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91. 发明授权

US07226731B1 PB 39, a gene dysregulated in prostate cancer, and uses thereof 失效
标题翻译： PB39，前列腺癌失调的基因及其用途
公开(公告)号：US07226731B1
公开(公告)日：2007-06-05
申请号：US09743825
申请日：1999-07-23
申请人： Rodrigo F. Chuaqui , Kristina A. Cole , Lance A. Liotta , Michael R. Emmert-Buck
发明人： Rodrigo F. Chuaqui , Kristina A. Cole , Lance A. Liotta , Michael R. Emmert-Buck
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： A novel gene, PB39, that is up-regulated, or over-expressed, in prostate cancer has been identified. The gene has been identified by means of its cDNA obtained by reverse transcription of the corresponding mRNA. Microdissection of prostate glands that had been surgically removed from prostate cancer patients revealed a novel up-regulated transcript in an aggressive prostate carcinoma. Differential analysis for the presence of this gene was carried out from the same glands by comparing transcription in microdissected normal prostatic epithelium versus that in microdissected invasive tumor. The transcript was over-expressed in 5 of 10 prostate carcinomas examined. A variant transcript was over-expressed in 4 of 4 prostate carcinomas, and was found in 1 of 4 normal samples. The invention provides a purified and isolated nucleic acid that includes the sequence of PB39 or its complement, the sequence of a variant of PB39 or its complement, and a primer or probe, that includes a sequence that is a fragment of these sequences. Additionally, the polypeptide encoded by these genes, an antibody to the polypeptide, and methods of detection of PB39 or its gene product are provided.
摘要翻译：已经鉴定出在前列腺癌中上调或过度表达的新基因PB39。该基因已通过其相应mRNA的逆转录获得的cDNA鉴定。从前列腺癌患者手术切除的前列腺的显微解剖显示在侵袭性前列腺癌中有一种新的上调的转录物。通过比较显微解剖正常前列腺上皮中的转录与微切割侵袭性肿瘤中的转录，从相同腺体进行差异分析。在检查的10个前列腺癌中的5个中，转录物过表达。在4个前列腺癌中的4个中，变体转录物过表达，并且在4个正常样品中的1个中发现。本发明提供了纯化和分离的核酸，其包括PB39或其互补序列，PB39或其互补序列变体的序列，以及引物或探针，其包括作为这些序列的片段的序列。另外，提供了由这些基因编码的多肽，多肽的抗体，以及检测PB39或其基因产物的方法。

92. 发明授权

US07223836B2 Peptides for chlamydophila pneumoniae vaccine and diagnosis 有权
标题翻译：肺炎衣原体疫苗的多肽和诊断
公开(公告)号：US07223836B2
公开(公告)日：2007-05-29
申请号：US10479503
申请日：2002-05-31
申请人： Eric L. Marston , Jackie S. Sampson , George M. Carlone , Edwin W. Ades
发明人： Eric L. Marston , Jackie S. Sampson , George M. Carlone , Edwin W. Ades
IPC分类号： A61K38/00 , A61K39/118 , C07K1/00 , C12P21/04 , G01N33/53
CPC分类号： C07K14/295 , A61K39/00 , Y10S530/811 , Y10S530/814 , Y10S530/82 , Y10S530/825
摘要： Peptides are disclosed that include SEQ ID NO:1, SEQ ID NO: 2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, and SEQ ID NO:6, or a conservative variant or mimic thereof, wherein the conservative variant or mimic specifically binds an antibody that specifically binds SEQ ID NO:1, SEQ ID NO: 2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID or NO:6. These peptides are of use in generating an immune response against C. pneumoniae, or in preventing infection with against C. pneumoniae.
摘要翻译：公开了包括SEQ ID NO：1，SEQ ID NO：2，SEQ ID NO：3，SEQ ID NO：4，SEQ ID NO：5和SEQ ID NO：6的保守变体或其模拟物，其中所述保守变体或模拟物特异性结合特异性结合SEQ ID NO：1，SEQ ID NO：2，SEQ ID NO：3，SEQ ID NO：4，SEQ ID NO：5，SEQ ID或NO：6的抗体。这些肽可用于产生针对肺炎支原体的免疫应答，或用于预防感染肺炎克雷伯氏杆菌。

93. 发明申请

US20060160230A1 Wipes and methods for removal of metal contamination from surfaces 有权
公开(公告)号：US20060160230A1
公开(公告)日：2006-07-20
申请号：US11039178
申请日：2005-01-18
申请人： Eric Esswein , Mark Boeniger , Kevin Ashley
发明人： Eric Esswein , Mark Boeniger , Kevin Ashley
IPC分类号： G01N33/00
CPC分类号： C11D17/049 , C11D1/58 , C11D1/62 , C11D3/2075 , C11D3/2086
摘要： Wipes, methods and kits useful for testing and/or removal of metal from surfaces (such as, dermal surfaces) are disclosed. Exemplar wipes, including the combination of a three-dimensionally textured absorbent support, a cationic surfactant, and a weak acid, are disclosed. In some examples, the cationic surfactant is isostearamidopropyl morpholine lactate (ISML), and the weak acid is citric acid.

