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91. 发明申请

US20100242538A1 CRYOGENIC RECTIFICATION METHOD 有权
标题翻译：低温重建方法
公开(公告)号：US20100242538A1
公开(公告)日：2010-09-30
申请号：US12411700
申请日：2009-03-26
申请人： Neil Mark Prosser , Wei Zhang
发明人： Neil Mark Prosser , Wei Zhang
IPC分类号： F25J3/04
CPC分类号： F25J3/0423 , F25J3/04084 , F25J3/0409 , F25J3/04218 , F25J3/04309 , F25J3/04387 , F25J3/04412 , F25J3/04678 , F25J2240/10 , F25J2240/22 , F25J2245/58
摘要： The present invention provides a method of rectifying an oxygen, nitrogen and argon containing feed stream that employs high and low pressure columns and an argon column. Refrigeration is imparted through turboexpansion of a nitrogen-rich vapor stream withdrawn from the high pressure column. The nitrogen-rich vapor stream has a sufficiently high flow rate that the flow of both vapor and liquid within the low pressure column is decreased to such an extent that the diameter of the low pressure column can be made substantially equal to or less than that of the high pressure column. The use of the argon column allows recovery of the oxygen to be increased over that which would otherwise be obtained given the draw of the nitrogen-rich vapor. The argon column can be an argon rejection column in which the separated argon is discarded as waste.
摘要翻译：本发明提供一种使含有高，低压塔和氩塔的含氧，氮和氩的进料流整流的方法。通过从高压塔排出的富氮蒸气流的涡轮膨胀来赋予制冷。富氮蒸汽流具有足够高的流速，使得低压塔内的蒸汽和液体两者的流量降低到使得低压塔的直径基本上等于或小于高压塔。使用氩气柱可以使氧气的回收率增加到超过在富氮蒸气的排出时否则将获得的氧气。氩塔可以是氩排除塔，其中分离的氩被浪费掉。

92. 发明授权

US07803858B2 Anti-flocculant coating composition 有权
标题翻译：抗絮凝剂涂料组合物
公开(公告)号：US07803858B2
公开(公告)日：2010-09-28
申请号：US11481310
申请日：2006-07-05
申请人： Ozzie Moore Pressley , Wei Zhang
发明人： Ozzie Moore Pressley , Wei Zhang
IPC分类号： C08K5/49 , C08F130/02
CPC分类号： C09D5/028 , C08K3/013 , C08K3/22 , C08K3/26 , C08K3/34 , C09D7/61 , C09D17/007 , C09D17/008 , C08L43/02
摘要： An aqueous composition containing pigment and an acrylic polymer and having reduced flocculation of pigment particles.
摘要翻译：含有颜料和丙烯酸类聚合物的水性组合物，并且颜料颗粒的絮凝减少。

93. 发明申请

US20100239496A1 Imaging agents for detecting neurological disorders 有权
标题翻译：用于检测神经系统疾病的成像剂
公开(公告)号：US20100239496A1
公开(公告)日：2010-09-23
申请号：US12661777
申请日：2010-03-23
申请人： Umesh B. Gangadharmath , Hartmuth C. Kolb , Peter J.H. Scott , Joseph C. Walsh , Wei Zhang , Anna Katrin Szardenings , Anjana Sinha , Gang Chen , Eric Wang , Vani P. Mocharia , Chul Yu , Changhui Liu , Daniel Kurt Cashion , Dhanalakshmi Kasi
发明人： Umesh B. Gangadharmath , Hartmuth C. Kolb , Peter J.H. Scott , Joseph C. Walsh , Wei Zhang , Anna Katrin Szardenings , Anjana Sinha , Gang Chen , Eric Wang , Vani P. Mocharia , Chul Yu , Changhui Liu , Daniel Kurt Cashion , Dhanalakshmi Kasi
IPC分类号： A61K51/04 , C07D401/04 , C07D215/06 , C07D413/10 , C07D235/18 , C07D405/04 , C07D409/04 , C07D413/14 , C07D497/04 , C12Q1/02
CPC分类号： A61K51/0455 , A61K51/04 , A61K51/0453 , A61K51/0459 , A61K51/0463 , C07B59/002 , C07D215/06 , C07D235/14 , C07D277/62 , C07D401/04 , C07D403/06 , C07D413/10 , C07D413/14 , C07D487/04
摘要： Imaging agents of formula (I) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formula (I) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Aβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formula (I) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.
摘要翻译：式（I）的成像剂和用于检测神经障碍的方法包括向需要的患者施用能够结合tau蛋白和β-淀粉样蛋白肽的式（I）化合物。本发明还涉及成像A＆bgr的方法; 和tau聚集体，其包括引入可检测量的包含放射性标记的式（I）化合物的药物制剂，并检测患者中与淀粉样蛋白沉积物和/或tau蛋白相关的标记化合物。这些方法和组合使得临床前诊断和监测AD和其他神经障碍的进展。

