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91. 发明申请

US20130023943A1 Battery Management for an Implantable Medical Device 有权
标题翻译：可植入医疗器械的电池管理
公开(公告)号：US20130023943A1
公开(公告)日：2013-01-24
申请号：US13489770
申请日：2012-06-06
申请人： Jordi Parramon , Goran N. Marnfeldt , Robert Ozawa , Emanuel Feldman , Dave Peterson
发明人： Jordi Parramon , Goran N. Marnfeldt , Robert Ozawa , Emanuel Feldman , Dave Peterson , Yuping He
IPC分类号： A61N1/36
CPC分类号： A61N1/3787 , A61N1/08
摘要： Battery management circuitry for an implantable medical device such as an implantable neurostimulator is described. The circuitry has a T-shape with respect to the battery terminal, with charging circuitry coupled between rectifier circuitry and the battery terminal on one side of the T, and load isolation circuitry coupled between the load and the battery terminal on the other side. The load isolation circuitry can comprise two switches wired in parallel. An undervoltage fault condition opens both switches to isolate the battery terminal from the load to prevent further dissipation of the battery. Other fault conditions will open only one the switches leaving the other closed to allow for reduced power to the load to continue implant operations albeit at safer low-power levels. The battery management circuitry can be fixed in a particular location on an integrated circuit which also includes for example the stimulation circuitry for the electrodes.
摘要翻译：描述了诸如可植入神经刺激器的可植入医疗装置的电池管理电路。电路相对于电池端子具有T形，充电电路耦合在整流器电路和T的一侧上的电池端子之间，负载隔离电路耦合在另一侧的负载和电池端子之间。负载隔离电路可以包括并联的两个开关。欠压故障条件打开两个开关以将电池端子与负载隔离，以防止电池进一步耗散。其他故障条件将仅打开一个开关，使另一个闭合，以允许降低负载的功率，以继续进行种植体操作，尽管处于更安全的低功率水平。电池管理电路可以固定在集成电路的特定位置，该集成电路还包括例如用于电极的刺激电路。

92. 发明申请

US20130013025A1 Fractionalized Stimulation Pulses in an Implantable Stimulator Device 有权
标题翻译：可植入刺激装置中的分数化刺激脉冲
公开(公告)号：US20130013025A1
公开(公告)日：2013-01-10
申请号：US13595746
申请日：2012-08-27
申请人： Jordi Parramon , Rafael Carbunaru , Matt I. Haller
发明人： Jordi Parramon , Rafael Carbunaru , Matt I. Haller
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36171 , A61N1/05 , A61N1/0551 , A61N1/36 , A61N1/36071 , A61N1/36125 , A61N1/36175 , A61N1/36178 , A61N1/37235
摘要： A method for configuring stimulation pulses in an implantable stimulator device having a plurality of electrodes is disclosed, which method is particularly useful in adjusting the electrodes by current steering during initialization of the device. In one aspect, a set of ideal pulses for patient therapy is determined, in which at least two of the ideal pulses are of the same polarity and are intended to be simultaneous applied to corresponding electrodes on the implantable stimulator device during an initial duration. These pulses are reconstructed into fractionalized pulses, each comprised of pulse portions. The fractionalized pulses are applied to the corresponding electrodes on the device during a final duration, but the pulse portions of the fractionalized pulses are not simultaneously applied during the final duration.
摘要翻译：公开了一种用于在具有多个电极的可植入刺激器装置中配置刺激脉冲的方法，该方法在装置的初始化期间通过电流转向来调节电极特别有用。在一个方面，确定用于患者治疗的一组理想脉冲，其中至少两个理想脉冲具有相同的极性并且旨在在初始持续时间期间同时施加到可植入刺激器装置上的对应电极。这些脉冲被重建成分数脉冲，每个脉冲包括脉冲部分。分数脉冲在最后的持续时间内施加到器件上的对应电极，但分数脉冲的脉冲部分在最后的持续时间内不被同时施加。

