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91. 发明授权

US06635311B1 Methods utilizing scanning probe microscope tips and products therefor or products thereby 有权
标题翻译：使用扫描探针显微镜尖端及其产品或其产品的方法
公开(公告)号：US06635311B1
公开(公告)日：2003-10-21
申请号：US09477997
申请日：2000-01-05
申请人： Chad A. Mirkin , Richard Piner , Seunghun Hong
发明人： Chad A. Mirkin , Richard Piner , Seunghun Hong
IPC分类号： B05D500
CPC分类号： B82B3/00 , B05D1/007 , B05D1/185 , B05D1/26 , G01Q80/00 , G03F7/0002 , G03F7/165 , Y10S977/84 , Y10S977/857 , Y10S977/863 , Y10S977/877 , Y10T428/24917 , Y10T436/24
摘要： A method of direct-write nanolithography comprising: providing a solid substrate comprising a surface; providing a nanoscopic tip coated with patterning compound; and contacting the coated tip with the substrate, so that the patterning compound is delivered to the substrate so as to produce a desired pattern in submicrometer dimensions. Nanolithographic resolution can be affected by substrate grain size, diffusion rate of the patterning compound, tip-substrate contact time, the rate of transport of the patterning compound from the tip to the substrate, and tip sharpness. The method is a useful tool for fabrication of nanoscale structures.
摘要翻译：一种直写式纳米光刻方法，包括：提供包含表面的固体基质; 提供涂有图案化合物的纳米级尖端; 并使涂覆的末端与基底接触，使得图案化化合物被递送到基底，从而在亚微米尺寸上产生所需的图案。纳米光刻分辨率可能受衬底晶粒尺寸，图形化合物的扩散速率，尖端 - 衬底接触时间，图案化合物从尖端到衬底的传输速率和尖端锐度的影响。该方法是制造纳米级结构的有用工具。

92. 发明授权

US5338571A Method of forming self-assembled, mono- and multi-layer fullerene film and coated substrates produced thereby 失效
标题翻译：形成自组装的单层和多层富勒烯膜的方法和由此制备的涂覆的基材
公开(公告)号：US5338571A
公开(公告)日：1994-08-16
申请号：US16820
申请日：1993-02-10
申请人： Chad A. Mirkin , Kaimin Chen , W. Brett Caldwell
发明人： Chad A. Mirkin , Kaimin Chen , W. Brett Caldwell
IPC分类号： B05D1/18 , H01L51/30 , B05D3/00
CPC分类号： B82Y30/00 , B05D1/185 , B82Y10/00 , B82Y40/00 , H01L51/0046 , Y10S977/842
摘要： A method is provided for forming a fullerene layer on a substrate by chemically treating a surface of the substrate to provide a bond-forming species at the surface effective to covalently bond with fullerenes in solution and contacting the treated substrate surface with a solution of fullerenes to form a fullerene layer covalently bonded to the treated substrate surface. Alternately or in addition, a fullerene layer is formed on a substrate by chemically modifying fullerenes to provide a bond-forming species thereon, chemically treating a surface of the substrate to provide a bond-forming species effective to covalently bond with the bond-forming species of the fullerenes in solution, and contacting a solution of treated fullerenes with the treated substrate surface to form a fullerene layer covalently bonded to the treated substrate surface.A three dimensional multilayer fullerene structure can be formed on the substrate surface by chemically modifying an initial fullerene layer formed thereon in the manner described above to provide chemical bridging species (e.g. piperazine) covalently bonded thereto and effective to covalently bond with fullerenes in solution. The modified fullerene film then is contacted with a solution of modified or unmodified fullerenes to form a second fullerene layer covalently bonded to the initial fullerene layer by the chemical bridging species. The method can be repeated to build up additional fullerene layers on the substrate surface.
摘要翻译：提供了一种通过化学处理基材的表面以在表面上形成键合形成物质的方法，该表面有效地与溶液中的富勒烯共价键合并使经处理的基底表面与富勒烯溶液接触，形成共价键合到经处理的基底表面的富勒烯层。或者或另外，通过化学修饰富勒烯以在其上形成结合形成物质，在基底上形成富勒烯层，化学处理基材的表面以提供有效共轭键合的成键物质的溶液中的富勒烯，并使经处理的富勒烯溶液与经处理的基材表面接触，以形成共价键合到经处理的基材表面的富勒烯层。可以通过以上述方式化学改性形成在其上的初始富勒烯层，从而提供三维多层富勒烯结构，以提供与其共价键合的化学桥接物质（例如哌嗪），并有效地与富勒烯在溶液中共价键合。然后将改性的富勒烯膜与改性或未改性的富勒烯的溶液接触，以形成通过化学桥接物质共价键合到初始富勒烯层的第二富勒烯层。可以重复该方法以在基底表面上建立额外的富勒烯层。

