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91. 发明申请

US20110275097A9 DRUG SELECTION FOR LUNG CANCER THERAPY USING ANTIBODY-BASED ARRAYS 有权
标题翻译：使用基于抗体的阵列进行肺癌治疗的药物选择
公开(公告)号：US20110275097A9
公开(公告)日：2011-11-10
申请号：US12172100
申请日：2008-07-11
申请人： Sharat Singh , Jeanne Harvey
发明人： Sharat Singh , Jeanne Harvey
IPC分类号： G01N33/574 , C12M1/34
CPC分类号： G01N33/57423 , G01N33/5041 , G01N33/5044 , G01N33/5082 , G01N2500/10 , G01N2800/52
摘要： The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.
摘要翻译：本发明提供用于检测肿瘤细胞中信号转导途径的组分的激活状态的组合物和方法。关于使用本发明的信号转导途径的组分的激活状态的信息可用于癌症诊断，预后和癌症治疗的设计。

92. 发明申请

US20110244465A1 METHODS OF PREDICTING AND MONITORING TYROSINE KINASE INHIBITOR THERAPY 审中-公开
标题翻译：预测和监测酪氨酸激酶抑制剂治疗方法
公开(公告)号：US20110244465A1
公开(公告)日：2011-10-06
申请号：US13024139
申请日：2011-02-09
申请人： Jeanne Harvey , Bruce Neri , Sharat Singh
发明人： Jeanne Harvey , Bruce Neri , Sharat Singh
IPC分类号： C12Q1/02 , C12Q1/68
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/106 , C12Q2600/154 , G01N2333/91215 , G01N2500/04 , G01N2800/52 , G16B20/00 , G16B40/00
摘要： The present invention provides methods for analyzing a combination of biomarkers to individualize tyrosine kinase inhibitor therapy in patients who have been diagnosed with cancer. In particular, the assay methods of the present invention are useful for predicting, identifying, or monitoring the response of a tumor, tumor cell, or patient to treatment with a tyrosine kinase inhibitor using an algorithm based upon biomarker profiling. The assay methods of the present invention are also useful for predicting whether a patient has a risk of developing toxicity or resistance to treatment with a tyrosine kinase inhibitor. In addition, the assay methods of the present invention are useful for monitoring tyrosine kinase inhibitor therapy in a patient receiving the drug to evaluate whether the patient will develop resistance to the drug. Furthermore, the assay methods of the present invention are useful for optimizing the dose of a tyrosine kinase inhibitor in a patient receiving the drug to achieve therapeutic efficacy and/or reduce toxic side-effects.
摘要翻译：本发明提供了用于分析已经被诊断患有癌症的患者中的酪氨酸激酶抑制剂治疗的生物标志物的组合的方法。特别地，本发明的测定方法可用于使用基于生物标志物分析的算法预测，鉴定或监测肿瘤，肿瘤细胞或患者用酪氨酸激酶抑制剂治疗的应答。本发明的测定方法也可用于预测患者是否具有产生毒性或抗酪氨酸激酶抑制剂治疗的风险。此外，本发明的测定方法可用于监测接受药物的患者中的酪氨酸激酶抑制剂治疗，以评估患者是否会产生对药物的抗药性。此外，本发明的测定方法可用于优化接受该药物的患者中的酪氨酸激酶抑制剂的剂量以达到治疗功效和/或减少毒副作用。