93. 发明授权

US08260424B2 Systems and methods for detecting a loss of electrical connectivity between components of implantable medical lead systems 失效
标题翻译：用于检测可植入医疗引线系统的部件之间的电连接损失的系统和方法
公开(公告)号：US08260424B2
公开(公告)日：2012-09-04
申请号：US12258324
申请日：2008-10-24
申请人： Michael A. Moffitt , Christopher B. Gould , Daniel Aghassian , Marco Henry Gin , Jordi Parramon
发明人： Michael A. Moffitt , Christopher B. Gould , Daniel Aghassian , Marco Henry Gin , Jordi Parramon
IPC分类号： A61N1/08
CPC分类号： A61N1/37 , A61B2562/227 , A61N1/3706 , A61N1/3752 , A61N2001/083 , H01R13/6683 , H01R2201/12
摘要： A connection monitoring system for an implantable medical lead system includes an implantable lead, a first trial system cable, an external trial system, and a sensor. The lead has a distal end and at least one proximal end. The lead includes a plurality of terminals disposed at each proximal end. The first trial system cable has a distal end and at least one proximal end. The distal end of the first trial system cable is configured and arranged to electrically couple with the lead. The external trial system is configured and arranged to electrically couple with the first trial system cable. The sensor is electrically coupled to the external trial system. The sensor is configured and arranged for detecting a loss of electrical connectivity between the external trial system and the lead when the lead becomes electrically decoupled from the external trial system.
摘要翻译：用于可植入医疗引线系统的连接监视系统包括可植入引线，第一试验系统电缆，外部试验系统和传感器。引线具有远端和至少一个近端。引线包括设置在每个近端处的多个端子。第一试验系统电缆具有远端和至少一个近端。第一试验系统电缆的远端被配置和布置成与引线电耦合。外部试验系统被配置和布置成与第一试验系统电缆电耦合。传感器电耦合到外部试验系统。传感器被配置和布置成用于当引线变得与外部试验系统电隔离时，检测外部试验系统和引线之间的电连接性的损失。

94. 发明申请

US20120092031A1 Sample and Hold Circuitry for Monitoring Voltages in an Implantable Neurostimulator 有权
标题翻译：用于监测植入式神经刺激器中的电压的采样和保持电路
公开(公告)号：US20120092031A1
公开(公告)日：2012-04-19
申请号：US13237172
申请日：2011-09-20
申请人： Jess W. Shi , Emanuel Feldman , Jordi Parramon
发明人： Jess W. Shi , Emanuel Feldman , Jordi Parramon
IPC分类号： G01R27/08 , A61N1/372
CPC分类号： A61N1/36125 , A61B5/04001 , A61N1/025 , A61N1/08 , A61N1/378 , A61N1/3937
摘要： Sample and hold circuitry for monitoring electrodes and other voltages in an implantable neurostimulator is disclosed. The sample and hold circuitry in one embodiment contains multiplexers to selected appropriate voltages and to pass them to two storage capacitors during two different measurement phases. The capacitors are in a later stage serially connected to add the two voltages stored on the capacitors, and voltages present at the top and bottom of the serial connection are then input to a differential amplifier to compute their difference. The sample and hold circuitry is particularly useful in calculating the resistance between two electrodes, and is further particularly useful when resistance is measured using a biphasic pulse. The sample and hold circuitry is flexible, and can be used to measure other voltages of interest during biphasic or monophasic pulsing.
摘要翻译：公开了用于在可植入神经刺激器中监测电极和其它电压的采样和保持电路。在一个实施例中，采样和保持电路包含多个选择的合适电压，并在两个不同的测量阶段期间将其传送到两个存储电容器。电容器串联连接以增加存储在电容器上的两个电压，然后将存在于串行连接顶部和底部的电压输入到差分放大器以计算其差值。采样和保持电路在计算两个电极之间的电阻时特别有用，当使用双相脉冲测量电阻时，采样和保持电路特别有用。采样和保持电路是灵活的，并且可以用于在双相或单相脉冲期间测量感兴趣的其他电压。

