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91. 发明申请

US20110172379A1 Ziegler-Natta Catalyst Systems and Polymers Formed Therefrom 有权
标题翻译：齐格勒 - 纳塔催化剂系统和聚合物形成于此
公开(公告)号：US20110172379A1
公开(公告)日：2011-07-14
申请号：US12685198
申请日：2010-01-11
申请人： Kayo Vizzini , David Knoeppel , Lei Zhang
发明人： Kayo Vizzini , David Knoeppel , Lei Zhang
IPC分类号： C08F10/02 , C08F4/60
CPC分类号： C08F10/00 , C08F110/02 , C08F4/6548 , C08F4/6555 , C08F2500/07 , C08F2500/26
摘要： Processes of forming catalyst systems, catalyst systems and polymers formed therefrom are described herein. The processes generally include providing a first compound including a magnesium dialkoxide, contacting the first compound with a second compound to form a solution of reaction product “A”, wherein the second compound is generally represented by the formula: Ti(OR1)4; wherein R1 is selected from C1 to C10 linear to branched alkyls, contacting the solution of reaction product “A” with a first metal halide to form a solid reaction product “B”, contacting solid reaction product “B” with a second metal halide to form reaction product “C” and contacting reaction product “C” with reducing agent to form a catalyst component.
摘要翻译：本文描述了形成催化剂体系，催化剂体系和由其形成的聚合物的方法。所述方法通常包括提供包含二烷氧基镁的第一化合物，使第一化合物与第二化合物接触以形成反应产物“A”的溶液，其中第二化合物通常由下式表示：Ti（OR 1）4; 其中R1选自C1至C10直链至支链烷基，使反应产物“A”的溶液与第一金属卤化物接触以形成固体反应产物“B”，使固体反应产物“B”与第二金属卤化物接触形成反应产物“C”并使反应产物“C”与还原剂接触以形成催化剂组分。

92. 发明授权

US07977193B1 Trench-gate MOSFET with capacitively depleted drift region 有权
标题翻译：具有电容耗尽漂移区的沟槽栅极MOSFET
公开(公告)号：US07977193B1
公开(公告)日：2011-07-12
申请号：US12908774
申请日：2010-10-20
申请人： Donald R. Disney , Tiesheng Li , Lei Zhang
发明人： Donald R. Disney , Tiesheng Li , Lei Zhang
IPC分类号： H01L29/78
CPC分类号： H01L29/7813 , H01L29/407 , H01L29/42376 , H01L29/66734
摘要： A trench-gate metal oxide semiconductor field-effect transistor includes a field plate that extends into a drift region of the transistor. The field plate is configured to deplete the drift region when the transistor is in the OFF-state. The field plate is formed in a field plate trench. The field plate trench may be formed using a self-aligned etch process. The conductive material of the field plate and gate of the transistor may be deposited in the same deposition process step. The conductive material may be etched thereafter to form the field plate and the gate in the same etch process step.
摘要翻译：沟槽栅极金属氧化物半导体场效应晶体管包括延伸到晶体管的漂移区域的场板。场板配置为在晶体管处于截止状态时耗尽漂移区域。场板形成在场板沟槽中。场板沟槽可以使用自对准蚀刻工艺形成。晶体管的场板和栅极的导电材料可以在相同的沉积工艺步骤中沉积。之后可以蚀刻导电材料，以在相同的蚀刻工艺步骤中形成场板和栅极。

93. 发明授权

US07972854B2 Methods and compositions for targeted cleavage and recombination 有权
标题翻译：用于靶向切割和重组的方法和组合物
公开(公告)号：US07972854B2
公开(公告)日：2011-07-05
申请号：US10587723
申请日：2005-02-03
申请人： Jeffrey C. Miller , Lei Zhang
发明人： Jeffrey C. Miller , Lei Zhang
IPC分类号： C12N15/00
CPC分类号： C12N15/10 , C07K14/4702 , C12N9/22
摘要： Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to the genomic region.
摘要翻译：本文公开了用于基因组序列的靶向切割，基因组序列的靶向改变以及基因组区域和与该基因组区域同源的外源多核苷酸之间的靶向重组的方法和组合物。

