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1. 发明申请

US20160368593A1 Cockpit seat armrest avionics cursor control device 审中-公开
标题翻译：驾驶舱座椅扶手航空电子游标控制装置
公开(公告)号：US20160368593A1
公开(公告)日：2016-12-22
申请号：US14545771
申请日：2015-06-18
申请人： Jeffrey C. Miller
发明人： Jeffrey C. Miller
IPC分类号： B64C13/04 , B64D11/06
CPC分类号： B64C13/042 , B60N2/797 , B64D11/0644 , B64D11/0689
摘要： The invention concerns an improved CCD integration within pilot seat armrests, with benefits including ease and accuracy of CCD use, premium space savings on cockpit consoles, the ability to be retracted when not in use, always remaining within comfortable and easy reach of tall and short pilots alike and not interfering with other devices such as “side-stick” flight controls. The compactness and accuracy of use of the invention, its ability to be stowed, and its space-saving features set this CCD apart from existing CCDs and improve cockpit structure and pilot operation of aircraft that employ this invention.
摘要翻译：本发明涉及在先导座椅扶手中的改进的CCD集成，其益处包括CCD使用的容易性和准确性，驾驶舱控制台上的优质空间节省，不使用时缩回的能力，始终保持在舒适和容易达到高和短飞行员都不会干扰其他设备，如“旁路”飞行控制。本发明使用的紧凑性和准确性，其被收起的能力以及其节省空间的特征使得该CCD与现有的CCD分离，并改善了采用本发明的飞机的驾驶舱结构和飞行员操作。

2. 发明授权

US09394531B2 Compositions for linking DNA-binding domains and cleavage domains 有权
公开(公告)号：US09394531B2
公开(公告)日：2016-07-19
申请号：US12455143
申请日：2009-05-28
申请人： Jeffrey C. Miller
发明人： Jeffrey C. Miller
IPC分类号： C07K2/00 , C12N9/22
CPC分类号： C12N9/22 , C07K2319/00 , C07K2319/80 , C12N15/907
摘要： Disclosed herein are compositions for linking DNA binding domains and cleavage domains (or cleavage half-domains) to form non-naturally occurring nucleases. Also described are methods of making and using compositions comprising these linkers.

3. 发明申请

US20110201055A1 Engineered cleavage half-domains 有权
公开(公告)号：US20110201055A1
公开(公告)日：2011-08-18
申请号：US12931660
申请日：2011-02-07
申请人： Yannick Doyon , Jeffrey C. Miller
发明人： Yannick Doyon , Jeffrey C. Miller
IPC分类号： C12P19/34 , C07K14/00 , C07H21/04 , C12N1/00 , C12N9/96
CPC分类号： C12N15/907 , C07K7/06 , C07K14/47 , C07K2319/50 , C07K2319/80 , C07K2319/81 , C12N9/22 , C12N15/85 , C12Y301/21004
摘要： Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.

4. 发明申请

US20110030076A1 Methods and compositions for targeted cleavage and recombination 有权
标题翻译：用于靶向切割和重组的方法和组合物
公开(公告)号：US20110030076A1
公开(公告)日：2011-02-03
申请号：US12804234
申请日：2010-07-16
申请人： Fyodor Urnov , Michael C. Holmes , Jeffrey C. Miller , Carl O. Pabo
发明人： Fyodor Urnov , Michael C. Holmes , Jeffrey C. Miller , Carl O. Pabo
IPC分类号： A01K67/027 , C12N15/01 , C12N15/09 , C12N5/071 , C12N5/04 , A01H5/00
CPC分类号： A61K35/12 , C07K14/43595 , C07K14/4717 , C07K14/715 , C07K2319/00 , C07K2319/09 , C07K2319/81 , C12N9/14 , C12N9/22 , C12N15/62 , C12N15/85 , C12N2800/80
摘要： Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain and polynucleotides encoding same. Methods for targeted cleavage include introduction of such fusion proteins, or polynucleotides encoding same, into a cell. Methods for targeted recombination additionally include introduction of an exogenous polynucleotide homologous to a genomic region into cells comprising the disclosed fusion proteins.
摘要翻译：本文公开了用于基因组序列的靶向切割，基因组序列的靶向改变以及基因组区域和与该基因组区域同源的外源多核苷酸之间的靶向重组的方法和组合物。组合物包括包含切割结构域（或切割半结构域）和工程化锌指结构域的融合蛋白和编码它们的多核苷酸。用于靶向切割的方法包括将这种融合蛋白或其编码的多核苷酸引入细胞。用于靶向重组的方法另外包括将与基因组区域同源的外源多核苷酸引入包含所公开的融合蛋白的细胞中。

5. 发明申请

US20100257638A1 ZINC FINGER NUCLEASE-MEDIATED HOMOLOGOUS RECOMBINATION 有权
标题翻译： ZINC指纹核介导的同源重建
公开(公告)号：US20100257638A1
公开(公告)日：2010-10-07
申请号：US12376871
申请日：2007-08-09
申请人： Qihua Cai , Jeffrey C. Miller , William M. Ainley , Robbi J. Garrison , Joseph F. Petolino , Beth C. Rubin-Wilson , Lisa L. Schulenberg , Andrew F. Worden
发明人： Qihua Cai , Jeffrey C. Miller , William M. Ainley , Robbi J. Garrison , Joseph F. Petolino , Beth C. Rubin-Wilson , Lisa L. Schulenberg , Andrew F. Worden
IPC分类号： A01H5/00 , C12N15/82 , C12N5/04 , A01H5/10
CPC分类号： C12N15/8213 , C07K14/00 , C07K2319/81 , C12N9/22
摘要： Disclosed herein are methods and compositions for targeted integration of an exogenous sequence into a predetermined target site in a plant genome.
摘要翻译：本文公开了用于将外源序列靶向整合到植物基因组中的预定靶位点的方法和组合物。

6. 发明申请

US20090311787A1 Engineered cleavage half-domains 有权
公开(公告)号：US20090311787A1
公开(公告)日：2009-12-17
申请号：US12217185
申请日：2008-07-02
申请人： Jeffrey C. Miller
发明人： Jeffrey C. Miller
IPC分类号： C12N15/09 , C12N15/87
CPC分类号： C12N9/22
摘要： Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.

