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91. 发明申请

US20080160007A1 Diagnosis and treatment of cancer related to human dormancy 有权
标题翻译：与人类休眠相关的癌症的诊断和治疗
公开(公告)号：US20080160007A1
公开(公告)日：2008-07-03
申请号：US12006462
申请日：2008-01-02
申请人： Michael Powell
发明人： Michael Powell
IPC分类号： A61K38/46 , A61K31/00 , A61K31/70 , A61K31/44 , A61K31/4965 , A61K31/65 , A61K31/522 , A61K31/35 , A61K31/12 , A61K31/727 , A61K31/47 , A61K31/715 , A61K31/20 , A61K31/40 , A01N45/00 , A61K31/415 , A61K31/19 , A61K31/13 , C12M1/34 , A61K33/04 , A61K33/32 , A61K33/06 , A61K47/00 , A61K33/44
CPC分类号： A61K45/06 , A61K31/12 , A61K31/13 , A61K31/19 , A61K31/20 , A61K31/35 , A61K31/40 , A61K31/415 , A61K31/44 , A61K31/47 , A61K31/4965 , A61K31/522 , A61K31/65 , A61K31/70 , A61K31/715 , A61K31/727 , A61K2300/00
摘要： New devices and methods for diagnosis and compositions and methods for treatment of cancers use combinations of antimicrobial agents and agents that can reverse dormancy and hibernation pathways. We unexpectedly found that surprisingly low doses of anti-hibernation compounds can substantially inhibit cancer cell growth in vitro and can successfully treat cancers, including metastatic cancer. We also unexpectedly found that antimicrobial agents and anti-HDS compounds together can increase the degree of inhibition of cancer cell growth in a synergistic fashion. We conclude that combination therapy with antimicrobial agents and anti-HDS compounds can be effective in treating human patients with cancer.
摘要翻译：用于诊断的新装置和方法以及用于治疗癌症的组合物和方法使用可逆转休眠和休眠途径的抗微生物剂和试剂的组合。我们意外地发现令人惊讶的是，低剂量的抗冬眠化合物可以在体外基本上抑制癌细胞生长，并且可以成功地治疗癌症，包括转移性癌症。我们也意外地发现，抗微生物剂和抗HDS化合物可以以协同的方式增加癌细胞生长的抑制程度。我们得出结论，用抗微生物剂和抗HDS化合物的联合治疗可以有效治疗癌症患者。

92. 发明申请

US20070221328A1 FIXTURE AND METHOD OF HOLDING AND DEBONDING A WORKPIECE WITH THE FIXTURE 有权
标题翻译：用工具夹持和去除工件的方法和方法
公开(公告)号：US20070221328A1
公开(公告)日：2007-09-27
申请号：US11460159
申请日：2006-07-26
申请人： Edward C. DeMeter , R. Michael Powell
发明人： Edward C. DeMeter , R. Michael Powell
IPC分类号： B32B37/12
CPC分类号： B32B38/10 , B23Q1/035 , B23Q3/084 , B25B11/00 , Y10T156/11 , Y10T156/1168 , Y10T156/19 , Y10T156/1961 , Y10T156/1972
摘要： A fixture for holding a workpiece during a manufacturing process includes a base and a rod received by and moveable relative to the base. The rod includes a proximal end presenting a bonding surface. Adhesive establishes an adhesive bond extending between and bonding to the bonding surface and the workpiece. The bonding surface is moveable with the rod relative to the base in an adhesive bond destroying motion. A method of holding the workpiece on the fixture includes the step of adjoining the adhesive to the bonding surface and to the workpiece to create the adhesive bond between the bonding surface and the workpiece during the manufacturing process. The method also includes the step of displacing the bonding surface relative to the base and relative to the workpiece to destroy the adhesive bond between the bonding surface and the workpiece after the manufacturing process has been performed on the workpiece.
摘要翻译：用于在制造过程中保持工件的固定装置包括基座和相对于底座接收并可移动的杆。杆包括具有接合表面的近端。粘合剂建立在粘合表面和工件之间延伸并粘合到粘合表面和工件上的粘合剂粘结。接合表面可以与棒相对于底座以粘合剂粘结破坏运动而移动。将工件保持在夹具上的方法包括将粘合剂与粘合表面和工件相邻的步骤，以在制造过程中在粘合表面和工件之间形成粘合剂粘结。该方法还包括相对于基座相对于工件移动接合表面的步骤，以便在对工件进行制造过程之后破坏接合表面和工件之间的粘结。

