinatorial Libraries and Applications 审中-公开
标题翻译：黑皮质素金属蛋白酶组合库和应用
公开(公告)号：US20060240481A1
公开(公告)日：2006-10-26
申请号：US11419557
申请日：2006-05-22
申请人： Shubh Sharma , Yiqun Shi , Wei Yang , Hui-Zhi Cai
发明人： Shubh Sharma , Yiqun Shi , Wei Yang , Hui-Zhi Cai
IPC分类号： C40B30/06 , C40B40/10
CPC分类号： C07K5/1016 , A61K38/00 , A61K51/086 , A61K51/088 , C07K5/1008 , C07K5/1024 , C07K14/665
摘要： Melanocortin receptor-specific peptide combinatorial libraries for forming metallopeptides and metallopeptide combinatorial libraries are provided for use in biological, pharmaceutical and related applications. The combinatorial libraries are constructed of peptides constructed from naturally occurring amino acids, stereoisomers and modifications of such amino acids, non-protein amino acids, post-translationally modified amino acids, enzymatically modified amino acids, or constructs or structures designed to mimic amino acids, in which the peptides are conformationally fixed on complexation of a metal ion-binding portion thereof with a metal ion.
摘要翻译：提供用于形成金属肽和金属肽组合文库的黑皮质素受体特异性肽组合文库，用于生物，药物和相关应用。组合文库由由天然存在的氨基酸构成的肽，这些氨基酸的立体异构体和修饰，非蛋白质氨基酸，翻译后修饰的氨基酸，酶修饰的氨基酸或被设计为模拟氨基酸的构建体或结构构成，其中肽与金属离子结合部分与金属离子的络合被构象地固定。

94. 发明申请

US20060136675A1 Method of storing data in blocks per operation 有权
标题翻译：每个操作以块的形式存储数据的方法
公开(公告)号：US20060136675A1
公开(公告)日：2006-06-22
申请号：US11111729
申请日：2005-04-22
申请人： David Ho , Wei Yang
发明人： David Ho , Wei Yang
IPC分类号： G06F12/00
CPC分类号： G06F3/0656 , G06F3/0613 , G06F3/0679 , G11C5/04
摘要： The present invention is to provide a method of storing data for driving an MMC or SD under an operating system (e.g., Linux), which comprises the steps of collecting data in a plurality of discreet blocks of a high-speed buffer for each writing request made by a device driver under the OS; temporarily storing data in a plurality of continuous blocks of another buffer; and writing data from the continuous blocks of another buffer into a continuous block of the MMC or the SD in one operation in the form of multiple blocks in due time. By utilizing this method, data writing speed is significantly increased.
摘要翻译：本发明提供一种在操作系统（例如Linux）下存储用于驱动MMC或SD的数据的方法，其包括以下步骤：在每个写入请求的高速缓冲器的多个离散块中收集数据由操作系统下的设备驱动程序制作; 将数据临时存储在另一缓冲器的多个连续块中; 并且在一段时间内以多个块的形式将数据从另一缓冲器的连续块写入到MMC或SD的连续块中。通过利用该方法，数据写入速度显着增加。

95. 发明申请

US20060115588A1 System and method of fabrication and application of thin-films with continuously graded or discrete physical property parameters to functionally broadband monolithic microelectronic optoelectronic/sensor/actuator device arrays 有权
标题翻译：具有连续分级或离散物理参数的薄膜的制造和应用的系统和方法，用于功能宽带单片微电子光电/传感器/致动器器件阵列
公开(公告)号：US20060115588A1
公开(公告)日：2006-06-01
申请号：US10998149
申请日：2004-11-29
申请人： Ichiro Takeuchi , Wei Yang , Kao-Shuo Chang , Ratnakar Vispute , Thirumalai Venkatesan
发明人： Ichiro Takeuchi , Wei Yang , Kao-Shuo Chang , Ratnakar Vispute , Thirumalai Venkatesan
IPC分类号： C23C16/00
CPC分类号： C23C14/08 , C23C14/0084
摘要： A system and method are provided to fabricate thin-films having different physical property parameters or having physical property parameters that continuously change across functionally broadband monolithic device arrays. The fabrication method deposits the thin-film including layers on a substrate of a monolithic chip. The method defines a desired gradient profile of each layer forming the thin-film, each gradient profile including a desired thinnest profile and a desired thickest profile. The method further aligns an aperture of a mask over the substrate to form the thin-film and calculates a shutter speed for the specified gradient profile of each layer across the desired area of the substrate, and deposits each layer on the substrate, through the aperture, as the aperture of the shutter moves at the calculated shutter speed from the desired thinnest profile of each layer to the desired thickest profile of each layer.
摘要翻译：提供了一种系统和方法来制造具有不同物理性质参数或具有在功能上宽带单片器件阵列上连续变化的物理性质参数的薄膜。制造方法将薄膜包括层沉积在单片芯片的基板上。该方法定义了形成薄膜的每个层的期望的梯度轮廓，每个梯度轮廓包括期望的最薄轮廓和期望的最厚轮廓。该方法进一步将掩模的孔径对准衬底上的孔径以形成薄膜，并且计算穿过衬底的期望区域的每层的指定梯度分布的快门速度，并通过孔径将每个层沉积在衬底上，因为快门的光圈以所计算的快门速度从每层的期望的最薄轮廓移动到每层的期望的最厚轮廓。