95. 发明授权

US08065019B2 Methods and systems for improving the reliability of the time basis for data logged in an implantable medical device 有权
标题翻译：用于提高记录在可植入医疗设备中的数据的时间基准的可靠性的方法和系统
公开(公告)号：US08065019B2
公开(公告)日：2011-11-22
申请号：US12272861
申请日：2008-11-18
申请人： Goran N. Marnfeldt , Jordi Parramon
发明人： Goran N. Marnfeldt , Jordi Parramon
IPC分类号： A61N1/00
CPC分类号： A61N1/37252 , H04J3/0638
摘要： Disclosed are methods for synchronizing the time basis of logged data between an implantable medical device such as an IPG and an external device. The IPG logs various operational parameters as data and associates the same with a possibly-inaccurate IPG time stamp and a sequence number. Periodically, the external device sends accurate true time data to the IPG, which, like the operational parameter data, is logged with an IPG time stamp and a next sequence number. The IPG then orders the data sequences and timing sequences by time stamp in a combined data log, and divides that data log into regions in accordance with reset conditions apparent in the time stamp data. Slopes indicative of the relation between true time and time stamps are calculated for various regions on an intra-region or inter-region basis, which then allows for true time estimates to be calculated for the data sequences, thus providing an accurate time basis for the logged data. The true time estimates for the data sequences may then be transmitted from the IPG to an external device for interpretation.
摘要翻译：公开了用于在诸如IPG的可植入医疗设备和外部设备之间同步记录数据的时间基准的方法。 IPG将各种操作参数记录为数据，并将其与可能不准确的IPG时间戳和序列号相关联。周期性地，外部设备向IPG发送准确的真实时间数据，其与操作参数数据一起记录IPG时间戳和下一个序列号。 IPG然后通过组合数据日志中的时间戳命令数据序列和定时序列，并根据时间戳数据中显而易见的复位条件将该数据记录划分为区域。针对区域内或区域间的各个区域计算表示真实时间和时间戳之间的关系的斜率，然后允许为数据序列计算真实时间估计，从而为记录数据。然后可以将数据序列的真实时间估计从IPG发送到外部设备以进行解释。

96. 发明申请

US20110121777A1 Efficient External Charger for Charging a Plurality of Implantable Medical Devices 有权
标题翻译：高效的外部充电器为多种植入式医疗设备充电
公开(公告)号：US20110121777A1
公开(公告)日：2011-05-26
申请号：US12624162
申请日：2009-11-23
申请人： Rafael Carbunaru , Jordi Parramon , Robert Ozawa , Jess Shi , Joey Chen , Md. Mizanur Rahman
发明人： Rafael Carbunaru , Jordi Parramon , Robert Ozawa , Jess Shi , Joey Chen , Md. Mizanur Rahman
IPC分类号： H02J7/00
CPC分类号： A61N1/3787 , A61N1/37223 , A61N1/37288
摘要： An improved external charger for a battery in an implantable medical device (implant), and technique for charging batteries in multiple implants using such improved external charger, is disclosed. During charging, values for a parameter measured in the implants are reported from the implants to the external charger. The external charger infers from the magnitudes of the parameters which of the implants has the highest and lowest coupling to the external charger, and so designates those implants as “hot” and “cold.” The intensity of the magnetic charging field is optimized for the cold implant consistent with the simulation to ensure that that the cold implant is charged with a maximum (fastest) battery charging current. The duty cycle of the magnetic charging field is also optimized for the hot implant consistent with the simulation to ensure that the hot implant does not exceed the power dissipation limit. As a result, charging is optimized to be fast for all of the implants, while still safe from a tissue heating perspective.
摘要翻译：公开了一种用于可植入医疗装置（植入物）中的电池的改进的外部充电器，以及使用这种改进的外部充电器为多个植入物中的电池充电的技术。在充电期间，在植入物中测量的参数的值从植入物报告给外部充电器。外部充电器从参数的大小推断出植入物中的哪一个具有与外部充电器最高和最低耦合的参数，因此将这些植入物称为“热”和“冷”。磁充电场的强度针对冷植入物与模拟一致，以确保冷植入物充电最大（最快）的电池充电电流。对于与模拟一致的热注入，磁充电场的占空比也被优化，以确保热植入物不超过功率耗散极限。因此，对于所有植入物，充电被优化为快速，同时从组织加热的角度来看仍然是安全的。

