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91. 发明申请

US20180156784A1 IMMUNE PROFILING AND MINIMAL RESIDUE DISEASE FOLLOWING STEM CELL TRANSPLANATION IN MULTIPLE MYELOMA 审中-公开
公开(公告)号：US20180156784A1
公开(公告)日：2018-06-07
申请号：US15829611
申请日：2017-12-01
申请人： The Charlotte Mecklenburg Hospital Authority d/b/a Carolinas Healthcare Syetem
发明人： Saad Z. Usmani , Manisha Bhutani , Qing Zhang , David M. Foureau
IPC分类号： G01N33/50 , G01N33/68 , G01N33/74 , G01N33/574
CPC分类号： G01N33/5091 , G01N33/57407 , G01N33/57426 , G01N33/6869 , G01N33/74 , G01N2333/475 , G01N2333/49 , G01N2333/50 , G01N2333/5434 , G01N2800/245
摘要： The present invention provides methods for determining the level or status of minimal residue disease (MRD) in a multiple myeloma (MM) patient including analyzing peripheral NK, NK-T and T cell distribution and/or activation, and quantifying inflammatory cytokines, chemokines and growth factors in a biological sample obtained from an MM patient to provide a peripheral immune profile; and obtaining a level or status of MRD in the MM patient from the peripheral immune profile, wherein if the peripheral immune profile exceeds a pre-determined threshold, the MM patient is positive for MRD.

92. 发明授权

US09907590B2 System for longitudinal closure of dissected sternums 有权
公开(公告)号：US09907590B2
公开(公告)日：2018-03-06
申请号：US14911541
申请日：2014-08-14
申请人： THE CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY
发明人： Jeko Metodiev Madjarov
IPC分类号： A61B17/80 , A61B17/82
CPC分类号： A61B17/8076 , A61B17/8004 , A61B17/8061 , A61B17/8085 , A61B17/823
摘要： Systems, devices, and methods for longitudinal closure of a dissected sternum are provided. The system includes first and second reinforcing members, fasteners, and closure members. Each reinforcing member is configured to be placed on an outer surface of a respective sternum portion, such that each reinforcing member is longitudinally disposed on an opposite side of a sternum opening with respect to the other reinforcing member. Fasteners may be placed in holes defined in the reinforcing members to secure a respective reinforcing member to a corresponding sternum portion. The closure members, which may be sternal closing wires, may then be wrapped around the sternum portions and the reinforcing members transversely to close the sternum opening. Because the reinforcing members include extended regions having lateral edges that extend away from a midline of the respective reinforcing member, the closure members are moved away from the edges of the bone.

93. 发明授权

US09381101B2 Hybrid graft for therapy of aortic pathology and associated method 有权
标题翻译：混合移植物治疗主动脉病变及相关方法
公开(公告)号：US09381101B2
公开(公告)日：2016-07-05
申请号：US13833665
申请日：2013-03-15
申请人： THE CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY
发明人： Jeko Metodiev Madjarov , Svetozar Madzharov
IPC分类号： A61F2/82 , A61F2/852 , A61F2/06 , A61B17/11
CPC分类号： A61F2/06 , A61B17/11 , A61B2017/1107 , A61B2017/1132 , A61F2/064 , A61F2/07 , A61F2/852 , A61F2002/061 , A61F2002/065 , A61F2230/006 , A61F2230/0067 , A61F2250/0039
摘要： Vascular devices and methods for addressing aortic pathologies are provided that facilitate hemostasis at the junctions of the ends of the device with the native aorta or other vessels to minimize or eliminate the risk of endoleaks. One or both ends of the device may include inner and outer skirts that are configured to receive a section of native blood vessel therebetween. The outer skirt may be flared in some cases or rolled up prior to placement at and engagement with the blood vessel to provide clearance for joining the blood vessel to the inner skirt of the device, such as via sutures. Once engaged, the outer skirt is disposed such that the blood vessel is between the inner and outer skirts. Devices and associated methods are also described that allow endografts to be deployed and engaged with an end of the device in areas with insufficient landing zones.
摘要翻译：提供用于解决主动脉病变的血管装置和方法，其促进装置末端与天然主动脉或其它血管的止血止血以最小化或消除内漏的风险。装置的一端或两端可包括被配置为在其间接收一段天然血管的内裙和外裙。外裙子在某些情况下可以展开，或者在放置在血管内并与血管接合之前卷起，以提供用于将血管连接到装置的内裙部的间隙，例如通过缝合线。一旦接合，外裙部被设置成使得血管位于内裙和外裙之间。还描述了装置和相关方法，其允许内移植物在具有不足的着陆区域的区域中部署并与装置的一端接合。

