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91. 发明申请

US20070117829A1 Oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone 有权
公开(公告)号：US20070117829A1
公开(公告)日：2007-05-24
申请号：US11653529
申请日：2007-01-16
申请人： Robert Chapman , Lonn Rider , Qi Hong , Donald Kyle , Robert Kupper
发明人： Robert Chapman , Lonn Rider , Qi Hong , Donald Kyle , Robert Kupper
IPC分类号： A61K31/485 , C07D489/02
CPC分类号： C07D489/08 , A61K9/14 , A61K9/20 , A61K9/2095 , A61K9/48 , A61K9/4833 , A61K31/485 , C07D489/02 , C07D489/04
摘要： In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.

92. 发明申请

US20060264638A1 Benzimidazole compounds having nociceptin receptor affinity 失效
标题翻译：具有伤害感受器受体亲和力的苯并咪唑化合物
公开(公告)号：US20060264638A1
公开(公告)日：2006-11-23
申请号：US11494826
申请日：2006-07-28
申请人： Donald Kyle , Richard Goehring , Bin Shao
发明人： Donald Kyle , Richard Goehring , Bin Shao
IPC分类号： C07D403/02
CPC分类号： C07D401/04
摘要： Disclosed are compounds of the formula (I) wherein A, R1, R2, R3, R4 and X1 are as disclosed herein. The compounds have affinity for the ORL1 receptor and are useful in the treatment of chronic and acute pain.
摘要翻译：公开了式（I）的化合物，其中A，R 1，R 2，R 3，R 4， >和X 1'如本文所公开的。该化合物对ORL1受体具有亲和力，可用于治疗慢性和急性疼痛。

93. 发明申请

US20060258669A1 Therapeutic agents useful for treating pain 有权
标题翻译：用于治疗疼痛的治疗剂
公开(公告)号：US20060258669A1
公开(公告)日：2006-11-16
申请号：US11344937
申请日：2006-01-31
申请人： Donald Kyle , Qun Sun
发明人： Donald Kyle , Qun Sun
IPC分类号： A61K31/496 , C07D403/04
CPC分类号： C07D401/04 , C07D213/74 , C07D213/85
摘要： Compounds of formulae: where X is S or O and Ar2, R1, R2, R3, R8, n, m, and t are disclosed herein, or a pharmaceutically acceptable salt thereof (a “3-substituted Pyridyl Compound”), compositions comprising an effective amount of a 3-substituted Pyridyl Compound, and methods for treating or preventing pain, urinary incontinence, an ulcer, inflammatory-bowel disease, irritable-bowel syndrome, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a 3-substituted Pyridyl Compound are disclosed herein.
摘要翻译：式的化合物：其中X是S或O和Ar 2，R 1，R 2，R 3，本文公开了R 8，n，m和t或其药学上可接受的盐（“3-取代的吡啶基化合物”），包含有效量的3-取代的吡啶基化合物以及用于治疗或预防疼痛，尿失禁，溃疡，炎性肠病，肠易激综合征，成瘾性疾病，帕金森病，帕金森综合征，焦虑症，癫痫症，中风，癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能，亨廷顿氏舞蹈病，肌萎缩性侧索硬化，痴呆，视网膜病，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，其包括向有需要的动物施用有效量的 3-取代的吡啶基化合物在本文中公开。

94. 发明申请

US20060235055A1 Therapeutic agents useful for treating pain 有权
标题翻译：用于治疗疼痛的治疗剂
公开(公告)号：US20060235055A1
公开(公告)日：2006-10-19
申请号：US11317832
申请日：2005-12-22
申请人： Donald Kyle , Qun Sun , Xiaoming Zhou
发明人： Donald Kyle , Qun Sun , Xiaoming Zhou
IPC分类号： A61K31/4439 , C07D403/02
CPC分类号： C07D401/04 , C07D401/12
摘要： The invention provides a compound of formula (I): (where R1, Q, A and R2 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Pyridine-alkynyl Compound”); pharmaceutical compositions comprising an effective amount of a Pyridine-alkynyl Compound; and methods for treating or preventing a condition such as pain, urinary incontinence, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, a seizure, stroke, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Pyridine-alkynyl Compound.
摘要翻译：本发明提供式（I）化合物：其中R 1，Q，A和R 2 2在本文中公开）或其药学上可接受的盐（“吡啶” - 炔基化合物“）; 包含有效量的吡啶 - 炔基化合物的药物组合物; 以及用于治疗或预防诸如疼痛，尿失禁，成瘾性障碍，帕金森病，帕金森综合征，焦虑，癫痫，癫痫发作，中风，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能亨廷顿舞蹈病，肌萎缩性侧索硬化症，痴呆症，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，包括向有需要的动物施用有效量的吡啶 - 炔基化合物。

