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91. 发明申请

US20120202817A1 COMPOUNDS HAVING 4-PYRIDYLALKYLTHIO GROUP AS A SUBSTITUENT 有权
标题翻译：具有4-PYRIDYLALKYLTHIO组的化合物作为替代物
公开(公告)号：US20120202817A1
公开(公告)日：2012-08-09
申请号：US13449921
申请日：2012-04-18
申请人： Takahiro Honda , Hisashi Tajima , Yoshimasa Sasabuchi , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto , Masakazu Ban
发明人： Takahiro Honda , Hisashi Tajima , Yoshimasa Sasabuchi , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto , Masakazu Ban
IPC分类号： A61K31/4409 , C07D409/12 , A61K31/4436 , C07D401/12 , A61K31/4709 , C07D413/14 , A61K31/5377 , C07D409/14 , A61K31/4545 , A61K31/4439 , C07D405/12 , A61K31/443 , A61P35/00 , A61P29/00 , A61P27/02 , A61P17/06 , A61P9/10 , C07D213/56
CPC分类号： C07D401/12 , C07D213/32 , C07D401/14
摘要： A compound having the following formula [I] or a pharmaceutically acceptable salt thereof: wherein A is an aromatic five-membered heterocycle which optionally is fused with a cycloalkane ring; B is an alkylene; R1 and R2 are hydrogen, hydroxyl, alkoxy, aryloxy, alkyl, cycloalkyl, aryl, heterocycle, amino, alkylamino, arylamino or acyl, or R1 and R2 join together to form a heterocycle; X and Y are hydrogen, halogen, hydroxyl, alkoxy, aryloxy, alkyl, cycloalkyl, aryl, mercapto, alkylthio, arylthio, carboxyl, an ester of carboxyl, an amide of carboxyl, cyano or nitro; p is 0, 1 or 2; and q is 0 or 1. The compound is useful for treating diseases in which angiogenesis or augmentation of vascular permeability is involved.
摘要翻译：具有下式[I]的化合物或其药学上可接受的盐：其中A是任选与环烷烃环稠合的芳族五元杂环; B是亚烷基; R 1和R 2是氢，羟基，烷氧基，芳氧基，烷基，环烷基，芳基，杂环，氨基，烷基氨基，芳基氨基或酰基，或R 1和R 2连接在一起形成杂环; X和Y是氢，卤素，羟基，烷氧基，芳氧基，烷基，环烷基，芳基，巯基，烷硫基，芳硫基，羧基，羧基的酯，羧基的酰胺，氰基或硝基; p为0,1或2; q为0或1.该化合物可用于治疗涉及血管生成或增加血管通透性的疾病。

