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91. 发明申请

US20050214281A1 G-protein coupled receptor 审中-公开
标题翻译： G蛋白偶联受体
公开(公告)号：US20050214281A1
公开(公告)日：2005-09-29
申请号：US10986025
申请日：2004-11-12
申请人： Yi Li , Craig Rosen , Jeannine Gocayne
发明人： Yi Li , Craig Rosen , Jeannine Gocayne
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61K48/00 , A61P1/04 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/00 , A61P25/24 , A61P25/26 , A61P37/08 , A61P43/00 , C07H21/04 , C07K14/705 , C07K16/28 , C12N5/00 , C12N5/06 , C12N5/10 , C12N15/00 , C12N15/02 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/15 , G01N33/53
CPC分类号： C07K14/705 , A61K38/00 , C12N2799/026
摘要： A human G-protein coupled receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying antagonists and agonists to such polypeptide. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequence.
摘要翻译：公开了人G-蛋白偶联受体多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这种多肽鉴定这种多肽的拮抗剂和激动剂的方法。还公开了用于检测G蛋白偶联受体核酸序列中的突变的诊断方法。

92. 发明申请

US20050214208A1 Antibodies that immunospecifically bind to TRAIL receptors 审中-公开
标题翻译：免疫特异性结合TRAIL受体的抗体
公开(公告)号：US20050214208A1
公开(公告)日：2005-09-29
申请号：US10981691
申请日：2004-11-05
申请人： Theodora Salcedo , Craig Rosen , Vivian Albert , Robin Humphreys , Tristan Vaughan
发明人： Theodora Salcedo , Craig Rosen , Vivian Albert , Robin Humphreys , Tristan Vaughan
IPC分类号： A61K39/395 , A61K51/00 , C07K16/28 , C07K16/30 , C07K16/46
CPC分类号： C07K16/2878 , A61K45/06 , A61K2039/505 , C07K16/30 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/30
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR7. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR7 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR7.
摘要翻译：本发明涉及免疫特异性结合TRAIL受体TR7的抗体和相关分子。这样的抗体具有例如用于预防和治疗癌症和其它增殖性疾病的用途。本发明还涉及编码抗TR7抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症和其它过度增殖性疾病的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段或其变体，或免疫特异性结合TRAIL受体TR7的相关分子。

93. 发明申请

US20050208622A1 50 human secreted proteins 失效
标题翻译： 50种人体分泌的蛋白质
公开(公告)号：US20050208622A1
公开(公告)日：2005-09-22
申请号：US10970493
申请日：2004-10-22
申请人： Paul Moore , Steven Ruben , David LaFleur , Yanggu Shi , Craig Rosen , Henrik Olsen , Reinhard Ebner , Laurie Brewer
发明人： Paul Moore , Steven Ruben , David LaFleur , Yanggu Shi , Craig Rosen , Henrik Olsen , Reinhard Ebner , Laurie Brewer
IPC分类号： A61K38/00 , A61K48/00 , C07H21/04 , C07K14/47
CPC分类号： C07H21/04 , A61K38/00 , A61K48/00 , C07K14/47 , G01N2800/042
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

94. 发明申请

US20050208602A1 89 human secreted proteins 审中-公开
标题翻译： 89人分泌蛋白
公开(公告)号：US20050208602A1
公开(公告)日：2005-09-22
申请号：US10773236
申请日：2004-02-09
申请人： Craig Rosen , Kevin Baker , Charles Birse , Gil Choi , Michele Fiscella , George Komatsoulis , Paul Moore , Jian Ni , Henrik Olsen , Steven Ruben , Ping Wei , D. Roxanne Duan , Yanggu Shi
发明人： Craig Rosen , Kevin Baker , Charles Birse , Gil Choi , Michele Fiscella , George Komatsoulis , Paul Moore , Jian Ni , Henrik Olsen , Steven Ruben , Ping Wei , D. Roxanne Duan , Yanggu Shi
IPC分类号： A61K38/00 , A61K38/17 , G01N33/53 , G01N33/537 , G01N33/543 , G01N33/68
CPC分类号： G01N33/68 , A61K38/00 , G01N33/5005 , G01N33/5008 , G01N33/502 , G01N33/6845
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及人分泌多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗与所述人分泌蛋白相关的疾病，病症和/或病症。结合这些多肽的抗体也包括在本发明中。本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

95. 发明申请

US20050192429A1 Vascular endothelial growth factor 2 失效
公开(公告)号：US20050192429A1
公开(公告)日：2005-09-01
申请号：US10992196
申请日：2004-11-19
申请人： Craig Rosen , Vivian Albert , Steven Ruben , Ruth Wager
发明人： Craig Rosen , Vivian Albert , Steven Ruben , Ruth Wager
IPC分类号： A61K39/395 , C07K16/22
CPC分类号： A61K39/39558 , C07K14/475 , C07K16/22 , C07K2317/73 , C07K2317/92 , A61K2300/00
摘要： Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention also relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.

