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91. 发明授权

US07625910B2 Co-crystal 失效
标题翻译：共晶
公开(公告)号：US07625910B2
公开(公告)日：2009-12-01
申请号：US11748651
申请日：2007-05-15
申请人： George Joseph Sependa , Richard Storey
发明人： George Joseph Sependa , Richard Storey
IPC分类号： A61K31/517
CPC分类号： C07D403/12 , C07F9/65583
摘要： The present invention relates to a novel co-crystal of 2-{ethyl[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)amino]quinazolin-7-yl}oxy)propyl]amino}ethyl dihydrogen phosphate (AZD1152) which is an aurora kinase inhibitor that is useful in the treatment of hyperproliferative diseases such as cancer.
摘要翻译：本发明涉及2- {乙基[3 - （{4 - [（5- {2 - [（3-氟苯基）氨基] -2-氧代乙基} -1H-吡唑-3-基）氨基]喹唑啉-7-基}氧基）丙基]氨基}乙基磷酸二氢酯（AZD1152），其是可用于治疗过度增殖性疾病如癌症的极光激酶抑制剂。

92. 发明申请

US20090138056A1 METHODS AND DEVICES FOR MINIMALLY INVASIVE SPINAL FIXATION ELEMENT PLACEMENT 有权
标题翻译：用于最小入路脊柱固定元件放置的方法和装置
公开(公告)号：US20090138056A1
公开(公告)日：2009-05-28
申请号：US12365711
申请日：2009-02-04
申请人： David Greg Anderson , Christopher Sicvol , George Joseph Ross , Sean P. Selover
发明人： David Greg Anderson , Christopher Sicvol , George Joseph Ross , Sean P. Selover
IPC分类号： A61F5/00
CPC分类号： A61B17/7085 , A61B17/00234 , A61B17/7011 , A61B17/7035 , A61B17/7037 , A61B17/7074 , Y10S606/914
摘要： Minimally invasive methods and devices for introducing a spinal fixation element into a surgical site in a patient's spinal column are provided. In general, the method involves advancing a spinal fixation element in a first, lengthwise orientation along a pathway extending from a minimally invasive percutaneous incision to a spinal anchor site. As the spinal fixation element approaches the spinal anchor site, the fixation element can be manipulated to extend in a second orientation, which is preferably substantially transverse to the first orientation, to position the fixation element in relation to one or more spinal anchors.
摘要翻译：提供了用于将脊柱固定元件引入患者脊柱的手术部位的微创方法和装置。通常，该方法包括沿着从微创经皮切口延伸到脊柱锚定部位的路径沿着第一长度方向前进脊柱固定元件。当脊骨固定元件接近脊椎锚固部位时，固定元件可以被操纵以在第二方向上延伸，该第二方向优选地基本上横向于第一方向，以将固定元件相对于一个或多个脊椎锚固件定位。

93. 发明申请

US20080269314A1 Process for Forming Amorphous Atorvastatin 有权
标题翻译：形成无定形阿托伐他汀的方法
公开(公告)号：US20080269314A1
公开(公告)日：2008-10-30
申请号：US11666707
申请日：2005-10-12
申请人： Antone John Debetten-Court , Peter Robert Rose , Evgenyi Yur'evich Shalaev , George Joseph Quallich , Carl Bernard Ziegler
发明人： Antone John Debetten-Court , Peter Robert Rose , Evgenyi Yur'evich Shalaev , George Joseph Quallich , Carl Bernard Ziegler
IPC分类号： A61K31/40
CPC分类号： C07D207/34 , A61K9/145 , A61K9/146 , A61K9/19 , A61K31/40
摘要： A process for forming amorphous atorvastatin comprising the steps of dissolving atorvastatin in a non-hydroxylic solvent and removing the solvent by freeze-drying, as well as processes of dissolving atorvastatin in a hydroxylic solvent with a solubilizing agent or an alkalizing agent or an antioxidant and removing the solvent by freeze-drying to afford amorphous atorvastatin.
摘要翻译：一种形成无定形阿托伐他汀的方法，包括以下步骤：将阿托伐他汀溶解在非羟基溶剂中并通过冷冻干燥除去溶剂，以及将阿托伐他汀溶解在羟基溶剂中与增溶剂或碱化剂或抗氧化剂，以及通过冷冻干燥除去溶剂，得到无定形的阿托伐他汀。