7. 发明授权

US08349810B2 Methods for targeted cleavage and recombination of CCR5 有权
标题翻译： CCR5靶向切割和重组的方法
公开(公告)号：US08349810B2
公开(公告)日：2013-01-08
申请号：US13165866
申请日：2011-06-22
申请人： Jeffrey C. Miller , Lei Zhang
发明人： Jeffrey C. Miller , Lei Zhang
IPC分类号： A61K48/00 , C12N5/0783 , C12N5/074 , C12N5/0789 , C12N15/00
CPC分类号： C12N15/10 , C07K14/4702 , C12N9/22
摘要： Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain, as well as polynucleotides encoding same. Fusion proteins comprising cleavage half-domains are used in pairs to reconstitute a functional cleavage domain. In these fusion proteins, the zinc finger domain can be N-terminal to the cleavage half-domain, or the cleavage half-domain can be N-terminal to the zinc finger domain. The availability of fusion endonucleases having these different polarities allows targeting of zinc finger endonucleases either to opposite strands of the DNA target or to the same strand of the DNA target, thereby increasing the number of possible sequences which can be targeted and cleaved by the fusion proteins.
摘要翻译：本文公开了用于基因组序列的靶向切割，基因组序列的靶向改变以及基因组区域和与该基因组区域同源的外源多核苷酸之间的靶向重组的方法和组合物。组合物包括包含切割结构域（或切割半结构域）和工程化锌指结构域的融合蛋白，以及编码它们的多核苷酸。包含切割半结构域的融合蛋白成对使用以重构功能性切割结构域。在这些融合蛋白中，锌指结构域可以是切割半结构域的N末端，或者切割半结构域可以是锌指结构域的N末端。具有这些不同极性的融合核酸内切酶的可获得性允许将锌指内切核酸酶靶向DNA靶的相对链或DNA靶的相同链，从而增加可由融合蛋白靶向和切割的可能序列的数目。

8. 发明申请

US20110301073A1 Novel DNA-binding proteins and uses thereof 有权
标题翻译：新型DNA结合蛋白及其用途
公开(公告)号：US20110301073A1
公开(公告)日：2011-12-08
申请号：US13068735
申请日：2011-05-17
申请人： Philip D. Gregory , Jeffrey C. Miller , David Paschon , Edward J. Rebar , Siyuan Tan , Fyodor Urnov , Lei Zhang
发明人： Philip D. Gregory , Jeffrey C. Miller , David Paschon , Edward J. Rebar , Siyuan Tan , Fyodor Urnov , Lei Zhang
IPC分类号： A61K38/02 , C07K19/00 , C12N9/16 , C12N5/071 , C12N5/04 , C12N1/21 , C07H21/00 , C12N1/19 , C12N5/10 , C12N1/15 , C12N1/13 , C12N1/11 , C07K14/00 , C12N1/16
CPC分类号： C12N15/907 , A61K38/00 , C07K14/195 , C07K2319/80 , C12N9/22 , C12N15/52 , C12N15/62 , C12N15/8213 , C12N15/85 , C12Y301/21004
摘要： Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
摘要翻译：本文公开了编码包含新的DNA结合结构域（包括TALE DNA结合结构域）的多肽，多核苷酸，细胞和生物体。还公开了使用这些新的DNA结合结构域来调节内源细胞序列的基因表达和/或基因组编辑的方法。

9. 发明申请

US20090305419A1 Compositions for linking DNA-binding domains and cleavage domains 有权
标题翻译：用于连接DNA结合结构域和切割结构域的组合物
公开(公告)号：US20090305419A1
公开(公告)日：2009-12-10
申请号：US12455143
申请日：2009-05-28
申请人： Jeffrey C. Miller
发明人： Jeffrey C. Miller
IPC分类号： C12N15/85 , C07K14/00 , C12N9/16 , C07H21/00 , C12N5/00
CPC分类号： C12N9/22 , C07K2319/00 , C07K2319/80 , C12N15/907
摘要： Disclosed herein are compositions for linking DNA binding domains and cleavage domains (or cleavage half-domains) to form non-naturally occurring nucleases. Also described are methods of making and using compositions comprising these linkers.
摘要翻译：本文公开了用于连接DNA结合结构域和切割结构域（或切割半结构域）以形成非天然存在的核酸酶的组合物。还描述了制备和使用包含这些接头的组合物的方法。

10. 发明授权

US08962281B2 Engineered cleavage half-domains 有权
公开(公告)号：US08962281B2
公开(公告)日：2015-02-24
申请号：US12931660
申请日：2011-02-07
申请人： Yannick Doyon , Jeffrey C. Miller
发明人： Yannick Doyon , Jeffrey C. Miller
IPC分类号： C12P21/06 , C12P19/34 , C12N9/96 , C12N1/20 , C12N15/00 , C12N5/02 , C07K1/00 , C07H21/04 , C12N15/85 , C12N9/22
CPC分类号： C12N15/907 , C07K7/06 , C07K14/47 , C07K2319/50 , C07K2319/80 , C07K2319/81 , C12N9/22 , C12N15/85 , C12Y301/21004
摘要： Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.

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