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91. 发明申请

US20110083509A1 Photoacoustic Spectroscopy With Focused Light 审中-公开
标题翻译：光聚焦光学光谱
公开(公告)号：US20110083509A1
公开(公告)日：2011-04-14
申请号：US12576377
申请日：2009-10-09
申请人： Youzhi Li , Edward McKenna , Andy S. Lin
发明人： Youzhi Li , Edward McKenna , Andy S. Lin
IPC分类号： G01N29/00 , G01N21/00
CPC分类号： A61B5/0059 , A61B5/0095 , A61B8/00
摘要： Photoacoustic measurements utilize emitted light to generate an acoustic response in tissue, with the acoustic response being proportional to the presence of an absorber of the light in the tissue. The present disclosure relates the use of focused light to acquire photoacoustic measurements. In one embodiment, the light is modulated, such as spatially modulated, such that the light may be focused within an otherwise scattering medium, such as tissue.
摘要翻译：光声测量利用发射光在组织中产生声响应，声响应与组织中光吸收体的存在成比例。本公开涉及聚焦光的使用以获得光声测量。在一个实施例中，光被调制，例如空间调制，使得光可以聚焦在否则散射介质（例如组织）内。

92. 发明申请

US20100280362A1 TIME OF FLIGHT BASED TRACHEAL TUBE PLACEMENT SYSTEM AND METHOD 有权
标题翻译：飞行时间管道放置系统及方法
公开(公告)号：US20100280362A1
公开(公告)日：2010-11-04
申请号：US12434770
申请日：2009-05-04
申请人： Youzhi Li , Edward McKenna , Andy Lin , Sarah Hayman
发明人： Youzhi Li , Edward McKenna , Andy Lin , Sarah Hayman
IPC分类号： A61B6/12
CPC分类号： A61M16/0488 , A61B1/267 , A61B5/0084 , A61B5/065 , A61B5/72 , A61B5/742 , A61B5/746 , A61M16/04 , A61M16/0434 , A61M16/0443 , A61M16/0486 , A61M2205/3306 , A61M2205/502 , A61M2205/6018 , G01S7/481 , G01S17/10 , G01S17/88
摘要： According to various embodiments, a tracheal tube may employ optical sensing techniques for determining a distance between the inserted tube and an anatomical structure, such as a carina. The distance information may provide an indication as to whether or not the tracheal tube is properly placed within the trachea. The optical techniques may include time of flight techniques.
摘要翻译：根据各种实施例，气管插管可以采用光学感测技术来确定插入的管和解剖结构之间的距离，例如小孔。距离信息可以提供关于气管管是否适当地放置在气管内的指示。光学技术可以包括飞行时间技术。

93. 发明申请

US20100261995A1 MEDICAL DEVICE AND TECHNIQUE FOR USING THE SAME 有权
标题翻译：医疗设备及其使用技术
公开(公告)号：US20100261995A1
公开(公告)日：2010-10-14
申请号：US12420148
申请日：2009-04-08
申请人： Edward McKenna , Youzhi Li , Andy Lin , Sarah Hayman
发明人： Edward McKenna , Youzhi Li , Andy Lin , Sarah Hayman
IPC分类号： A61B6/12 , A61M16/04
CPC分类号： A61M16/0488 , A61B1/267 , A61B5/0084 , A61B5/06 , A61B5/065 , A61B5/742 , A61M16/04 , A61M16/0434 , A61M16/0443 , A61M2205/3306
摘要： According to various embodiments, a tracheal tube may employ optical sensing techniques for determining a distance between the inserted tube and an anatomical structure such as a carina. The distance information may provide an indication as to whether or not the tracheal tube is properly placed within the trachea. The optical techniques may include interferometry.
摘要翻译：根据各种实施例，气管管可以采用光学感测技术来确定插入的管和解剖结构（例如小孔）之间的距离。距离信息可以提供关于气管管是否适当地放置在气管内的指示。光学技术可以包括干涉测量。

