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1. 发明申请

US20050249671A9 Neutrokine-alpha conjugate, neutrokine-alpha complex, and uses thereof 审中-公开
标题翻译：中性粒细胞α偶联物，中性粒细胞α复合物及其应用
公开(公告)号：US20050249671A9
公开(公告)日：2005-11-10
申请号：US10742634
申请日：2003-12-22
申请人： David Parmelee , Ren-Hwa Yeh , Olga Galperina , David Hilbert , Craig Rosen
发明人： David Parmelee , Ren-Hwa Yeh , Olga Galperina , David Hilbert , Craig Rosen
IPC分类号： A61K47/48 , C07K14/52 , A61K49/00 , C07K14/525
CPC分类号： C07K14/52 , A61K47/66 , A61K47/6903 , B82Y5/00
摘要： The present invention is directed to a Neutrokine-alpha conjugate, wherein said Neutrokine-alpha conjugate comprises a Neutrokine-alpha protein and a chelator. The present invention is also directed to a Neutrokine-alpha complex, wherein said Neutrokine-alpha complex comprises a Neutrokine-alpha conjugate and a metal ion wherein said metal ion is noncovalently associated with the chelator of said conjugate. The present invention is further directed to compositions, specifically pharmaceutical and diagnostic compositions, comprising a Neutrokine-alpha conjugate or complex as described herein. Therapeutic and diagnostic uses of said conjugate, complex, and compositions are described.
摘要翻译：本发明涉及一种Neutrokine-α缀合物，其中所述Neutrokine-α缀合物包含Neutrokine-α蛋白和螯合剂。本发明还涉及一种中枢神经素α复合物，其中所述中枢神经素α复合物包含中枢神经素α偶联物和金属离子，其中所述金属离子与所述缀合物的螯合剂非共价结合。本发明进一步涉及包含如本文所述的中和型α结合物或复合物的组合物，特别是药物和诊断组合物。描述了所述缀合物，复合物和组合物的治疗和诊断用途。

2. 发明申请

US20050163747A1 Heteromultimeric TNF ligand family members 审中-公开
标题翻译：异源多聚体TNF配体家族成员
公开(公告)号：US20050163747A1
公开(公告)日：2005-07-28
申请号：US11028780
申请日：2005-01-05
申请人： David Hilbert , Craig Rosen
发明人： David Hilbert , Craig Rosen
IPC分类号： A61K38/00 , A61K38/19 , A61K39/395 , C07K14/52 , C07K14/525 , C07K16/24 , C12N15/12 , C12N15/63 , C12P21/02
CPC分类号： C07K14/525 , A61K38/00
摘要： The present invention relates to compositions comprising heteromultimeric complexes, and particularly heterotrimeric complexes, of TNF ligand family members, and methods of using such complexes in the detection, prevention, and treatment of disease. Heteromultimeric TNF ligand polypeptide complexes comprising human TNF ligand polypeptides, including soluble forms of the extracellular domains, as well as membrane bound forms of TNF ligand polypeptides are provided. Heteromultimeric TNF ligand polypeptide complexes are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of heteromultimeric TNF ligand polypeptide complexes. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及包含TNF配体家族成员的异多聚体复合物，特别是异三聚体复合物的组合物，以及在疾病的检测，预防和治疗中使用这些复合物的方法。提供了包含人TNF配体多肽，包括细胞外结构域的可溶形式以及TNF结合形式的TNF配体多肽的多组胺TNF配体多肽复合物。还提供了异源多聚体TNF配体多肽复合物，载体，宿主细胞和用于制备其的重组方法。本发明还涉及用于鉴定异源多聚体TNF配体多肽复合物的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

3. 发明授权

US09187548B2 Antibodies that immunospecifically bind to B lymphocyte stimulator protein 有权
公开(公告)号：US09187548B2
公开(公告)日：2015-11-17
申请号：US13356314
申请日：2012-01-23
申请人： Steven M. Ruben , Steven C. Barash , Gil H. Choi , Tristan Vaughan , David Hilbert
发明人： Steven M. Ruben , Steven C. Barash , Gil H. Choi , Tristan Vaughan , David Hilbert
IPC分类号： C07H21/04 , C07K14/705 , A61K47/48 , A61K49/00 , C07K14/52 , C07K16/28 , G01N33/564 , A61K39/00
CPC分类号： C07K14/70575 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07K14/52 , C07K16/2875 , C07K2317/21 , C07K2317/622 , G01N33/564
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.