94. 发明授权

US07067635B2 Nucleotide and deduced amino acid sequences of tumor gene Int6 失效
标题翻译：肿瘤基因Int6的核苷酸和推导的氨基酸序列
公开(公告)号：US07067635B2
公开(公告)日：2006-06-27
申请号：US10783415
申请日：2004-02-19
申请人： Antonio Marchetti , Fiamma Buttitta , Gilbert H. Smith , Robert Callahan
发明人： Antonio Marchetti , Fiamma Buttitta , Gilbert H. Smith , Robert Callahan
IPC分类号： C07K16/00
CPC分类号： C07K14/82 , A61K38/00
摘要： The present invention discloses the isolation of the human and murine wild-type Int6 gene and the cDNAs sorresponding to these genes. The invention further describes the use of reagents derived from the nucleic acid and amino acid sequences of the Int6 gene in diagnostic methods, immunotherapy, gene therapy and as vaccines.
摘要翻译：本发明公开了人和鼠野生型Int6基因的分离以及与这些基因相对应的cDNA。本发明进一步描述了在诊断方法，免疫治疗，基因治疗和疫苗中源自Int6基因的核酸和氨基酸序列的试剂的用途。

95. 发明授权

US07052703B1 T-cell receptorγ alternate reading frame protein, (TARP) and uses thereof 有权
标题翻译： T细胞接受体交替阅读框蛋白（TARP）及其用途
公开(公告)号：US07052703B1
公开(公告)日：2006-05-30
申请号：US10031158
申请日：2000-07-12
申请人： Ira Pastan , Magnus Essand , Byungkook Lee , George Vasmatzis , Curt Wolfgang , Ulrich Brinkmann
发明人： Ira Pastan , Magnus Essand , Byungkook Lee , George Vasmatzis , Curt Wolfgang , Ulrich Brinkmann
IPC分类号： A61K39/00
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00
摘要： This invention provides nucleic acids containing sequences from a TCRγ transcript from prostate epithelial cells and many breast cancer cells and a T-cell receptor gamma Alternate Reading frame Protein (“TARP”) expressed from the translation of those sequences. Vaccines made from TARP are useful in raising immune responses to cells in which the protein is expressed, including prostate cancer cells and cells of many breast cancers. The invention also provides methods for diagnosing the presence of prostate cancer and TARP-expressing breast cancers, as well as methods of administering TARP and nucleic acids encoding TARP to subjects.
摘要翻译：本发明提供了含有来自前列腺上皮细胞的TCRγ转录物和许多乳腺癌细胞的序列的核酸，以及从这些序列翻译表达的T细胞受体γ替代阅读框架蛋白（“TARP”）。由TARP制成的疫苗可用于提高蛋白质表达细胞的免疫应答，包括前列腺癌细胞和许多乳腺癌细胞。本发明还提供了用于诊断前列腺癌和TARP表达乳腺癌的存在的方法，以及将TARP和编码TARP的核酸给予受试者的方法。

96. 发明授权

US07001720B1 Cloning of a gene mutation for parkinson's disease 失效
标题翻译：克隆帕金森病基因突变
公开(公告)号：US07001720B1
公开(公告)日：2006-02-21
申请号：US09446628
申请日：1998-06-25
申请人： Mihael H. Polymeropoulous , Christian Lavedan , Elisabeth Leroy , Robert L. Nussbaum , William G. Johnson , Roger C. Duvoisin
发明人： Mihael H. Polymeropoulous , Christian Lavedan , Elisabeth Leroy , Robert L. Nussbaum , William G. Johnson , Roger C. Duvoisin
IPC分类号： C12Q1/68 , C07H21/04 , C12N5/00 , C12N15/00
CPC分类号： C12Q1/6883 , C07K14/47 , C12Q2600/156 , C12Q2600/172
摘要： Parkinson's disease (PD) is a common neurodegenrative disorder with a lifetime incidence of approximately 2 percent. It was recently reported that a PD susceptibility gene is located on the long arm of human chromosome four. The present invention reports the subsequent identification of a mutation in the alpha synuclein gene, which codes for a presynaptic protein thought to be involved in neuronal plasticity. The finding of a specific molecular alteration which is causative for PD will permit the detailed understanding of the pathophysiology of the disorder, which will lead to potential therapetuic interventions, as well as a means for diagnosing individuals having an increased risk of developing the disease.
摘要翻译：帕金森病（PD）是一种常见的神经退行性疾病，其终生发病率约为2％。最近报道，PD易感基因位于人类四染色体的长臂上。本发明报道了随后鉴定的α突触核蛋白基因中的突变，其编码认为涉及神经元可塑性的突触前蛋白质。发现PD具有致病性的特异性分子改变将能够详细了解病症的病理生理学，这将导致潜在的治疗干预措施，以及诊断患有发展疾病风险增加的个体的手段。