94. 发明申请

US20160183977A1 DEVICE FOR PLACEMENT OF AN INTRAUTERINE BALLOON 审中-公开
标题翻译：内置气囊放置装置
公开(公告)号：US20160183977A1
公开(公告)日：2016-06-30
申请号：US14911422
申请日：2014-08-19
申请人： THE CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY D/B/A CAROLINAS HEALTHCARE SYSTEM
发明人： Paul B. MARSHBURN
IPC分类号： A61B17/42 , A61B17/12 , A61B17/02
CPC分类号： A61B17/4241 , A61B17/02 , A61B17/0218 , A61B17/12136 , A61B17/42 , A61B2017/00225 , A61B2017/00336 , A61B2017/00557 , A61B2017/0212 , A61B2017/0225 , A61B2017/1205 , A61B2017/4216
摘要： A device, system, and method that may help reduce complications associated with placing an intrauterine balloon in the uterine cavity of a patient is provided. In one aspect, the system includes an inflatable balloon, an inflation line having a distal end in communication with the balloon; an inner member comprising an elongate tubular body having a distal and proximal end; a slot extending from the distal to proximal end of the inner member, and an outer sheath in which the inner member is removably insertable. The outer sheath is configured to receive the balloon in a furled state therein such that the balloon may be introduced into the uterine cavity by transvaginally inserting the outer sheath through an endocervical canal of the patient and then introducing the balloon into the uterine cavity by moving the inner member through the outer sheath in the direction of uterine cavity.
摘要翻译：提供了可以帮助减少将子宫内球囊放置在患者的子宫腔中相关联的并发症的装置，系统和方法。在一个方面，该系统包括可充气气囊，充气线具有与球囊连通的远端; 内部构件，其包括具有远端和近端的细长管状体; 从内部构件的远端延伸到近端，以及外部护套，内部构件可拆卸地插入其中。外护套构造成在其中接收气囊，其中气囊可通过经阴道将外鞘插入患者的子宫颈管内而引入到子宫腔中，然后通过移动内部构件通过外鞘在子宫腔的方向。

95. 发明授权

US09066824B2 Method and apparatus for endovascular therapy of aortic pathology 有权
标题翻译：主动脉病变血管内治疗的方法和装置
公开(公告)号：US09066824B2
公开(公告)日：2015-06-30
申请号：US13651920
申请日：2012-10-15
申请人： The Charlotte-Mecklenburg Hospital Authority
发明人： Jeko Metodiev Madjarov
IPC分类号： A61F2/07 , A61F2/95 , A61F2/852 , A61F2/954 , A61F2/06
CPC分类号： A61F2/852 , A61F2/06 , A61F2/954 , A61F2002/061 , A61F2250/0039 , A61F2250/006
摘要： Assemblies, devices, and methods for positioning the same proximate a target site within a body lumen are provided. The assembly includes first and second components that can function independently of one another to address a patient's vascular abnormalities or can cooperate to form an assembly. The assembly is designed to address aortic pathologies near clusters of arterial branches in a way that allows blood to continue flowing to the arterial branches during the procedure while providing an adequate landing zone for the adjoining component. One of the components may include a tapered portion near one end that can be received by a corresponding end of the other component. Alternatively, one of the components may include an invaginated end that is able to receive a corresponding end of the other component such that the position of each component is substantially fixed with respect to the other.
摘要翻译：提供了用于将物体，装置和方法定位在体腔内的目标部位附近。该组件包括能够彼此独立地起作用以解决患者的血管异常或可以协作以形成组件的第一和第二组件。该组件旨在以使得血液在手术期间继续流动到动脉分支的方式来解决动脉分支群附近的主动脉病变，同时为邻接部件提供适当的着陆区域。其中一个部件可以包括靠近一端的锥形部分，该锥形部分可以由另一部件的相应端部接收。或者，组件中的一个可以包括能够接收另一组件的对应端的内陷端，使得每个组件的位置相对于另一组件基本固定。