93. 发明申请

US20070132578A1 MONITORING SYSTEM AND METHOD 审中-公开
标题翻译：监测系统及方法
公开(公告)号：US20070132578A1
公开(公告)日：2007-06-14
申请号：US11610213
申请日：2006-12-13
申请人： Michael Powell
发明人： Michael Powell
IPC分类号： G08B1/08 , G08B23/00
CPC分类号： G08B21/023 , G08B21/025 , G08B21/088 , G08B21/22
摘要： A monitoring system (10) for monitoring people in swimming pools and other similar environments has a child unit (12) and a parent unit (14) that are in wireless communication with each other. The child unit is intended to be worn by a person near a swimming pool. The child unit includes a water sensor and a proximity sensor that detect when the child unit is immersed in water or when it is removed from the person—potentially hazardous environments. The child unit sends signals to the parent unit indicative of the state of the environment. If the state of the environment is detected as being hazardous, then the parent unit is operable to emit an alarm. The emission of the alarm is delayed by a predetermined time delay, which is variable depending upon the needs of the person being monitored.
摘要翻译：用于监视游泳池和其他类似环境中的人的监视系统（10）具有彼此无线通信的子单元（12）和父单元（14）。小孩单位打算由游泳池附近的人穿戴。子单元包括水传感器和接近传感器，用于检测子单元何时浸入水中或何时从人身危险环境中移除。子单元向母单元发送指示环境状态的信号。如果环境状况被检测为危险，则母机能够发出警报。警报的发射被延迟预定的时间延迟，这是根据被监视者的需要而变化的。

94. 发明申请

US20060200423A1 System and Method to Facilitate and Support Exchange of Proprietary Information 审中-公开
标题翻译：促进和支持专有信息交换的系统和方法
公开(公告)号：US20060200423A1
公开(公告)日：2006-09-07
申请号：US11379935
申请日：2006-04-24
申请人： Michael Powell
发明人： Michael Powell
IPC分类号： G06Q99/00
CPC分类号： G06Q50/184 , G06F16/21 , G06Q10/10 , G06Q30/00 , G06Q30/06 , G06Q40/04 , G06Q50/188 , H04L63/0421 , H04L63/0442 , H04L63/123 , H04L63/126 , H04L2463/102
摘要： A method and apparatus effectuates bilateral commerce in ideas. An originator and user-driven on-line commercial network system is designed to facilitate idea submission, purchase, and licensing, and is easily adapted to business-to-business transfers of innovation as well as consumer-to-business transfers of innovation. The invention allows originators of ideas to communicate nondisclosing synopses of ideas globally to potential users, for users conveniently to search for relevant ideas and for users potentially to bind an originator to a limited duration license granting user the exclusive right to access and consider confidentially the originator's fully disclosed idea. The invention also allows users to communicate confidentially or nonconfidentially unsolved problems or needs globally to potential originators, for originators conveniently to search for relevant unsolved problems or needs, and for originators to submit and communicate confidentially proposed solutions to the soliciting user.
摘要翻译：一种方法和手段实现了双边商业观念。创始人和用户驱动的在线商业网络系统旨在促进提交，购买和许可的想法，并且易于适应创新的企业对企业转移以及创新的消费者到企业的转移。本发明允许创始人的想法将潜在用户的全球想法概要传达给潜在用户，为用户方便地搜索相关想法，并为用户提供可能将发起人绑定到有限持续时间的许可授予用户专有访问权限，并考虑到发起者充分披露的想法。本发明还允许用户在全球范围内向潜在的发起人传达秘密或非自主未解决的问题或需求，为发起人方便地搜索相关的未解决的问题或需求，并且发起人向招揽用户提交和传达秘密提出的解决方案。