92. 发明授权

US08076332B2 N- (2-aminophenyl) benzamide derivative having urea structure 有权
标题翻译：具有尿素结构的N-（2-氨基苯基）苯甲酰胺衍生物
公开(公告)号：US08076332B2
公开(公告)日：2011-12-13
申请号：US12448259
申请日：2007-12-26
申请人： Hiroyuki Mogi , Hisashi Tajima , Noriko Mishina , Yusuke Yamazaki , Shinji Yoneda , Katsuhiko Watanabe , Junko Fujikawa , Minoru Yamamoto
发明人： Hiroyuki Mogi , Hisashi Tajima , Noriko Mishina , Yusuke Yamazaki , Shinji Yoneda , Katsuhiko Watanabe , Junko Fujikawa , Minoru Yamamoto
IPC分类号： A61K31/535
CPC分类号： C07D207/09 , C07C275/24 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/40 , C07C275/42 , C07C2601/08 , C07C2602/08 , C07C2602/10 , C07D207/27 , C07D211/26 , C07D213/40 , C07D213/75 , C07D215/38 , C07D235/32 , C07D261/14 , C07D277/46 , C07D277/82 , C07D295/12 , C07D307/79 , C07D317/50 , C07D319/18 , C07D333/36 , C07D405/12
摘要： The present invention relates to a study on the synthesis of a novel N-(2-aminophenyl)benzamide derivative having an urea structure and represented by the general formula (1); and the utilization of a pharmacological effect of the derivative. A compound represented by the general formula (1) or a salt thereof has an effect of cellular morphological change on trabecular meshwork cells and is effective in the prevention and/or treatment of a disease considered to be related to intraocular pressure. In the formula, R1 and R2 represent a hydrogen atom, a lower alkyl group, or the like; R3 represents a hydroxy group, a lower alkoxy group, a lower cycloalkyloxy group, an aryloxy group, or the like; R4 and R5 represent a halogen atom, a lower alkyl group, a hydroxy group, a lower alkoxy group, or the like; X represents a lower alkylene group or the like; Y represents a single bond, a lower alkylene group, or the like; l and m represent 0, 1, 2, or the like.
摘要翻译：本发明涉及一种具有尿素结构并由通式（1）表示的新型N-（2-氨基苯基）苯甲酰胺衍生物的合成研究。并利用衍生物的药理作用。由通式（1）表示的化合物或其盐具有小梁网细胞的细胞形态学变化的作用，并且有效预防和/或治疗被认为与眼内压有关的疾病。在该式中，R 1和R 2表示氢原子，低级烷基等; R3表示羟基，低级烷氧基，低级环烷氧基，芳氧基等; R4和R5表示卤素原子，低级烷基，羟基，低级烷氧基等; X表示低级亚烷基等; Y表示单键，低级亚烷基等; l和m表示0,1,2等。

93. 发明授权

US08012972B2 Pyridinecarboxylic acid (2-aminophenyl) amide derivative having urea structure 有权
标题翻译：具有尿素结构的吡啶羧酸（2-氨基苯基）酰胺衍生物
公开(公告)号：US08012972B2
公开(公告)日：2011-09-06
申请号：US12450387
申请日：2008-03-28
申请人： Hiroyuki Mogi , Hisashi Tajima , Noriko Mishina , Yusuke Yamazaki , Shinji Yoneda , Katsuhiko Watanabe , Junko Fujikawa , Minoru Yamamoto
发明人： Hiroyuki Mogi , Hisashi Tajima , Noriko Mishina , Yusuke Yamazaki , Shinji Yoneda , Katsuhiko Watanabe , Junko Fujikawa , Minoru Yamamoto
IPC分类号： A61K31/5377 , A61K31/44 , C07D413/12 , C07D213/81
CPC分类号： C07D213/81 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Objects of the present invention are to study the synthesis of a novel pyridinecarboxylic acid (2-aminophenyl)amide derivative having a novel urea structure and to find a pharmacological effect of the derivative. The invention provides a compound represented by the formula (1) or a salt thereof. In the formula, R1 and R2 represent a hydrogen atom, a lower alkyl group or the like; R3 represents a hydroxy group, a lower alkoxy group, a lower cycloalkyloxy group, an aryloxy group, a carboxy group, a lower alkoxycarbonyl group, —OCONRaRb, —NRcRd or the like; R4 and R5 represent a halogen atom, a lower alkyl group, a hydroxy group, a lower alkoxy group or the like; Ra and Rb represent a hydrogen atom, a lower alkyl group, a lower cycloalkyl group, an aryl group, a heterocyclic group or the like; Rc and Rd represent a hydrogen atom, a lower alkyl group, a lower cycloalkyl group, an aryl group or the like; X represents a lower alkylene group; Y represents a single bond, a lower alkylene group; W1-W2 represents N—C or C—N; and l and m represent 0, 1, 2 or 3.
摘要翻译：本发明的目的是研究具有新型尿素结构的新型吡啶羧酸（2-氨基苯基）酰胺衍生物的合成，并找到该衍生物的药理作用。本发明提供由式（1）表示的化合物或其盐。在该式中，R 1和R 2表示氢原子，低级烷基等; R3表示羟基，低级烷氧基，低级环烷氧基，芳氧基，羧基，低级烷氧基羰基，-OCONRaRb，-NRcRd等; R4和R5代表卤原子，低级烷基，羟基，低级烷氧基等; Ra和Rb表示氢原子，低级烷基，低级环烷基，芳基，杂环基等; Rc和R d表示氢原子，低级烷基，低级环烷基，芳基等; X表示低级亚烷基; Y表示单键，低级亚烷基; W1-W2表示N-C或C-N; l和m表示0,1,2或3。

