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91. 发明授权

US4642458A Polarimetric fibre sensor 失效
标题翻译：偏光纤传感器
公开(公告)号：US4642458A
公开(公告)日：1987-02-10
申请号：US774589
申请日：1985-09-05
申请人： David A. Jackson , Michael Corke , Alan D. Kersey
发明人： David A. Jackson , Michael Corke , Alan D. Kersey
IPC分类号： G01D5/34 , G01K11/32 , G02F1/01
CPC分类号： G01D5/344 , G01K11/32
摘要： A polarmetric fiber sensor comprises a lead fiber (1) and a shorter length of sensing fiber (2). Both fibers comprise higly birefringent optical fiber having orthogonal eigen modes and are spliced together with their eigen modes mutually rotated by 45.degree.. The sensing fiber (2) has a reflective distal end (6). Linearly polarized light from a laser source (3) is launched into one mode of the lead fiber (1) and light reflected from the distal end of the sensing fiber is recovered from the other mode of the lead fiber via a beam splitter (7) and photodiode (8). The resulting electrical signal produced by the photodiode (8) corresponds to the modal birefringence of the sensing fiber (2) and changes in this birefringence are monitored by processing means (9) to detect changes in a physical parameter sensed by the sensing fiber.
摘要翻译： PCT No.PCT / GB85 / 00017 Sec。 371日期：1985年9月5日 102（e）1985年9月5日PCT 1985年1月18日PCT PCT。出版物WO85 / 03124 日期：1985年7月18日。一种光纤传感器包括引线光纤（1）和较短长度的传感光纤（2）。两根纤维均包含具有正交本征模的高双折射光纤，并将其本征模式相互旋转45度而拼接在一起。感测光纤（2）具有反射的远端（6）。来自激光源（3）的线偏振光发射到引导光纤（1）的一种模式中，并且从感测光纤的远端反射的光通过分束器（7）从引线光纤的另一种模式恢复，和光电二极管（8）。由光电二极管（8）产生的电信号对应于感测光纤（2）的模式双折射，并且通过处理装置（9）监视该双折射的变化，以检测由感测光纤感测到的物理参数的变化。

92. 发明授权

US11324425B2 Apparatus and method for assessment of cancer margin 有权
公开(公告)号：US11324425B2
公开(公告)日：2022-05-10
申请号：US17073611
申请日：2020-10-19
申请人： Alan D. Kersey
发明人： Alan D. Kersey
IPC分类号： A61B5/1459 , A61B1/00 , A61B5/00 , A61B5/145 , G01N33/574 , G01N33/483 , G01J3/44 , G01N21/27 , G01N21/65
摘要： An apparatus for inspecting a biological tissue uses a pH-sensitive coating material to determine whether the tissue is normal or cancerous. The coating material is placed in contact with the tissue to be excited by an excitation light. The coating material is arranged to provide a response signal indicative of the pH value of the tissue. Using a fiber bundle having a plurality of optical fibers forming a linear array or a two-dimensional array adjacent the coating material, the imaging of localized surface pH in the biological tissue can be achieved using the response signal through each of the optical fibers. The fiber bundle can be arranged as a probe to examine the tissue for providing direct mapping of the tumor margin via a display, so that a surgeon can inspect the tissue in real-time.

93. 发明申请

US20150047438A1 ACOUSTIC PROBING TECHNIQUE FOR THE DETERMINATION OF MULTIPLE LIQUID/FROTH INTERFACES IN SEPARATION AND STORAGE VESSELS BASED ON AN OBLIQUE TOMOGRAPHIC ANALYSIS APPROACH 有权
标题翻译：用于基于OBIIQUE TOMOGRAPHIC ANALYSIS方法确定分离和存储容器中多个液体/快速接口的声学探测技术
公开(公告)号：US20150047438A1
公开(公告)日：2015-02-19
申请号：US14240519
申请日：2012-08-23
申请人： Alan D. Kersey , John Viega
发明人： Alan D. Kersey , John Viega
IPC分类号： G01F1/66
CPC分类号： G01F1/66 , G01F23/2965
摘要： Apparatus is provided featuring a signal processor configured to receive from an array of ultrasonic transponders around a tank, container or flow pipe signaling containing information about acoustic waves of energy penetrating a fluid in the tank, container or flow pipe; and determine using tomography a three-dimensional image of layers of the fluid in the tank, container or flow pipe based at least partly on the signalling received and. The signal processor provides corresponding signal containing information about the three-dimensional image of the layers of the fluid in the tank, container or flow pipe. The array is an obliquely oriented array of ultrasonic transponders arranged on an oblique plane to the axis of the tank or column; or the array is placed normal to the flow around the exterior of the flow pipe.
摘要翻译：提供的装置具有信号处理器，其被配置为从围绕罐，容器或流管的一组超声波应答器接收信号，该信号包含关于穿过罐，容器或流管中的流体的能量声波的信息; 并且至少部分地基于所接收的信令和使用层析成像来确定罐，容器或流管中的液体层的三维图像。信号处理器提供相应的信号，该信号包含关于罐，容器或流管中流体层的三维图像的信息。该阵列是倾斜方向排列的超声波应答器阵列，其布置在与罐或柱的轴线倾斜的平面上; 或者阵列与流动管的外部的流动方向垂直。

