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91. 发明申请

US20110270191A1 Fast-acting or rotating transseptal needle 有权
标题翻译：快速或旋转经口针
公开(公告)号：US20110270191A1
公开(公告)日：2011-11-03
申请号：US13142957
申请日：2009-12-23
申请人： Saurav Paul , Todd R. Stangenes , Reer R. Heimbecher
发明人： Saurav Paul , Todd R. Stangenes , Reer R. Heimbecher
IPC分类号： A61B17/34
CPC分类号： A61B17/3403 , A61B17/3478 , A61B17/3498 , A61B2017/00243 , A61B2017/3405 , A61M29/00
摘要： A transseptal medical device (10, 110) is provided including a dilator (12, 112), a needle (14, 114), and a needle control mechanism (22, 122). The needle (14, 114) may be disposed within the dilator (12, 112), and the needle control mechanism (22, 122) may be operably connected to a proximal end (24, 124, 16, 116) of the needle (14, 114) or the dilator (12, 112) for selective adjustment of the distal end (26, 126) of the needle (14, 114) from a first position within the dilator (12, 112) to a second position external to the dilator (12, 112). The needle control mechanism (22) may include an actuator (32) configured for rotation within the dilator in one embodiment.
摘要翻译：提供了一种经血管医疗装置（10,110），其包括扩张器（12,112），针（14,114）和针控制机构（22,122）。针（14,114）可以设置在扩张器（12,112）内，并且针控制机构（22,122）可以可操作地连接到针的近端（24,124,16,116） 14,114）或扩张器（12,112），用于选择性地将针（14,114）的远端（26,126）从扩张器（12,112）内的第一位置调节到第二位置扩张器（12,112）。针控制机构（22）可以包括在一个实施例中构造成用于在扩张器内旋转的致动器（32）。

92. 发明授权

US07824377B2 Tissue anchoring catheter systems and methods 有权
标题翻译：组织锚固导管系统及方法
公开(公告)号：US07824377B2
公开(公告)日：2010-11-02
申请号：US11962512
申请日：2007-12-21
申请人： James V. Kauphusman , Israel A. Byrd , Saurav Paul
发明人： James V. Kauphusman , Israel A. Byrd , Saurav Paul
IPC分类号： A61M5/178
CPC分类号： A61M25/04 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2090/065 , A61M25/0084 , A61M2025/0089 , A61M2025/0095
摘要： Catheter systems and methods are disclosed for anchoring the catheter system to tissue, e.g., for delivery of biologic or chemical agents, or other therapeutic fluid during various procedures. An exemplary tissue anchoring catheter comprises an outer catheter shaft connected to a catheter handle. A delivery sheath is provided within the outer catheter shaft, the delivery sheath housing a needle. At least one anchor is operatively associated with the delivery sheath, the at least one anchor operable at the catheter handle to secure the delivery sheath to tissue for conveying biologic or chemical agents, or other therapeutic fluid from the needle to the tissue. The tissue anchoring catheter may further comprise sensing means such as piezoelectric, pressure, thermistor, thermocouple, or ultrasound sensors.
摘要翻译：公开了用于将导管系统锚定到组织的导管系统和方法，例如用于在各种程序期间递送生物或化学试剂或其它治疗性流体。示例性组织锚定导管包括连接到导管手柄的外导管轴。输送护套设置在外导管轴内，输送护套容纳针。至少一个锚定件与输送护套可操作地相关联，所述至少一个锚固件可在导管手柄处操作以将输送护套固定到组织，用于将生物或化学试剂或其它治疗流体从针输送到组织。组织锚定导管还可以包括诸如压电，压力，热敏电阻，热电偶或超声波传感器的感测装置。

93. 发明申请

US20090163904A1 System and Method for Assessing Coupling Between an Electrode and Tissue 有权
标题翻译：用于评估电极和组织之间耦合的系统和方法
公开(公告)号：US20090163904A1
公开(公告)日：2009-06-25
申请号：US12253637
申请日：2008-10-17
申请人： Stephan P. Miller , Don Curtis Deno , Saurav Paul
发明人： Stephan P. Miller , Don Curtis Deno , Saurav Paul
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B5/053 , A61B18/1233 , A61B18/14 , A61B2018/00178 , A61B2018/00875 , A61B2090/065
摘要： A system and method for assessing a degree of coupling between an electrode and tissue in a body is provided. Values for first and second components of a complex impedance (e.g., resistance and reactance or impedance magnitude and phase angle) between the electrode and the tissue are obtained. From these values, a coupling index is calculated that that is indicative of a degree of coupling between the electrode and the tissue. The coupling index may be displayed to a clinician in a variety of ways to indicate the degree of coupling to the clinician. The system and method find particular application in ablation of tissue by permitting a clinician to create lesions in the tissue more effectively and safely.
摘要翻译：提供了一种用于评估身体中电极和组织之间的耦合程度的系统和方法。获得电极和组织之间的复阻抗的第一和第二分量的值（例如，电阻和电抗或阻抗幅度和相位角）。根据这些值，计算出表示电极和组织之间的耦合程度的耦合指数。耦合指数可以以各种方式显示给临床医生以指示与临床医生的耦合程度。该系统和方法通过允许临床医生更有效和安全地在组织中产生损伤来发现组织消融中的特定应用。