97. 发明申请

US20100286749A1 Current Generation Architecture for an Implantable Stimulator Device Having Coarse and Fine Current Control 有权
标题翻译：具有粗细电流控制的植入式刺激器装置的当前一代架构
公开(公告)号：US20100286749A1
公开(公告)日：2010-11-11
申请号：US12838260
申请日：2010-07-16
申请人： Jordi Parramon , David K.L. Peterson , Paul J. Griffith
发明人： Jordi Parramon , David K.L. Peterson , Paul J. Griffith
IPC分类号： A61N1/36
CPC分类号： A61N1/36125 , A61N1/0531 , A61N1/0534 , A61N1/0541 , A61N1/0543 , A61N1/0551 , A61N1/36071
摘要： Disclosed herein is a current generation architecture for an implantable stimulator device such as an Implantable Pulse Generator (IPG). Current source and sink circuitry are both divided into coarse and fine portions, which respectively can provide a coarse and fine current resolution to a specified electrode on the IPG. The coarse portion is distributed across all of the electrodes and so can source or sink current to any of the electrodes. The coarse portion is divided into a plurality of stages, each of which is capable via an associated switch bank of sourcing or sinking a coarse amount of current to or from any one of the electrodes on the device. The fine portion of the current generation circuit preferably includes source and sink circuitry dedicated to each of the electrode on the device, which can comprise digital-to-analog current converters (DACs). The DACs also receives the above-noted reference current, which is amplified by the DACs in fine increments by appropriate selection of fine current control signals. When the coarse and fine current control circuitry are used in tandem, ample current with a fine current resolution can be achieved at any electrode and in a space- and power-efficient manner.
摘要翻译：本文公开了用于植入式脉冲发生器（IPG）的植入式刺激器装置的当前一代架构。电流源和接收电路都分为粗细部分，分别可以为IPG上的指定电极提供粗细和精细的电流分辨率。粗糙部分分布在所有电极上，因此可以将电流吸收或吸收到任何电极。粗略部分被分成多个级，每个级能够经由相关联的开关组，该器件对设备上的任何一个电极进行粗电流的吸收或吸收。电流产生电路的优良部分优选地包括专用于器件上每个电极的源极和漏极电路，其可以包括数模转换器（DAC）。 DAC还接收上述参考电流，其通过适当选择精细电流控制信号以细微增量由DAC放大。当粗调和精细电流控制电路串联使用时，可以在任何电极上以空间和功率有效的方式实现具有精细电流分辨率的充足电流。

98. 发明申请

US20090204174A1 Low Power Loss Current Digital-to-Analog Converter Used in an Implantable Pulse Generator 有权
标题翻译：用于可植入脉冲发生器的低功耗电流数模转换器
公开(公告)号：US20090204174A1
公开(公告)日：2009-08-13
申请号：US12424916
申请日：2009-04-16
申请人： Jordi Parramon , Yuping He , Kiran Nimmagadda
发明人： Jordi Parramon , Yuping He , Kiran Nimmagadda
IPC分类号： A61N1/36
CPC分类号： A61N1/36071 , A61N1/025 , A61N1/36125 , A61N1/378
摘要： In one embodiment, the present invention provides an implantable stimulation device that includes output current sources and/or sinks configured to provide an output current for a load (i.e., tissue). The output path of the output current source or sink comprises a transistor which operates in a linear mode instead of a saturation mode. Because operation in a linear mode results in smaller drain-to-source voltage drops, power consumption in the output current source or sink (and hence in the implantable stimulator) is reduced, reducing battery or other power source requirements. Operation in the linear mode is facilitated in useful embodiments by a load in an input path (into which a reference current is sent) and a load in the output path (which bears the output current). The loads can be active transistors or passive resistors. A feedback circuit (e.g., an operational amplifier) receives voltages that build up across these loads, and sends a control signal to the gate of the transistor to ensure its linear operation.
摘要翻译：在一个实施例中，本发明提供了一种植入式刺激装置，其包括被配置为提供负载（即组织）的输出电流的输出电流源和/或接收器。输出电流源或吸收器的输出路径包括以线性模式而不是饱和模式操作的晶体管。因为在线性模式下的操作会导致较小的漏极 - 源极电压降，所以输出电流源或接收器（以及因此在可植入的刺激器中）的功耗降低，从而减少电池或其他电源要求。在有用的实施例中，通过输入路径（发送参考电流）中的负载和输出路径（承担输出电流）中的负载来促进线性模式的操作。负载可以是有源晶体管或无源电阻。反馈电路（例如，运算放大器）接收跨越这些负载的电压，并将控制信号发送到晶体管的栅极，以确保其线性运行。