94. 发明授权

US07786330B2 Process for producing 1,2-dialkoxy-3-fluorobenzene 失效
公开(公告)号：US07786330B2
公开(公告)日：2010-08-31
申请号：US12379553
申请日：2009-02-24
申请人： Mingjian Qiu , Wei Zhang , Zhaohui Chen , Chunshan Zhang , Yali Zhang
发明人： Mingjian Qiu , Wei Zhang , Zhaohui Chen , Chunshan Zhang , Yali Zhang
IPC分类号： C07C37/04 , C07C41/26
CPC分类号： C07C39/27 , C07C41/16 , C07C41/26 , C07C43/225 , C07C43/23
摘要： The present invention relates to a process for producing a 2-fluoro-6-halophenol as an intermediate; a process for producing a 2-alkoxy-3-fluorophenol and further a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; a second process for producing a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; and a 2-alkoxy-3-fluorophenol. The 2-fluoro-6-halophenol can be obtained using a 2-fluorophenol as a starting material and through a sulfonation reaction, a halogenation reaction, and a deprotection reaction. The 2-fluoro-6-halophenol is alkyl-etherified, and subsequently the halogen atom is converted into a hydroxyl group to obtain the 2-alkoxy-3-fluorophenol, which is further alkyl-etherified to thereby obtain the 1,2-dialkoxy-3-fluorobenzene. Alternatively, a 1,2-dialkoxy-3-fluorobenzene is also obtained by converting the halogen atom of the 2-fluoro-6-halophenol into a hydroxyl group to thereby form 3-fluorocatechol and subsequently alkyl-etherifying two hydroxyl groups thereof. The processes of the invention realize low production costs and high process yields, and thus are suitable for industrial production of a 1,2-dialkoxy-3-fluorobenzene.

95. 发明申请

US20100197927A1 Protein Tyrosine Phosphatase 1B Inhibitor, Preparation Methods and Uses Thereof 失效
标题翻译：蛋白酪氨酸磷酸酶1B抑制剂，其制备方法和用途
公开(公告)号：US20100197927A1
公开(公告)日：2010-08-05
申请号：US12530281
申请日：2008-02-26
申请人： Fajun Nan , Jia Li , Yi Wei , Wei Zhang , Jingya Li , Lei Shi
发明人： Fajun Nan , Jia Li , Yi Wei , Wei Zhang , Jingya Li , Lei Shi
IPC分类号： C07D277/30 , C07D417/12
CPC分类号： C07D277/30 , C07D417/12
摘要： PTP1B inhibitors with the following structure (formula I). Experiments indicate that these inhibitors can effectively inhibit the activity of protein tyrosine phosphatase 1B (PTP1B). They can be used as insulin sensitisers. They can be used to prevent, delay or treat diseases which are related to insulin antagonism mediated by PTP1B, especially diabetes type II and obesity. The invention also provides methods for preparing these inhibitors.
摘要翻译：具有以下结构的PTP1B抑制剂（式I）。实验表明，这些抑制剂能有效抑制蛋白酪氨酸磷酸酶1B（PTP1B）的活性。它们可以用作胰岛素敏化剂。它们可用于预防，延迟或治疗与PTP1B介导的胰岛素拮抗相关的疾病，特别是II型糖尿病和肥胖症。本发明还提供了制备这些抑制剂的方法。

96. 发明申请

US20100114639A1 ARRANGEMENT COMPRISING MEDICAL TREATMENT UNITS AND PERIPHERAL DEVICES AS WELL AS A PERIPHERAL DEVICE AND TREATMENT UNIT FOR USE IN SUCH AN ARRANGEMENT 有权
标题翻译：包括医疗治疗单位和外围设备的安排，作为外围设备和治疗单元，用于这种安排
公开(公告)号：US20100114639A1
公开(公告)日：2010-05-06
申请号：US12596613
申请日：2008-04-17
申请人： Claus Leiendecker , Carsten Müller , Elke Schulte , Wei Zhang
发明人： Claus Leiendecker , Carsten Müller , Elke Schulte , Wei Zhang
IPC分类号： G06Q10/00 , A61M1/14 , G06F15/16
CPC分类号： A61M1/14 , A61B5/002 , A61B5/021 , A61B5/024 , A61B90/90 , A61B90/98 , A61B2017/00119 , A61B2017/00221 , A61B2017/00482 , A61B2562/08 , A61M2205/3569 , A61M2205/3576 , A61M2205/6018 , A61M2205/6054 , A61M2205/8237 , A61M2205/84 , G06F19/00 , G06Q50/24 , G16H10/60
摘要： An assembly includes at least two medical treatment units, each of which can be allocated to a patient and at least two peripheral devices, each of which can be allocated to a patient. The peripheral devices and the treatment units have means for allocating a peripheral device to a treatment unit and means for verifying the allocation of a peripheral device to a patient. To allocate a peripheral device to a treatment unit, the peripheral device is placed by operators in a receiving unit belonging to the treatment unit. Said receiving unit is preferably designed as a charging station for the battery of the peripheral device. In the event of a successful allocation of peripheral device and patient, confirmed by the receipt of physiological data of the patient, the operators verify the correct allocation of a peripheral device to the patient and must confirm the correct allocation by confirmation means. The peripheral device is only released if the operator has confirmed the correct allocation, preferably within a predefined time period.
摘要翻译：组件包括至少两个医疗单元，每个医疗单元可以分配给患者和至少两个外围设备，每个外围设备可以分配给患者。外围设备和治疗单元具有用于将外围设备分配给治疗单元的装置和用于验证外围设备对患者的分配的装置。为了将外围设备分配给治疗单元，外围设备由操作员放置在属于治疗单元的接收单元中。所述接收单元优选地被设计为用于外围设备的电池的充电站。在外部设备和患者的成功分配的情况下，通过接收患者的生理数据确认，操作者验证外部设备对患者的正确分配，并且必须通过确认手段确认正确的分配。如果操作者已经确定了正确的分配，则优选地在预定的时间段内，外围设备才被释放。