94. 发明申请

US20110158957A1 Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases 有权
标题翻译：使用工程化锌指蛋白核酸酶靶向破坏T细胞受体基因
公开(公告)号：US20110158957A1
公开(公告)日：2011-06-30
申请号：US12927292
申请日：2010-11-10
申请人： Maria Chiara Bonini , Pietro Genovese , Philip D. Gregory , Michael C. Holmes , Luigi Naldini , David Paschon , Elena Provasi , Lei Zhang
发明人： Maria Chiara Bonini , Pietro Genovese , Philip D. Gregory , Michael C. Holmes , Luigi Naldini , David Paschon , Elena Provasi , Lei Zhang
IPC分类号： A61K35/12 , C12N9/16 , C07H21/04 , C12N15/63 , C12N5/07 , C12N5/00 , A61P35/00 , A61P37/06 , A61P31/00
CPC分类号： A61K35/28 , A61K35/00 , A61K35/17 , A61K38/00 , C07K14/7051 , C07K2319/81 , C07K2319/95 , C12N9/22 , C12N15/01
摘要： Disclosed herein are methods and compositions for inactivating TCR genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain in conditions able to preserve cell viability. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided. Disclosed herein are also methods and compositions for expressing a functional exogenous TCR in the absence of endogenous TCR expression in T lymphocytes, including lymphocytes with a central memory phenotype. Polynucleotides encoding exogenous TCR, vectors comprising polynucleotides encoding exogenous TCR and cells comprising polynucleotides encoding exogenous TCR and/or cells comprising exogenous TCR are also provided.
摘要翻译：本文公开了在能够保持细胞活力的条件下使用锌指核酸酶（ZFN）灭活TCR基因的方法和组合物，所述锌指核酸酶包含锌指蛋白和切割结构域或切割半结构域。还提供了编码ZFN的多核苷酸，包含编码ZFN的多核苷酸的载体和包含编码ZFN和/或包含ZFN的细胞的多核苷酸的细胞。本文公开的也是在T淋巴细胞（包括具有中枢记忆表型的淋巴细胞）中不存在内源性TCR表达时表达功能性外源性TCR的方法和组合物。还提供了编码外源性TCR的多核苷酸，包含编码外源性TCR的多核苷酸的载体和包含编码外源性TCR的多核苷酸的细胞和/或包含外源TCR的细胞。

95. 发明申请

US20110136916A1 6-SHOGAOL FOR USING IN A METHOD FOR THE TREATMENT OF LEUKEMIA 审中-公开
标题翻译： 6-SHOGAOL用于治疗低密度脂蛋白的方法
公开(公告)号：US20110136916A1
公开(公告)日：2011-06-09
申请号：US12938949
申请日：2010-11-03
申请人： Ping Li , Yongbo Peng , Lianwen Qi , Xiaodong Wen , Jiang Ma , Ping Zhou , Lei Zhang , Qun Liu , Ehu Liu , Jun Chen
发明人： Ping Li , Yongbo Peng , Lianwen Qi , Xiaodong Wen , Jiang Ma , Ping Zhou , Lei Zhang , Qun Liu , Ehu Liu , Jun Chen
IPC分类号： A61K31/122 , C07C49/255 , A61P35/02
CPC分类号： A61K31/122
摘要： The present invention relates to the field of natural drugs, particularly to 6-shogaol for using in a method for the treatment of leukemia. The present invention provides a method for treating leukemia by applying a therapeutically effective dose of 6-shogaolt and this therapeutic method can be used for treating leukemia in mammals including human being.
摘要翻译：本发明涉及天然药物领域，特别涉及用于治疗白血病的方法中的6-shoolol。本发明提供了通过施用治疗有效剂量的6-shogaolt治疗白血病的方法，并且该治疗方法可用于治疗包括人在内的哺乳动物的白血病。

