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91. 发明申请

US20110133734A1 Method for regulating RF signals in an NMR system and probe head for carrying out the method 有权
标题翻译：用于调节NMR系统中的RF信号的方法和用于执行该方法的探针头
公开(公告)号：US20110133734A1
公开(公告)日：2011-06-09
申请号：US12926695
申请日：2010-12-06
申请人： Nicolas Freytag
发明人： Nicolas Freytag
IPC分类号： G01R33/44
CPC分类号： G01R33/3614
摘要： A method for regulating radio frequency (RF) signals in a nuclear magnetic resonance (NMR) system, comprising a spectrometer, a control loop, and an NMR probe head with RF components (BE, LE, BK), wherein the spectrometer comprises a transmitter that transmits RF signals at measuring frequencies with a transmission power (PS), the NMR probe head contains an RF oscillating circuit, and the RF oscillating circuit comprises an RF coil (LE), is characterized in that the control loop controls the duration and/or the phase and/or the power of the transmitted RF signals. Measurement of a parameter is performed by means of the NMR probe head, via which parameter the current in or the voltage across one of the RF components (BE, LE, BK) can be determined, and the transmission powers (PS) and/or the phases and/or the duration of the RF signals are regulated in dependence on the measured parameter. Any occurring losses can thereby be compensated for without reducing the pulse duration.
摘要翻译：一种用于在核磁共振（NMR）系统中调节射频（RF）信号的方法，包括具有RF分量（BE，LE，BK）的光谱仪，控制回路和NMR探头，其中所述光谱仪包括发射器以传输功率（PS）在测量频率上传输RF信号，NMR探头包含RF振荡电路，RF振荡电路包括RF线圈（LE），其特征在于控制回路控制持续时间和/ 或发射的RF信号的相位和/或功率。参数的测量通过NMR探针头进行，通过该探头头可以确定射频组件（BE，LE，BK）中的一个的电流或电压，以及发射功率（PS）和/或根据测量的参数调节RF信号的相位和/或持续时间。因此可以补偿任何发生的损失而不减少脉冲持续时间。

92. 发明申请

US20110001475A1 Methods for nuclear magnetic resonance (NMR) or magnetic resonance imaging (MRI) measurements using long-lived states 有权
标题翻译：使用长寿命状态的核磁共振（NMR）或磁共振成像（MRI）测量方法
公开(公告)号：US20110001475A1
公开(公告)日：2011-01-06
申请号：US12662723
申请日：2010-04-30
申请人： Paul Romeo Vasos , Arnaud Comment , Riddhiman Sarkar , Sami Antoine Jannin , Geoffrey Bodenhausen
发明人： Paul Romeo Vasos , Arnaud Comment , Riddhiman Sarkar , Sami Antoine Jannin , Geoffrey Bodenhausen
IPC分类号： G01R33/44
CPC分类号： G01R33/4608 , G01R33/282 , G01R33/5605 , G01R33/563 , G01R33/56308
摘要： A method for nuclear magnetic resonance (NMR) or magnetic resonance imaging (MRI) measurements, includes creation of enhanced polarization of nuclei of a first kind within a sample in a magnetic field at cryogenic temperatures and transfer of the polarised sample to room temperature. The enhanced polarization of nuclei of the first kind is thereby transformed into long-lived states (LLS) of nuclei of a second kind and these LLS are sustained. The LLS is at least partially converted into observable magnetisation and an NMR or MRI measurement is carried out. The method allows one to extend the time needed between hyperpolarised magnetisation and NMR detection.
摘要翻译：核磁共振（NMR）或磁共振成像（MRI）测量的方法包括在低温下在磁场中在样品内产生第一种核的增强的极化，并将极化样品转移到室温。因此，第一种核的增强的极化被转化为第二种核的长寿命状态（LLS），并且这些LLS是持续的。 LLS至少部分转化为可观察到的磁化，并进行NMR或MRI测量。该方法允许扩展超极化磁化和NMR检测所需的时间。