97. 发明申请

US20100098634A1 Imaging Agents Useful for Identifying AD Pathology 有权
标题翻译：用于识别AD病理学的成像剂
公开(公告)号：US20100098634A1
公开(公告)日：2010-04-22
申请号：US12509259
申请日：2009-07-24
申请人： Hartmuth C. Kolb , Joseph C. Walsh , Wei Zhang , Umesh B. Gangadharmath , Dhanalakshmi Kasi , Kai Chen , Anjana Sinha , Eric Wang , Gang Chen , Peter J.H. Scott , Henry Clifton Padgett , Qianwa Liang , Zhiyong Gao , Tieming Zhao , Chunfang Xia
发明人： Hartmuth C. Kolb , Joseph C. Walsh , Wei Zhang , Umesh B. Gangadharmath , Dhanalakshmi Kasi , Kai Chen , Anjana Sinha , Eric Wang , Gang Chen , Peter J.H. Scott , Henry Clifton Padgett , Qianwa Liang , Zhiyong Gao , Tieming Zhao , Chunfang Xia
IPC分类号： A61K51/04 , C07D277/02 , C07D495/02 , C07D209/34 , C07D221/02 , C07D455/00 , C07D417/00 , C07D487/00 , C07D401/02 , C07D471/00 , C07D209/82 , C07D307/91 , A61P25/28 , G01N33/53
CPC分类号： C07D417/14 , A61K51/0406 , A61K51/0453 , A61K51/0455 , A61K51/0459 , C07D277/64 , C07D277/68 , C07D417/04 , C07D471/04 , C07D498/14 , C07D513/04 , C07D513/14
摘要： Provided herein are compounds and compositions which comprise the formulae as disclosed herein, wherein the compound is an amyloid binding compound. An amyloid binding compound according to the invention may be administered to a patient in amounts suitable for in vivo imaging of amyloid deposits, and distinguish between neurological tissue with amyloid deposits and normal neurological tissue. Amyloid probes of the invention may be used to detect and quantitate amyloid deposits in diseases including, for example, Down's syndrome, familial Alzheimer's Disease. In another embodiment, the compounds may be used in the treatment or prophylaxis of neurodegenerative disorders. Also provided herein are methods of allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing a neurodegenerative disease.
摘要翻译：本文提供了包含本文公开的式的化合物和组合物，其中所述化合物是淀粉样蛋白结合化合物。根据本发明的淀粉样蛋白结合化合物可以以适于淀粉样蛋白沉积物的体内成像的量施用于患者，并且可以区分具有淀粉样沉积物的神经组织和正常神经组织。本发明的淀粉样蛋白探针可用于检测和定量疾病中的淀粉样蛋白沉积物，包括例如唐氏综合症，家族性阿尔茨海默氏病。在另一个实施方案中，所述化合物可用于治疗或预防神经变性疾病。本文还提供了允许化合物分布到脑组织中并对脑组织成像的方法，其中与正常对照结合水平相比，化合物与脑组织的结合增加指示哺乳动物患有或有发展神经变性疾病的风险。

