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91. 发明授权

US5958729A Human G-protein receptor HCEGH45 失效
公开(公告)号：US5958729A
公开(公告)日：1999-09-28
申请号：US982412
申请日：1997-12-02
申请人： Daniel R. Soppet , Yi Li , Craig A. Rosen , Steven M. Ruben
发明人： Daniel R. Soppet , Yi Li , Craig A. Rosen , Steven M. Ruben
IPC分类号： A61K38/00 , C07K14/705 , C07K14/72 , C12N5/10 , C12N15/12
CPC分类号： C07K14/72 , C07K14/705 , A61K38/00
摘要： A human G-protein receptor HCEGH45 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying antagonists and agonists to such polypeptide. Antagonists against such polypeptides may be used therapeutically to treat PACAP hypersecretory conditions and to create pharmacological amnesia models while the agonists may be employed to treat amnesia and Alzheimer's disease. Also disclosed are diagnostic methods for detecting a mutation in the receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

92. 发明授权

US5789223A Human galactokinase gene 失效
公开(公告)号：US5789223A
公开(公告)日：1998-08-04
申请号：US451777
申请日：1995-05-26
申请人： Derk Jon Bergsma , Dwight Edward Stambolian , Steven M. Ruben , Craig A. Rosen
发明人： Derk Jon Bergsma , Dwight Edward Stambolian , Steven M. Ruben , Craig A. Rosen
IPC分类号： A61K38/00 , A61K48/00 , C12N9/12 , C12N15/54 , C12N15/85
CPC分类号： C12N9/1205 , C12Y207/01006 , A01K2217/05 , A61K38/00 , A61K48/00
摘要： This invention relates to human galactokinase and the identification of galactokinase mutations, a missense and nonsense, as well as isolated nucleic acids encoding same, recombinant host cell transformed with DNA encoding such proteins and to uses of the expressed proteins and nucleic acid sequences in therapeutic and diagnostic applications.

93. 发明申请

US20120213777A1 VASCULAR ENDOTHELIAL GROWTH FACTOR 2 审中-公开
标题翻译：血管内皮生长因子2
公开(公告)号：US20120213777A1
公开(公告)日：2012-08-23
申请号：US13460217
申请日：2012-04-30
申请人： Craig A. Rosen , Vivian R. Albert , Steven M. Ruben , Ruth E. Wager
发明人： Craig A. Rosen , Vivian R. Albert , Steven M. Ruben , Ruth E. Wager
IPC分类号： A61K39/395 , A61P37/00 , A61P41/00 , A61P29/00 , A61P3/02 , A61P31/00 , A61P17/02
CPC分类号： C07K16/22 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/52 , C07K16/24 , C07K2317/21 , C07K2317/622 , C12N2799/026 , G01N33/574 , G01N33/74 , Y02A50/41 , Y02A50/422 , Y10S435/81
摘要： Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.
摘要翻译：公开了人VEGF-2抗体，抗体片段或其变体。还提供了产生这种抗体的方法。本发明涉及用于预防，治疗或改善疾病或病症的方法和组合物，包括向动物（优选人）施用有效量的一种或多种VEGF-2抗体或其片段或变体。

94. 发明授权

US08071539B2 Albumin fusion proteins 有权
标题翻译：白蛋白融合蛋白
公开(公告)号：US08071539B2
公开(公告)日：2011-12-06
申请号：US12836447
申请日：2010-07-14
申请人： Craig A. Rosen , William A. Haseltine , Steven M. Ruben
发明人： Craig A. Rosen , William A. Haseltine , Steven M. Ruben
IPC分类号： C07K14/00
CPC分类号： C07K14/765 , A61K31/155 , A61K31/426 , A61K31/4439 , A61K31/4965 , A61K38/00 , A61K38/04 , A61K38/17 , A61K38/28 , A61K39/21 , C07K7/06 , C07K14/005 , C07K14/435 , C07K14/4713 , C07K14/4723 , C07K14/475 , C07K14/50 , C07K14/505 , C07K14/51 , C07K14/521 , C07K14/525 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/55 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/575 , C07K14/57563 , C07K14/5759 , C07K14/585 , C07K14/59 , C07K14/60 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/655 , C07K14/665 , C07K14/705 , C07K14/7151 , C07K14/82 , C07K16/00 , C07K16/241 , C07K16/26 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C07K2319/20 , C07K2319/30 , C07K2319/31 , C12N7/00 , C12N9/0006 , C12N9/0008 , C12N15/62 , C12N2501/335 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12Y101/01105 , C12Y102/01 , C12Y207/01095
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译：本发明包括白蛋白融合蛋白。编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法酸，载体和/或宿主细胞。另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，病症或病症的方法。