94. 发明申请

US20140183104A1 MINERAL SEPARATION USING SIZED-, WEIGHT- OR MAGNETIC-BASED POLYMER BUBBLES OR BEADS 有权
标题翻译：使用尺寸，重量或磁性的聚合物泡沫或珠子的矿物分离
公开(公告)号：US20140183104A1
公开(公告)日：2014-07-03
申请号：US14117534
申请日：2012-05-25
申请人： Paul J. Rothman , Mark R. Fernald , Francis K. Didden , Christian V. O'keefe , Alan D. Kersey , Douglas H. Adamson
发明人： Paul J. Rothman , Mark R. Fernald , Francis K. Didden , Christian V. O'keefe , Alan D. Kersey , Douglas H. Adamson
IPC分类号： B03D1/14
CPC分类号： B03C5/00 , B01D15/02 , B01D37/02 , B01D39/00 , B03B1/04 , B03C1/01 , B03C5/02 , B03D1/016 , B03D1/023 , B03D1/14 , B04C1/00 , B07B1/00 , C02F1/24 , C22B15/0063 , Y10T428/2982
摘要： Apparatus for use in, or forming part of, a separation process to be implemented in separation processor technology, the apparatus comprising synthetic bubbles or beads configured with a polymer or polymer-based material functionalized to attach to a valuable material in a mixture so as to form an enriched synthetic bubbles or beads having the valuable material attached thereto, and also configured to be separated from the mixture based at least partly on a difference in a physical property between the enriched synthetic bubbles or beads having the valuable material attached thereto and the mixture.
摘要翻译：在分离处理器技术中使用或组成部分分离过程的装置，该装置包括由聚合物或基于聚合物的材料构成的合成气泡或珠粒，所述聚合物或聚合物基材料被官能化以连接到混合物中的有价值材料，以便形成富集的合成气泡或具有附着于其上的有价值材料的珠粒，并且还构造成至少部分地基于富集的合成气泡或附着于其上的有价值材料的珠粒与混合物之间的物理性质的差异与混合物分离。

95. 发明授权

US08614852B2 Elongated microparticles having an optically detectable code configured to at least one of reflect or filter light 有权
标题翻译：具有配置成反射或过滤光中的至少一种的光学可检测代码的细长微粒
公开(公告)号：US08614852B2
公开(公告)日：2013-12-24
申请号：US12876927
申请日：2010-09-07
申请人： Alan D. Kersey , John A. Moon , Martin A. Putnam
发明人： Alan D. Kersey , John A. Moon , Martin A. Putnam
IPC分类号： G02B5/18
CPC分类号： G03F7/001 , G02B5/1857 , G02B5/203 , G03H1/18 , G03H1/182 , G03H2230/10 , Y10S359/90 , Y10T428/2982 , Y10T428/2991 , Y10T436/143333
摘要： An encoded microparticle including an optical substrate including a material that permits light to propagate therethrough. The optical substrate has an elongated body that extends in a direction along a central axis. The optical substrate includes an outer region that extends about the central axis. The encoded microparticle also includes an optically detectable code that is disposed within the optical substrate and extends along the central axis. The outer region surrounds the optically detectable code about the central axis. The optically detectable code is readable when the light propagates through the outer region and is at least one of reflected or filtered by the optically detectable code. Said at least one of reflected or filtered light propagates through the outer region to be detected for reading the optically detectable code.
摘要翻译：一种编码的微粒，其包括含有允许光从其传播的材料的光学基底。光学基板具有沿着中心轴线的方向延伸的细长主体。光学基板包括围绕中心轴线延伸的外部区域。编码的微粒还包括光学可检测的代码，其设置在光学基底内并沿着中心轴线延伸。外部区域围绕围绕中心轴的光学检测码。当光传播通过外部区域并且是由光学可检测的代码反射或过滤的至少一个时，光学可检测的代码是可读的。所述至少一个反射或滤光的光传播通过待检测的外部区域以读取光学可检测的代码。