94. 发明申请

US20110136794A1 NOVEL PYRROLE DERIVATIVE HAVING, AS SUBSTITUENTS, UREIDO GROUP, AMINOCARBONLY GROUP AND BICYCLIC GROUP WHICH MAY HAVE SUBSTITUENT 失效
标题翻译：作为替代品的新奇派生物有限公司，UREIDO集团，可能具有替代品的亚洲集团和双子座组
公开(公告)号：US20110136794A1
公开(公告)日：2011-06-09
申请号：US12737807
申请日：2009-08-25
申请人： Kenji Kawashima , Noriko Kawashima , Hiroshi Enomoto , Minoru Yamamoto , Massaaki Murai
发明人： Kenji Kawashima , Noriko Kawashima , Hiroshi Enomoto , Minoru Yamamoto , Massaaki Murai
IPC分类号： A61K31/5415 , C07D207/34 , C07D405/04 , C07D409/04 , C07D409/10 , C07D405/10 , C07D417/04 , C07D413/10 , C07D417/10 , C07D403/10 , A61K31/40 , A61K31/4025 , A61K31/428 , A61K31/538 , A61K31/404 , A61P29/00 , A61P27/02
CPC分类号： C07D207/34 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04
摘要： A compound represented by the following formula (1) or a salt thereof: The compound has an inhibitory activity on the production of interleukin-6, and is therefore useful as a preventive and/or therapeutic agent for a disease associated with interleukin-6, ocular inflammatory diseases and the like. In the formula, R1 represents a halogen atom, a hydrogen atom, a lower alkyl group which may have a substituent, a formyl group, or a lower alkylcarbonyl group which may have a substituent, R2 represents a bicyclic hydrocarbon group which may have a substituent or a bicyclic heterocyclic group which may have a substituent, R3 represents a hydrogen atom, a lower alkyl group which may have a substituent, an aryl group which may have a substituent, or an acyl group.
摘要翻译：由下式（1）表示的化合物或其盐：该化合物对白介素-6的产生具有抑制活性，因此可用作与白细胞介素-6相关疾病的预防和/或治疗剂，眼部炎症性疾病等。式中，R 1表示卤素原子，氢原子，可具有取代基的低级烷基，甲酰基或可具有取代基的低级烷基羰基，R 2表示可具有取代基的二环烃基，或可以具有取代基的二环杂环基，R 3表示氢原子，可以具有取代基的低级烷基，可以具有取代基的芳基或酰基。

95. 发明申请

US20110124646A1 Novel cyclic compound having pyrimidinylalkylthio group 有权
标题翻译：具有嘧啶基烷硫基的新型环状化合物
公开(公告)号：US20110124646A1
公开(公告)日：2011-05-26
申请号：US12931072
申请日：2011-01-24
申请人： Hisashi Tajima , Takahiro Honda , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto
发明人： Hisashi Tajima , Takahiro Honda , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto
IPC分类号： A61K31/5377 , A61K31/506 , A61P35/00 , A61P29/00 , A61P27/02 , A61P17/06 , A61P9/10
CPC分类号： C07D401/14 , C07D239/42 , C07D401/12 , C07D409/12
摘要： A method of treating a disease associated with angiogenesis by administering a therapeutically effective amount of a compound represented by the formula (1) or a salt thereof wherein the ring X represents R1 and R2 independently represent a hydrogen atom, an alkyl, an aryl or an aromatic heterocyclic; R3 represents a hydrogen atom, a halogen atom, a hydroxy, an alkoxy, an aryloxy, an alkyl, an aryl, an amino, an alkylamino, a cycloalkylamino, an arylamino, an alkylcarbonylamino, an arylcarbonylamino, a mercapto, an alkylthio, an arylthio, an alkylsulfinyl or a nonaromatic heterocyclic; A1 represents a sulfur atom, a sulfinyl or a sulfonyl; and A2 represents an alkylene.
摘要翻译：通过施用治疗有效量的由式（1）表示的化合物或其盐来治疗与血管生成相关的疾病的方法，其中环X表示R 1和R 2独立地表示氢原子，烷基，芳基或芳香杂环; R 3表示氢原子，卤素原子，羟基，烷氧基，芳氧基，烷基，芳基，氨基，烷基氨基，环烷基氨基，芳基氨基，烷基羰基氨基，芳基羰基氨基，巯基，烷硫基芳硫基，烷基亚磺酰基或非芳族杂环; A1表示硫原子，亚磺酰基或磺酰基; A2表示亚烷基。