95. 发明授权

US07077889B2 Surface modification of porous metal substrates 有权
标题翻译：多孔金属基材的表面改性
公开(公告)号：US07077889B2
公开(公告)日：2006-07-18
申请号：US10408058
申请日：2003-04-04
申请人： Anand Chellappa , Charles Call , Michael Powell
发明人： Anand Chellappa , Charles Call , Michael Powell
IPC分类号： B01D53/22 , B01D71/02
CPC分类号： B01D67/009 , B01D53/228 , B01D67/0069 , B01D69/10 , B01D71/022 , B01D2325/04 , C01B3/503 , C01B2203/0405 , C01B2203/047 , C01B2203/0475 , C01B2203/048 , Y10S55/05 , Y10T428/12479
摘要： A method for reducing the surface variance of a porous metal substrate. The method does not significantly reduce the bulk porosity. The method can be used to reduce the surface pore diameter. A membrane, can be deposited on the reduced variance surface to form a separation membrane.
摘要翻译：一种减少多孔金属基材的表面变化的方法。该方法不会显着降低体积孔隙率。该方法可用于降低表面孔径。膜可以沉积在减少的方差表面上以形成分离膜。

96. 发明申请

US20060051183A1 Ground anchors 审中-公开
标题翻译：地锚
公开(公告)号：US20060051183A1
公开(公告)日：2006-03-09
申请号：US11178696
申请日：2005-07-11
申请人： Michael Powell , Brent Powell , Jade Powell
发明人： Michael Powell , Brent Powell , Jade Powell
IPC分类号： F16B25/00
CPC分类号： E02D5/801
摘要： A ground anchor is adapted for anchoring in the ground. The anchor includes a ground engaging portion which comprises an elongate member and a spiral extending around at least part of the elongate member. The spiral has gaps therein spaced along its length.
摘要翻译：地锚适于锚固在地面上。锚固件包括地面接合部分，其包括细长构件和围绕细长构件的至少一部分延伸的螺旋。螺旋线沿其长度间隔开间隙。

97. 发明申请

US20060035248A1 Assays employing electrochemiluminescent labels and electrochemiluminescence quenchers 审中-公开
标题翻译：测定采用电化学发光标记和电化学发光淬灭剂
公开(公告)号：US20060035248A1
公开(公告)日：2006-02-16
申请号：US11124407
申请日：2005-05-09
申请人： Mark Richter , Michael Powell , Christopher Belisle
发明人： Mark Richter , Michael Powell , Christopher Belisle
IPC分类号： C12Q1/68
CPC分类号： G01N33/542 , C09B57/10 , C09B69/109 , G01N33/582
摘要： This invention pertains to the general field of chemical and biological assays which employ electrochemiluminescence (ECL), also referred to as electrogenerated chemiliminescence. More particularly, the present invention pertains to certain classes of chemical moieties which strongly quench ECL, and the use of these ECL quenchers in combination with ECL labels, for example, in ECL assay methods which employ an ECL quencher and an ECL label. One class of such quenching moieties are those which comprise at least one benzene moiety. Sub-classes of such quenching moieties are those which comprise at least one phenol moiety, quinone moiety, benzene carboxylic acid, and/or benzene carboxylate moiety.
摘要翻译：本发明涉及使用电化学发光（ECL）的化学和生物测定的一般领域，也被称为电生化学发光。更具体地说，本发明涉及强烈猝灭ECL的某些类别的化学部分，以及这些ECL猝灭剂与ECL标记的组合的使用，例如在采用ECL猝灭剂和ECL标记的ECL测定方法中。一类这样的猝灭部分是包含至少一个苯部分的那些。这种猝灭部分的亚类是包含至少一个苯酚部分，醌部分，苯羧酸和/或苯羧酸酯部分的那些。

98. 发明申请

US20050221302A1 Tissue transglutaminase 审中-公开
标题翻译：组织转谷氨酰胺酶
公开(公告)号：US20050221302A1
公开(公告)日：2005-10-06
申请号：US10467587
申请日：2002-02-07
申请人： Michael Powell , Jadwiga Furmaniak , Bernard Smith
发明人： Michael Powell , Jadwiga Furmaniak , Bernard Smith
IPC分类号： C12N9/10 , C12Q1/68 , C07H21/04 , C07K16/42 , C12N5/06
CPC分类号： C12N9/1044
摘要： The present invention relates to tissue transglutaminase (tTG), and more particularly to DNA coding for and polypeptides containing, the primary structural conformaion of one or more epitopes of tTG and to the use thereof in the detection of autoantibodies and/or lymphocytes produced in response to tTG.
摘要翻译：本发明涉及组织转谷氨酰胺酶（tTG），更具体地涉及编码和含有tTG的一个或多个表位的主要结构构象的多肽的DNA及其在检测响应中产生的自身抗体和/或淋巴细胞中的用途到tTG。