96. 发明申请

US20140249837A1 Methods And Systems For Facilitating Use Of Healthcare And Social Service Resources In A Community 审中-公开
标题翻译：促进社区医疗保健和社会服务资源利用的方法和系统
公开(公告)号：US20140249837A1
公开(公告)日：2014-09-04
申请号：US14193445
申请日：2014-02-28
申请人： The Charlotte-Mecklenburg Hospital Authority d/b/a Carolinas Healthcare System
发明人： Michael Dulin , Ed Connors
IPC分类号： G06Q50/22 , G06Q30/06 , G06F17/30
CPC分类号： G06Q50/22 , G06Q30/0631 , G16H40/20
摘要： Methods and systems are provided to facilitate the identification and connection of unique, relevant, and personalized healthcare and social service resources in a distributed user community in an automated manner to support and improve the health of communities. A method is provided that at least includes aggregating data about a plurality of community healthcare and social service resources, wherein resource profiles are generated for each of the plurality of community resources; generating user profiles for one or more community users, wherein the user profiles comprise indications of needs and preferences for the one or more community users in regard to healthcare and social services; receiving a query from one of the community users regarding a need for healthcare or social services; and generating a list of recommendations from the community resources based on the query and the user profile of the one of the community users. A corresponding system is also provided.
摘要翻译：提供方法和系统，以便以自动化的方式在分布式用户社区中识别和连接独特的，相关的和个性化的医疗保健和社会服务资源，以支持和改善社区的健康。提供了一种方法，其至少包括聚集关于多个社区医疗保健和社会服务资源的数据，其中为多个社区资源中的每一个生成资源简档; 为一个或多个社区用户生成用户简档，其中所述用户简档包括关于医疗保健和社会服务的一个或多个社区用户的需求和偏好的指示; 从社区用户那里收到有关医疗保健或社会服务需求的查询; 以及根据社区用户的查询和用户简档，从社区资源生成建议列表。还提供了相应的系统。

97. 发明申请

US20130282103A1 HYBRID GRAFT FOR THERAPY OF AORTIC PATHOLOGY AND ASSOCIATED METHOD 有权
标题翻译：用于治疗病理学和相关方法的混合物
公开(公告)号：US20130282103A1
公开(公告)日：2013-10-24
申请号：US13833665
申请日：2013-03-15
申请人： THE CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY d/b/a CAROLINAS HEALTHCARE SYSTEM
发明人： Jeko Metodiev Madjarov , Svetozar Madzharov
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61B17/11 , A61B2017/1107 , A61B2017/1132 , A61F2/064 , A61F2/07 , A61F2/852 , A61F2002/061 , A61F2002/065 , A61F2230/006 , A61F2230/0067 , A61F2250/0039
摘要： Vascular devices and methods for addressing aortic pathologies are provided that facilitate hemostasis at the junctions of the ends of the device with the native aorta or other vessels to minimize or eliminate the risk of endoleaks. One or both ends of the device may include inner and outer skirts that are configured to receive a section of native blood vessel therebetween. The outer skirt may be flared in some cases or rolled up prior to placement at and engagement with the blood vessel to provide clearance for joining the blood vessel to the inner skirt of the device, such as via sutures. Once engaged, the outer skirt is disposed such that the blood vessel is between the inner and outer skirts. Devices and associated methods are also described that allow endografts to be deployed and engaged with an end of the device in areas with insufficient landing zones.
摘要翻译：提供用于解决主动脉病变的血管装置和方法，其促进装置末端与天然主动脉或其它血管的止血止血以最小化或消除内漏的风险。装置的一端或两端可包括被配置为在其间接收一段天然血管的内裙和外裙。外裙可能在某些情况下展开，或者在放置在血管内并与血管接合之前卷起，以提供用于将血管连接到装置的内裙部的间隙，例如通过缝合线。一旦接合，外裙部被设置成使得血管位于内裙和外裙之间。还描述了装置和相关方法，其允许内移植物在具有不足的着陆区域的区域中部署并与装置的一端接合。

98. 发明申请

US20130190639A1 UTILIZING LIPOPOLYSACCHARIDE IN EXHALED BREATH CONDENSATE TO DIAGNOSE GRAM NEGATIVE PNEUMONIA 审中-公开
标题翻译：在呼吸道呼吸中使用脂多糖
公开(公告)号：US20130190639A1
公开(公告)日：2013-07-25
申请号：US13795370
申请日：2013-03-12
申请人： The Charlotte-Mecklenburg Hospital Authority
发明人： Jeffrey A. Kline , Jackeline Hernandez , John Albert Watts, JR.
IPC分类号： A61B5/08
CPC分类号： A61B5/082 , A61B5/097 , A61B5/412 , C12Q1/04 , C12Q1/14 , G01N33/579 , G01N33/92 , G01N2400/50
摘要： A device for collecting exhaled breath condensate from a subject. The device comprises a plunger assembly and a stopper. The stopper is connected to the plunger disk of the plunger assembly by a plurality of support pins and is configured for sealing engagement. The device is utilized to collect exhaled breath condensate from both spontaneously breathing and mechanically ventilated subjects and the devices utilized to determine whether lipopolysaccharide is present in the collected exhaled breath condensate.
摘要翻译：用于从受试者收集呼出的凝结水的装置。该装置包括柱塞组件和塞子。止动器通过多个支撑销连接到柱塞组件的柱塞盘，并且构造成用于密封接合。该装置用于从自发呼吸和机械通气的受试者收集呼出的呼吸冷凝物，并且用于确定所收集的呼出气体凝结物中是否存在脂多糖的装置。