94. 发明申请

US20070210513A1 CASINO CRAPS CARD GAME 有权
标题翻译： CASINO CRAPS卡游戏
公开(公告)号：US20070210513A1
公开(公告)日：2007-09-13
申请号：US11308223
申请日：2006-03-13
申请人： Cynthia Bunn , Kirk Myrick , JR Mathews , George Joseph
发明人： Cynthia Bunn , Kirk Myrick , JR Mathews , George Joseph
IPC分类号： A63F9/24 , A63B71/00 , A63F9/04 , A63F3/08
CPC分类号： A63F3/00157 , A63F9/04 , A63F2001/0425
摘要： A method for playing a game played by at least one player having both numbered playing cards and a pair of dice. The method for the game includes randomizing at least six of the playing cards, wherein each card contains a single digit from one to six. The playing cards are then inserted into a series of boxes or slots on a table wherein the boxes or slots correspond to the digits one through six. One player is offered an opportunity to be a dealer and is provided with a pair of six-sided dice. The dice are rolled by the dealer and the outcome of the playing card or cards is determined and the total of the cards is determined by the outcome of the dice. Winners and losers are determined from the card or the cards. A series of additional steps may be employed thereafter in accordance with traditional casino craps gaming rules.
摘要翻译：一种用于播放由至少一个具有编号的扑克牌和一对骰子的玩家所玩的游戏的方法。游戏的方法包括随机化至少六张扑克牌，其中每张牌包含从一到六的单个数字。然后将纸牌插入到桌子上的一系列盒子或插槽中，其中盒子或插槽对应于数字1到6。一名玩家被提供一个成为经销商的机会，并提供一双六面骰子。骰子由经销商滚动，纸牌或卡的结果被确定，并且卡的总数由骰子的结果确定。优胜者和输家由卡片或卡片决定。此后可以根据传统的赌场游戏规则采用一系列附加步骤。

95. 发明申请

US20070206516A1 AUTOMATED INSTALLATION OF NETWORK SERVICE IN A TELECOMMUNICATIONS NETWORK 有权
标题翻译：在电信网络中自动安装网络服务
公开(公告)号：US20070206516A1
公开(公告)日：2007-09-06
申请号：US11745361
申请日：2007-05-07
申请人： Richard Wall , Gary Ryczek , James Loukatos , Alex Henes , Jeffrey Martin , Brett Hollman , Thomas Hoople , George Joseph , Troy Kau
发明人： Richard Wall , Gary Ryczek , James Loukatos , Alex Henes , Jeffrey Martin , Brett Hollman , Thomas Hoople , George Joseph , Troy Kau
IPC分类号： H04L12/26
CPC分类号： H04L12/56
摘要： A communication line is installed in a network by automating a design phase and a configuration phase for the service and by automating failure recovery in either of the phases. In the design phase, an optimal route for the communication line is found, and the network components are provisioned and assigned. If the assigned network components are not available or can not be validated, the components causing the failure are marked, and the design phase is retried without the marked components. After the design phase, the configuration phase begins. The circuit design is tested against actual network components. If the test is passed, the actual network is configured according to the circuit design and the circuit is activated. If there is a network component failure during the configuration phase, the good route elements in the design are released while the failed network components are marked. The design phase is retried.
摘要翻译：通过自动化服务的设计阶段和配置阶段以及通过自动化任一阶段的故障恢复来在网络中安装通信线路。在设计阶段，找到通信线路的最佳路由，并配置和分配网络组件。如果分配的网络组件不可用或无法验证，则会导致导致故障的组件，并在没有标记组件的情况下重试设计阶段。在设计阶段之后，配置阶段开始。电路设计是针对实际网络组件进行测试的。如果测试通过，实际网络根据电路设计进行配置，电路被激活。如果在配置阶段出现网络组件故障，设计中的良好路由元素将被释放，同时标记出现故障的网络组件。设计阶段重试。

96. 发明授权

US07081560B1 Absorbent articles utilizing breathable composite sheet 失效
标题翻译：使用透气复合片材的吸收制品
公开(公告)号：US07081560B1
公开(公告)日：2006-07-25
申请号：US09980330
申请日：2000-06-02
申请人： Hyun Sung Lim , George Joseph Ostapchenko
发明人： Hyun Sung Lim , George Joseph Ostapchenko
IPC分类号： A61F13/15
CPC分类号： A61F13/51458
摘要： The present invention relates to absorbent articles having a topsheet, a backsheet, and an absorbent core between the topsheet and the backsheet. The backsheet comprises a moisture vapor permeable, substantially liquid impermeable composite sheet material includes a powder-bonded nonwoven web adhered to a moisture vapor permeable thermoplastic film. The nonwoven web includes a first layer comprised primarily of fibers that are compatible with an adhesive used to bond the web, and a second layer comprised of a blend of fibers, some of which are compatible with, and some of which are incompatible with the bonding adhesive and the thermoplastic film. A method for making the composite sheet material and an item of apparel made from the sheet material are also provided.
摘要翻译：本发明涉及在顶片和底片之间具有顶片，底片和吸收芯的吸收制品。底片包括透湿水分的，基本上液体不可渗透的复合片材，其包括粘附在水蒸汽可渗透热塑性薄膜上的粉末粘合非织造纤维网。非织造纤维网包括主要由与用于粘合纤维网的粘合剂相容的纤维组成的第一层，以及由纤维共混物组成的第二层，其中一些纤维的混合物与其粘合，其中一些与粘合不相容粘合剂和热塑性薄膜。还提供了制造复合片材的方法和由片材制成的服饰物品。