96. 发明申请

US20060111281A1 Cyclic peptide compositions for treatment of sexual dysfunction 有权
标题翻译：用于治疗性功能障碍的循环肽组合物
公开(公告)号：US20060111281A1
公开(公告)日：2006-05-25
申请号：US11269271
申请日：2005-11-09
申请人： Shubh Sharma , Wei Yang
发明人： Shubh Sharma , Wei Yang
IPC分类号： A61K38/12 , C07K7/64
CPC分类号： A61K38/12 , A61K31/519 , A61K31/565 , C07K7/56 , C07K14/665 , C07K14/685 , Y10S436/811 , A61K2300/00
摘要： A cyclic peptide of the structural formula: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, m and p are as defined. Further provided are compositions for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction, by administration of a cyclic peptide including a C-terminus —OH group. Routes of administration include injection, oral, urethral, vaginal, nasal and mucosal administration.
摘要翻译：结构式的环状肽或其药学上可接受的盐，其中R 1，R 2，R 3，R 3， R 5，R 5，R 6，m和p如上所定义。还提供了通过施用包括C末端-OH基团的环肽来治疗哺乳动物的性功能障碍的组合物，包括男性性功能障碍，例如勃起功能障碍和女性性功能障碍。给药途径包括注射，口服，尿道，阴道，鼻和粘膜给药。

97. 发明申请

US20060083685A1 Opioid metallopeptide compositions and methods 审中-公开
标题翻译：阿片类金属肽组合物和方法
公开(公告)号：US20060083685A1
公开(公告)日：2006-04-20
申请号：US11291389
申请日：2005-12-01
申请人： Shubh Sharma , Wei Yang , Hui-Zhi Cai
发明人： Shubh Sharma , Wei Yang , Hui-Zhi Cai
IPC分类号： A61K51/00 , C40B40/10 , C07K7/06
CPC分类号： C07K5/1027 , A61K51/0478 , C07K1/047 , C07K5/1008 , C07K5/1016
摘要： Metallopeptides and metallopeptide combinatorial libraries specific for opioid receptors are provided, for use in biological, pharmaceutical and related applications. The metallopeptides and combinatorial libraries are made of peptides, peptidomimetics and peptide-like constructs, in which the peptide, peptidomimetic or construct is conformationally fixed in a biologically active configuration specific for one or more opioid receptors on complexation of a metal ion-binding portion thereof with a metal ion.
摘要翻译：提供了特异于阿片受体的金属肽和金属肽组合文库，用于生物，药物和相关应用。金属肽和组合文库由肽，肽模拟物和肽样构建体制成，其中肽，拟肽或构建体在一种或多种阿片受体特异性的生物活性构型中被构象地固定在金属离子结合部分的络合物上与金属离子。

98. 发明申请

US20060063991A1 Method and apparatus for non-invasive measurement of blood analytes with dynamic spectral calibration 审中-公开
标题翻译：用动态光谱校准对血液分析物进行非侵入性测量的方法和装置
公开(公告)号：US20060063991A1
公开(公告)日：2006-03-23
申请号：US10914761
申请日：2004-08-09
申请人： Dejin Yu , Wei Yang
发明人： Dejin Yu , Wei Yang
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/6826 , A61B5/6838 , A61B5/702 , G01N21/65
摘要： The present invention discloses a method and apparatus and method for achieving non-invasive measurement of analytes from human and animal blood through the skin using Raman lightwave technology. The apparatus includes a confocal signal collection system that effectively reduces the interferences from out-of-focus signals. The apparatus further includes a tissue permeation unit, which controls the amount of blood in the laser tissue interaction region. The change of aggregate spectra with time is used to construct a new series of differenced spectra, from which the spectral effects from surrounding static substances are calibrated out dynamically using the data processing method described.
摘要翻译：本发明公开了一种使用拉曼光波技术从人体和动物血液通过皮肤非侵入性地测量分析物的方法和装置和方法。该装置包括共焦信号收集系统，其有效地减少了离焦信号的干扰。该装置还包括组织渗透单元，其控制激光组织相互作用区域中的血液量。聚合谱随时间的变化被用来构建一系列新的差分光谱，使用所描述的数据处理方法动态校正周围静态物质的光谱效应。