93. 发明申请

US20100244826A1 Device for monitoring a living object during a magnetic resonance experiment 有权
标题翻译：用于在磁共振实验期间监测活体的装置
公开(公告)号：US20100244826A1
公开(公告)日：2010-09-30
申请号：US12659237
申请日：2010-03-02
申请人： Daniel Schmidig
发明人： Daniel Schmidig
IPC分类号： G01R33/44
CPC分类号： G01R33/288 , A61B2562/222 , G01R33/3685 , G01R33/5673
摘要： A device for monitoring a living object during a magnetic resonance (MRI) experiment in an MRI tomograph, wherein the device comprises one or more individual electrodes which are connected in an electrically conducting fashion to the living object to be examined, and are connected to a monitoring device via signal lines, wherein each signal line comprises individual parts that are electrically connected to each other via impedances. The eigenfrequencies of these parts are higher than the NMR measuring frequency, preferably more than twice as high, and the parts are electrically connected to each other via frequency-dependent impedances Zn. The electro-magnetic coupling from the RF antenna and the gradient coils to the signal lines can thereby also be minimized in a simple fashion.
摘要翻译：一种用于在MRI断层摄影机中的磁共振（MRI）实验期间监测活体的装置，其中所述装置包括以导电方式连接到待检查的生物体上的一个或多个单独的电极，并且连接到监控设备，其中每个信号线包括通过阻抗彼此电连接的各个部件。这些部件的本征频率高于NMR测量频率，优选高于两倍高，并且部件通过频率相关阻抗Zn彼此电连接。因此，从RF天线和梯度线圈到信号线的电磁耦合也可以以简单的方式被最小化。

94. 外观设计

USD624196S1 Holder for sample containers 有权
标题翻译：样品容器支架
公开(公告)号：USD624196S1
公开(公告)日：2010-09-21
申请号：US29357897
申请日：2010-03-18
申请人： Kurt Himmelsbach , Beat Grossniklaus
设计人： Kurt Himmelsbach , Beat Grossniklaus

95. 发明授权

US07626386B2 Singlet-state exchange NMR spectroscopy for the study of very slow dynamic processes 有权
标题翻译：用于研究非常慢的动态过程的单态态交换NMR光谱
公开(公告)号：US07626386B2
公开(公告)日：2009-12-01
申请号：US11808950
申请日：2007-06-14
申请人： Geoffrey Bodenhausen , Paul Vasos , Riddhiman Sarkar
发明人： Geoffrey Bodenhausen , Paul Vasos , Riddhiman Sarkar
IPC分类号： G01V3/00
CPC分类号： G01R33/4608 , G01R33/46 , G01R33/465
摘要： A nuclear magnetic resonance (NMR) method for singlet-state exchange NMR-spectroscopy comprises steps of excitation of single-quantum in-phase coherences, generation of single-quantum anti-phase coherences, excitation of zero-quantum coherences ZQx and/or longitudinal two-spin order 2IzSz (=“ZZ order”) using a π/4 pulse, reversal of the sign of the zero-quantum coherences ZQx under the effect of the difference of the chemical shifts of the examined spins, transformation of the zero-quantum coherences ZQx and/or longitudinal two-spin ZZ order into singlet-state populations by means of RF irradiation during a mixing period τm, reconversion of the singlet-state populations remaining at the end of the mixing period τm into zero-quantum coherences ZQx and/or ZZ order, reversal of the sign of the zero-quantum coherences ZQx under the effect of the difference of the chemical shifts of the examined spins, and reconversion of zero-quantum coherences ZQx and/or ZZ order into single-quantum anti-phase coherences. With the broadband method for the excitation of single state population, NMR can monitor correlations between states that are connected through very slow processes.
摘要翻译：用于单态态NMR核磁共振（NMR）的核磁共振（NMR）方法包括单量子同相相干激发的步骤，产生单量子反相相干，激发零量子相干ZQx和/或纵向使用pi / 4脉冲的双自旋次数2IzSz（=“ZZ顺序”），在检测的自旋的化学位移的差异的影响下反转零量子相干ZQx的符号，量子相干ZQx和/或纵向双自旋ZZ顺序在混合期间通过RF辐射进入单重态群体，将混合期间结束时保留的单态态群重新转化为零量子相干ZQx 和/或ZZ顺序，在检测的自旋的化学位移的差异的作用下逆转零量子相干ZQx的符号，以及将零量子相干ZQx和/或ZZ顺序重新转换为单量子反相相干。通过宽带方法激发单态群体，NMR可以监测通过非常慢的过程连接的状态之间的相关性。