96. 发明授权

US08541172B2 Method for sequencing a polynucelotide template 有权
标题翻译：多菌肽模板测序方法
公开(公告)号：US08541172B2
公开(公告)日：2013-09-24
申请号：US13445072
申请日：2012-04-12
申请人： Alan D. Kersey , Jonathan Mark Boutell
发明人： Alan D. Kersey , Jonathan Mark Boutell
IPC分类号： C12Q1/68 , C12P19/34 , G01N33/48
CPC分类号： C12Q1/6874 , C12Q1/6806 , C12Q2565/543 , C12Q2563/107 , C12Q2535/122
摘要： Improved compositions, methods, apparatus, and kits for high-throughput nucleic acid amplification, detection and sequencing are disclosed. A nucleic acid cluster having an identifiable center is produced by generating on a solid support an immobilized nucleic acid complement from a template, one of which comprises a detectable label; and amplifying the complement and the template to obtain a nucleic acid cluster on the support, the cluster having a substantially central location marked by the detectable label and a surrounding region comprising immobilized copies. Also disclosed are nucleotide sequence determination in nucleic acid clusters so produced, center position annotation in the clusters, assignment of sequence information to overlapping clusters, and related compositions and methods.
摘要翻译：公开了用于高通量核酸扩增，检测和测序的改进的组合物，方法，装置和试剂盒。具有可识别中心的核酸簇通过在固体支持物上产生来自模板的固定化核酸补体产生，其中之一包含可检测标记; 并扩增补体和模板以获得载体上的核酸簇，所述簇具有由可检测标记标记的基本中心位置和包含固定拷贝的周围区域。还公开了如此生成的核酸簇中的核苷酸序列测定，簇中的中心位置注释，重叠簇的序列信息的分配以及相关的组合物和方法。

97. 发明授权

US08049893B2 Methods of identifying analytes and using encoded particles 有权
标题翻译：识别分析物和使用编码的粒子的方法
公开(公告)号：US08049893B2
公开(公告)日：2011-11-01
申请号：US12941568
申请日：2010-11-08
申请人： John A. Moon , Alan D. Kersey , Martin A. Putnam , Tuo Li
发明人： John A. Moon , Alan D. Kersey , Martin A. Putnam , Tuo Li
IPC分类号： G01N21/25
CPC分类号： G01N33/552 , G01N21/4788 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/7743 , G01N33/54306 , G01N33/54313 , G01N33/54366 , G01N33/54386 , G03H1/0005 , G03H1/02 , G03H1/0236 , G03H1/26 , G03H2001/0033 , G03H2001/0044 , G03H2210/53 , G03H2210/63 , G03H2230/10 , G03H2250/12 , G06K19/04 , G06K19/06009
摘要： A method of identifying analytes that react with probes on encoded particles. The method includes providing a support substrate that has a plurality of the particles randomly distributed on the support substrate. The particles have elongated bodies with codes that extend along the corresponding bodies. The codes identify probes that are attached to the corresponding bodies, wherein at least some of the probes include fluorescent labels from reactions with the analytes. The method also includes detecting fluorescent signals that are emitted from the fluorescent labels. The fluorescent signals emit from random spatial locations along the support substrate. The method also includes detecting the codes of the particles at the random spatial locations along the support substrate and analyzing the codes and the fluorescent signals to identify the analytes that react with the probes on the particles.
摘要翻译：识别与编码粒子上的探针反应的分析物的方法。该方法包括提供具有随机分布在支撑衬底上的多个颗粒的支撑衬底。颗粒具有细长体，其具有沿相应体部延伸的代码。代码识别附着于相应体的探针，其中至少一些探针包括与分析物反应的荧光标记。该方法还包括检测从荧光标记物发射的荧光信号。荧光信号沿着支撑衬底从随机空间位置发射。该方法还包括沿着支撑衬底的随机空间位置检测颗粒的代码并分析代码和荧光信号以识别与颗粒上的探针反应的分析物。

98. 发明授权

US07796333B2 Encoded microparticles and a method for fabricating 有权
标题翻译：编码微粒及其制造方法
公开(公告)号：US07796333B2
公开(公告)日：2010-09-14
申请号：US12235834
申请日：2008-09-23
申请人： Alan D. Kersey , John A. Moon , Martin A. Putnam
发明人： Alan D. Kersey , John A. Moon , Martin A. Putnam
IPC分类号： G02B5/18
CPC分类号： G03F7/001 , G02B5/1857 , G02B5/203 , G03H1/18 , G03H1/182 , G03H2230/10 , Y10S359/90 , Y10T428/2982 , Y10T428/2991 , Y10T436/143333
摘要： A method for fabricating microparticles. The method includes providing a removable substrate that has a photosensitive material. The substrate has a plurality of inner regions. Each inner region surrounds a corresponding outer region. The method also includes providing at least one optically detectable code within at least one of the inner regions of the substrate and etching lines into the substrate to create a plurality of microparticles having at least one optically detectable code therein. The microparticles have elongated bodies that extend in an axial direction. The optically detectable codes extend in the axial direction within the microparticles.
摘要翻译：一种微粒制造方法。该方法包括提供具有感光材料的可移除基底。衬底具有多个内部区域。每个内部区域围绕相应的外部区域。该方法还包括在衬底的内部区域中的至少一个内部提供至少一个可光学检测的代码，并将蚀刻线蚀刻到衬底中以产生其中具有至少一个光学可检测代码的多个微粒。微粒具有沿轴向延伸的细长体。可光学检测的代码沿着微粒内的轴向延伸。