96. 发明申请

US20100063045A1 NOVEL PYRIDINECARBOXYLIC ACID (2-AMINOPHENYL) AMIDE DERIVATIVE HAVING UREA STRUCTURE 有权
标题翻译：具有尿素结构的新型吡啶羧酸（2-氨基苯基）酰胺衍生物
公开(公告)号：US20100063045A1
公开(公告)日：2010-03-11
申请号：US12450387
申请日：2008-03-28
申请人： Hiroyuki Mogi , Hasashi Tajima , Noriko Mishina , Yusuke Yamazaki , Shinji Yoneda , Katsuhiko Watanabe , Junko Fujikawa , Minoru Yamamoto
发明人： Hiroyuki Mogi , Hasashi Tajima , Noriko Mishina , Yusuke Yamazaki , Shinji Yoneda , Katsuhiko Watanabe , Junko Fujikawa , Minoru Yamamoto
IPC分类号： C07D213/60 , A61K31/44 , C07D413/12 , A61K31/5377 , C07D417/12 , C07D407/12 , C07D401/12 , C07D409/12 , C07D411/12 , A61K31/496 , C07D213/44
CPC分类号： C07D213/81 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Objects of the present invention are to study the synthesis of a novel pyridinecarboxylic acid (2-aminophenyl)amide derivative having a novel urea structure and to find a pharmacological effect of the derivative. The invention provides a compound represented by the formula (1) or a salt thereof. In the formula, R1 and R2 represent a hydrogen atom, a lower alkyl group or the like; R3 represents a hydroxy group, a lower alkoxy group, a lower cycloalkyloxy group, an aryloxy group, a carboxy group, a lower alkoxycarbonyl group, —OCONRaRb, —NRcRd or the like; R4 and R5 represent a halogen atom, a lower alkyl group, a hydroxy group, a lower alkoxy group or the like; Ra and Rb represent a hydrogen atom, a lower alkyl group, a lower cycloalkyl group, an aryl group, a heterocyclic group or the like; Rc and Rd represent a hydrogen atom, a lower alkyl group, a lower cycloalkyl group, an aryl group or the like; X represents a lower alkylene group; Y represents a single bond, a lower alkylene group; W1-W2 represents N—C or C—N; and l and m represent 0, 1, 2 or 3.
摘要翻译：本发明的目的是研究具有新型尿素结构的新型吡啶羧酸（2-氨基苯基）酰胺衍生物的合成，并找到该衍生物的药理作用。本发明提供由式（1）表示的化合物或其盐。在该式中，R 1和R 2表示氢原子，低级烷基等; R3表示羟基，低级烷氧基，低级环烷氧基，芳氧基，羧基，低级烷氧基羰基，-OCONRaRb，-NRcRd等; R4和R5代表卤原子，低级烷基，羟基，低级烷氧基等; Ra和Rb表示氢原子，低级烷基，低级环烷基，芳基，杂环基等; Rc和R d表示氢原子，低级烷基，低级环烷基，芳基等; X表示低级亚烷基; Y表示单键，低级亚烷基; W1-W2表示N-C或C-N; l和m表示0,1,2或3。