95. 发明申请

US20110223178A1 Antibodies That Specifically Bind to Chemokine Beta-4 审中-公开
标题翻译：特异性结合趋化因子β-4的抗体
公开(公告)号：US20110223178A1
公开(公告)日：2011-09-15
申请号：US13017658
申请日：2011-01-31
申请人： Craig A. Rosen , Steven M. Ruben
发明人： Craig A. Rosen , Steven M. Ruben
IPC分类号： A61K39/395 , C12N5/071 , C07K16/24 , C12N9/96 , A61P17/06 , A61P17/00 , A61P37/06
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies and related molecules that specifically bind to CK-β4. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including cancers, as well as immune system diseases and disorders including autoimmune disease, inflammatory disorders, immunodeficiencies, infections, HIV, arthritis, allergy, psoriasis, dermatitis, and inflammatory bowel disease. The invention also relates to nucleic acid molecules encoding anti-CK-β4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancers, as well as immune system diseases and disorders including autoimmune disease, inflammatory disorders, immunodeficiencies, infections, HIV, arthritis, allergy, psoriasis, dermatitis, and inflammatory bowel disease, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to CK-β4.
摘要翻译：本发明涉及与CK-和bgr特异性结合的抗体和相关分子。这样的抗体具有例如用于预防和治疗癌症以及包括癌症的免疫系统疾病和病症，以及免疫系统疾病和病症，包括自身免疫性疾病，炎症性疾病，免疫缺陷，感染，HIV，关节炎，过敏，牛皮癣，皮炎和炎性肠病。本发明还涉及编码抗CK-bgr4抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症以及免疫系统疾病和病症的方法和组合物，包括自身免疫性疾病，炎症性疾病，免疫缺陷，感染，HIV，关节炎，过敏，牛皮癣，皮炎和炎症性肠病，包括向动物，优选人类施用有效量的一种或多种特异性结合CK-1的抗体或其片段或变体或相关分子。

96. 发明申请

US20110190223A1 HEMCM42 NUCLEIC ACIDS 审中-公开
标题翻译： HEMCM42核酸
公开(公告)号：US20110190223A1
公开(公告)日：2011-08-04
申请号：US13027141
申请日：2011-02-14
申请人： Steven M. Ruben , Craig A. Rosen , Gregory A. Endress
发明人： Steven M. Ruben , Craig A. Rosen , Gregory A. Endress
IPC分类号： A61K38/16 , C12Q1/68 , C12P21/06 , C12N5/10 , C12N5/16 , C12N15/63 , G01N33/566 , C07K14/435 , C07K16/18 , C07H21/04
CPC分类号： C07K14/47 , A61K38/00 , C07K16/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

97. 发明授权

US07968689B2 Antibodies to HSDEK49 polypeptides 失效
标题翻译： HSDEK49多肽的抗体
公开(公告)号：US07968689B2
公开(公告)日：2011-06-28
申请号：US12198817
申请日：2008-08-26
申请人： Craig A. Rosen , Steven M. Ruben , Paul A. Moore
发明人： Craig A. Rosen , Steven M. Ruben , Paul A. Moore
IPC分类号： C07K16/00
CPC分类号： C07K16/2803
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating immune disorders and diseases. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及人分泌的多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗免疫疾病和疾病。结合这些多肽的抗体也包括在本发明中。本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