96. 发明申请

US20110128889A1 Method for Selecting and Configuring Network Supernodes 失效
标题翻译：选择和配置网络超频的方法
公开(公告)号：US20110128889A1
公开(公告)日：2011-06-02
申请号：US12730866
申请日：2010-03-24
申请人： Jianxin Liao , Jing Wang , Chun Wang , Wei Li , Li Wan , Xiaomin Zhu , Lei Zhang , Tong Xu , Lejian Zhang , Qiwei Shen , Limin Fan , Li Cheng
发明人： Jianxin Liao , Jing Wang , Chun Wang , Wei Li , Li Wan , Xiaomin Zhu , Lei Zhang , Tong Xu , Lejian Zhang , Qiwei Shen , Limin Fan , Li Cheng
IPC分类号： H04L12/28
CPC分类号： H04L41/0893 , H04L45/04 , H04L67/1051 , H04L67/1093
摘要： A method for selecting and configuring network supernodes including the following operational steps: in a first set period T1, each node other than the control node in a network sends information on interactions between the node and other nodes to the control node regularly; and in a second set period T2, the control node divides the nodes into a plurality of node clusters according to the received information on interactions among the nodes, and selects supernodes from each node cluster, each node belonging uniquely to a node cluster. The supernode selection according to the invention takes into account both performance and resource conditions of itself and interactions with other nodes. Therefore, when implementing control over other nodes in the node cluster to which it belongs, the selected supernode can find the corresponding node in a short time and shorten the searching time and path, thereby improving the working efficiency. Meanwhile, parameters such as the acquiring period of node interaction information, and the division and adjustment periods of node clusters can be adjusted dynamically with the actual interaction conditions of the network.
摘要翻译：一种用于选择和配置网络超节点的方法，包括以下操作步骤：在第一设定周期T1中，除了网络中的控制节点之外的每个节点向节点定期向控制节点发送关于节点与其他节点之间的交互的信息; 并且在第二设定周期T2中，控制节点根据接收到的关于节点之间的交互的信息将节点划分为多个节点簇，并且从每个节点簇选择每个节点的节点簇唯一的节点。根据本发明的超级节点选择考虑了自身的性能和资源状况以及与其他节点的交互。因此，当对其所属的节点集群中的其他节点实施控制时，所选择的超节点可以在短时间内找到相应的节点，缩短搜索时间和路径，从而提高工作效率。同时，可以根据网络的实际交互条件动态调整节点交互信息采集周期等参数，节点集群划分和调整周期。

97. 发明申请

US20110082078A1 Methods and compositions for treating neuropathies 有权
标题翻译：治疗神经病的方法和组合物
公开(公告)号：US20110082078A1
公开(公告)日：2011-04-07
申请号：US12658258
申请日：2010-02-04
申请人： Carolyn Dent , Josee Laganiere , Xiangdong Meng , David Paschon , Siyuan Tan , Lei Zhang , Steve H. Zhang
发明人： Carolyn Dent , Josee Laganiere , Xiangdong Meng , David Paschon , Siyuan Tan , Lei Zhang , Steve H. Zhang
IPC分类号： A61K38/17 , C07K14/00 , C07H21/04 , A61P3/10 , A61P25/16 , A61P27/02 , C12N5/00
CPC分类号： C07K14/4702 , A61K38/00
摘要： Disclosed herein are methods and compositions for treating neuropathies by modulating endogenous NT-3 of GDNF gene expression.
摘要翻译：本文公开了通过调节GDNF基因表达的内源性NT-3来治疗神经病的方法和组合物。