94. 发明授权

US09579483B2 Pressure-sensitive conductive composite contact sensor and method for contact sensing 有权
标题翻译：压敏导电复合接触传感器和接触感应方法
公开(公告)号：US09579483B2
公开(公告)日：2017-02-28
申请号：US11647314
申请日：2006-12-29
申请人： Kedar Ravindra Belhe , Saurav Paul
发明人： Kedar Ravindra Belhe , Saurav Paul
IPC分类号： A61B5/00 , A61M25/00 , A61B18/14
CPC分类号： A61B18/1492 , A61B5/6885 , A61B2018/00083 , A61B2018/00577 , A61B2018/00875 , A61B2018/00988 , A61B2090/064 , A61B2090/065 , A61B2562/0209 , A61M25/00 , A61M2025/0002 , G01L1/20
摘要： A catheter assembly for assessing contact between the catheter assembly and tissue is disclosed. The assembly includes a catheter shaft and a pressure sensitive conductive composite member whose electrical resistance varies with pressure applied to the catheter assembly. The assembly also includes at least one measurement terminal to permit the measurement of changes in the electrical characteristics of the pressure sensitive conductive composite member. The assembly may optionally include a measurement device to measure resistance, impedance and/or other electrical characteristics. The assembly may utilize a reference electrode secured to the patient's tissue, which permits the measurement device to measure changes between the reference electrode and the at least one measurement terminal. Optionally, the assembly may include a conductive outer layer. Also disclosed are sensor assemblies, contact sensor, methods of contact sensing, and methods of manufacturing relating to the use of pressure sensitive conductive composites.
摘要翻译：公开了一种用于评估导管组件和组织之间的接触的导管组件。组件包括导管轴和压力敏感的导电复合构件，其电阻随着施加到导管组件的压力而变化。组件还包括至少一个测量端子，以允许测量压敏导电复合构件的电特性的变化。组件可以可选地包括测量电阻，阻抗和/或其他电特性的测量装置。组件可以利用固定到患者组织的参考电极，其允许测量装置测量参考电极和至少一个测量终端之间的变化。可选地，组件可以包括导电外层。还公开了传感器组件，接触传感器，接触感测方法以及与使用压敏导电复合材料有关的制造方法。

95. 发明授权

US09198726B2 Photodynamic-based cardiac ablation device and method via the esophagus 有权
标题翻译：基于光动力学的心脏消融装置和通过食道的方法
公开(公告)号：US09198726B2
公开(公告)日：2015-12-01
申请号：US11967350
申请日：2007-12-31
申请人： Saurav Paul , Israel A. Byrd
发明人： Saurav Paul , Israel A. Byrd
IPC分类号： A61B18/18 , A61B18/24 , A61N5/06 , A61B18/22
CPC分类号： A61B18/24 , A61B2018/2272 , A61N5/0601 , A61N5/062
摘要： A method and system for ablation of cardiac tissue in a living being via the esophagus is provided. The method includes the step of introducing a photodynamic substance to the cardiac tissue. A deformable, elongated body defining a proximal end and a distal end is inserted into an esophagus of the living being. The distal end of the elongated body is located proximate the cardiac tissue. A first set of electromagnetic radiation is then directed from the distal end of the elongated body towards the cardiac tissue. Reflective and opaque surfaces at the distal end of the elongated body may be used to direct the electromagnetic radiation and an expandable membrane at the distal end may be used to urge the distal end of the elongated body to a predetermined position within the esophagus.
摘要翻译：提供了一种通过食道消融心脏组织的方法和系统。该方法包括将光动力学物质引入心脏组织的步骤。限定近端和远端的可变形的细长主体被插入到生命的食道中。细长体的远端位于心脏组织附近。然后将第一组电磁辐射从细长体的远端引向心脏组织。在细长体的远端处的反射和不透明表面可以用于引导电磁辐射，并且在远端处的可扩张膜可以用于将细长体的远端推动到食道内的预定位置。