96. 发明授权

US07605589B2 Method for automatic shimming for nuclear magnetic resonance spectroscopy 有权
标题翻译：核磁共振波谱自动匀场方法
公开(公告)号：US07605589B2
公开(公告)日：2009-10-20
申请号：US11975207
申请日：2007-10-18
申请人： Markus Weiger , Michael Fey , Thomas Speck
发明人： Markus Weiger , Michael Fey , Thomas Speck
IPC分类号： G01V3/00
CPC分类号： G01R33/3875 , G01R33/243 , G01R33/4625 , G01R33/56572
摘要： A method for homogenizing a static magnetic field with a magnetic field distribution B0(r) for nuclear magnetic resonance spectroscopy by adjusting the currents Ci through the shim coils, thus creating spatial field distributions Ci·Si(r), where r stands for one, two, or three of the spatial dimensions x, y, and z, and said magnetic field distribution B0(r) has only a field component along z, in a working volume of a magnetic resonance apparatus with one or more radio frequency (=RF) coils (5) for inducing RF pulses and receiving RF signals within a working volume, said RF coils having a spatial sensitivity distribution of magnitudes B1k(r), and with shim coils (6) for homogenizing the magnetic field within the working volume, said shim coils (6) being characterized by their magnetic field distributions per unit current Si(r) and having components only along z, includes the following steps: (a) Mapping the magnetic field distribution B0(r) of the main magnetic field, (b) calculating a simulated spectrum IS(f) based on the sum of the magnetic field distribution B0(r) and the additional field distributions Ci·Si(r) generated by the shim coils (6), and on the sensitivity distributions B1k(r) of the RF coils(5), (c) optimising a quality criterion derived from the simulated spectrum IS(f) by using an optimisation procedure within a search range with the shim currents Ci as a set of parameters, whereby for each new set of parameter values step (b) has to be repeated, (d) realising the found optimum of the quality criterion of step (c) by generating the associated target field distribution B0T(r). In this way a direct one-to-one link is obtained between a set of shim currents and the associated NMR spectrum The quality of the desired NMR spectra can be improved with this method.
摘要翻译：一种用于核磁共振光谱的磁场分布B0（r）使静态磁场均匀化的方法，通过调整通过垫片线圈的电流Ci，从而产生空间场分布Ci.Si（r），其中r表示一个，空间尺寸x，y和z中的两个或三个，并且所述磁场分布B0（r）在具有一个或多个射频（= RF）的磁共振装置的工作体积中仅具有z的场分量）线圈（5），用于感应RF脉冲并在工作体积内接收RF信号，所述RF线圈具有大小B1k（r）的空间灵敏度分布，以及用于使工作体积内的磁场均匀化的垫片线圈（6）所述垫片线圈（6）的特征在于它们每单位电流Si（r）的磁场分布并且仅沿着z具有分量，包括以下步骤：（a）映射主磁场的磁场分布B0（r）（b）计算a 基于磁场分布B0（r）和由垫片线圈（6）产生的附加场分布Ci.Si（r）之和的和（f）的灵敏度分布B1k（r）的模拟频谱IS（f） RF线圈（5），（c）通过使用以电流Ci为一组参数的搜索范围内的优化程序来优化从模拟频谱IS（f）导出的质量标准，由此对于每组新的参数值集必须重复步骤（b），（d）通过产生相关的目标场分布B0T（r）来实现步骤（c）的质量标准的找到最佳。以这种方式，在一组垫片电流和相关的NMR光谱之间获得直接的一对一链接。可以通过该方法改善期望NMR光谱的质量。

97. 发明授权

US07567158B2 Superconducting magnet arrangement with hysteresis free field coil 有权
公开(公告)号：US07567158B2
公开(公告)日：2009-07-28
申请号：US12149639
申请日：2008-05-06
申请人： Francesca Venturini , Robert Schauwecker , Pierre-Alain Bovier
发明人： Francesca Venturini , Robert Schauwecker , Pierre-Alain Bovier
IPC分类号： H01F6/00
CPC分类号： G01R33/3815 , G01R33/3802 , G01R33/445 , G01R33/60 , H01F6/00
摘要： A magnet arrangement (M, M′, M″, M′″) for generating a magnetic field in the direction of a z-axis in a working volume (V) disposed on the z-axis about z=0, with a magnet coil system (A, A′, A″, A′″) which comprises one or more superconducting magnet partial coil systems (A1, A1′, A1″, A1′″, A2′″, . . ., An′″), each forming superconductingly short-circuited current paths in the operating state, and with a further coil system (C, C′, C″, C′″) which can be charged or discharged independently of the magnet coil system (A, A′, A″, A′″) and comprises a first and a second partial coil system (C1, C2, C1′ C2′, C1″, C2″, C1′″, C2′″), wherein the first partial coil system (C1, C1′, C1″, C1′″) and the second partial coil system (C2, C2′, C2″, C2′″) each comprise at least one coil, wherein all coils of the further coil system (C, C′, C″, C′″) are connected in series, wherein gCeff,diamag>0.1 mT/A, is characterized in that gC1eff,diamag>0.1 mT/A, gC2eff,diamag>0.1 mT/A, g C ⁢ ⁢ 1 eff , class g C ⁢ ⁢ 1 eff , diamag ∉ [ 0.95 , 1.05 ] , g C ⁢ ⁢ 2 eff , class g C ⁢ ⁢ 2 eff , diamag ∉ [ 0.95 , 1.05 ] , wherein g C eff , class g C eff , diamag ∈ [ 0.95 , 1.05 ] . A substantially linear field change can thereby be realized in the working volume in dependence on a current change in the further coil system (C, C′, C″, C′″).

