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1. 发明授权

US07625910B2 Co-crystal 失效
标题翻译：共晶
公开(公告)号：US07625910B2
公开(公告)日：2009-12-01
申请号：US11748651
申请日：2007-05-15
申请人： George Joseph Sependa , Richard Storey
发明人： George Joseph Sependa , Richard Storey
IPC分类号： A61K31/517
CPC分类号： C07D403/12 , C07F9/65583
摘要： The present invention relates to a novel co-crystal of 2-{ethyl[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)amino]quinazolin-7-yl}oxy)propyl]amino}ethyl dihydrogen phosphate (AZD1152) which is an aurora kinase inhibitor that is useful in the treatment of hyperproliferative diseases such as cancer.
摘要翻译：本发明涉及2- {乙基[3 - （{4 - [（5- {2 - [（3-氟苯基）氨基] -2-氧代乙基} -1H-吡唑-3-基）氨基]喹唑啉-7-基}氧基）丙基]氨基}乙基磷酸二氢酯（AZD1152），其是可用于治疗过度增殖性疾病如癌症的极光激酶抑制剂。

2. 发明申请

US20110152297A1 QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS 有权
标题翻译：喹唑啉衍生物作为酪氨酸激酶抑制剂
公开(公告)号：US20110152297A1
公开(公告)日：2011-06-23
申请号：US11884923
申请日：2006-02-24
申请人： Christopher Thomas Halsall , Laurent Francois Andre Hennequin , Alleyn Thomas Plowright , Richard Storey , Kieran Lennon
发明人： Christopher Thomas Halsall , Laurent Francois Andre Hennequin , Alleyn Thomas Plowright , Richard Storey , Kieran Lennon
IPC分类号： A61K31/517 , C07D401/12 , A61P35/00
CPC分类号： C07D401/12
摘要： The invention concerns quinazoline derivatives of the Formula I, or pharmaceutically acceptable salts thereof: wherein each of R1, R2, R3, R4 and m are as defined in the description; processes for their preparation; pharmaceutical compositions containing them and their use in the manufacture of a medicament for providing an anti-proliferative effect. The quinazoline derivatives of Formula I are expected to be useful in the treatment of diseases such as certain cancers mediated by erbB receptor tyrosine kinases, and, for example, EGFR tyrosine kinase.
摘要翻译：本发明涉及式I的喹唑啉衍生物或其药学上可接受的盐：其中R1，R2，R3，R4和m各自如说明书中所定义; 其准备过程; 含有它们的药物组合物及其在制备用于提供抗增殖作用的药物中的用途。预期式I的喹唑啉衍生物可用于治疗疾病，例如由erbB受体酪氨酸激酶介导的某些癌症，以及例如EGFR酪氨酸激酶。

3. 发明申请

US20080045481A1 NOVEL CO-CRYSTAL 失效
公开(公告)号：US20080045481A1
公开(公告)日：2008-02-21
申请号：US11748651
申请日：2007-05-15
申请人： George Sependa , Richard Storey
发明人： George Sependa , Richard Storey
IPC分类号： A61K31/66 , A61P35/00 , C07F9/02
CPC分类号： C07D403/12 , C07F9/65583
摘要： The present invention relates to a novel co-crystal of 2-{ethyl[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)amino]quinazolin-7-yl}oxy)propyl]amino}ethyl dihydrogen phosphate (AZD1152) which is an aurora kinase inhibitor that is useful in the treatment of hyperproliferative diseases such as cancer.
摘要翻译：本发明涉及2- {乙基[3 - （{4 - [（5- {2 - [（3-氟苯基）氨基] -2-氧代乙基} -1H-吡唑-3-基）氨基]喹唑啉-7-基}氧基）丙基]氨基}乙基磷酸二氢酯（AZD1152），其是可用于治疗过度增殖性疾病如癌症的极光激酶抑制剂。