96. 发明授权

US08449535B2 System and method for assessing coupling between an electrode and tissue 有权
标题翻译：用于评估电极和组织之间的耦合的系统和方法
公开(公告)号：US08449535B2
公开(公告)日：2013-05-28
申请号：US12253637
申请日：2008-10-17
申请人： Don Curtis Deno , Stephan Paul Miller , Saurav Paul
发明人： Don Curtis Deno , Stephan Paul Miller , Saurav Paul
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B5/053 , A61B18/1233 , A61B18/14 , A61B2018/00178 , A61B2018/00875 , A61B2090/065
摘要： A system and method for assessing a degree of coupling between an electrode and tissue in a body is provided. Values for first and second components of a complex impedance (e.g., resistance and reactance or impedance magnitude and phase angle) between the electrode and the tissue are obtained. From these values, a coupling index is calculated that is indicative of a degree of coupling between the electrode and the tissue. The coupling index may be displayed to a clinician in a variety of ways to indicate the degree of coupling to the clinician. The system and method find particular application in ablation of tissue by permitting a clinician to create lesions in the tissue more effectively and safely.
摘要翻译：提供了一种用于评估身体中电极和组织之间的耦合程度的系统和方法。获得电极和组织之间的复阻抗的第一和第二分量的值（例如，电阻和电抗或阻抗幅度和相位角）。根据这些值，计算表示电极和组织之间的耦合程度的耦合指数。耦合指数可以以各种方式显示给临床医生以指示与临床医生的耦合程度。该系统和方法通过允许临床医生更有效和安全地在组织中产生损伤来发现组织消融中的特定应用。

97. 发明授权

US08403925B2 System and method for assessing lesions in tissue 有权
标题翻译：用于评估组织病变的系统和方法
公开(公告)号：US08403925B2
公开(公告)日：2013-03-26
申请号：US12622488
申请日：2009-11-20
申请人： Stephan P. Miller , Don Curtis Deno , Saurav Paul , Liane R. Teplitsky
发明人： Stephan P. Miller , Don Curtis Deno , Saurav Paul , Liane R. Teplitsky
IPC分类号： A61B18/12
CPC分类号： A61B18/1492 , A61B18/1233 , A61B18/14 , A61B2018/00178 , A61B2018/00577 , A61B2018/00648 , A61B2018/00696 , A61B2018/00773 , A61B2018/00791 , A61B2018/00863 , A61B2018/00875 , A61B2090/065
摘要： A method and system for assessing lesion formation in tissue is provided. The system includes an electronic control unit (ECU). The ECU is configured to acquire values for first and second components of a complex impedance between the electrode and the tissue, and to calculate an index responsive to the first and second values. The ECU is further configured to process the ECI to assess lesion formation in the tissue.
摘要翻译：提供了一种用于评估组织中病变形成的方法和系统。该系统包括电子控制单元（ECU）。 ECU被配置为获取电极和组织之间的复阻抗的第一和第二分量的值，并且响应于第一和第二值来计算索引。 ECU还被配置为处理ECI以评估组织中的病变形成。

98. 发明申请

US20110276046A1 Monitoring, Managing and/or Protecting System and Method for Non-Targeted Tissue 有权
标题翻译：非目标组织的监测，管理和/或保护系统和方法
公开(公告)号：US20110276046A1
公开(公告)日：2011-11-10
申请号：US13101755
申请日：2011-05-05
申请人： Reed R. Heimbecher , Saurav Paul , John M. Berns , Jeffrey A. Schweitzer
发明人： Reed R. Heimbecher , Saurav Paul , John M. Berns , Jeffrey A. Schweitzer
IPC分类号： A61B18/12
CPC分类号： A61B18/1492 , A61B18/18 , A61B34/30 , A61B90/04 , A61B2018/0022 , A61B2018/00285 , A61B2018/00642 , A61B2018/00696 , A61B2018/00714 , A61B2018/00779 , A61B2018/00869 , A61B2018/00875 , A61B2018/00898 , A61B2018/00904 , A61B2034/301
摘要： A monitoring, managing and protecting system is provided that includes a monitoring probe working in conjunction with an ablating device. The probe is configured to be positioned in close proximity to a region of non-targeted tissue proximate an ablation site of targeted tissue and to be operatively connected to an electrical response assessment system or component. The probe includes an elongate shaft having proximal and distal ends, with a handle disposed at the proximal end thereof and a tissue monitoring and protecting apparatus disposed at the distal end thereof. The ablating device includes an elongate shaft having proximal and distal ends, with a handle mounted at the proximal end thereof and an ablation element mounted at the distal end thereof. The monitoring probe measures electrical characteristics of the non-targeted tissue and/or of the tissue between the monitoring electrode and the ablation electrode. The electrical response assessment system determines whether the tissue is being damaged based on the electrical measurements. The monitoring, managing and protecting system can notify a practitioner based on the determination, or modify or stop the ablation procedure.
摘要翻译：提供了一个监测，管理和保护系统，其中包括与消融装置一起工作的监测探头。探针被配置为定位成紧邻目标组织的消融部位附近的非目标组织的区域并且可操作地连接到电响应评估系统或部件。探针包括具有近端和远端的细长轴，其近端处设有手柄，以及设置在其远端处的组织监测和保护装置。该烧蚀装置包括具有近端和远端的细长轴，其手柄安装在其近端处，并且消融元件安装在其远端处。监测探针测量监测电极和消融电极之间的非目标组织和/或组织的电特性。电响应评估系统基于电测量确定组织是否被损坏。监测，管理和保护系统可以根据确定或修改或停止消融程序通知医生。