96. 发明申请

US20050186637A1 Neutrokine-alpha and neutrokine-alpha splice variant 有权
标题翻译： Neutrokine-alpha和中性粒细胞-α剪接变体
公开(公告)号：US20050186637A1
公开(公告)日：2005-08-25
申请号：US11054539
申请日：2005-02-10
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig Rosen , Stephen Ullrich
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig Rosen , Stephen Ullrich
IPC分类号： A61K38/00 , A61K47/48 , A61K49/00 , C07K14/52 , C07K14/705 , C07K14/715 , C07K16/24 , C07K16/28 , G01N33/564 , A61K39/395 , G01N33/53
CPC分类号： G01N33/56972 , A61K31/519 , A61K38/00 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/70575 , C07K14/715 , C07K16/24 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N2333/52 , G01N2800/24
摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.
摘要翻译：本发明涉及编码Neutrokine-α和/或Neutrokine-αSV多肽的核酸分子，包括细胞外结构域的可溶形式。还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及使用这些抗体特异性结合中枢神经素α和/或中枢神经素-αSV的诊断和治疗方法的抗体或其部分。还提供了用于检测免疫系统相关疾病的诊断方法和使用本发明的组合物治疗免疫系统相关疾病的治疗方法。

97. 发明申请

US20050181371A1 70 human secreted proteins 审中-公开
标题翻译： 70种人体分泌的蛋白质
公开(公告)号：US20050181371A1
公开(公告)日：2005-08-18
申请号：US10644765
申请日：2003-08-21
申请人： Craig Rosen , George Komatsoulis , Kevin Baker , Michele Fiscella , Paul Moore , Ping Wei , D. Duan , Yanggu Shi , Ram Gupta
发明人： Craig Rosen , George Komatsoulis , Kevin Baker , Michele Fiscella , Paul Moore , Ping Wei , D. Duan , Yanggu Shi , Ram Gupta
IPC分类号： C07H21/04 , C07K14/47 , C12Q1/68
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

98. 发明申请

US20050176044A1 Polynucleotides and polypeptides encoding receptors 审中-公开
标题翻译：编码受体的多核苷酸和多肽
公开(公告)号：US20050176044A1
公开(公告)日：2005-08-11
申请号：US11041419
申请日：2005-01-25
申请人： Jian Ni , Craig Rosen , Reiner Gentz
发明人： Jian Ni , Craig Rosen , Reiner Gentz
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61K48/00 , A61P35/00 , C07K14/47 , C07K14/705 , C07K14/735 , C07K16/18 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/64 , C12N15/12 , C12Q1/68 , G01N33/15 , G01N33/50 , A61K38/17 , C07H21/04
CPC分类号： C07K14/70535 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C12N9/6421 , C12N9/6475 , C12N9/6489 , C12N9/6491 , C12N2799/026
摘要： Receptor polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing receptor polypeptides and polynucleotides in the design of protocols for the treatment of diseases and diagnostic assays for such conditions.
摘要翻译：公开了受体多肽和多核苷酸以及通过重组技术产生这种多肽的方法。还公开了在设计用于治疗疾病的方案和用于这些病症的诊断测定中使用受体多肽和多核苷酸的方法。

99. 发明申请

US20050163747A1 Heteromultimeric TNF ligand family members 审中-公开
标题翻译：异源多聚体TNF配体家族成员
公开(公告)号：US20050163747A1
公开(公告)日：2005-07-28
申请号：US11028780
申请日：2005-01-05
申请人： David Hilbert , Craig Rosen
发明人： David Hilbert , Craig Rosen
IPC分类号： A61K38/00 , A61K38/19 , A61K39/395 , C07K14/52 , C07K14/525 , C07K16/24 , C12N15/12 , C12N15/63 , C12P21/02
CPC分类号： C07K14/525 , A61K38/00
摘要： The present invention relates to compositions comprising heteromultimeric complexes, and particularly heterotrimeric complexes, of TNF ligand family members, and methods of using such complexes in the detection, prevention, and treatment of disease. Heteromultimeric TNF ligand polypeptide complexes comprising human TNF ligand polypeptides, including soluble forms of the extracellular domains, as well as membrane bound forms of TNF ligand polypeptides are provided. Heteromultimeric TNF ligand polypeptide complexes are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of heteromultimeric TNF ligand polypeptide complexes. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及包含TNF配体家族成员的异多聚体复合物，特别是异三聚体复合物的组合物，以及在疾病的检测，预防和治疗中使用这些复合物的方法。提供了包含人TNF配体多肽，包括细胞外结构域的可溶形式以及TNF结合形式的TNF配体多肽的多组胺TNF配体多肽复合物。还提供了异源多聚体TNF配体多肽复合物，载体，宿主细胞和用于制备其的重组方法。本发明还涉及用于鉴定异源多聚体TNF配体多肽复合物的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

100. 发明申请

US20050154193A1 Human G-protein chemokine receptor (CCR5) HDGNR10 有权
标题翻译：人类G蛋白趋化因子受体（CCR5）HDGNR10
公开(公告)号：US20050154193A1
公开(公告)日：2005-07-14
申请号：US10994679
申请日：2004-11-23
申请人： Viktor Roschke , Craig Rosen , Steven Ruben
发明人： Viktor Roschke , Craig Rosen , Steven Ruben
IPC分类号： A61K38/00 , A61K48/00 , C07K14/715 , C07K16/24 , C07K16/46
CPC分类号： C07K14/7158 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K16/24 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to a novel human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed to human antibodies that bind Human G-protein Chemokine Receptor (CCR5) HDGNR10 and to polynucleotides encoding those antibodies. Also provided are vectors, host cells, antibodies, and recombinant methods for producing Human G-protein Chemokine Receptor (CCR5) HDGNR10 and human anti-Human G-protein Chemokine Receptor (CCR5) HDGNR10 antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to this novel human protein and these novel human antibodies.
摘要翻译：本发明涉及一种称为人G蛋白趋化因子受体（CCR5）HDGNR10的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。本发明还涉及结合人G蛋白趋化因子受体（CCR5）HDGNR10的人抗体和编码那些抗体的多核苷酸。还提供了用于产生人G蛋白趋化因子受体（CCR5）HDGNR10和人抗人G蛋白趋化因子受体（CCR5）HDGNR10抗体的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与该新型人蛋白质和这些新型人抗体相关的疾病，病症和/或病症的诊断和治疗方法。

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