99. 发明授权

US06854611B2 Lock for preventing inadvertent removal of a first frame component of an adjustable storage system from a second frame component of the adjustable storage system and the adjustable storage system 失效
标题翻译：锁定，用于防止可调节存储系统的第一框架部件从可调节存储系统的第二框架部件和可调节存储系统
公开(公告)号：US06854611B2
公开(公告)日：2005-02-15
申请号：US10385277
申请日：2003-07-11
申请人： Michael Powell
发明人： Michael Powell
IPC分类号： A47B57/50 , F16B5/00 , F16B7/04 , F16B21/09 , A47B43/00 , F16B9/00
CPC分类号： F16B21/09 , A47B57/50 , F16B5/0036 , F16B7/0486 , Y10T403/59 , Y10T403/602
摘要： A lock for preventing inadvertent removal of a first frame component from a second frame component of an adjustable storage system. The lock includes a housing having a distal end extending into the first frame component, a shaft having a proximal end and a distal end and being movable between an extended position and a retracted position relative to the housing, with the distal end thereof extending into the second frame component when the shaft is in the extended position and not extending into the second frame component when the shaft is in the retracted position, a head being slender and elongated, joined to the proximal end of the shaft, and extending radially outwardly therefrom, radially outwardly through the housing, when the shaft is in the extended position and the retracted position, and a spring joined between the head and the housing and biasing the shaft into the extended position.
摘要翻译：一种用于防止意外从可调节存储系统的第二框架部件移除第一框架部件的锁。锁包括具有延伸到第一框架部件中的远端的壳体，具有近端和远端的轴，并且可相对于壳体在延伸位置和缩回位置之间移动，其远端延伸到当所述轴处于所述延伸位置并且当所述轴处于所述缩回位置时不延伸到所述第二框架部件中的第二框架部件，与所述轴的近端连接并且从其径向向外延伸的头部细长且细长，当轴处于延伸位置和缩回位置时，径向向外通过壳体，以及弹簧，其连接在头部和壳体之间并将轴偏压到伸出位置。

100. 发明授权

US06637986B2 Drilling apparatus and method 失效
标题翻译：钻孔设备及方法
公开(公告)号：US06637986B2
公开(公告)日：2003-10-28
申请号：US09994305
申请日：2001-11-26
申请人： Michael Powell
发明人： Michael Powell
IPC分类号： B23B3500
CPC分类号： G05B19/182 , B23B35/00 , G05B2219/49397 , Y10T408/03 , Y10T408/17 , Y10T408/23
摘要： The invention provides a drilling apparatus and method for drilling a hole in a workpiece. The drilling apparatus includes means for rotating a drill bit and means for advancing the rotating drill bit into a workpiece to a first depth. The drilling apparatus further includes means for dwelling the drill bit within the workpiece at the first depth for a dwell time and means for further advancing the rotating bit to a second depth after the dwell time has expired. The drilling method includes rotating a drill bit and advancing the rotating drill bit into the workpiece to a first depth. The method farther includes dwelling the drill bit within the workpiece at the first depth for a dwell time and further advancing the rotating bit to a second depth after the dwell time has expired.
摘要翻译：本发明提供一种在工件上钻孔的钻孔装置和方法。钻孔装置包括用于旋转钻头的装置和用于将旋转的钻头前进到工件到第一深度的装置。所述钻孔设备还包括用于在所述第一深度处将所述钻头留在所述停留时间内的装置，以及用于在所述停留时间到期之后将所述旋转钻头进一步前进到第二深度的装置。钻孔方法包括旋转钻头并将旋转钻头推入工件到第一深度。该方法还包括在第一深度处将工件中的钻头居住停留时间，并且在停留时间到期之后进一步将旋转钻头推进到第二深度。

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