98. 发明授权

US07914665B2 Method for making a lubricating oil with improved low temperature properties 有权
标题翻译：制造具有改善的低温性能的润滑油的方法
公开(公告)号：US07914665B2
公开(公告)日：2011-03-29
申请号：US11667236
申请日：2005-11-14
申请人： Lei Zhang , Elizabeth Stavens , Lisa I-Ching Yeh , Ian A. Cody , William J. Murphy , Thomas R. Palmer
发明人： Lei Zhang , Elizabeth Stavens , Lisa I-Ching Yeh , Ian A. Cody , William J. Murphy , Thomas R. Palmer
IPC分类号： C10G29/20 , C10G47/02
CPC分类号： G01N33/30 , C10G67/04 , C10G2300/1022 , C10G2300/1037 , C10G2300/1062 , C10G2300/1074 , C10G2300/202 , C10G2300/301 , C10G2300/302 , C10G2300/304 , C10G2300/4018 , C10G2300/4025 , C10G2300/44 , C10G2400/10 , G01N30/463 , G01N2030/025
摘要： The invention relates to a process for preparing lube oil basestocks from lube oil boiling range feeds. More particularly, the present invention is directed toward a process wherein a wax containing feed is solvent dewaxed to produce at least a partially dewaxed lube oil boiling range stream, which is hydrodewaxed to produce a first lube basestock. The first lube basestock is added to an independently selected second lube basestock and additives to make a lubricating oil.
摘要翻译：本发明涉及从润滑油沸程饲料制备润滑油基础油料的方法。更具体地，本发明涉及一种方法，其中将含蜡进料溶剂脱蜡以产生至少部分脱蜡的润滑油沸程流，其被加氢脱蜡以产生第一润滑油基础油料。将第一润滑油基础油加入到独立选择的第二润滑油基础油和添加剂中以制备润滑油。

99. 发明申请

US20100320746A1 PIPING CONNECTOR AND METHOD ON CONNECTING PIPE 审中-公开
标题翻译：管道连接器和连接管道的方法
公开(公告)号：US20100320746A1
公开(公告)日：2010-12-23
申请号：US12516531
申请日：2007-11-28
申请人： Michael Lin , Lei Zhang
发明人： Michael Lin , Lei Zhang
IPC分类号： F16L21/00 , F16L25/00
CPC分类号： F16L13/141 , F16L2201/10
摘要： A method to connect piping and a piping connection, having the features of a ring connector configured to snugly fit around an external diameter of a pipe; and a piping shield connected to the ring connector, the piping shield having at least one observation window cut into the shield, wherein the piping shield covers an abutment end of the pipe to be connected, wherein a joint between the ring connector and the piping shield forms a connection.
摘要翻译：一种连接管道和管道连接的方法，其具有环形连接器的特征，其被配置为紧密地配合在管的外径周围; 以及连接到所述环形连接器的管道屏蔽件，所述管道屏蔽件具有切割到所述屏蔽件中的至少一个观察窗口，其中所述管道屏蔽罩覆盖要连接的所述管道的邻接端，其中所述环形连接器和所述管道屏蔽形成一个连接。

100. 发明授权

US07806109B2 Fuel supply apparatus 有权
标题翻译：燃油供应装置
公开(公告)号：US07806109B2
公开(公告)日：2010-10-05
申请号：US12149672
申请日：2008-05-06
申请人： Mamoru Tateishi , Yasuo Hosokawa , Tetsuji Inoue , Lei Zhang , Hiroya Abe
发明人： Mamoru Tateishi , Yasuo Hosokawa , Tetsuji Inoue , Lei Zhang , Hiroya Abe
IPC分类号： F02M37/08 , F02M37/04
CPC分类号： F02M37/103 , B01D35/027 , B01D35/26
摘要： A fuel pump unit includes a fuel pump which is driven by a motor, a secondary filter case placed to surround the fuel pump and contains a filter, a reserve cup which houses the fuel pump and the secondary filter case, and a pump controller which drivingly controls the fuel pump. A shielding material is provided in the reserve cup to shield electrical noise generated by the fuel pump. The shielding material is grounded. The pump controller includes a pump drive circuit which is provided with an electric filter.
摘要翻译：燃料泵单元包括由电动机驱动的燃料泵，放置在燃料泵周围并包含过滤器的二次过滤器壳体，容纳燃料泵和辅助过滤器壳体的储备杯以及驱动的泵控制器控制燃油泵。在储备杯中设置屏蔽材料以屏蔽由燃料泵产生的电噪声。屏蔽材料接地。泵控制器包括具有电过滤器的泵驱动电路。

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