93. 发明申请

US20100167945A1 DRUG SELECTION FOR BREAST CANCER THERAPY USING ANTIBODY-BASED ARRAYS 有权
标题翻译：使用基于抗体的阵列进行乳腺癌治疗的药物选择
公开(公告)号：US20100167945A1
公开(公告)日：2010-07-01
申请号：US12511017
申请日：2009-07-28
申请人： Sharat Singh , Jeanne Harvey , Phillip Kim , Xinjun Liu , Limin Liu , Robert Barham , Bruce Neri
发明人： Sharat Singh , Jeanne Harvey , Phillip Kim , Xinjun Liu , Limin Liu , Robert Barham , Bruce Neri
IPC分类号： C40B30/04 , C12Q1/26 , G01N33/566 , C12Q1/28 , C40B40/10
CPC分类号： G01N33/57415 , G01N33/5011 , G01N2800/52 , G01N2800/60
摘要： The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.
摘要翻译：本发明提供用于检测肿瘤细胞中信号转导途径的组分的激活状态的组合物和方法。关于使用本发明的信号转导途径的组分的激活状态的信息可用于癌症诊断，预后和癌症治疗的设计。

94. 发明申请

US20100022408A1 ADDRESSABLE ANTIBODY ARRAYS AND METHODS OF USE 有权
标题翻译：可接受的抗体阵列和使用方法
公开(公告)号：US20100022408A1
公开(公告)日：2010-01-28
申请号：US12500553
申请日：2009-07-09
申请人： Sharat Singh , Shui Long Wang
发明人： Sharat Singh , Shui Long Wang
IPC分类号： C40B30/04
CPC分类号： G01N33/6854 , G01N33/564 , G01N33/6851 , G01N2800/24
摘要： Systems and assay methods are disclosed for detecting an autoantibody in a sample. In certain instances, the systems and methods employ a mass tag releasably connected to an antigen. The tag is thereafter released for detection. A tag can be detected by mass spectrometry or in certain instances the tag is fluorescent. Methods for diagnosing a disease or disorder in a subject are also disclosed.
摘要翻译：公开了用于检测样品中的自身抗体的系统和测定方法。在某些情况下，系统和方法采用可释放地连接到抗原的质量标签。此后标签被释放以进行检测。标签可以通过质谱检测或在某些情况下标签是荧光的。还公开了用于诊断受试者中的疾病或病症的方法。

95. 发明申请

US20080233602A1 Detecting and profiling molecular complexes 有权
标题翻译：检测和分析分子复合物
公开(公告)号：US20080233602A1
公开(公告)日：2008-09-25
申请号：US11717760
申请日：2007-03-12
申请人： Po-Ying Chan-Yui , Sharat Singh , Hossein Salimi-Mossavi , Yining Shi , Sailaja Pidaparthi , Rajiv Dua , Ali Mukherjee
发明人： Po-Ying Chan-Yui , Sharat Singh , Hossein Salimi-Mossavi , Yining Shi , Sailaja Pidaparthi , Rajiv Dua , Ali Mukherjee
IPC分类号： C12Q1/48 , G01N33/00 , G01N33/536
CPC分类号： G01N33/566 , G01N33/542 , Y10S436/824
摘要： Methods are provided for detecting the formation of complexes of molecules, especially proteins, in a sample, such as a cell or tissue lysate. In one aspect, a cleaving probe specific for a first protein in a complex and one or more binding compounds specific for one or more second proteins in a complex are provided. Upon binding, the cleaving probe is induced to generate an active species, such as singlet oxygen, that cleaves molecular tags attached to the binding compounds only in the local region of the cleaving probe. The released molecular tags are separated from the assay mixture and from one another to provide a readout that is related to the number and types of proteins present in the complex.
摘要翻译：提供了用于检测样品（例如细胞或组织裂解物）中分子复合物（特别是蛋白质）的形成的方法。在一个方面，提供了对复合物中的第一种蛋白质特异性的切割探针和一种或多种特异于复合物中的一种或多种第二种蛋白质的结合化合物。在结合时，诱导切割探针以产生仅在切割探针的局部区域中切割附着于结合化合物的分子标签的活性物质，例如单线态氧。将释放的分子标签与测定混合物和彼此分离，以提供与复合物中存在的蛋白质的数量和类型相关的读数。