97. 发明授权

US06432982B1 Benzothiophenes, and formulations and methods using same 失效
标题翻译：苯并噻吩类，以及使用其的制剂和方法
公开(公告)号：US06432982B1
公开(公告)日：2002-08-13
申请号：US08783160
申请日：1997-01-14
申请人： George Joseph Cullinan , Kennan Joseph Fahey
发明人： George Joseph Cullinan , Kennan Joseph Fahey
IPC分类号： A61K31445
CPC分类号： C07D333/56
摘要： The invention provides novel benzothiophenes of the formula: wherein R1 is —H, —OH, —O(C1-C4 alkyl), —O—CO(C1-C6 alkyl), —OSO2(C4-C6 alkyl, or —OCOAr where Ar is optionally substituted phenyl; R2 is —H, —OH, —Cl, —Br, —O(C1-C4 alkyl), —OCO(C1-C6 alkyl), —OSO2(C4-C6 alkyl, or —OCOAr where Ar is optionally substituted phenyl; R3 is —H, —F, —Cl, —(C1-C4 alkyl), —CN, or —O(C1-C3 alkyl); R4 is —H, —F, —Cl, —(C1-C4 alkyl), —CN or —O(C1-C3 alkyl); R5 is —H, —F, —Cl, —(C1-C4 alkyl), or —O(C1-C3 alkyl); and R6 is —H, —F, —Cl, —(C1-C4 alkyl), or —O(C1-C3 alkyl); with the provisos that R3, R4, R5 and R6 can not all be hydrogen, and that when one of R3, R4, R5 or R6 is C1-C4 alkyl, no more than two of R3, R4, R5 and R6 can be hydrogen; Y is —CO—, —CHOH—, or —CH2—; R7 and R8 are independently C1-C4 alkyl or combine to form, with the nitrogen to which they are attached, 1-piperidinyl, 1-pyrrolidinyl, 1-hexamethyleneimino, or morpholino; or a pharmaceutically acceptable salt thereof. The present invention further provides pharmaceutical compositions containing compounds of formula I, optionally containing estrogen opr progestin, and the use of such compounds alone, or in combination with estrogen or progestin or alleviating the symptoms of post-menopausal syndrome, particularly osteoporosis, cardiovascular related pathological conditions, and estrogen-dependent cancer.
摘要翻译：本发明提供下式的新型苯并噻吩：其中R1是-H，-OH，-O（C1-C4烷基），-O-CO（C1-C6烷基），-OSO2（C4-C6烷基或-OCOAr，其中 Ar是任选取代的苯基; R 2是-H，-OH，-Cl，-Br，-O（C 1 -C 4烷基），-OCO（C 1 -C 6烷基），-OSO 2（C 1 -C 6烷基或-OCOAr Ar是任选取代的苯基; R 3是-H，-F，-Cl， - （C 1 -C 4烷基），-CN或-O（C 1 -C 3烷基）; R 4是-H，-F，-Cl，（C1-C4烷基），-CN或-O（C1-C3烷基）; R5是-H，-F，-Cl， - （C1-C4烷基）或-O（C1-C3烷基）是-H，-F，-Cl， - （C 1 -C 4烷基）或-O（C 1 -C 3烷基）;条件是R 3，R 4，R 5和R 6不能都是氢， R3，R4，R5或R6是C1-C4烷基，R3，R4，R5和R6中不超过2个可以是氢; Y是-CO-，-CHOH-或-CH2-; R7和R8独立地是C1 -C 1-4烷基或与它们所连接的氮原子一起形成1-哌啶基，1-吡咯烷基，1-六亚甲基亚氨基或吗啉代;或其药学上可接受的盐。进一步提供含有式I化合物的药物组合物，任选地含有雌激素opr孕激素，以及单独使用这些化合物，或与雌激素或孕激素组合或减轻绝经后综合征的症状，特别是骨质疏松症，心血管相关病理状况，和爱死