95. 发明申请

US20060191205A1 Door operator drive system 审中-公开
标题翻译：门操作驱动系统
公开(公告)号：US20060191205A1
公开(公告)日：2006-08-31
申请号：US11067828
申请日：2005-02-28
申请人： Willis Mullet , Donald Kyle
发明人： Willis Mullet , Donald Kyle
IPC分类号： E05F15/00
CPC分类号： E05F15/686 , E05D13/1261 , E05F15/668 , E05Y2201/22 , E05Y2201/238 , E05Y2201/434 , E05Y2201/726 , E05Y2600/11 , E05Y2800/20 , E05Y2800/205 , E05Y2900/106
摘要： A drive system for a door (10) having an operator (35) and a counterbalance system (25). A drive tube (27) of the counterbalance system (25) interconnects the operator (35) and the door (10). A gear assembly (65) of the operator (35) engages the drive tube (27) for transferring rotational forces from the operator (35) to the drive tube (27). An aperture (105) extends through the gear assembly (65), and a fastener (106) extends through the aperture (105) to deform the drive tube (105). The fastener (106) sufficiently deforms the drive tube (27) to permit transfer of operating torque of the operator (35) to the drive tube (27), but not to an extent that prevents the gear assembly (65) from being removed from the drive tube (27).
摘要翻译：一种具有操作器（35）和平衡系统（25）的门（10）的驱动系统。平衡系统（25）的驱动管（27）将操作者（35）和门（10）相互连接。操作器（35）的齿轮组件（65）与驱动管（27）接合，用于将来自操作者（35）的旋转力传递到驱动管（27）。孔（105）延伸穿过齿轮组件（65），并且紧固件（106）延伸穿过孔（105）以使驱动管（105）变形。紧固件（106）使驱动管（27）充分变形，以允许操作者（35）的操作扭矩传递到驱动管（27），但不能防止齿轮组件（65）从驱动管（27）。

96. 发明申请

US20060148814A1 Therapeutic agents useful for treating pain 有权
标题翻译：用于治疗疼痛的治疗剂
公开(公告)号：US20060148814A1
公开(公告)日：2006-07-06
申请号：US11368133
申请日：2006-03-02
申请人： Donald Kyle , Sun Qun
发明人： Donald Kyle , Sun Qun
IPC分类号： A61K31/496 , C07D403/02
CPC分类号： C07D405/12 , C07D213/74 , C07D417/12
摘要： A Compound of formula (wherein X is O or S and R1-R5 are disclosed herein) or a pharmaceutically acceptable salt thereof (each being a “Piperazine Compound”), pharmaceutical compositions comprising a Piperazine Compound and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Piperazine Compound are disclosed.
摘要翻译：式（其中X是O或S和R 1 -R 5）的化合物在此公开）或其药学上可接受的盐（各自为“哌嗪化合物”），包含哌嗪化合物的药物组合物和治疗或预防疼痛，UI，溃疡，IBD，IBS，成瘾性障碍，帕金森病，帕金森综合征，焦虑症，癫痫，中风，癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能，亨廷顿氏舞蹈病，肌萎缩性侧索硬化，痴呆，视网膜病，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，包括向有需要的动物施用有效量的哌嗪化合物被公开。

97. 发明申请

US20060074090A1 1,2,5-Thiadiazol-3-yl-piperazine therapeutic agents useful for treating pain, depression and anxiety 有权
标题翻译：可用于治疗疼痛，抑郁和焦虑的1,2,5-噻二唑-3-基 - 哌嗪治疗剂
公开(公告)号：US20060074090A1
公开(公告)日：2006-04-06
申请号：US11246498
申请日：2005-10-07
申请人： Donald Kyle , Qun Sun
发明人： Donald Kyle , Qun Sun
IPC分类号： A61K31/496
CPC分类号： C07D285/10
摘要： A compound of formula: (wherein X, R1, R3, R4, and R5 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Thiadiazolylpiperazine Compound”), pharmaceutical compositions comprising a Thiadiazolylpiperazine Compound, and methods for treating or preventing, e.g., pain, depression and anxiety, in a patient comprising administering to a patient in need thereof an effective amount of a Thiadiazolylpiperazine Compound are disclosed.
摘要翻译：下式化合物：其中X，R 1，R 3，R 4和R 5均为本文公开的）或其药学上可接受的盐（“噻二唑基哌嗪化合物”），包含噻二唑基哌嗪化合物的药物组合物，以及用于治疗或预防例如疼痛，抑郁和焦虑的方法，包括向有需要的患者施用公开了有效量的噻二唑基哌嗪化合物。