93. 发明申请

US20140294927A1 SYNTHETIC NANOSTRUCTURES INCLUDING NUCLEIC ACIDS AND/OR OTHER ENTITIES 有权
标题翻译：合成纳米结构包括核酸和/或其他实体
公开(公告)号：US20140294927A1
公开(公告)日：2014-10-02
申请号：US14215569
申请日：2014-03-17
申请人： C. Shad Thaxton , Chad A. Mirkin , Kaylin M. McMahon , Sushant Tripathy , Raja Kannan Mutharasan , David M. Leander , Andrea Luthi
发明人： C. Shad Thaxton , Chad A. Mirkin , Kaylin M. McMahon , Sushant Tripathy , Raja Kannan Mutharasan , David M. Leander , Andrea Luthi
IPC分类号： A61K9/127 , A61K31/7105 , A61K31/713 , C12N15/113 , A61K31/7088
CPC分类号： A61K9/127 , A61K9/1271 , A61K9/5115 , A61K9/5123 , A61K31/7088 , A61K47/544 , A61K47/554 , A61K47/6917 , A61K47/6923 , B82Y5/00 , C12N15/111 , C12N15/87 , C12N2310/113 , C12N2310/3515 , C12N2320/32
摘要： Articles, compositions, kits, and methods relating to nanostructures, including synthetic nanostructures, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanostructure core may be surrounded by a shell including a material, such as a lipid bilayer, and may include other components such as oligonucleotides. In some embodiments, the structures, when introduced into a subject, can be used to deliver nucleic acids and/or can regulate gene expression. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions. In some cases, the structures are both a therapeutic agent and a diagnostic agent.
摘要翻译：提供了与纳米结构相关的制品，组合物，试剂盒和方法，包括合成纳米结构。本文描述的某些实施例包括具有核 - 壳型布置的结构; 例如，纳米结构核心可以被包括诸如脂双层的材料的壳包围，并且可以包括其它成分如寡核苷酸。在一些实施方案中，当引入受试者时，结构可用于递送核酸和/或可调节基因表达。因此，本文所述的结构可用于诊断，预防，治疗或管理某些疾病或身体状况。在一些情况下，结构既是治疗剂又是诊断剂。

94. 发明申请

US20130040856A1 Generation of Combinatorial Patterns by Deliberate Tilting of a Polymer-Pen Array 有权
标题翻译：通过有意图倾斜聚合物笔阵列来产生组合模式
公开(公告)号：US20130040856A1
公开(公告)日：2013-02-14
申请号：US13513618
申请日：2010-12-02
申请人： Chad A. Mirkin , Adam B. Braunschweig , Jinan Chai , Dan J. Eichelsdoerfer , Louise R. Giam , Xing Liao , Lu Shin Wong
发明人： Chad A. Mirkin , Adam B. Braunschweig , Jinan Chai , Dan J. Eichelsdoerfer , Louise R. Giam , Xing Liao , Lu Shin Wong
IPC分类号： C40B50/14 , C40B50/18 , C40B40/18 , C40B40/04 , C40B30/08 , C40B40/00 , B82Y5/00
CPC分类号： G03F7/0002 , B01J2219/00387 , B82Y10/00 , B82Y40/00
摘要： The disclosure relates to a method of forming a pattern having pattern elements with a plurality of sizes on a substrate surface with a tilted pen array that includes choosing a tilt geometry for a pen array with respect to a substrate, inducing the tilt geometry between the pen array and the substrate surface, and forming a pattern having pattern elements on the substrate surface with the titled pen array, whereby the size of the formed pattern elements varies across the substrate surface along the tilted axis or axes. For example, the tilt geometry is in reference to the substrate surface and comprises a first angle with respect to a first axis of the substrate and a second angle with respect to a second axis of the substrate, the second axis being perpendicular to the first axis, and at least one of the first and second angles being non-zero.
摘要翻译：本公开涉及一种在衬底表面上形成具有多个尺寸的图案元件的图案的方法，该倾斜笔阵列包括相对于衬底选择笔阵列的倾斜几何形状，从而引起笔之间的倾斜几何形状阵列和衬底表面，并且用标称笔阵列在衬底表面上形成具有图形元素的图案，由此形成的图案元素的尺寸沿着倾斜的轴线或轴线跨越衬底表面变化。例如，倾斜几何形状参考衬底表面并且包括相对于衬底的第一轴线的第一角度和相对于衬底的第二轴线的第二角度，第二轴线垂直于第一轴线并且第一和第二角度中的至少一个是非零。