94. 发明申请

US20060183793A1 Method of treating hematologic tumors and cancers 审中-公开
公开(公告)号：US20060183793A1
公开(公告)日：2006-08-17
申请号：US11315430
申请日：2005-12-21
申请人： Arthur Pardee , Kenneth Anderson , Deepak Gupta , Chiang Li , Youzhi Li
发明人： Arthur Pardee , Kenneth Anderson , Deepak Gupta , Chiang Li , Youzhi Li
IPC分类号： A61K31/353
CPC分类号： A61K45/06 , A61K31/136 , A61K31/337 , A61K31/352 , A61K31/353 , A61K31/4184 , A61K31/4745 , A61K31/475 , A61K31/704 , A61K31/7048 , A61K2300/00
摘要： Multiple myeloma and other hematologic tumors and/or malignancies can be treated by administration of a G1 and/or S phase drug, which is preferably β-lapachone, or a derivative or analog thereof, combined with a G2/M phase drug such as a taxane derivative, which is advantageously paclitaxel. This combination of the G1 and/or S phase drug with the G2/M phase drug results in an unexpectedly greater than additive (i.e., synergistic) apoptosis in multiple myeloma cells. The invention includes methods of treating multiple myeloma by administering the combination of the G1 and/or S phase drug and the G2/M phase drug, pharmaceutical compositions comprising the combination of drugs used in these methods, as well as pharmaceutical kits.

95. 发明申请

US20050171031A1 Method and composition for the treatment of cancer 审中-公开
标题翻译：治疗癌症的方法和组成
公开(公告)号：US20050171031A1
公开(公告)日：2005-08-04
申请号：US11069637
申请日：2005-03-01
申请人： Arthur Pardee , Chiang Li , Youzhi Li
发明人： Arthur Pardee , Chiang Li , Youzhi Li
IPC分类号： C07D311/92 , A61K31/122 , A61K31/337 , A61K31/35 , A61K31/352 , A61K31/4184 , A61K31/427 , A61K31/437 , A61K31/704 , A61K31/7042 , A61K38/00 , A61K45/00 , A61K45/06 , A61P35/00 , A61K31/7048 , A61K31/4745 , A61K31/404 , A61K31/12
CPC分类号： A61K31/337 , A61K31/122 , A61K31/35 , A61K45/06 , Y10S514/922 , A61K31/335 , A61K2300/00
摘要： We have discovered that the administration of a G1 and/or S phase drug such as β-lapachone in combination with a G2/M drug such as a taxane derivative such as paclitaxel resulted in a unexpected greater than additive (i.e., synergistic) reduction in the number of tumors (and tumor volume) as compared with the administration of these agents alone. In addition, no signs of toxicity or weight loss were observed. The present invention relates to a method for treating a mammalian tumor using combinations such as a taxane derivative, preferably paclitaxel, and a β-lapachone, or a derivative or analog thereof.
摘要翻译：我们已经发现，G1和/或S期药物如β-拉帕酮与G2 / M药物如紫杉烷衍生物如紫杉醇的组合的给药导致意想不到的大于添加剂（即协同）的减少与单独施用这些药物相比，肿瘤的数量（和肿瘤体积）。此外，没有观察到毒性或体重减轻的迹象。本发明涉及使用组合例如紫杉烷衍生物，优选紫杉醇和β-拉帕酮或其衍生物或类似物来治疗哺乳动物肿瘤的方法。

96. 发明申请

US20050119352A1 Method of treating cancers 失效
标题翻译：治疗癌症的方法
公开(公告)号：US20050119352A1
公开(公告)日：2005-06-02
申请号：US10726467
申请日：2003-12-02
申请人： Chiang Li , Youzhi Li
发明人： Chiang Li , Youzhi Li
IPC分类号： A61K31/12 , A61K31/35 , A61K45/06
CPC分类号： A61K45/06 , A61K31/35 , A61K31/506 , A61K2300/00
摘要： Cancers and/or malignancies can be treated by administration of a cell cycle checkpoint activator, which is preferably β-lapachone, or a derivative or analog thereof, combined with an oncogenic kinase modulator, preferably imatinib. This combination of the cell cycle checkpoint activator with the oncogenic kinase modulator results in an unexpectedly greater than additive (i.e., synergistic) apoptosis in cancer cells. The invention includes methods of treating cancers by administering the combination of the cell cycle checkpoint activator and the oncogenic kinase modulator, pharmaceutical compositions comprising the combination of drugs used in these methods, as well as pharmaceutical kits.
摘要翻译：癌症和/或恶性肿瘤可以通过施用细胞周期检查点激活剂来治疗，细胞周期检查点激活剂优选地是β-拉帕酮，或其衍生物或类似物，与致癌激酶调节剂，优选伊马替尼组合。细胞周期检查点激活剂与致癌激酶调节剂的这种组合导致意想不到的大于癌细胞中的添加（即协同）凋亡。本发明包括通过施用细胞周期检查点激活剂和致癌激酶调节剂的组合来治疗癌症的方法，包括在这些方法中使用的药物的组合的药物组合物以及药物试剂盒。

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