98. 发明申请

US20060041954A1 Genetic loci associated with fusarium solani tolerance in soybean 有权
标题翻译：与大豆镰刀菌耐药性相关的遗传基因座
公开(公告)号：US20060041954A1
公开(公告)日：2006-02-23
申请号：US11200526
申请日：2005-08-08
申请人： Hong Lu , Feng Han , Scott Sebastian , Donald Kyle , Paul Stephens , Thomas Corbin , Jeffrey Thompson
发明人： Hong Lu , Feng Han , Scott Sebastian , Donald Kyle , Paul Stephens , Thomas Corbin , Jeffrey Thompson
IPC分类号： A01H5/00 , A01H1/00 , C12Q1/68
CPC分类号： C12Q1/6895 , A01H1/04 , A01H5/10 , C12N15/8282 , C12Q2600/13 , C12Q2600/156
摘要： The invention relates to methods and compositions for identifying soybean plants that are tolerant, have improved tolerance or are susceptible to Fusarium solani infection (the causative agent of sudden death syndrome or SDS). The methods use molecular genetic markers to identify, select and/or construct disease-tolerant plants or identify and counterselect disease-susceptible plants. Soybean plants that display tolerance or improved tolerance to Fusaruim solani infection that are generated by the methods of the invention are also a feature of the invention.
摘要翻译：本发明涉及用于鉴定耐受性好，具有改善的耐受性或易受镰孢镰刀菌感染（猝死综合征或SDS的致病因子）的大豆植物的方法和组合物。该方法使用分子遗传标记来鉴定，选择和/或构建耐病植物或识别并对抗疾病敏感植物。通过本发明的方法产生的显示对Fusaruim solani感染的耐受性或改善的耐受性的大豆植物也是本发明的特征。

99. 发明申请

US20060002232A1 Acoustic telemetry transceiver 有权
标题翻译：声学遥测收发器
公开(公告)号：US20060002232A1
公开(公告)日：2006-01-05
申请号：US10898884
申请日：2004-07-26
申请人： Vimal Shah , Eugene Linyaev , Donald Kyle , Wallace Gardner , Jeffrey Moore
发明人： Vimal Shah , Eugene Linyaev , Donald Kyle , Wallace Gardner , Jeffrey Moore
IPC分类号： H04H9/00
CPC分类号： G01V11/002 , E21B47/16
摘要： One embodiment includes an apparatus that includes a piezoelectric transducer to generate an acoustic signal that is to modulate along a mandrel, wherein the piezoelectric transducer includes at least one piezoelectric element and at least one electrode that is without non-permanent joints.
摘要翻译：一个实施例包括一种装置，其包括压电换能器以产生将沿心轴进行调制的声学信号，其中压电换能器包括至少一个压电元件和至少一个没有非永久性接头的电极。

100. 发明申请

US20050148580A1 Nociceptin analogs 有权
标题翻译：伤害感受类似物
公开(公告)号：US20050148580A1
公开(公告)日：2005-07-07
申请号：US11069728
申请日：2005-03-01
申请人： R. Goehring , Zhengming Chen , John Whitehead , Parviz Gharagozloo , Sam Victory , Donald Kyle
发明人： R. Goehring , Zhengming Chen , John Whitehead , Parviz Gharagozloo , Sam Victory , Donald Kyle
IPC分类号： C07D285/16 , A61K31/454 , A61K31/4709 , A61K31/549 , A61P25/04 , A61P29/00 , A61P37/08 , C07D401/04 , C07D417/04
CPC分类号： C07D417/04 , C07D401/04
摘要： A compound of the having the general formula (I) or general formula (II): wherein Z, Z, B, C, R1, R2, Q, W, and n are as described herein.
摘要翻译：具有通式（I）或通式（II）的化合物：其中Z，Z，B，C，R 1，R 2，Q，W ，和n如本文所述。

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