4. 发明授权

US4364087A Movement detector for television signals 失效
标题翻译：运动检测器用于电视信号
公开(公告)号：US4364087A
公开(公告)日：1982-12-14
申请号：US174426
申请日：1980-08-01
申请人： Richard Storey , Alan Roberts
发明人： Richard Storey , Alan Roberts
IPC分类号： H04N5/14 , H04N7/18
CPC分类号： H04N5/144 , H04N5/147
摘要： A movement detector for television signals measures the difference between maximum and minimum values of the movement components of a picture difference signal over a chosen interval. A television signal at an input (12) is delayed in a picture delay (2), and the delayed and undelayed signals subtracted in a subtractor (1) to form a picture difference signal. This is rectified in rectifier (3) and smoothed in a filter (4). A maximum detector (6) and a minimum detector (7) are coupled to the filter output and are re-set at prescribed intervals. A subtractor (8) determines the difference between the output of detectors (6) and (7) and this is compared with a reference value in a comparator (9), the output of which is sampled and stored in a store (10).
摘要翻译：用于电视信号的移动检测器测量在所选择的间隔上的图像差分信号的运动分量的最大值和最小值之间的差异。在输入端（12）处的电视信号在图像延迟（2）中延迟，并且延迟和未延迟的信号在减法器（1）中减去以形成图像差分信号。这在整流器（3）中整流并在滤波器（4）中平滑化。最大检测器（6）和最小检测器（7）耦合到滤波器输出，并以规定的间隔重新设定。减法器（8）确定检测器（6）和（7）的输出之间的差异，并且将其与比较器（9）中的参考值进行比较，比较器（9）的输出被采样并存储在存储器（10）中。

5. 发明授权

US4942466A Bandwidth compression for television signals 失效
标题翻译：电视信号的带宽压缩
公开(公告)号：US4942466A
公开(公告)日：1990-07-17
申请号：US90584
申请日：1987-10-05
申请人： Charles P. Sandbank , Ian Childs , Richard Storey
发明人： Charles P. Sandbank , Ian Childs , Richard Storey
IPC分类号： G06T7/20 , H04N5/14 , H04N7/015 , H04N7/12 , H04N7/26 , H04N7/36 , H04N7/46 , H04N9/64 , H04N11/00 , H04N11/02 , H04N11/16 , H04N11/24
CPC分类号： H04N11/167 , G06T7/206 , H04N11/006 , H04N11/02 , H04N19/43 , H04N19/51 , H04N19/523 , H04N19/527 , H04N19/547 , H04N19/59 , H04N19/80 , H04N5/145 , H04N7/0155 , H04N7/0157 , H04N7/125 , H04N9/646
摘要： A video signal received from a source (10) is bandwidth-compressed by filters (12, 14, 16), filter (14) being a temporal filter and filter (16) being a spatial filter. Selection of the filter to be used is dependent upon picture content. The transmitter reconstitutes in interpolators (44, 46) the signal which would be regenerated at the receiver, determines which filter gives the best results, and transmits an indication of which filter has been used in a digital signal associated with the analogue video signal. Preferably a determination of motion vectors associated with the signal is made and the digital signal indicates which of the determined motion vectors is applicable to different areas of the picture. By transmitting the control signal digitally with the analogue video signal the receiver circuitry is greatly simplified while its reliability is improved.
摘要翻译： PCT No.PCT / GB86 / 00799 Sec。 371日期：1987年10月5日 102（e）日期1987年10月5日PCT申请日1986年12月23日PCT公布。公开号WO87 / 04034 日期1987年7月2日。从源（10）接收的视频信号被滤波器（12,14,16）带宽压缩，作为时间滤波器的滤波器（14）和作为空间滤波器的滤波器（16）。要使用的滤波器的选择取决于图像内容。发射机在内插器（44,46）中重建将在接收机处重新生成的信号，确定哪个滤波器给出最佳结果，并且发送与在模拟视频信号相关联的数字信号中使用哪个滤波器的指示。优选地，确定与信号相关联的运动矢量，并且数字信号指示哪个确定的运动矢量适用于图像的不同区域。通过用模拟视频信号数字地发送控制信号，大大简化了接收机电路，同时提高了其可靠性。