4. 发明申请

US20070153128A1 Smart cable for controlling video capture device 有权
标题翻译：用于控制视频采集设备的智能电缆
公开(公告)号：US20070153128A1
公开(公告)日：2007-07-05
申请号：US11324859
申请日：2006-01-04
申请人： John Adcock , Laurent Denoue , David Hilbert , Matthew Cooper
发明人： John Adcock , Laurent Denoue , David Hilbert , Matthew Cooper
IPC分类号： H04N5/268
CPC分类号： G11B31/00 , G11B33/10
摘要： An element, such as a plug on a VGA cable, can communicate with a media storage unit to enable or disable media storage.
摘要翻译：诸如VGA电缆上的插头的元件可以与媒体存储单元通信以启用或禁用媒体存储。

5. 发明申请

US20060090134A1 System and method for detecting user actions in a video stream 有权
标题翻译：用于检测视频流中的用户动作的系统和方法
公开(公告)号：US20060090134A1
公开(公告)日：2006-04-27
申请号：US10973198
申请日：2004-10-26
申请人： John Adcock , Laurent Denoue , Jonathan Trevor , David Hilbert
发明人： John Adcock , Laurent Denoue , Jonathan Trevor , David Hilbert
IPC分类号： G06F9/00 , G11B27/00
CPC分类号： G06F3/04842 , G06F3/0482 , H04N21/4728 , H04N21/6581
摘要： Embodiments of the present invention include a video server that can detect and track the image of a pointing indicator in an input video stream representation of a computer display. The video server checks ordered frames of the video signal and determines movements for a pointing indicator such as a mouse arrow. Certain motions by the pointing indicator, such as lingering over a button or menu item or circling a button or menu item can provoke a control action on the server.
摘要翻译：本发明的实施例包括可以在计算机显示器的输入视频流表示中检测和跟踪指示指示符的图像的视频服务器。视频服务器检查视频信号的有序帧，并确定诸如鼠标箭头的指示指示器的移动。指示指示器的某些运动，例如挥动按钮或菜单项或旋转按钮或菜单项可能会引起服务器上的控制动作。

6. 发明申请

US20060062789A1 Antibodies that immunospecifically bind to B lymphocyte stimulator protein 有权
公开(公告)号：US20060062789A1
公开(公告)日：2006-03-23
申请号：US11266444
申请日：2005-11-04
申请人： Steven Ruben , Steven Barash , Gil Choi , Tristan Vaughan , David Hilbert
发明人： Steven Ruben , Steven Barash , Gil Choi , Tristan Vaughan , David Hilbert
IPC分类号： C07K16/24 , A61K39/395 , G01N33/53
CPC分类号： C07K14/70575 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07K14/52 , C07K16/2875 , C07K2317/21 , C07K2317/622 , G01N33/564
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.

7. 发明申请

US20050255532A1 Antibodies that immunospecifically bind to B lymphocyte stimulator 有权
标题翻译：免疫特异性结合B淋巴细胞刺激物的抗体
公开(公告)号：US20050255532A1
公开(公告)日：2005-11-17
申请号：US11054515
申请日：2005-02-10
申请人： Steven Ruben , Steven Barash , Gil Choi , Tristan Vaughan , David Hilbert
发明人： Steven Ruben , Steven Barash , Gil Choi , Tristan Vaughan , David Hilbert
IPC分类号： C07H21/04 , C07K16/28 , C07K16/30 , C12N5/06 , G01N33/50 , G01N33/574 , G01N33/68
CPC分类号： C07K16/2875 , A61K35/12 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07K14/52 , C07K14/70575 , C07K2317/21 , C07K2317/622 , G01N33/5008 , G01N33/5011 , G01N33/5052 , G01N33/5091 , G01N33/564 , G01N33/574 , G01N33/68
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated vith aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.
摘要翻译：本发明涉及免疫特异性结合B淋巴细胞刺激物的抗体和相关分子。本发明还涉及用于检测或诊断与异常B淋巴细胞刺激物表达相关的疾病或病症的方法和组合物，其包含抗体或其片段或变体，或免疫特异性结合B淋巴细胞刺激物的相关分子的B淋巴细胞刺激物的不适当功能。本发明还涉及用于预防，治疗或改善与异常B淋巴细胞刺激物表达或不适当B淋巴细胞刺激因子功能相关的疾病或病症的方法和组合物，包括向动物施用有效量的一种或多种抗体或其片段或变体或免疫特异性结合B淋巴细胞刺激物的相关分子。