99. 发明申请

US20050164914A1 Metallopeptide compositions for treatment of sexual dysfunction 失效
标题翻译：用于治疗性功能障碍的金属肽组合物
公开(公告)号：US20050164914A1
公开(公告)日：2005-07-28
申请号：US11036273
申请日：2005-01-14
申请人： Shubh Sharma , Annette Shadiack , Wei Yang , Ramesh Rajpurohit
发明人： Shubh Sharma , Annette Shadiack , Wei Yang , Ramesh Rajpurohit
IPC分类号： A61K38/00 , A61K51/04 , A61K51/08 , C07K5/117 , C07K7/06 , C07K14/575 , C07K14/68 , A61K38/40 , A61K38/16
CPC分类号： C07K7/06 , A61K38/00 , A61K51/0497 , A61K2121/00 , A61K2123/00 , C07K5/1024 , C07K14/575 , C07K14/68
摘要： Metallopeptide compositions are provided for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction. The metallopeptides include at least one, and preferably two, aromatic amino acid side chain moieties, and are further characterized in that the metallopeptides preferably do not bind or significantly bind to a melanocortin receptor.
摘要翻译：提供金属肽组合物用于治疗哺乳动物的性功能障碍，包括男性性功能障碍，如勃起功能障碍和女性性功能障碍。金属肽包括至少一个，优选两个芳族氨基酸侧链部分，其特征还在于金属肽优选不结合或显着结合黑皮质素受体。

100. 发明授权

US06248416B1 Highly oriented magnetic thin films, recording media, transducers, devices made therefrom and methods of making 失效
标题翻译：高取向磁性薄膜，记录介质，换能器，由其制成的装置和制造方法
公开(公告)号：US06248416B1
公开(公告)日：2001-06-19
申请号：US08967669
申请日：1997-11-10
申请人： David N. Lambeth , David E. Laughlin , Wei Yang , Heng Gong , Jie Ziou
发明人： David N. Lambeth , David E. Laughlin , Wei Yang , Heng Gong , Jie Ziou
IPC分类号： G11B566
CPC分类号： G11B5/667 , G11B5/7325 , Y10T428/12611 , Y10T428/265
摘要： The present invention provides for magnetic and magneto-optic recording media, transducers and data storage devices constructed therefrom that have highly oriented films having long range order in the crystal structure of the film. The recording medium includes a magnetic recording layer comprised of Co-based material, such as Co or one or more Co alloys having a (10{overscore (1)}0) crystal texture, a substrate, a first underlayer having a fcc structure and a (110) crystal texture disposed between the substrate and the magnetic recording layer. A second underlayer having a bcc structure and a (112) crystal texture is also disposed between the magnetic recording layer and the first underlayer. In particular, if a (110) Si single crystal substrate is non-oxidized certain metals having fcc structures, such as Ag, Cu, Al, and Au and fcc derivative structures, such L10 and L12 structures, can be epitaxially grown on the Si surface. While the one unit cell to one unit cell lattice match between fcc Ag and A4 (diamond) Si is quite poor, multiples of the Ag unit cell distance fit very well on the Si surface. The long range order of the Si surface induces the epitaxial growth of the Ag fcc structure. Upon this fcc structure, a bcc structure, such as Cr, or a bcc derivative, such as B2, DO3 and/or L21 can be epitaxially grown.
摘要翻译：本发明提供了由其构成的磁和磁光记录介质，换能器和数据存储装置，其具有在膜的晶体结构中具有长距离顺序的高取向膜。记录介质包括由Co基材料组成的磁记录层，例如Co或具有（10 {overscore（1）} O）晶体结构的一种或多种Co合金，衬底，具有fcc结构的第一底层和设置在基板和磁记录层之间的（110）晶体结构。具有bcc结构和（112）晶体结构的第二底层也设置在磁记录层和第一底层之间。特别地，如果（110）Si单晶衬底不被氧化，则可以在Si上外延生长具有fcc结构的某些金属，例如Ag，Cu，Al和Au以及fcc衍生结构，如L10和L12结构表面。虽然fcc Ag和A4（金刚石）Si之间的一个单元电池与一个单元电池晶格匹配相当差，但是Ag单元电池距离的倍数在Si表面上很好地匹配。 Si表面的长距离顺序引起Ag fcc结构的外延生长。在该fcc结构中，可以外延生长诸如Cr的bcc结构或bcc衍生物，例如B2，DO3和/或L21。

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