95. 发明申请

US20120288935A1 "Click" Nanoparticle Conjugates 审中-公开
标题翻译： “点击”纳米颗粒共轭体
公开(公告)号：US20120288935A1
公开(公告)日：2012-11-15
申请号：US13497214
申请日：2010-09-22
申请人： Chad A. Mirkin , Joshua I. Cutler
发明人： Chad A. Mirkin , Joshua I. Cutler
IPC分类号： C07F15/02 , C12N5/071 , B82Y5/00
CPC分类号： B82Y5/00 , A61K41/0052 , A61K47/6923 , A61K49/0002 , A61K49/0093 , A61K49/1833 , A61K49/1857 , Y10T428/2982
摘要： Modified nanoparticles are disclosed. More specifically, nanoparticles modified with an agent through a triazole linkage are disclosed. Also disclosed are methods of preparing modified nanoparticles and methods of using these modified nanoparticles.
摘要翻译：公开了改性纳米粒子。更具体地，公开了通过三唑键用药剂改性的纳米颗粒。还公开了制备改性纳米颗粒的方法和使用这些改性纳米颗粒的方法。

96. 发明申请

US20120269730A1 Intracellular Delivery of Contrast Agents with Functionalized Nanoparticles 审中-公开
标题翻译：功能化纳米颗粒的对比剂的细胞内递送
公开(公告)号：US20120269730A1
公开(公告)日：2012-10-25
申请号：US13388629
申请日：2010-08-09
申请人： Chad A. Mirkin , Thomas J. Meade , Ying Song , Xiaoyang Xu
发明人： Chad A. Mirkin , Thomas J. Meade , Ying Song , Xiaoyang Xu
IPC分类号： C07H21/04 , C12Q1/02 , A61K49/00 , B82Y15/00
CPC分类号： A61K49/128 , A61K49/0002 , A61K49/1881
摘要： The present invention is directed to compositions and methods for intracellular delivery of a contrast agent with a functionalized nanoparticle.
摘要翻译：本发明涉及用官能化纳米颗粒细胞内递送造影剂的组合物和方法。

97. 发明申请

US20120164396A1 MATRIX ASSISTED INK TRANSPORT 审中-公开
标题翻译： MATRIX辅助墨水运输
公开(公告)号：US20120164396A1
公开(公告)日：2012-06-28
申请号：US12140780
申请日：2008-06-17
申请人： Chad A. Mirkin , Ling Huang , Fengwei Huo , Sarah J. Hurst , Lidong Qin , Jae-Won Jang , Joseph J. Kakkassery
发明人： Chad A. Mirkin , Ling Huang , Fengwei Huo , Sarah J. Hurst , Lidong Qin , Jae-Won Jang , Joseph J. Kakkassery
IPC分类号： B05D5/00 , B32B3/10 , B82Y40/00
CPC分类号： C09D11/03 , B01J19/0046 , B01J2219/00382 , B01J2219/00387 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00648 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00734 , B82Y30/00 , C09D11/30 , C40B50/14 , Y10T428/24802 , Y10T436/143333 , Y10T436/25 , Y10T436/2575
摘要： Provided is a direct write patterning method utilizing a mixture comprising an ink of choice and an ink carrier matrix. The method involves disposing the mixture on a tip or stamp and transporting the mixture from the tip or stamp on a surface to form a pattern that contains the ink. The method does not require chemical or physical modification of either the tip or stamp or the surface prior to transporting the mixture to the surface. The method can be applied for patterning hard inks such as nanomaterials and crystallized polymers and soft inks such as biomaterials including peptides and proteins. Also provided are related biomaterial and hard ink arrays.
摘要翻译：提供了一种使用包括选择的墨水和墨水载体基质的混合物的直接写入图案化方法。该方法包括将混合物设置在尖端或印模上，并将混合物从尖端或印模输送到表面上以形成包含油墨的图案。在将混合物输送到表面之前，该方法不需要对尖端或印模或表面进行化学或物理改性。该方法可以应用于诸如纳米材料和结晶聚合物的硬油墨和软油墨如包括肽和蛋白质的生物材料的图形化。还提供了相关的生物材料和硬油墨阵列。