98. 发明授权

US07688199B2 Smoke and fire detection in aircraft cargo compartments 有权
标题翻译：飞机货舱中的烟雾和火灾探测
公开(公告)号：US07688199B2
公开(公告)日：2010-03-30
申请号：US11555992
申请日：2006-11-02
申请人： Wei Zhang , Chao-Hsin Lin
发明人： Wei Zhang , Chao-Hsin Lin
IPC分类号： G08B1/08 , G08B21/00 , G08B25/00
CPC分类号： G08B17/00 , A62C3/08 , G08B31/00
摘要： A detection system may include at least one sensor located in an enclosable space, each sensor being configured to detect at least one environmental feature and provide a corresponding at least one environmental feature signal. The system may process the at least one environmental feature signal and provide at least one processed feature signal, the at least one processed feature signal corresponding to a transformed at least one environmental feature signal. The system may further provide a hosted function configured to provide instructions for processing, the hosted function comprising a computational algorithm adapted to perform numerical transformation operations based on the at least one environmental feature signal, the hosted function being configured to provide a map image based on the at least one processed feature signal.
摘要翻译：检测系统可以包括位于可封闭空间中的至少一个传感器，每个传感器被配置成检测至少一个环境特征并提供对应的至少一个环境特征信号。所述系统可以处理所述至少一个环境特征信号并提供至少一个经处理的特征信号，所述至少一个经处理的特征信号对应于经变换的至少一个环境特征信号。所述系统还可以提供被配置为提供用于处理的指令的托管功能，所述托管功能包括适于基于所述至少一个环境特征信号执行数字变换操作的计算算法，所述托管功能被配置为基于所述至少一个经处理的特征信号。

99. 发明申请

US20100074551A1 LEARNING-BASED PARTIAL DIFFERENTIAL EQUATIONS FOR COMPUTER VISION 审中-公开
标题翻译：用于计算机视觉的基于学习的部分差分方程
公开(公告)号：US20100074551A1
公开(公告)日：2010-03-25
申请号：US12235488
申请日：2008-09-22
申请人： Zhouchen Lin , Wei Zhang
发明人： Zhouchen Lin , Wei Zhang
IPC分类号： G06K9/40
CPC分类号： G06K9/40 , G06T5/001 , G06T7/10 , G06T2207/20081
摘要： Partial differential equations (PDEs) are used in the invention for various problems in computer the vision space. The present invention provides a framework for learning a system of PDEs from real data to accomplish a specific vision task. In one embodiment, the system consists of two PDEs. One controls the evolution of the output. The other is for an indicator function that helps collect global information. Both PDEs are coupled equations between the output image and the indicator function, up to their second order partial derivatives. The way they are coupled is suggested by the shift and rotational invariance that the PDEs should hold. The coupling coefficients are learnt from real data via an optimal control technique. The invention provides learning-based PDEs that make a unified framework for handling different vision tasks, such as edge detection, denoising, segementation, and object detection.
摘要翻译：局部微分方程（PDE）用于本发明的计算机视觉空间中的各种问题。本发明提供了一种用于从实际数据学习PDE系统以完成特定视觉任务的框架。在一个实施例中，系统由两个PDE组成。一个控制输出的演变。另一个是用于帮助收集全球信息的指标功能。两个PDE是输出图像和指示符函数之间的耦合方程，直到它们的二阶偏导数。它们耦合的方式是由PDE应该保持的移动和旋转不变性来提出的。通过最优控制技术从实数数据中学习耦合系数。本发明提供了基于学习的PDE，其构成用于处理不同视觉任务的统一框架，例如边缘检测，去噪，分割和对象检测。

100. 发明授权

US07672494B2 Processing medical image information to detect anatomical abnormalities 有权
标题翻译：处理医学图像信息以检测解剖异常
公开(公告)号：US07672494B2
公开(公告)日：2010-03-02
申请号：US11419980
申请日：2006-05-23
申请人： Takeshi Doi , Wei Zhang
发明人： Takeshi Doi , Wei Zhang
IPC分类号： G06K9/00 , A61B6/04
CPC分类号： G06T7/0012 , G06T2207/30068
摘要： A method, system, and related computer program products are provided for processing a medical image of a body part according to a computer-aided detection (CAD) algorithm, the medical image having an image border, the body part comprising imaged tissue appearing inside the image border and outlying tissue not appearing in the medical image, wherein likely anatomical abnormalities in the outlying tissue near the imaged tissue border are detected by the CAD algorithm. In one example, the detected likely abnormalities in the outlying tissue are located within a first distance from the imaged tissue border, wherein the first distance corresponds to a spatial ambit of a neighborhood-based feature computed by the CAD algorithm.
摘要翻译：提供了一种根据计算机辅助检测（CAD）算法来处理身体部位的医学图像的方法，系统和相关的计算机程序产品，所述医学图像具有图像边界，所述身体部分包括出现在内部的成像组织图像边界和不存在于医学图像中的外围组织，其中通过CAD算法检测在成像组织边界附近的外围组织中可能的解剖异常。在一个示例中，所检测到的外围组织中可能的异常位于距成像组织边界的第一距离内，其中第一距离对应于由CAD算法计算的基于邻域的特征的空间范围。

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