99. 发明申请

US20090018618A1 TELEMETRY LISTENING WINDOW MANAGEMENT FOR AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：远程医疗窗口管理用于可植入医疗设备
公开(公告)号：US20090018618A1
公开(公告)日：2009-01-15
申请号：US11776170
申请日：2007-07-11
申请人： Jordi Parramon , Jess W. Shi
发明人： Jordi Parramon , Jess W. Shi
IPC分类号： A61N1/02
CPC分类号： A61N1/37252 , A61N1/3605 , A61N1/37205 , Y10S128/903
摘要： An improved arbitration scheme for allowing concurrent stimulation and telemetry listening in a microstimulator is disclosed. A listening window for telemetry is permitted to proceed, and access to the microstimulator's coil granted, during at least a portion of the inter-pulse period that follows the issuance of a stimulation pulse. This is permissible because access to the coil is not needed during the entirety of the inter-pulse period. For example, the listening window can issue during that portion of the inter-pulse period when the decoupling capacitor is discharged, but cannot issue during that portion of the inter-pulse period when the compliance voltage is being generated for the next stimulation pulse. However, because compliance voltage generation occupies only a small portion of the inter-pulse period, the technique is not substantially limited. By allowing the listening window to issue during the majority of the inter-pulse period, the listening window produces smaller gaps between the pulses, and stimulation therapy is thus brought closer to its ideal.
摘要翻译：公开了一种用于允许微型激励器中的并发刺激和遥测监听的改进的仲裁方案。在发出刺激脉冲之后的脉冲间期间的至少一部分期间，允许遥测监听窗口继续进行微型刺激器线圈的访问。这是允许的，因为在整个脉冲间期间不需要对线圈的访问。例如，当解耦电容器放电时，在脉冲周期的该部分期间可以发出监听窗口，但是当为下一个刺激脉冲产生顺从性电压时，不能在脉冲间期间的那部分期间发出监听窗口。然而，由于顺应性电压产生仅占脉冲周期的一小部分，所以该技术基本上不受限制。通过允许在大多数脉冲间期间发出听音窗口，收听窗口在脉冲之间产生较小的间隙，因此刺激疗法更接近其理想。

100. 发明申请

US20070135867A1 Telemetry System for Use With Microstimulator 有权
标题翻译：用于微型激励器的遥测系统
公开(公告)号：US20070135867A1
公开(公告)日：2007-06-14
申请号：US11624364
申请日：2007-01-18
申请人： Daniel Klosterman , Kelly McClure , Goran Marnfeldt , Jordi Parramon , Matthew Haller , Rudolph Park
发明人： Daniel Klosterman , Kelly McClure , Goran Marnfeldt , Jordi Parramon , Matthew Haller , Rudolph Park
IPC分类号： A61N1/36
CPC分类号： A61N1/37276 , A61N1/36007 , A61N1/3605 , A61N1/37205 , A61N1/37217 , A61N1/37223 , A61N1/37229 , A61N1/37235 , A61N1/3727 , A61N1/375 , A61N1/3787 , H01L2224/45144 , H01L2224/45147 , H01L2224/48465 , H01L2224/49175 , H01L2924/00011 , H01L2924/1461 , H01L2924/19105 , H01L2924/19107 , H01L2924/3011 , H01L2924/30111 , H02J7/025 , H02J7/345 , H04B5/0037 , H04B5/0081 , H04L27/02 , H04L27/10 , Y10T29/4902 , Y10T29/49071 , Y10T29/49073 , Y10T29/49128 , Y10T29/4913 , Y10T29/49155 , Y10T29/49169 , Y10T29/49826 , Y10T29/49945 , Y10T29/49968 , Y10T428/12264 , Y10T428/12271 , Y10T428/12347 , Y10T428/12375 , Y10T428/12396 , Y10T428/12535 , Y10T428/12806 , H01L2924/00 , H01L2924/01005 , H01L2924/01033
摘要： An implantable microstimulator configured to be implanted beneath a patient's skin for tissue stimulation employs a bi-directional RF telemetry link for allowing data-containing signals to be sent to and from the implantable microstimulator from at least two external devices. Further, a separate electromagnetic inductive telemetry link allows data containing signals to be sent to the implantable microstimulator from at least one of the two external devices. The RF bidirectional telemetry link allows the microstimulator to inform the patient or clinician regarding the status of the microstimulator device, including the charge level of a power source, and stimulation parameter states. The microstimulator has a cylindrical hermetically sealed case having a length no greater than about 27 mm and a diameter no greater than about 3.3 mm. A reference electrode is located on one end of the case and an active electrode is located on the other end of the case.
摘要翻译：被配置为植入在患者皮肤下方进行组织刺激的可植入微型刺激器使用双向RF遥测链路，用于允许从至少两个外部设备向可植入微型激励器发送含数据信号。此外，单独的电磁感应遥测链路允许从两个外部设备中的至少一个将包含信号的数据发送到可植入微型激励器。 RF双向遥测链路允许微刺激器通知患者或临床医生关于微刺激器装置的状态，包括电源的充电水平和刺激参数状态。微型激励器具有圆柱形密封的外壳，其长度不大于约27mm，直径不大于约3.3mm。参考电极位于壳体的一端，有源电极位于壳体的另一端。

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