98. 发明授权

US08192795B2 Etching and hole arrays 失效
标题翻译：蚀刻孔阵列
公开(公告)号：US08192795B2
公开(公告)日：2012-06-05
申请号：US11770477
申请日：2007-06-28
申请人： Chad A. Mirkin , Khalid Salaita
发明人： Chad A. Mirkin , Khalid Salaita
IPC分类号： B05D5/00 , B05D1/28 , B05D3/10 , B05D3/14
CPC分类号： G03F7/0002 , Y10S977/849 , Y10S977/855 , Y10S977/856 , Y10S977/857 , Y10S977/888 , Y10T428/24479 , Y10T428/24802
摘要： Lithographic and nanolithographic methods that involve patterning a first compound on a substrate surface, exposing non-patterned areas of the substrate surface to a second compound and removing the first compound while leaving the second compound intact. The resulting hole patterns can be used as templates for either chemical etching of the patterned area of the substrate or metal deposition on the patterned area of the substrate.
摘要翻译：包括在基底表面上图案化第一化合物的平版印刷和纳米光刻方法，将基底表面的未图案化区域暴露于第二化合物并除去第一化合物同时保留第二化合物。所得到的孔图案可以用作用于对衬底的图案化区域进行化学蚀刻或在衬底的图案化区域上的金属沉积的模板。

99. 发明申请

US20110132220A1 POLYMER PEN LITHOGRAPHY 有权
标题翻译：聚合物平版印刷
公开(公告)号：US20110132220A1
公开(公告)日：2011-06-09
申请号：US12989279
申请日：2009-04-25
申请人： Chad A. Mirkin , Fengwei Huo , Zijian Zheng , Gengfeng Zheng
发明人： Chad A. Mirkin , Fengwei Huo , Zijian Zheng , Gengfeng Zheng
IPC分类号： B41F33/00 , B05D3/00 , C03C25/24
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y30/00 , B82Y40/00 , Y10S977/856 , Y10S977/874 , Y10S977/878 , Y10S977/887 , Y10S977/888 , Y10S977/902
摘要： The disclosure relates to methods of printing indicia on a substrate using a tip array comprised of elastomeric, compressible polymers. The tip array can be prepared using conventional photolithographic methods and can be tailored to have any desired number and/or arrangement of tips. Numerous copies (e.g., greater than 15,000, or greater than 11 million) of a pattern can be made in a parallel fashion in as little as 40 minutes.
摘要翻译：本公开涉及使用由弹性体，可压缩聚合物组成的尖端阵列在基底上印刷标记的方法。尖端阵列可以使用常规光刻方法制备，并且可以被定制成具有任何期望的数量和/或尖端的布置。可以在短短40分钟的时间内以平行的方式制作多种图案（例如，大于15,000，或大于1100万）。

100. 发明授权

US07954166B2 Independently-addressable, self-correcting inking for cantilever arrays 失效
标题翻译：用于悬臂阵列的独立寻址，自校正上墨
公开(公告)号：US07954166B2
公开(公告)日：2011-05-31
申请号：US12222464
申请日：2008-08-08
申请人： Chad A. Mirkin , Yuhuang Wang , Louise R. Giam , Matthew Park
发明人： Chad A. Mirkin , Yuhuang Wang , Louise R. Giam , Matthew Park
IPC分类号： G01Q60/38
CPC分类号： G03F7/0002 , B01L3/0255 , B01L2200/12 , B01L2400/0484 , B41M5/00 , G01Q80/00
摘要： An improved method of loading tips and other surfaces with patterning compositions or inks for use in deposition. A method of patterning is described, the method comprising: (i) providing at least one array of tips; (ii) providing a plurality of patterning compositions; (iii) ink jet printing at least some of the patterning compositions onto some of the tips; and (iv) depositing at least some of the patterning compositions onto a substrate surface; wherein the ink jet printing is adapted to prevent substantial cross-contamination of the patterning composition on the tips. Good printing reproducibility and control of printing rate can be achieved. The surfaces subjected to ink jet printing can be treated to encourage localization of the ink at the tip. The method is particularly important for high density arrays.
摘要翻译：用于沉积的图案化组合物或油墨加载尖端和其它表面的改进方法。描述了一种图案化方法，该方法包括：（i）提供至少一个尖端阵列; （ii）提供多个图案化组合物; （iii）将至少一些图案化组合物喷墨印刷到一些尖端上; 和（iv）将至少一些所述图案化组合物沉积到基底表面上; 其中喷墨印刷适于防止图案化组合物在尖端上的显着交叉污染。可以实现良好的打印再现性和打印速度的控制。可以处理进行喷墨印刷的表面以促进墨水在尖端处的定位。该方法对于高密度阵列特别重要。

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