98. 发明授权

US06410465B1 Composite sheet material 失效
标题翻译：复合片材
公开(公告)号：US06410465B1
公开(公告)日：2002-06-25
申请号：US09421135
申请日：1999-10-19
申请人： Hyun Sung Lim , George Joseph Ostapchenko
发明人： Hyun Sung Lim , George Joseph Ostapchenko
IPC分类号： B32B526
CPC分类号： B32B5/26 , B32B5/022 , B32B7/12 , B32B2305/20 , B32B2307/7246 , B32B2307/7265 , B32B2367/00 , B32B2437/00 , D04H1/593 , D04H1/60 , Y10T428/2973 , Y10T442/2139 , Y10T442/60 , Y10T442/608 , Y10T442/609 , Y10T442/611 , Y10T442/659 , Y10T442/668 , Y10T442/671 , Y10T442/674 , Y10T442/675 , Y10T442/676
摘要： A moisture vapor permeable, substantially liquid impermeable composite sheet material includes a powder-bonded nonwoven web adhered to a moisture vapor permeable thermoplastic film. The nonwoven web includes a first layer comprised primarily of fibers that are compatible with an adhesive used to bond the web, and a second layer comprised of a blend of fibers, some of which are compatible with, and some of which are incompatible with the bonding adhesive and the thermoplastic film. A method for making the composite sheet material and an item of apparel made from the sheet material are also provided.
摘要翻译：透湿透湿的，基本上液体不可渗透的复合片材包括粘附在水蒸汽可渗透的热塑性薄膜上的粉末粘合的非织造纤维网。非织造纤维网包括主要由与用于粘合纤维网的粘合剂相容的纤维组成的第一层，以及由纤维共混物组成的第二层，其中一些与纤维的混合物相容，其中一些与粘合不相容粘合剂和热塑性薄膜。还提供了制造复合片材的方法和由片材制成的服饰物品。

99. 发明授权

US06387925B1 Polymorphs of a crystalline azo-bicyclo (2.2.2) oct-3-yl amine citrate and their pharmaceutical compositions 失效
标题翻译：结晶偶氮二环（2.2.2）辛-3-基胺柠檬酸盐的多晶型物及其药物组成
公开(公告)号：US06387925B1
公开(公告)日：2002-05-14
申请号：US09887682
申请日：2000-05-12
申请人： George Joseph Quallich , Lewin Theophilus Wint , Peter Robert Rose , Stephen S. Massett
发明人： George Joseph Quallich , Lewin Theophilus Wint , Peter Robert Rose , Stephen S. Massett
IPC分类号： A61K31439
CPC分类号： C07D453/02
摘要： Two crystalline polymorphic forms of (2-Benzhydryl-1-azo-bicyclo[2.2.2]oct-3-yl)-(5-isopropyl-2-methoxybenzyl)-amine citrate monohydrate (the monohydrates) are Form A and Form B. The pharmaceutical composition containing at least one of these polymorphs has advantageous stability for formulation to treat acute emesis in patient receiving chemotherapy. The administration of this pharmaceutical composition is conventional oral by preferably tablet or capsule and intravenous. A method of making A and B Forms is also disclosed.
摘要翻译：（2-二苯甲基-1-偶氮 - 双环[2.2.2]辛-3-基） - （5-异丙基-2-甲氧基苄基） - 胺柠檬酸一水合物（一水合物）的两种结晶多晶型形式为A型和B型含有这些多晶型物中的至少一种的药物组合物在接受化疗的患者中具有治疗急性呕吐的制剂的有利的稳定性。该药物组合物的给药优选为片剂或胶囊和静脉内口服。还公开了制作A和B表格的方法。

100. 发明授权

US06349496B1 Safety locking device for a firearm 失效
标题翻译：枪支的安全锁定装置
公开(公告)号：US06349496B1
公开(公告)日：2002-02-26
申请号：US09387295
申请日：1999-08-31
申请人： George Joseph Neely
发明人： George Joseph Neely
IPC分类号： F41A1700
CPC分类号： F41C33/0209 , F41A17/02 , F41C33/0263 , F41C33/029 , F41C33/04
摘要： A safety locking device for engaging the trigger guard assembly of a firearm. A preferred embodiment includes a housing having a slot formed therein and configured to receive the trigger and trigger guard portion of a firearm, and a locking mechanism to prevent removal of the firearm from the device. The locking mechanism further comprises a locking assembly operably attached to a locking rod which can be moved into or out of a channel containing a ball that when held in place by the rod causes the slot that contains the trigger guard to narrow sufficiently to prevent the removal of the trigger guard and thus the firearm. The lock may comprise a conventional key-operated lock or an electronic lock. The locking device is designed primarily to be incorporated into a holster.
摘要翻译：用于接合枪支的扳机保护组件的安全锁定装置。优选实施例包括具有形成在其中并被配置为容纳枪支的触发器和触发器保护部分的槽的壳体，以及用于防止从该装置移除火器的锁定机构。锁定机构还包括可操作地附接到锁定杆的锁定组件，其可以移入或移出包含球的通道，当通过杆保持在适当位置时，锁定组件使得包含触发器护罩的狭槽足够窄以防止移除的扳机，因此是枪支。锁可以包括常规的钥匙操作的锁或电子锁。锁定装置主要被设计成并入皮套中。

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