96. 发明申请

US20050053939A1 Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents 审中-公开
标题翻译：用于增强使用可切割电泳标签试剂的测定中检测的方法和组合物
公开(公告)号：US20050053939A1
公开(公告)日：2005-03-10
申请号：US10494879
申请日：2002-11-08
申请人： Ahmed Chenna , Sharat Singh
发明人： Ahmed Chenna , Sharat Singh
IPC分类号： G01N33/532 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/532
摘要： Probe sets for the multiplexed detection of the binding of, or interaction between, one or more ligands and target antiligands are provided. Detection involves the release of identifying tags as a consequence of target recognition. The probe sets include electrophoretic tag probes or e-tag probes, comprising a detection region and a mobility-defining region, both linked to a target-binding moiety. In a multiplexed assay, different released e-tag reporters may be separated and detected providing for target identification. The probes comprise interactive functionalities adjacent the cleaved portion positioned in the probes such that the interactive functionality does not form part of the e-tag reporters. Also described are biopolymers and nucleosides containing such interactive functionalities.
摘要翻译：提供了用于多个检测一个或多个配体和靶抗配糖体的结合或相互作用的探针组。检测涉及到识别标签作为目标识别的结果。探针组包括电泳标签探针或e-标签探针，其包含与靶结合部分连接的检测区域和迁移率定义区域。在多重测定中，可以分离和检测不同的释放的电子标签记录器，以提供目标识别。这些探针包括与位于探针中的切割部分相邻的交互功能，使得交互功能不构成电子标签记录器的一部分。还描述了含有这种相互作用功能的生物聚合物和核苷。

97. 发明申请

US20050048553A1 Multiplexed analysis by chromatographic separation of molecular tags 审中-公开
标题翻译：通过色谱分离分子标签的多重分析
公开(公告)号：US20050048553A1
公开(公告)日：2005-03-03
申请号：US10918876
申请日：2004-08-16
申请人： Ahmed Chenna , Tracy Matray , Vincent Hernandez , Herbert Hooper , Sharat Singh
发明人： Ahmed Chenna , Tracy Matray , Vincent Hernandez , Herbert Hooper , Sharat Singh
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/58 , C12Q1/6809 , G01N33/6845 , G01N2030/027 , C12Q2565/102 , C12Q2565/137
摘要： Methods and kits are disclosed for determining, either in a homogeneous or heterogeneous assay format, one or more target analytes in a sample using binding compositions coupled to molecular tags by cleavable linkages. Generally, an assay mixture is formed comprising a sample and a reagent comprising multiple such binding compositions under conditions that permit stable complexes to form between the binding compositions and analytes. In one aspect of the invention, the interaction between the binding compositions and their respective binding sites brings a cleavage-inducing moiety into close proximity to cleavable linkages or provides a recognizable substrate for a cleavage-inducing moiety. In this way, one or more molecular tags for each of the analytes are released from the complexes. Released molecular tags are chromatographically separated and the presence and/or amount of the target analytes are determined based on the analysis of the released and separated molecular tags.
摘要翻译：公开了用于以同质或非均相测定形式测定样品中一种或多种目标分析物的方法和试剂盒，其使用通过可切割键连接分子标签的结合组合物。通常，在允许在结合组合物和分析物之间形成稳定的复合物的条件下，形成包含样品和包含多种这样的结合组合物的试剂的测定混合物。在本发明的一个方面，结合组合物和它们各自的结合位点之间的相互作用使切割诱导部分靠近可裂解连接，或为切割诱导部分提供可识别的底物。以这种方式，每个分析物的一个或多个分子标签从配合物中释放出来。释放的分子标签被色谱分离，并且基于释放和分离的分子标签的分析确定靶分析物的存在和/或量。