97. 发明授权

US06963769B1 Method for enhancing contrast produced by MRI 失效
标题翻译：增强MRI产生的对比度的方法
公开(公告)号：US06963769B1
公开(公告)日：2005-11-08
申请号：US09959138
申请日：2000-04-20
申请人： Robert S. Balaban , Kathleen M. Ward , Anthony H. Aletras
发明人： Robert S. Balaban , Kathleen M. Ward , Anthony H. Aletras
IPC分类号： A61B5/055 , A61K49/00 , A61K49/06 , A61K49/10
CPC分类号： A61B5/055 , A61B5/416 , A61K49/06 , A61K49/10 , G01R33/5601
摘要： A method for obtaining an image by MRI, comprising: administering at least one contrast agent to a subject in amounts effective to perform CEDST MRI analysis; and performing CEDST MRI analysis to produce an image of the subject. A number of different contast agents can be used to practice the present method including, without limitation, sugars, animo acids, nitrogen-containing heterocycles, purines and pyrimidines, nucleosides; imidazole and derivatives thereof, imino acids, barbituric acid and analogs thereof, and miscellaneous materials, such as guanidine hydantoin, parabanic acid, and biologically active salts thereof.
摘要翻译：一种用于通过MRI获得图像的方法，包括：以有效执行CEDST MRI分析的量向对象施用至少一种造影剂; 并进行CEDST MRI分析以产生受试者的图像。许多不同的耐受剂可用于实施本发明的方法，包括但不限于糖，阿莫西酸，含氮杂环，嘌呤和嘧啶，核苷; 咪唑及其衍生物，亚氨基酸，巴比妥酸及其类似物，以及其它各种材料，例如胍乙内酰脲，对乙酰苯胺和其生物活性盐。

98. 发明授权

US06903184B1 Multiple antigenic peptides immunogenic against Streptococcus pneumonia 有权
标题翻译：针对肺炎链球菌免疫原性的多种抗原肽
公开(公告)号：US06903184B1
公开(公告)日：2005-06-07
申请号：US09613092
申请日：2000-07-10
申请人： Edwin W. Ades , Scott E. Johnson , Danny L. Jue , Jacquelyn S. Sampson , George M. Carlone
发明人： Edwin W. Ades , Scott E. Johnson , Danny L. Jue , Jacquelyn S. Sampson , George M. Carlone
IPC分类号： A61K38/00 , A61K39/00 , C07K7/08 , C07K14/315 , C07K2/00 , A61K39/02 , A61K39/09 , C07K1/00 , C07K5/00
CPC分类号： C07K7/08 , A61K38/00 , A61K39/00 , C07K14/3156 , Y10S530/806 , Y10S530/825
摘要： The invention provides a nucleic acid encoding the 37-kDa pneumococcal surface adhesion A protein (PsaA) from Streptococcus pneumoniae. The invention also provides purified polypeptides encoded by the nucleic acid encoding the 37-kDa protein from and the nucleic acids comprising unique fragment of at least 10 nucleotides of the 37-kDa protein. Additionally, multiple antigenic peptides that provide protection against S. pneumoniae challenge are provided. These multiple antigen peptides comprise the peptides that immunospecifically bind to the monoclonal antibodies. Also provided are vaccines comprising such immunogenic peptides, and methods of conferring protective immunity against Streptococcus pneumoniae infection by administering therapeutic composition comprising the immunogenic peptides of the invention. Also provided are methods of detecting the presence of Streptococcus pneumoniae in a sample using antibodies or antigens and methods of preventing and treating Streptococcus pneumoniae infection in a subject.
摘要翻译：本发明提供编码来自肺炎链球菌的37-kDa肺炎球菌表面粘附A蛋白（PsaA）的核酸。本发明还提供由编码37-kDa蛋白质的核酸编码的纯化多肽和包含37-kDa蛋白质至少10个核苷酸的独特片段的核酸。另外，提供了提供针对肺炎链球菌攻击的保护的多种抗原肽。这些多重抗原肽包含免疫特异性结合单克隆抗体的肽。还提供了包含这种免疫原性肽的疫苗，以及通过施用包含本发明的免疫原性肽的治疗组合物来赋予对肺炎链球菌感染的保护性免疫的方法。还提供了使用抗体或抗原检测样品中肺炎链球菌存在的方法以及在受试者中预防和治疗肺炎链球菌感染的方法。