8. 发明申请

US20050188026A1 Email distribution system and method 审中-公开
标题翻译：电子邮件分发系统和方法
公开(公告)号：US20050188026A1
公开(公告)日：2005-08-25
申请号：US10777571
申请日：2004-02-11
申请人： David Hilbert , Jonathan Trevor
发明人： David Hilbert , Jonathan Trevor
IPC分类号： G06F13/00 , G06F15/16 , H04L12/58
CPC分类号： H04L51/08 , H04L51/00 , H04L51/063
摘要： Embodiments of the present invention include systems, methods, and computer readable media for processing electronic mail attachments. Embodiments of the present invention intercept electronic mail messages containing attachments, and transmit the attachments to a file server. A message parser removes the file attachments from the messages and inserts hypertext links or executables directing the recipient to the copy of the attachment stored on the file server.
摘要翻译：本发明的实施例包括用于处理电子邮件附件的系统，方法和计算机可读介质。本发明的实施例拦截包含附件的电子邮件消息，并将附件发送到文件服务器。消息解析器从消息中删除文件附件，并插入将收件人指向存储在文件服务器上的附件副本的超文本链接或可执行文件。

9. 发明授权

US08101181B2 Antibodies that immunospecifically bind to B lymphocyte stimulator protein 有权
标题翻译：免疫特异性结合B淋巴细胞刺激蛋白的抗体
公开(公告)号：US08101181B2
公开(公告)日：2012-01-24
申请号：US12552915
申请日：2009-09-02
申请人： Steven M. Ruben , Gil H. Choi , Tristan Vaughan , David Hilbert
发明人： Steven M. Ruben , Gil H. Choi , Tristan Vaughan , David Hilbert
IPC分类号： A61K39/395
CPC分类号： C07K14/70575 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07K14/52 , C07K16/2875 , C07K2317/21 , C07K2317/622 , G01N33/564
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.
摘要翻译：本发明涉及免疫特异性结合B淋巴细胞刺激物的抗体和相关分子。本发明还涉及用于检测或诊断与异常B淋巴细胞刺激物表达或B淋巴细胞刺激因子不适当功能相关的疾病或病症的方法和组合物，其包含免疫特异性结合B淋巴细胞刺激物的抗体或其片段或变体或相关分子。本发明还涉及用于预防，治疗或改善与异常B淋巴细胞刺激物表达或不适当B淋巴细胞刺激因子功能相关的疾病或病症的方法和组合物，包括向动物施用有效量的一种或多种抗体或其片段或变体或免疫特异性结合B淋巴细胞刺激物的相关分子。

10. 发明申请

US20090006371A1 SYSTEM AND METHOD FOR RECOMMENDING INFORMATION RESOURCES TO USER BASED ON HISTORY OF USER'S ONLINE ACTIVITY 有权
标题翻译：基于用户在线活动历史向用户推荐信息资源的系统和方法
公开(公告)号：US20090006371A1
公开(公告)日：2009-01-01
申请号：US11771799
申请日：2007-06-29
申请人： Laurent Denoue , Daniel Billsus , David Hilbert , John Adcock , Gene Golovchinsky
发明人： Laurent Denoue , Daniel Billsus , David Hilbert , John Adcock , Gene Golovchinsky
IPC分类号： G06F17/30
CPC分类号： G06F17/30867
摘要： Blogs (and other information sources) are recommended to a user based history of user's online activities. The system: (1) processes the user's web history, (2) identifies blog posts (and web pages) that link to pages read by the user, (3) generates multiple relevance scores for each identified post/page, and (4) produces multiple rankings of the corresponding source blogs (and web sites) by aggregating individual relevance scores (or combinations of relevance scores), according to users' preferences. The system allows the discovery of information sources that are likely to be interesting to the user and allows sources lost in the “long tail” to be seamlessly discovered.
摘要翻译：推荐用户基于用户的在线活动历史的博客（和其他信息来源）。系统：（1）处理用户的网络历史，（2）识别链接到用户阅读的页面的博文（和网页），（3）为每个标识的帖子/页面生成多个相关性分数，以及（4）根据用户的喜好，通过聚合个人相关性分数（或相关性分数的组合）来生成相应源博客（和网站）的多个排名。该系统允许发现可能对用户感兴趣的信息源，并允许无缝发现“长尾巴”中丢失的信息源。

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