98. 发明授权

US06770439B2 Sets of generalized target-binding e-tag probes 有权
标题翻译：一套广泛的目标绑定电子标签探针
公开(公告)号：US06770439B2
公开(公告)日：2004-08-03
申请号：US09825244
申请日：2001-04-02
申请人： Sharat Singh , Tracy Matray , Ahmed Chenna
发明人： Sharat Singh , Tracy Matray , Ahmed Chenna
IPC分类号： C12Q168
CPC分类号： C07H19/06 , C07H19/10 , C07H21/00 , C40B70/00 , G01N33/561 , Y10S435/81
摘要： Probe sets for the multiplexed detection of the binding of, or interaction between, one or more ligands and target antiligands are provided. Detection involves the release of identifying tags as a consequence of target recognition. The probe sets include electrophoretic tag probes or e-tag probes, comprising a detection region and a mobility-defining region called the mobility modifier, both linked to a target-binding moiety. Target antiligands are contacted with a set of e-tag probes and the contacted antiligands are treated with a selected cleaving agent resulting in a mixture of e-tag reporters and uncleaved and/or partially cleaved e-tag probes. The mixture is exposed to a capture agent effective to bind to uncleaved or partially cleaved e-tag probes, followed by electrophoretic separation. In a multiplexed assay, different released e-tag reporters may be separated and detected providing for target identification.
摘要翻译：提供了用于多个检测一个或多个配体和靶抗配糖体的结合或相互作用的探针组。检测涉及到识别标签作为目标识别的结果。探针组包括电泳标签探针或e-标签探针，其包含检测区域和称为迁移率调节剂的迁移率限定区域，两者都连接到靶结合部分。将目标抗配糖与一组电子标签探针接触，并用选择的切割剂处理接触的抗配糖剂，导致电子标签报告子与未切割和/或部分切割的e-标签探针的混合物。将混合物暴露于有效结合未切割或部分切割的e-标签探针的捕获剂，然后进行电泳分离。在多重测定中，可以分离和检测不同的释放的电子标签记录器，以提供目标识别。

99. 发明授权

US06627400B1 Multiplexed measurement of membrane protein populations 有权
标题翻译：膜蛋白种群的多重测量
公开(公告)号：US06627400B1
公开(公告)日：2003-09-30
申请号：US09698846
申请日：2000-10-27
申请人： Sharat Singh , Tracy Matray
发明人： Sharat Singh , Tracy Matray
IPC分类号： C12Q168
CPC分类号： C07H19/06 , C07H19/10 , C07H21/00 , C40B20/08 , C40B40/08 , C40B50/16 , C40B70/00
摘要： Families of compositions are provided as labels, referred to as eTag reporters for attaching to polymeric compounds and assaying based on release of the eTag reporters from the polymeric compound and separation and detection. For oligonucleotides, the eTag reporters are synthesized at the end of the oligonucleotide by using phosphite or phosphate chemistry, whereby mass-modifying regions, charge-modifying regions and detectable regions are added sequentially to produce the eTag labeled reporters. By using small building blocks and varying their combination large numbers of different eTag reporters can be readily produced attached to a binding compound specific for the target compound of interest for identification. Protocols are used that release the eTag reporter when the target compound is present in the sample.
摘要翻译：提供组合物家族作为标记，被称为eTag报告基因，用于附着于聚合物上，并基于从高分子化合物释放eTag报告物并进行分离和检测。对于寡核苷酸，通过使用亚磷酸酯或磷酸酯化学在寡核苷酸的末端合成eTag报告物，由此顺序加入质量修饰区域，电荷修饰区域和可检测区域以产生eTag标记的记录。通过使用小的构建块并改变它们的组合，可以容易地产生大量不同的eTag报告物，其连接到目的化合物特异性的结合化合物用于鉴定。当目标化合物存在于样品中时，使用释放eTag报告物的方案。

100. 外观设计

USD463031S1 Microvolume sample plate 失效
标题翻译：微量体积样品板
公开(公告)号：USD463031S1
公开(公告)日：2002-09-17
申请号：US29131142
申请日：2000-10-11
申请人： David Slomski , Travis Boone , Sharat Singh
设计人： David Slomski , Travis Boone , Sharat Singh

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