98. 发明授权

US07943741B2 Antibodies that specifically bind to chemokine β-4 失效
标题翻译：特异性结合趋化因子的抗体;
公开(公告)号：US07943741B2
公开(公告)日：2011-05-17
申请号：US12123419
申请日：2008-05-19
申请人： Craig A. Rosen , Steven M. Ruben
发明人： Craig A. Rosen , Steven M. Ruben
IPC分类号： C07K16/00
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies and related molecules that specifically bind to CK-B4. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including cancers, as well as immune system diseases and disorders including autoimmune disease, inflammatory disorders, immunodeficiencies, infections, HIV, arthritis, allergy, psoriasis, dermatitis, and inflammatory bowel disease. The invention also relates to nucleic acid molecules encoding anti-CK-B4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancers, as well as immune system diseases and disorders including autoimmune disease, inflammatory disorders, immunodeficiencies, infections, HIV, arthritis, allergy, psoriasis, dermatitis, and inflammatory bowel disease, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to CK-B4.
摘要翻译：本发明涉及特异性结合CK-B4的抗体和相关分子。这样的抗体具有例如用于预防和治疗癌症以及包括癌症的免疫系统疾病和病症，以及免疫系统疾病和病症，包括自身免疫性疾病，炎症性疾病，免疫缺陷，感染，HIV，关节炎，过敏，牛皮癣，皮炎和炎性肠病。本发明还涉及编码抗CK-B4抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症以及免疫系统疾病和病症的方法和组合物，包括自身免疫性疾病，炎症性疾病，免疫缺陷，感染，HIV，关节炎，过敏牛皮癣，皮炎和炎性肠病，包括向动物，优选人类施用有效量的与CK-B4特异性结合的一种或多种抗体或其片段或变体或相关分子。

99. 发明申请

US20110003383A1 ANTIBODIES TO HT5GJ57 失效
标题翻译：抗体HT5GJ57
公开(公告)号：US20110003383A1
公开(公告)日：2011-01-06
申请号：US12268263
申请日：2008-11-10
申请人： Steven M. Ruben , George A. Komatsoulis , D. Roxanne Duan , Craig A. Rosen , Paul A. Moore , Yanggu Shi , David W. LaFleur , Reinhard Ebner , Henrik S. Olsen , Laurie A. Brewer , Kimberly A Florence , Paul E. Young , Michael Mucenski , Gregory A. Endress , Daniel R. Soppet
发明人： Steven M. Ruben , George A. Komatsoulis , D. Roxanne Duan , Craig A. Rosen , Paul A. Moore , Yanggu Shi , David W. LaFleur , Reinhard Ebner , Henrik S. Olsen , Laurie A. Brewer , Kimberly A Florence , Paul E. Young , Michael Mucenski , Gregory A. Endress , Daniel R. Soppet
IPC分类号： C12N5/07 , G01N33/53 , C12P21/06 , C07K16/00
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/30
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

100. 发明授权

US07850963B2 Vascular endothelial growth factor 2 有权
标题翻译：血管内皮生长因子2
公开(公告)号：US07850963B2
公开(公告)日：2010-12-14
申请号：US11730696
申请日：2007-04-03
申请人： Craig A. Rosen , Vivian R. Albert , Steven M. Ruben , Ruth Wager
发明人： Craig A. Rosen , Vivian R. Albert , Steven M. Ruben , Ruth Wager
IPC分类号： A61K39/395 , A61K39/44 , A61K39/00 , C12P21/08 , C07K16/22 , C07K16/46 , C12N5/10 , C12N5/12
CPC分类号： C07K16/22 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/52 , C07K16/24 , C07K2317/21 , C07K2317/622 , C12N2799/026 , G01N33/574 , G01N33/74 , Y02A50/41 , Y02A50/422 , Y10S435/81
摘要： Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.
摘要翻译：公开了人VEGF-2抗体，抗体片段或其变体。还提供了产生这种抗体的方法。本发明涉及用于预防，治疗或改善疾病或病症的方法和组合物，包括向动物（优选人）施用有效量的一种或多种VEGF-2抗体或其片段或变体。

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