6. 发明授权

US4884138A Video transmission systems 失效
标题翻译：视频传输系统
公开(公告)号：US4884138A
公开(公告)日：1989-11-28
申请号：US174792
申请日：1988-04-04
申请人： Richard Storey
发明人： Richard Storey
IPC分类号： H04N11/00 , H04N7/00 , H04N7/015 , H04N11/24
CPC分类号： H04N11/006
摘要： An HDTV video signal with 1249 lines per picture is transmitted over a transmission channel designed for 625 lines per picture by transmitting alternate samples of two lines of the 1249 line signal on a single line of the 625 line signal. An HDTV receiver can interpolate to give a 1249 line picture but a 625 line receiver will still receive a signal that is adequately compatible to give a display.
摘要翻译： PCT No.PCT / GB86 / 00797 Sec。 371日期：1988年4月4日 102（e）日期1988年4月4日PCT Filted 1986年12月23日PCT公布。出版物WO88 / 01462 日期：1988年2月25日。每个图像具有1249行的HDTV视频信号通过专为每个图像625行设计的传输通道传输，通过在625行信号的单行上发送1249行信号的两行的替代采样。 HDTV接收机可以插值以提供1249线路图像，但是625线路接收机仍将接收到足够兼容的信号以给出显示。

7. 发明授权

US4288810A Method of and apparatus for deriving a PAL color television signal corresponding to any desired field in an 8-field PAL sequence from one stored field or picture of a PAL signal 失效
标题翻译：用于从PAL信号的一个存储的场或图像中导出与8场PAL序列中的任何所需场对应的PAL彩色电视信号的方法和装置
公开(公告)号：US4288810A
公开(公告)日：1981-09-08
申请号：US43540
申请日：1979-05-29
申请人： John O. Drewery , Richard Storey
发明人： John O. Drewery , Richard Storey
IPC分类号： G06T7/20 , H04N5/14 , H04N5/262 , H04N9/64 , H04N9/877 , H04N9/39 , H04N9/535
CPC分类号： H04N9/877 , G06T7/2053 , H04N5/144 , H04N5/2625 , H04N9/64
摘要： A single field of a PAL color television signal is stored in a store (50) and provides a signal at an input (52). The signal is delayed by one-line delays (56,58) in series to provide one and two-line delayed signals. Separate switching units (60,62) select desired ones or combinations of the input and delayed signals to constitute respectively the low-frequency and chrominance part of the signal at the output (82). The switch positions are changed between fields, and for at least some fields of the PAL sequence each component of the output signal is formed by combining signals from more than one line, i.e. a halving adder (64;66) averages successive lines for the low frequency part of the signal and a halving subtractor (68) forms the difference between lines two lines apart for the chrominance part. The selector unit outputs are combined in an adder (78) which receives the output of the first selector (60), and also the difference between the output of the two selectors after band pass filtering (76). The store (50) can be replaced by a random access store capable of outputting three successive lines simultaneously. The apparatus has special utility in equipment for movement portrayal.
摘要翻译： PAL彩色电视信号的单个场被存储在存储器（50）中，并在输入端（52）提供信号。信号被串行延迟一行延迟（56,58），以提供一行和两行延迟信号。分离的开关单元（60,62）选择所需的输入和延迟信号的组合，分别构成输出端（82）处的信号的低频和色度部分。开关位置在场之间改变，并且对于PAL序列的至少一些场，输出信号的每个分量通过组合来自多于一个线的信号形成，即，一半加法器（64; 66）将连续的线平均为低信号的频率部分和减法减法器（68）形成色度部分两行分开的行之间的差异。选择器单元输出在接收第一选择器（60）的输出的加法器（78）中以及带通滤波后的两个选择器的输出之间的差（76）组合。存储器（50）可以由能够同时输出三个连续行的随机存取存储器代替。该装置在运动描绘设备中具有特殊效用。