99. 发明申请

US20130178906A1 METHOD AND SYSTEM FOR LONGITUDINAL CLOSURE OF DISSECTED STERNUMS 有权
标题翻译：方法和系统用于长期关闭不同的STERNUMS
公开(公告)号：US20130178906A1
公开(公告)日：2013-07-11
申请号：US13679095
申请日：2012-11-16
申请人： The Charlotte-Mecklenburg Hospital Authority d/b/a Carolinas HealthCare System
发明人： Jeko Metodiev Madjarov
IPC分类号： A61B17/80
CPC分类号： A61B17/8076 , A61B17/8004 , A61B17/8061 , A61B17/8085 , A61B17/823
摘要： Systems, devices, and methods for longitudinal closure of a dissected sternum are provided. The system includes first and second reinforcing members, fasteners, and closure members. Each reinforcing member is configured to be placed on an outer surface of a respective sternum portion, such that each reinforcing member is longitudinally disposed on an opposite side of a sternum opening with respect to the other reinforcing member. Fasteners may be placed in holes defined in the reinforcing members to secure a respective reinforcing member to a corresponding sternum portion. The closure members, which may be sternal closing wires, may then be wrapped around the sternum portions and the reinforcing members transversely to close the sternum opening. The system provides for a low installed profile, enhancing patient comfort and facilitating healing, and also provides for quick and easy access to the thoracic cavity for re-do sternotomies, if needed.
摘要翻译：提供了用于解剖胸骨纵向闭合的系统，装置和方法。该系统包括第一和第二加强构件，紧固件和闭合构件。每个加强构件被构造成放置在相应的胸骨部分的外表面上，使得每个加强构件纵向地设置在相对于另一加强构件的胸骨开口的相对侧。紧固件可以放置在限定在加强构件中的孔中，以将相应的加强构件固定到相应的胸骨部分。闭合构件（其可以是胸骨闭合线）然后可以横向地缠绕在胸骨部分和加强构件上以闭合胸骨开口。该系统提供低安装的轮廓，增强患者的舒适度并促进愈合，并且还提供快速和容易地进入胸腔以用于重新进行胸骨切开术（如果需要）。

100. 发明申请

US20130103132A1 METHOD AND APPARATUS FOR ENDOVASCULAR THERAPY OF AORTIC PATHOLOGY 有权
标题翻译：方法和装置用于动态病理学的内分泌治疗
公开(公告)号：US20130103132A1
公开(公告)日：2013-04-25
申请号：US13651920
申请日：2012-10-15
申请人： The Charlotte-Mecklenburg Hospital Authority d/b/
发明人： Jeko Metodiev Madjarov
IPC分类号： A61F2/852 , A61F2/954
CPC分类号： A61F2/852 , A61F2/06 , A61F2/954 , A61F2002/061 , A61F2250/0039 , A61F2250/006
摘要： Assemblies, devices, and methods for positioning the same proximate a target site within a body lumen are provided. The assembly includes first and second components that can function independently of one another to address a patient's vascular abnormalities or can cooperate to form an assembly. The assembly is designed to address aortic pathologies near clusters of arterial branches in a way that allows blood to continue flowing to the arterial branches during the procedure while providing an adequate landing zone for the adjoining component. One of the components may include a tapered portion near one end that can be received by a corresponding end of the other component. Alternatively, one of the components may include an invaginated end that is able to receive a corresponding end of the other component such that the position of each component is substantially fixed with respect to the other.
摘要翻译：提供了用于将物体，装置和方法定位在体腔内的目标部位附近。该组件包括能够彼此独立地起作用以解决患者的血管异常或可以协作以形成组件的第一和第二组件。该组件旨在以使得血液在手术期间继续流动到动脉分支的方式来解决动脉分支群附近的主动脉病变，同时为邻接部件提供适当的着陆区域。其中一个部件可以包括靠近一端的锥形部分，该锥形部分可以由另一部件的相应端部接收。或者，组件中的一个可以包括能够接收另一组件的对应端的内陷端，使得每个组件的位置相对于另一组件基本固定。

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