98. 发明授权

US07505800B2 Superconductive element containing Nb3Sn 有权
标题翻译：含Nb3Sn的超导元件
公开(公告)号：US07505800B2
公开(公告)日：2009-03-17
申请号：US11279282
申请日：2006-04-11
申请人： René Flükiger , Vital Abächerli , Davide Uglietti , Daniel Eckert
发明人： René Flükiger , Vital Abächerli , Davide Uglietti , Daniel Eckert
IPC分类号： H01B12/06
CPC分类号： H01L39/14 , H01L39/2409 , Y10S505/806 , Y10S505/821 , Y10S505/917 , Y10S505/919 , Y10S505/92 , Y10T29/49014
摘要： A superconductive element containing Nb3Sn, in particular a multifilament wire, comprising at least one superconductive filament (8) which is obtained by a solid state diffusion reaction from a preliminary filament structure (1), said preliminary filament structure (1) containing an elongated hollow pipe (2) having an inner surface (3) and an outer surface (4), wherein said hollow pipe (2) consists of Nb or an Nb alloy, in particular NbTa, wherein the outer surface (4) is in close contact with a surrounding bronze matrix (5) containing Cu and Sn, and wherein the inner surface (3) is in close contact with an inner bronze matrix (5) also containing Cu and Sn, is characterized in that the inner bronze matrix (5) of the preliminary filament structure (1) encloses in its central region an elongated core (6) consisting of a metallic material, said metallic material having at room temperature (=RT) a thermal expansion coefficient αcore 300 MPa, said metallic material having at RT an elongation at rupture A>20%, and wherein the metallic material of the core (6) is chemically inert with respect to the material of the inner bronze matrix (5) up to a reaction temperature T of the solid state diffusion reaction. This element has improved superconductive properties in a large volume fraction of its superconductive filaments, in particular a high critical temperature Tc and a high critical magnetic filed strength Bc2, and is mechanically stable enough for commercial applications such as magnet coils.
摘要翻译：包含Nb 3 Sn的超导元件，特别是复丝线，其包含至少一个通过来自预备丝状结构（1）的固态扩散反应获得的超导细丝（8），所述预丝细丝结构（1）包含细长的中空具有内表面（3）和外表面（4）的管（2），其中所述中空管（2）由Nb或Nb合金特别是NbTa组成，其中外表面（4）与包含Cu和Sn的周围青铜基体（5），并且其中所述内表面（3）与还含有Cu和Sn的内部青铜基体（5）紧密接触，其特征在于，所述内部青铜基体（5）预备细丝结构（1）在其中心区域包围由金属材料组成的细长芯（6），所述金属材料在室温（= RT）下具有热膨胀系数α1<17 * 10-6K-1，优选我说，alphacore <= 8 * 10-6 K-1 所述金属材料在室温下具有屈服强度R p 0.2> 300MPa，所述金属材料在RT处具有断裂伸长率> 20％，并且其中所述芯体（6）的金属材料相对于内部青铜基质（5）直至固态扩散反应的反应温度T. 该元件在其超导细丝的大体积分数，特别是高临界温度Tc和高临界磁场强度Bc2中具有改进的超导性能，并且对于商业应用如磁体线圈具有机械稳定性。

