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1. 发明申请

US20060235055A1 Therapeutic agents useful for treating pain 有权
标题翻译：用于治疗疼痛的治疗剂
公开(公告)号：US20060235055A1
公开(公告)日：2006-10-19
申请号：US11317832
申请日：2005-12-22
申请人： Donald Kyle , Qun Sun , Xiaoming Zhou
发明人： Donald Kyle , Qun Sun , Xiaoming Zhou
IPC分类号： A61K31/4439 , C07D403/02
CPC分类号： C07D401/04 , C07D401/12
摘要： The invention provides a compound of formula (I): (where R1, Q, A and R2 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Pyridine-alkynyl Compound”); pharmaceutical compositions comprising an effective amount of a Pyridine-alkynyl Compound; and methods for treating or preventing a condition such as pain, urinary incontinence, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, a seizure, stroke, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Pyridine-alkynyl Compound.
摘要翻译：本发明提供式（I）化合物：其中R 1，Q，A和R 2 2在本文中公开）或其药学上可接受的盐（“吡啶” - 炔基化合物“）; 包含有效量的吡啶 - 炔基化合物的药物组合物; 以及用于治疗或预防诸如疼痛，尿失禁，成瘾性障碍，帕金森病，帕金森综合征，焦虑，癫痫，癫痫发作，中风，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能亨廷顿舞蹈病，肌萎缩性侧索硬化症，痴呆症，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，包括向有需要的动物施用有效量的吡啶 - 炔基化合物。

2. 发明授权

US07855210B2 Therapeutic agents useful for treating pain 有权
标题翻译：用于治疗疼痛的治疗剂
公开(公告)号：US07855210B2
公开(公告)日：2010-12-21
申请号：US12240688
申请日：2008-09-29
申请人： Qun Sun , Xiaoming Zhou
发明人： Qun Sun , Xiaoming Zhou
IPC分类号： C07D403/04 , C07D403/14 , C07D401/12 , C07D401/14 , C07D417/04 , C07D417/14 , A61K31/433 , A61K31/44 , A61K31/496 , A61P19/02 , A61P25/02 , A61P29/02
CPC分类号： C07D401/04 , C07D403/04 , C07D417/04
摘要： A compound of formula: wherein Ar, Ar1, Ar2, R3, R4, R5, R6, R13, m, t, and x are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Hydroxyiminopiperazine Compound”); compositions comprising an effective amount of a Hydroxyiminopiperazine Compound; and methods for treating or preventing pain and other conditions in an animal comprising administering to an animal in need thereof an effective amount of a Hydroxyiminopiperazine Compound are disclosed.
摘要翻译：式中的化合物：其中Ar，Ar1，Ar2，R3，R4，R5，R6，R13，m，t和x在本文中公开，或其药学上可接受的盐（“羟基亚氨基哌嗪化合物”）; 包含有效量的羟基亚氨基哌嗪化合物的组合物; 以及用于治疗或预防动物中的疼痛和其它病症的方法，包括向有需要的动物施用有效量的羟基亚氨基哌嗪化合物。

3. 发明授权

US07799786B2 Therapeutic agents useful for treating pain 有权
标题翻译：用于治疗疼痛的治疗剂
公开(公告)号：US07799786B2
公开(公告)日：2010-09-21
申请号：US11899379
申请日：2007-09-04
申请人： Donald J. Kyle , Qun Sun , Laykea Tafesse , Chongwu Zhang , Xiaoming Zhou
发明人： Donald J. Kyle , Qun Sun , Laykea Tafesse , Chongwu Zhang , Xiaoming Zhou
IPC分类号： C07D237/00 , C07D241/00 , A61K31/50 , A61K31/497
CPC分类号： C07D213/74 , C07D213/85 , C07D237/20 , C07D239/42 , C07D241/20 , C07D285/06 , C07D333/16
摘要： A compound of formula: wherein A, Ar, R3, R6, and m are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Cyanoiminopiperazine Compound”), compositions comprising an effective amount of a Cyanoiminopiperazine Compound, and methods for treating or preventing pain, urinary incontinence, an ulcer, inflammatory-bowel disease, irritable-bowel syndrome, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Cyanoiminopiperazine Compound are disclosed.
摘要翻译：本文公开的其中A，Ar，R 3，R 6和m的化合物或其药学上可接受的盐（“氰基亚氨基哌嗪化合物”），包含有效量的氰基亚氨基哌嗪化合物的组合物，以及治疗或预防的方法疼痛，尿失禁，溃疡，炎性肠病，肠易激综合征，成瘾性疾病，帕金森病，帕金森综合征，焦虑症，癫痫，中风，癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能，亨廷顿氏舞蹈病，肌萎缩性侧索硬化，痴呆，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，包括向有需要的动物施用有效量的氰基亚氨基哌嗪化合物。