97. 发明申请

US20100014567A1 AUTOMATIC ADJUSTMENT METHOD FOR SERIAL INTERFACE CIRCUIT AND ELECTRONIC DEVICE HAVING SERIAL INTERFACE CIRCUIT 审中-公开
标题翻译：用于串行接口电路的自动调整方法和具有串行接口电路的电子设备
公开(公告)号：US20100014567A1
公开(公告)日：2010-01-21
申请号：US12475100
申请日：2009-05-29
申请人： Minoru Yamamoto
发明人： Minoru Yamamoto
IPC分类号： H04B1/38
CPC分类号： G06F13/4286
摘要： An automatic adjustment method for a serial interface circuit and an electronic device having a serial interface circuit perform automatic adjustment to optimum values of the transmitter, under any connection conditions, and without causing rule violations of the serial interface protocol. Various setting values are used in a transmitter and transmission frame retransmit instructions stipulated by the interface protocol are utilized. The frames are transmitted to a connected device using various setting values, and the results from the connected device (5) are used to adjust to the optimum transmitter values, operation specifications (conditions) of the interface protocol can be satisfied, and through retry of frame transfer the optimum values can be calculated.
摘要翻译：用于串行接口电路的自动调整方法和具有串行接口电路的电子设备在任何连接条件下对发射机的最佳值执行自动调整，并且不引起规则违反串行接口协议。在发送机中使用各种设定值，利用由接口协议规定的发送帧重发指令。使用各种设置值将帧发送到连接的设备，并且使用来自连接设备（5）的结果来调整到最佳发射机值，可以满足接口协议的操作规范（条件），并且通过重试帧传输可以计算最佳值。

98. 发明申请

US20090326009A1 Novel 1-2-Dihydroquinoline Derivative Having Glucocorticoid Receptor Binding Activity 有权
标题翻译：具有糖皮质激素受体结合活性的新型1-2-二氢喹啉衍生物
公开(公告)号：US20090326009A1
公开(公告)日：2009-12-31
申请号：US11992088
申请日：2006-09-14
申请人： Mamoru Matsuda , Toshiyuki Mori , Kenji Kawashima , Masato Nagatsuka , Sachiko Kobayashi , Minoru Yamamoto , Masatomo Kato , Miwa Takai , Tomoko Oda
发明人： Mamoru Matsuda , Toshiyuki Mori , Kenji Kawashima , Masato Nagatsuka , Sachiko Kobayashi , Minoru Yamamoto , Masatomo Kato , Miwa Takai , Tomoko Oda
IPC分类号： A61K31/4725 , C07D215/12 , A61K31/47 , A61P3/10
CPC分类号： C07D215/14 , C07D215/20 , C07D215/48 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： An object of the present invention is to study synthesis of a novel 1,2-dihydroquinoline derivative and to find a pharmacological action of the derivative. A compound represented by the general formula (1) or a salt thereof is effective in the treatment of a glucocorticoid receptor-related disease. In the formula, the ring X represents a benzene ring or a pyridine ring; R1 represents a halogen atom, an alkyl group, a hydroxy group, an alkoxy group, an amino group or the like; p represents an integer of 0 to 5; R2 represents a halogen atom, an alkyl group, a hydroxy group or the like; q represents an integer of 0 to 2; R3 represents a hydrogen atom, an alkyl group, an alkenyl group or the like; R4 and R5 represent a hydrogen atom or the like; R6 represents a hydrogen atom or the like; A represents an alkylene group or the like; and R7 represents OR8, NR8R9, SR8, S(O)R8 or S(O)2R8, wherein R8 represents an aryl group, a heterocyclic group or the like and R9 represents a hydrogen atom or the like.
摘要翻译：本发明的目的是研究新型1,2-二氢喹啉衍生物的合成，并找到衍生物的药理作用。由通式（1）表示的化合物或其盐在治疗糖皮质激素受体相关疾病方面是有效的。在该式中，环X表示苯环或吡啶环; R1表示卤素原子，烷基，羟基，烷氧基，氨基等; p表示0〜5的整数， R2表示卤素原子，烷基，羟基等; q表示0〜2的整数， R3表示氢原子，烷基，烯基等; R4和R5表示氢原子等; R6表示氢原子等; A表示亚烷基等; 并且R 7表示OR 8，NR 8 R 9，SR 8，S（O）R 8或S（O）2 R 8，其中R 8表示芳基，杂环基等，R 9表示氢原子等。