99. 发明授权

US07476281B2 Method for producing a superconductive element 有权
标题翻译：超导元件的制造方法
公开(公告)号：US07476281B2
公开(公告)日：2009-01-13
申请号：US11223053
申请日：2005-09-12
申请人： René Fluekiger , Vital Abaecherli
发明人： René Fluekiger , Vital Abaecherli
IPC分类号： H01L39/24
CPC分类号： H01L39/2409 , Y10T29/49014
摘要： A method for producing a superconductive element, in particular a multifilament wire, starting from a composite (1) comprising a bronze matrix containing Cu and Sn, in which at least one elongated structure containing Nb or an Nb alloy, in particular NbTa, is embedded, whereby in a first step the composite is extruded at a temperature between 300° C. and 750° C., followed by cold or hot working and annealing steps in which the composite is elongated in parallel to the elongated structure and softened by a temperature treatment (=“intermediate annealing”), followed by a stacking step, in which a multitude of elongated composites from the preceding cold or hot working steps are bundled, the steps of extruding, elongating, annealing and stacking being repeated one or more times, followed by a final elongating process, including intermediate annealing processes, in which the composite is elongated to its final length, the superconductive phase being obtained by a heat treatment including a solid state diffusion reaction is characterized in that at least part of the elongating steps and annealing steps are performed by cold working preceded by an intermediate annealing between 520° C. and 750° C., i.e. above the normal Cu—Sn recrystallization temperature, and by a fast cooling within less than 30 s to 100° C. or below (=“Rapid Intermediate Quenching” [RIQ]).
摘要翻译：一种由包含Cu和Sn的青铜基体的复合材料（1）开始制造超导元件，特别是复丝的方法，其中至少包含Nb或Nb合金，特别是NbTa的细长结构被嵌入，其中在第一步骤中，将复合材料在300℃和750℃之间的温度下挤出，随后冷或热加工和退火步骤，其中复合材料与细长结构平行延伸并软化温度处理（=“中间退火”），然后进行堆叠步骤，其中将来自先前冷或热加工步骤的多个细长复合材料捆扎在一起，挤出，拉伸，退火和堆叠的步骤重复一次或多次，然后进行最终拉伸工艺，包括中间退火工艺，其中复合材料延伸到其最终长度，超导相通过热处理获得，包括固态扩散反应的特征在于，至少部分拉伸步骤和退火步骤通过在520℃和750℃之间的中间退火之前的冷加工进行，即高于正常Cu-Sn重结晶温度，并通过在低于30秒至100℃或更低的速度（=“快速中间淬火”[RIQ]）内的快速冷却。

100. 发明授权

US07474099B2 NMR apparatus with commonly cooled probe head and cryogenic container and method for the operation thereof 有权
标题翻译：具有通常冷却的探针头和低温容器的NMR装置及其操作方法
公开(公告)号：US07474099B2
公开(公告)日：2009-01-06
申请号：US11509778
申请日：2006-08-25
申请人： Johannes Boesel , Agnès Glémot , Daniel Eckert , Daniel Guy Baumann
发明人： Johannes Boesel , Agnès Glémot , Daniel Eckert , Daniel Guy Baumann
IPC分类号： G01V3/00
CPC分类号： F25D19/006 , F25B9/10 , F25B9/145 , F25B2309/1418 , F25B2400/17 , G01R33/31 , G01R33/3815
摘要： An NMR apparatus comprising an NMR magnet system disposed in a first cryocontainer (2) of a cryostat (9), and an NMR probe head (1), wherein the first cryocontainer (2) is installed in an evacuated outer jacket and is surrounded by a radiation shield (24) and/or a further cryocontainer (3), wherein a cooling device is provided for cooling the NMR probe head (1) and a cryocontainer (2, 3), which comprises a cold head (4, 4a, 4b, 4c) with several cold stages (12a, 12b, 12c, 18a, 18b, 18c, 19a), wherein one cold stage (12a, 12b, 12c, 18a, 18b, 18c, 19a) is connected to a heat-transferring device, and wherein a cooling circuit is provided between the cooling device and the NMR probe head (1), is characterized in that the cooling device is disposed in a separate, evacuated housing (6) which is positioned directly above the cryostat (9), wherein the heat-transferring device is inserted directly into suspension tubes (29a, 29c) of the cryocontainer (2, 3) and/or is in contact with the radiation shield (24). This effects a simple construction that is efficient for cooling an NMR apparatus.
摘要翻译：一种NMR装置，包括设置在低温恒温器（9）的第一低温容器（2）中的NMR磁体系统和NMR探针头（1），其中第一低温容器（2）安装在抽真空的外护套中并被辐射屏蔽（24）和/或另外的低温容器（3），其中提供冷却装置用于冷却NMR探针头（1）和低温容器（2,3），冷冻装置包括冷头（4,4a， 4b，4c）具有多个冷段（12a，12b，12c，18a，18b，18c，19a），其中一个冷段（12a，12b，12c，18a，18b，18c，19a）连接到传热装置，并且其中在所述冷却装置和所述NMR探针头（1）之间设置有冷却回路，其特征在于，所述冷却装置设置在分开的真空壳体（6）中，所述外壳直接位于所述低温恒温器（9）的正上方，，其中所述传热装置直接插入所述低温容器（2,3）的悬挂管（29a，29c）中和/或与所述辐射接触在屏蔽（24）上。这实现了用于冷却NMR装置的有效的简单结构。

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