4. 发明授权

US07767699B2 Therapeutic agents useful for treating pain 有权
标题翻译：用于治疗疼痛的治疗剂
公开(公告)号：US07767699B2
公开(公告)日：2010-08-03
申请号：US11317832
申请日：2005-12-22
申请人： Donald J. Kyle , Qun Sun , Xiaoming Zhou
发明人： Donald J. Kyle , Qun Sun , Xiaoming Zhou
IPC分类号： A61K31/4439 , C07D401/04 , C07D401/12
CPC分类号： C07D401/04 , C07D401/12
摘要： The invention provides a compound of formula (I): (where R1, Q, A and R2 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Pyridine-alkynyl Compound”); pharmaceutical compositions comprising an effective amount of a Pyridine-alkynyl Compound; and methods for treating or preventing a condition such as pain, urinary incontinence, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, a seizure, stroke, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Pyridine-alkynyl Compound.
摘要翻译：本发明提供式（I）化合物：其中R 1，Q，A和R 2在本文中公开）或其药学上可接受的盐（“吡啶 - 炔基化合物”）; 包含有效量的吡啶 - 炔基化合物的药物组合物; 以及用于治疗或预防诸如疼痛，尿失禁，成瘾性障碍，帕金森病，帕金森综合征，焦虑，癫痫，癫痫发作，中风，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能亨廷顿舞蹈病，肌萎缩性侧索硬化症，痴呆症，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，包括向有需要的动物施用有效量的吡啶 - 炔基化合物。

5. 发明授权

US07157462B2 Therapeutic agents useful for treating pain 有权
公开(公告)号：US07157462B2
公开(公告)日：2007-01-02
申请号：US10669823
申请日：2003-09-23
申请人： Qun Sun , Xiaoming Zhou
发明人： Qun Sun , Xiaoming Zhou
IPC分类号： C07D401/04 , C07D401/14 , A61K31/4427 , C07D403/04 , C07D403/14 , C07D417/04 , C07D417/14 , A61K31/496 , A61K31/497 , A61K31/506
CPC分类号： C07D401/04 , C07D403/04 , C07D417/04
摘要： A compound of formula: wherein Ar, Ar1, Ar2, R3–R6, R13, m, and t are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Hydroxyiminopiperazine Compound”); compositions comprising an effective amount of a Hydroxyiminopiperazine Compound; and methods for treating or preventing pain and other conditions in an animal comprising administering to an animal in need thereof an effective amount of a Hydroxyiminopiperazine Compound are disclosed.

6. 发明申请

US20050059671A1 Therapeutic agents useful for treating pain 有权
标题翻译：用于治疗疼痛的治疗剂
公开(公告)号：US20050059671A1
公开(公告)日：2005-03-17
申请号：US10669823
申请日：2003-09-23
申请人： Qun Sun , Xiaoming Zhou
发明人： Qun Sun , Xiaoming Zhou
IPC分类号： A61P29/00 , C07D401/04 , C07D403/04 , C07D417/04 , A61K31/496 , C07D43/04 , C07D43/14
CPC分类号： C07D401/04 , C07D403/04 , C07D417/04
摘要： A compound of formula: wherein Ar, Ar1, Ar2, R3-R6, R13, m, and t are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Hydroxyiminopiperazine Compound”); compositions comprising an effective amount of a Hydroxyiminopiperazine Compound; and methods for treating or preventing pain and other conditions in an animal comprising administering to an animal in need thereof an effective amount of a Hydroxyiminopiperazine Compound are disclosed.
摘要翻译：式中的化合物：其中Ar，Ar1，Ar2，R3-R6，R13，m和t在本文中公开，或其药学上可接受的盐（“羟基亚氨基哌嗪化合物”）; 包含有效量的羟基亚氨基哌嗪化合物的组合物; 以及用于治疗或预防动物中的疼痛和其它病症的方法，包括向有需要的动物施用有效量的羟基亚氨基哌嗪化合物。

7. 发明授权

US06864261B2 Therapeutic agents useful for treating pain 有权
标题翻译：用于治疗疼痛的治疗剂
公开(公告)号：US06864261B2
公开(公告)日：2005-03-08
申请号：US10429078
申请日：2003-05-02
申请人： Parviz Gharagozloo , Khondaker Islam , Donald J. Kyle , Qun Sun , Laykea Tafesse , John William Frank Whitehead , Ji Yang , Xiaoming Zhou
发明人： Parviz Gharagozloo , Khondaker Islam , Donald J. Kyle , Qun Sun , Laykea Tafesse , John William Frank Whitehead , Ji Yang , Xiaoming Zhou
IPC分类号： A61P25/00 , A61P29/00 , C07D213/74 , C07D213/80 , C07D213/85 , C07D401/04 , C07D401/14 , C07D405/12 , A61K31/496
CPC分类号： C07D213/74 , C07D213/80 , C07D213/85 , C07D401/04 , C07D401/14 , C07D405/12
摘要： A compound of formula (wherein A, R1, R2, R6, m and n are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Piperazine Compound”); pharmaceutical compositions comprising a Piperazine Compound; and methods for treating pain, urinary incontinence (UI), an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis (ALS), dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia and depression in an animal comprising administering to an animal in need thereof an effective amount of a Piperazine Compound are disclosed.
摘要翻译：式（其中A，R 1，R 2，R 6，m和n在本文中公开）的化合物或其药学上可接受的盐（“哌嗪化合物”）; 包含哌嗪化合物的药物组合物; 和治疗疼痛，尿失禁（UI），成瘾性障碍，帕金森病，帕金森综合征，焦虑症，癫痫，中风，癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能，亨廷顿氏舞蹈症，肌萎缩性侧索硬化（ALS），痴呆，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍和抑郁症，包括向有需要的动物施用有效量的哌嗪化合物。