99. 发明授权

US07623976B2 System of distributed configurable flowmeters 有权
标题翻译：分布式可配置流量计系统
公开(公告)号：US07623976B2
公开(公告)日：2009-11-24
申请号：US10875858
申请日：2004-06-24
申请人： Daniel L. Gysling , Alan D. Kersey , F. Kevin Didden
发明人： Daniel L. Gysling , Alan D. Kersey , F. Kevin Didden
IPC分类号： G01N11/00
CPC分类号： G01F1/363 , G01F1/662 , G01F1/7082 , G01F1/74
摘要： A system of one or more configurable flowmeters allows an individual, locally or remotely, to selectively activate one or more functions of the flowmeters. The individual is capable of selecting which parameter of the process flow that the flowmeter is to measure, thereby effectively providing latent functions that may be selectively brought on line or shut off. The system may also allow an individual, locally or remotely, to selectively activate one or more latent flowmeters in the system. The system may be a distributed control system (DCS), which receives input signals from conventional meters and devices in the process flow and provides control signals to one or more devices in the flow process. The system may also provide a method of flowmeter selection and billing.
摘要翻译：一个或多个可配置流量计的系统允许个体在本地或远程地选择性地激活流量计的一个或多个功能。个人能够选择流量计要测量的工艺流程的哪个参数，从而有效地提供潜在的功能，这些潜在功能可以被选择性地引入或关闭。系统还可允许个体在本地或远程地选择性地激活系统中的一个或多个潜在流量计。该系统可以是分布式控制系统（DCS），其从过程流中的常规仪表和设备接收输入信号，并在流程中向一个或多个设备提供控制信号。该系统还可以提供流量计选择和计费的方法。

100. 发明授权

US07400985B2 Apparatus having an array of clamp on piezoelectric film sensors for measuring parameters of a process flow within a pipe 有权
标题翻译：具有用于测量管道内的工艺流程的参数的压电膜传感器上的夹具阵列的装置
公开(公告)号：US07400985B2
公开(公告)日：2008-07-15
申请号：US10712818
申请日：2003-11-12
申请人： Mark R. Fernald , Michael A. Davis , Alan D. Kersey , Timothy J. Bailey
发明人： Mark R. Fernald , Michael A. Davis , Alan D. Kersey , Timothy J. Bailey
IPC分类号： G06F19/00
CPC分类号： G01F1/668 , G01F1/666 , G01F1/7082 , G01F1/712 , G01F1/74
摘要： A apparatus 10,110,170 is provided that measures the speed of sound and/or vortical disturbances propagating in a single phase fluid flow and/or multiphase mixture to determine parameters, such as mixture quality, particle size, vapor/mass ratio, liquid/vapor ratio, mass flow rate, enthalpy and volumetric flow rate of the flow in a pipe, by measuring acoustic and/or dynamic pressures. The apparatus includes a spatial array of unsteady pressure sensors 15-18 placed at predetermined axial locations x1-xN disposed axially along the pipe 14. The pressure sensors 15-18 provide acoustic pressure signals P1(t)-PN(t) to a signal processing unit 30 which determines the speed of sound amix propagating through of the process flow 12 flowing in the pipe 14. The pressure sensors are piezoelectric film sensors that are clamped onto the outer surface of the pipe at the respective axial location.
摘要翻译：提供了一种装置10,110,170，其测量在单相流体流和/或多相混合物中传播的声速和/或涡流干扰的速度，以确定参数，例如混合质量，粒度，蒸气/质量比，液体/蒸气比，质量流量，管道中流量的焓和体积流量，通过测量声学和/或动态压力。该装置包括放置在沿着管14轴向设置的预定轴向位置x 1 -x N 1 / N 2的非稳态压力传感器15-18的空间阵列。压力传感器15-18向信号处理单元30提供声压信号P 1（t）-P N N（t），该信号处理单元30确定声速a _{混合物传播通过在管道14中流动的工艺流程12。压力传感器是在相应的轴向位置处夹紧在管的外表面上的压电膜传感器。}

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