8. 发明申请

US20060183890A1 Isopropanolate of azithromycin and method of manufacturing 审中-公开
标题翻译：阿奇霉素的异丙醇酸酯及其制造方法
公开(公告)号：US20060183890A1
公开(公告)日：2006-08-17
申请号：US10550104
申请日：2004-03-19
申请人： Tim Tam , Khashayar Karimian , Shui Hu , Anna Chow , Richard Storey
发明人： Tim Tam , Khashayar Karimian , Shui Hu , Anna Chow , Richard Storey
IPC分类号： A61K31/7052 , C07H17/08
CPC分类号： C07H17/08 , C07H17/00
摘要： Azithromycin isopropanolate of the empirical formula azithromycin:[H20]x:[isopropanol]y is obtained from the crystallization of azithromycin in isopropanol and water. The x and y values is confirmed by single X-ray diffraction determination. In one embodiment x=1.5 and y=0.25. In another embodiment x=0.75 and y=0.5.
摘要翻译：经验式阿奇霉素的阿奇霉素异丙醇化物：阿奇霉素在异丙醇中的结晶和异丙醇中的结晶得到：[异丙基] 水。通过单次X射线衍射测定确认x和y值。在一个实施方案中，x = 1.5和y = 0.25。在另一个实施方案中，x = 0.75和y = 0.5。

9. 发明授权

US5053857A Television signals 失效
标题翻译：电视信号
公开(公告)号：US5053857A
公开(公告)日：1991-10-01
申请号：US387022
申请日：1989-07-28
申请人： Charles P. Sandbank , Richard Storey , Martin Weston
发明人： Charles P. Sandbank , Richard Storey , Martin Weston
IPC分类号： H04N7/12 , H04N11/02 , H04N11/16 , H04N11/20 , H04N11/24
CPC分类号： H04N11/20 , H04N11/006 , H04N11/02 , H04N7/125 , H04N11/167
摘要： In order to achieve increased resolution and to minimise cross-colour and cross-luminance effects in a PAL, NTSC or SECAM encoded signal, a high definition source (20) is pre-filtered at a higher line rate according to one of at least two methods (22, 24, 26). The filtered signal is sub-sampled (at 30, 32) at the source line standard where necessary, depending upon the degree of bandwidth reduction employed and one of the methods of pre-filtering and sub-sampling selected according (at 34) to a control signal (36) dependent on picture content. The luminance and chrominance components of the selected encoded signal are band pass filtered (46, 50, 52) and the chrominance signal modulated onto a sub-carrier (54) such that the frequency spectrum of the luminance and chrominance signals do not overlap.

10. 发明授权

US4249209A Video noise reduction system 失效
标题翻译：视频降噪系统
公开(公告)号：US4249209A
公开(公告)日：1981-02-03
申请号：US023592
申请日：1979-03-26
申请人： Richard Storey
发明人： Richard Storey
IPC分类号： H04N5/21
CPC分类号： H04N5/21
摘要： Reduction of noise in a television signal is achieved by comparing signals from successive scans to produce a difference signal. Low amplitude differences are assumed to represent noise and are attenuated. Differences above a predetermined level are assumed to represent movement and are not so attenuated. The attenuation is achieved by a multiplier which receives as multiplier the output of a non-linear transfer characteristic element. The non-linear element receives the differences after rectification and after passing through a variable-gain element. The non-linear element is such that above a predetermined value a constant predetermined minimum attenuation factor applies. A noise measurement circuit measures the noise present in the difference signal and controls the gain of the variable-gain element accordingly. Several noise-measurement circuits may be provided, a selected one of which is used in dependence upon the magnitude of the input signal to the apparatus.
摘要翻译：通过比较来自连续扫描的信号来产生差分信号来实现电视信号中的噪声的降低。假设低幅度差异表示噪声并被衰减。假设高于预定水平的差异表示运动并且不是如此衰减。通过乘法器实现衰减，该乘法器作为乘法器接收非线性传递特征元素的输出。非线性元件在整流后通过可变增益元件后接收差分。非线性元件使得高于预定值时，应用恒定的预定最小衰减系数。噪声测量电路测量差分信号中存在的噪声并相应地控制可变增益元件的增益。可以提供若干噪声测量电路，其中选择的一个噪声测量电路根据输入到设备的信号的大小来使用。

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