99. 发明申请

US20110160584A1 Acoustic coupling for assessment and ablation procedures 有权
标题翻译：用于评估和消融程序的声耦合
公开(公告)号：US20110160584A1
公开(公告)日：2011-06-30
申请号：US12979475
申请日：2010-12-28
申请人： Saurav Paul , Troy T. Tegg , Reed R. Heimbecher
发明人： Saurav Paul , Troy T. Tegg , Reed R. Heimbecher
IPC分类号： A61B8/14 , A61N7/00
CPC分类号： A61N7/022 , A61B8/0883 , A61B8/12 , A61B8/445 , A61B8/4494 , A61B2017/00106
摘要： Acoustic coupling systems and methods are disclosed as these can be used for assessment and ablation procedures. An exemplary acoustic assessment system for a catheter may comprise a flexible catheter shaft. At least one acoustic transducer is positioned in the flexible catheter shaft. The at least one acoustic transducer emits a generated acoustic signal for reflection by adjacent tissue. The at least one acoustic transducer receives a reflected acoustic signal from the adjacent tissue and generates electrical signals corresponding to one or more property of the tissue. An output device is electrically connected to the at least one acoustic transducer. The output device receives the electrical signals and generate output for a user for assessing the tissue.
摘要翻译：公开了声耦合系统和方法，因为这些系统和方法可用于评估和消融程序。用于导管的示例性声学评估系统可以包括柔性导管轴。至少一个声换能器被定位在柔性导管轴中。所述至少一个声换能器发射产生的声信号以供相邻组织反射。所述至少一个声换能器接收来自相邻组织的反射声信号，并产生对应于组织的一个或多个属性的电信号。输出装置电连接到至少一个声换能器。输出设备接收电信号并产生用于用户评估组织的输出。

100. 发明申请

US20100168777A1 TISSUE PUNCTURE ASSEMBLIES AND METHODS FOR PUNCTURING TISSUE 有权
标题翻译：组织支架组件和组织的组织方法
公开(公告)号：US20100168777A1
公开(公告)日：2010-07-01
申请号：US12345243
申请日：2008-12-29
申请人： Todd R. Stangenes , Saurav Paul
发明人： Todd R. Stangenes , Saurav Paul
IPC分类号： A61B17/34
CPC分类号： A61B17/320016 , A61B8/12 , A61B17/00234 , A61B17/3415 , A61B18/1492 , A61B2017/00084 , A61B2017/00247 , A61B2018/00392 , A61B2090/3782
摘要： A tissue puncture assembly includes an elongate tubular member having a lumen, a distal portion having a side wall, a side port opening extending through the side wall and, and a guiding surface having a distal end that extends adjacent to a distal edge of the side port opening. The tissue puncture assembly further includes a flexible puncture member insertable through the lumen of the elongate tubular member. The flexible puncture member deflects upon contacting the guiding surface to exit the elongate tubular member through the side port in a lateral direction relative to a longitudinal direction of the elongate tubular member. The tissue puncture member is capable of puncturing tissue at an oblique angle. The tissue puncture member may further adopt a pre-formed shape at its distal end to prevent inadvertent puncture of tissue and to maintain access to the puncture site. The transseptal puncture assembly may include various sensors to identify tissue structures and precisely locate the desired puncture site.
摘要翻译：组织穿刺组件包括具有内腔的细长管状构件，具有侧壁的远侧部分，延伸穿过侧壁的侧面开口，以及具有与侧面的远侧边缘相邻延伸的远端的引导表面港口开放。组织穿刺组件还包括可插入通过细长管状构件的内腔的柔性穿刺构件。柔性穿刺构件在接触引导表面时偏转，以相对于细长管状构件的纵向在横向方向上通过侧端口离开细长管状构件。组织穿刺构件能够以倾斜的角度刺穿组织。组织穿刺构件还可以在其远端处采用预成形的形状，以防止组织的无意的穿刺并且保持对穿刺部位的通路。经腔穿刺组件可以包括用于识别组织结构并精确定位所需穿刺部位的各种传感器。

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