99. 发明授权

US06894068B2 Substituted benzimidazoles as non-nucleoside inhibitors of reverse transcriptase 失效
标题翻译：取代的苯并咪唑作为逆转录酶的非核苷抑制剂
公开(公告)号：US06894068B2
公开(公告)日：2005-05-17
申请号：US10119634
申请日：2002-04-09
申请人： Christopher J. Michejda , Marshall Morningstar , Thomas Roth
发明人： Christopher J. Michejda , Marshall Morningstar , Thomas Roth
IPC分类号： A61K31/4184 , A61K31/4439 , A61P31/18 , A61P37/04 , A61P43/00 , C07D235/06 , C07D235/08 , C07D235/12 , C07D235/18 , C07D235/22 , C07D401/04 , C07D401/06 , A61K31/415 , A61K31/47 , A61K31/495 , A61K31/70 , A61K43/42
CPC分类号： C07D235/06 , C07D235/08 , C07D235/12 , C07D235/18 , C07D401/04 , C07D401/06
摘要： The present invention provides compositions and methods for the treatment of HIV infection. In particular, the present invention provides non-nucleoside inhibitors of reverse transcriptase (RT), as well as methods to treat HIV infection using these non-nucleoside inhibitors of RT. In preferred embodiments, the present invention provides a novel class of substituted benzimidazoles, effective in the inhibition of human immunodeficiency virus (HIV) RT.
摘要翻译：本发明提供了用于治疗HIV感染的组合物和方法。特别地，本发明提供了逆转录酶（RT）的非核苷抑制剂，以及使用这些RT的非核苷抑制剂治疗HIV感染的方法。在优选的实施方案中，本发明提供了有效抑制人类免疫缺陷病毒（HIV）RT的新型取代的苯并咪唑。

100. 发明授权

US06869767B1 Detection of Streptococcus pneumoniae and immunization against Streptococcus pneumoniae infection 失效
标题翻译：检测肺炎链球菌和肺炎链球菌感染免疫
公开(公告)号：US06869767B1
公开(公告)日：2005-03-22
申请号：US10168602
申请日：1999-06-14
申请人： Jacqueline S. Sampson , Katherine E. Morrison , Jennifer Crook Whitmon , Edwin Ades , George M. Carlone
发明人： Jacqueline S. Sampson , Katherine E. Morrison , Jennifer Crook Whitmon , Edwin Ades , George M. Carlone
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , Y10S435/975
摘要： The present invention relates to oligonucleotide primers, and methods of diagnosis using the primers, wherein particular primer pairs prime the universal amplification of an amplicon for specific Streptococcus pneumoniae from all 90 known serotypes. The amplicon includes at least a portion of the psaA gene of Steptococcus pneumoniae. In the methods, amplification of a biological sample using the primer pairs of the invention provide an amplicon only if the sample contains a serotype of Streptococcus pneumoniae. The invention further relates to an isolated nucleic acid including a nucleic acid amplicon obtained using a pair of oligonucleotide primers of the invention. In still a further aspect, the invention discloses a polypeptide including an amino acid sequence encoded by a nucleic acid amplicon obtained using oligonucleotide primers. Additionally, methods of stimulating an immune response against a serotype of Streptococcus pneumoniae in a mammal include either administering a polypeptide encoded by a nucleic acid amplicon obtained using the pair of oligonucleotide primers of the invention, or administering a nucleic acid containing a nucleic acid amplicon obtained using the pair of oligonucleotide primers of the invention.
摘要翻译：本发明涉及寡核苷酸引物，以及使用引物进行诊断的方法，其中特定的引物对引发来自所有90种已知血清型的特异性肺炎链球菌特异性肺炎链球菌的扩增子的通用扩增。扩增子包括肺炎链球菌的psaA基因的至少一部分。在该方法中，使用本发明的引物对的生物样品的扩增仅在样品含有肺炎链球菌血清型时提供扩增子。本发明还涉及包含使用本发明的一对寡核苷酸引物获得的核酸扩增子的分离的核酸。在另一方面，本发明公开了一种多肽，其包含由寡核苷酸引物获得的核酸扩增子编码的氨基酸序列。此外，哺乳动物刺激针对肺炎链球菌血清型的免疫应答的方法包括施用由本发明的一对寡核苷酸引物获得的核酸扩增子编码的多肽，或施用含有获得的核酸扩增子的核酸使用本发明的一对寡核苷酸引物。

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