99. 发明授权

US07629063B2 Flame retardant and flame-retardant resin composition 失效
标题翻译：阻燃和阻燃树脂组合物
公开(公告)号：US07629063B2
公开(公告)日：2009-12-08
申请号：US10585824
申请日：2005-01-05
申请人： Minoru Yamamoto , Daisuke Suzuki
发明人： Minoru Yamamoto , Daisuke Suzuki
IPC分类号： B32B19/02
CPC分类号： C09K21/02 , B82Y30/00 , C01P2004/61 , C09C1/3676 , C09K21/14
摘要： A flame-retardant, characterized in that it comprises a layered titanic acid in the form of a nano sheet which is formed by a method comprising treating a layered titanic acid salt with an acid or warm water and then reacting the resultant mixture with an organic basic compound, or carrying out the step of treating a layered titanic acid salt with an acid or warm water and the step of reacting with an organic basic compound, in one pot, to thereby swell or separate the layers; and a flame-retardant resin composition, characterized in that it comprises 100 parts by weight of a resin and 0.5 to 50 parts by weight of the above layered titanic acid in the form of a nano sheet.
摘要翻译：一种阻燃剂，其特征在于，其包含纳米片形式的层状钛酸，其通过包括用酸或温水处理层状钛酸盐然后使所得混合物与有机碱或者用酸或温水进行层状钛酸盐处理的步骤和在一锅中与有机碱性化合物反应的步骤，从而使层膨胀或分离; 和阻燃性树脂组合物，其特征在于，其包含100重量份树脂和0.5至50重量份的纳米片形式的上述层状钛酸。

100. 发明申请

US20090291951A1 Novel Cyclic Compound Having Pyrimidinylalkylthio Group 有权
标题翻译：具有嘧啶基烷硫基的新型环状化合物
公开(公告)号：US20090291951A1
公开(公告)日：2009-11-26
申请号：US11887308
申请日：2006-03-31
申请人： Hisashi Tajima , Takahiro Honda , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto
发明人： Hisashi Tajima , Takahiro Honda , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto
IPC分类号： A61K31/5377 , C07D239/02 , C07D413/02 , A61K31/506 , A61P35/00
CPC分类号： C07D401/14 , C07D239/42 , C07D401/12 , C07D409/12
摘要： The present invention has its object to study synthesis of novel cyclic compounds having a pyrimidinylalkylthio group and to find pharmacological actions of the compounds. According to the present invention, a compound represented by the formula (1) or a salt thereof is provided. In the formula, the ring X represents: R1 and R2 independently represent a hydrogen atom, an alkyl group, an aryl group, an aromatic heterocyclic group or the like; R3 represents a hydrogen atom, a halogen atom, a hydroxy group, an alkoxy group, an aryloxy group, an alkyl group, an aryl group, an amino group, an alkylamino group or the like; A1 represents a sulfur atom or the like; and A2 represents an alkylene group.
摘要翻译：本发明的目的是研究具有嘧啶基烷硫基的新型环状化合物的合成，并找到化合物的药理作用。根据本发明，提供由式（1）表示的化合物或其盐。在该式中，环X表示：R 1和R 2分别表示氢原子，烷基，芳基，芳香族杂环基等， R 3表示氢原子，卤素原子，羟基，烷氧基，芳氧基，烷基，芳基，氨基，烷基氨基等; A1表示硫原子等; A2表示亚烷基。

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