8. 发明申请

US20100210686A1 THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN 有权
标题翻译：治疗药物有用的治疗药物
公开(公告)号：US20100210686A1
公开(公告)日：2010-08-19
申请号：US12506040
申请日：2009-07-20
申请人： Qun Sun , Kate Xin Wen , Xiaoming Zhou
发明人： Qun Sun , Kate Xin Wen , Xiaoming Zhou
IPC分类号： A61K31/4545 , C07D401/04 , C07D417/14 , A61P29/00 , C12N5/07
CPC分类号： C07D417/14 , C07D401/04
摘要： Piperidine Compounds; compositions comprising a Piperidine Compound; and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Piperidine Compound are disclosed. In one embodiment, the Piperidine Compound has the formula: and pharmaceutically acceptable salts thereof, wherein Ar1, Ar2, X, R3, R4, and m are as disclosed herein.
摘要翻译：哌啶化合物; 包含哌啶化合物的组合物; 以及用于治疗或预防疼痛，UI，溃疡，IBD，IBS，成瘾性障碍，帕金森病，帕金森综合征，焦虑，癫痫，中风，癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷，受限制脑功能，亨廷顿舞蹈病，肌萎缩性侧索硬化，痴呆，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，包括向有需要的动物施用有效量的哌啶化合物。在一个实施方案中，哌啶化合物具有下式：及其药学上可接受的盐，其中Ar1，Ar2，X，R3，R4和m如本文所公开。

9. 发明授权

US07737148B2 Therapeutic agents useful for treating pain 有权
标题翻译：用于治疗疼痛的治疗剂
公开(公告)号：US07737148B2
公开(公告)日：2010-06-15
申请号：US11601792
申请日：2006-11-16
申请人： Qun Sun , Xiaoming Zhou
发明人： Qun Sun , Xiaoming Zhou
IPC分类号： A61K31/44 , A61K31/496 , A61K31/497 , A61K31/506 , A61P19/02 , A61P25/02 , A61P29/02 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D417/04 , C07D417/14
CPC分类号： C07D401/04 , C07D403/04 , C07D417/04
摘要： A compound of formula: wherein Ar, Ar1, Ar2, R3-R6, R13, m, and t are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Hydroxyiminopiperazine Compound”); compositions comprising an effective amount of a Hydroxyiminopiperazine Compound; and methods for treating or preventing pain and other conditions in an animal comprising administering to an animal in need thereof an effective amount of a Hydroxyiminopiperazine Compound are disclosed.
摘要翻译：式中的化合物：其中Ar，Ar1，Ar2，R3-R6，R13，m和t在本文中公开，或其药学上可接受的盐（“羟基亚氨基哌嗪化合物”）; 包含有效量的羟基亚氨基哌嗪化合物的组合物; 以及用于治疗或预防动物中的疼痛和其它病症的方法，包括向有需要的动物施用有效量的羟基亚氨基哌嗪化合物。

10. 发明授权

US07572812B2 Therapeutic agents useful for treating pain 有权
标题翻译：用于治疗疼痛的治疗剂
公开(公告)号：US07572812B2
公开(公告)日：2009-08-11
申请号：US11337271
申请日：2006-01-20
申请人： Qun Sun , Kate Xin Wen , Xiaoming Zhou
发明人： Qun Sun , Kate Xin Wen , Xiaoming Zhou
IPC分类号： C07D401/12 , C07D403/12 , C07D401/14 , C07D403/14 , A61K31/444
CPC分类号： C07D417/14 , C07D401/04
摘要： Piperidine Compounds; compositions comprising a Piperidine Compound; and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Piperidine Compound are disclosed. In one embodiment, the Piperidine Compound has the formula: and pharmaceutically acceptable salts thereof, wherein Ar1, Ar2, X, R3, R4, and m are as disclosed herein.
摘要翻译：哌啶化合物; 包含哌啶化合物的组合物; 以及用于治疗或预防疼痛，UI，溃疡，IBD，IBS，成瘾性障碍，帕金森病，帕金森综合征，焦虑，癫痫，中风，癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷，受限制脑功能，亨廷顿舞蹈病，肌萎缩性侧索硬化，痴呆，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，包括向有需要的动物施用有效量的哌啶化合物。在一个实施方案中，哌啶化合物具有下式：及其药学上可接受的盐，其中Ar1，Ar2，X，R3，R4和m如本文所公开。

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