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91. 发明授权

US07612563B2 Flow-through microfluidic nuclear magnetic resonance(=NMR)-chip 有权
标题翻译：流通微流核磁共振（= NMR）芯片
公开(公告)号：US07612563B2
公开(公告)日：2009-11-03
申请号：US11905637
申请日：2007-10-03
申请人： Charles Massin , Michael Fey
发明人： Charles Massin , Michael Fey
IPC分类号： G01V3/00
CPC分类号： G01R33/302 , G01R33/307
摘要： A flow-through microfluidic NMR-chip comprising a substrate (5) which is planar in an yz-plane with a sample chamber (2) within the substrate (5), the sample chamber (2) being elongated and having walls which run parallel to the z-direction, the substrate (5) having a thickness in x-direction of a Cartesian xyz-coordinate system between 100 μm and 2 mm, and at least one planar receiving and/or transmission coil (1, 1′) with conductor sections (11) the coil (1, 1′) being arranged at least on one planar surface of the substrate (5), wherein the extension of the sample chamber (2) along the z-direction exceeds the extension of the coil (1) along the z-direction is characterized in that the extension of the coil (1, 1′) along the z-direction is larger than its extension along the y-direction. The inventive NMR-chip facilitated NMR-spectroscopic measurements with improved resolution, sensitivity as well as B1 homogeneity.
摘要翻译：一种流通微流体NMR芯片，包括在衬底（5）内具有样品室（2）的yz平面平面的衬底（5），样品室（2）是细长的并具有平行的壁在z方向上，基板（5）具有在100m和2mm之间的笛卡尔xyz坐标系的x方向上的厚度，以及至少一个平面接收和/或传输线圈（1,1'），具有导体部分（11），所述线圈（1,1'）布置在所述基板（5）的至少一个平坦表面上，其中所述样品室（2）沿着z方向的延伸超过所述线圈 1）沿着z方向的特征在于，线圈（1,1'）沿着z方向的延伸大于沿着y方向的延伸。本发明的NMR芯片促进了NMR光谱测量，具有改进的分辨率，灵敏度以及B1同质性。

92. 发明授权

US07606019B2 Magnet coil system with active drift compensation for two independent current paths 有权
标题翻译：具有两个独立电流路径的有源漂移补偿的磁体线圈系统
公开(公告)号：US07606019B2
公开(公告)日：2009-10-20
申请号：US12068038
申请日：2008-02-01
申请人： Rolf Spreiter , Patrik Vonlanthen
发明人： Rolf Spreiter , Patrik Vonlanthen
IPC分类号： H01F6/00
CPC分类号： H01F6/005 , G01R33/3815 , H01F6/008 , Y10S505/851
摘要： A magnet coil system (2) which is at least partially superconducting at a cryogenic temperature, comprising at least two partial coils (3, 4, 5) which are connected in series and are each bridged by a superconducting switch (6, 7, 8), such that the partial coils form independent electric loops (11, 12, 13) when the superconducting switches (6, 7, 8) are closed, is characterized in that two electric loops (11, 12) have a common section and a flux pump (10) is provided which is circuited in the common section (14) of the electric loops (11, 12) of two partial coils (3, 4), wherein the sum of the currents of the two partial coils (3, 4) flows through the flux pump (10) in the operating state. In this fashion, the drifts of two independent electric loops can be compensated for with a few devices.
摘要翻译：一种在低温下至少部分地超导的电磁线圈系统（2），包括至少两个串联连接并且由超导开关（6,7,8）桥接的部分线圈（3,4,5）），使得当超导开关（6,7,8）闭合时，部分线圈形成独立的电回路（11,12,13），其特征在于两个电气回路（11,12）具有公共部分和提供了在两个部分线圈（3,4）的电气回路（11,12）的公共部分（14）中进行耦合的通量泵（10），其中两个部分线圈（3， 4）在操作状态下流过助焊剂泵（10）。以这种方式，两个独立电路的漂移可以用几个装置来补偿。

93. 发明授权

US07564244B2 RF resonator system and method for tuning an RF resonator system 有权
标题翻译： RF谐振器系统和用于调谐RF谐振器系统的方法
公开(公告)号：US07564244B2
公开(公告)日：2009-07-21
申请号：US11979755
申请日：2007-11-08
申请人： Nicolas Freytag
发明人： Nicolas Freytag
IPC分类号： G01V3/00
CPC分类号： G01R33/3628 , G01R33/34007 , G01R33/34023 , G01R33/34061 , G01R33/34092 , G01R33/341
摘要： A radio-frequency (RF) resonator system, in particular, for a magnetic resonance (MR) probe, comprising at least one RF resonator with a substrate, on which a conductive structure is applied, wherein the conductive structure comprises regions of capacitive and inductive elements, is characterized in that the conductive structure is coated at least in the regions of the capacitive elements with at least one dielectric layer that covers the regions of the capacitive elements at least partially, wherein the local thickness of at least one of the dielectric layers is set in dependence on the resonance frequency of the uncoated RF resonator, on a defined resonance frequency of the resonator once it is coated, on the dielectric constant of the substrate and on the dielectric constant of the materials of the dielectric layers. The inventive resonator system can be set to the required resonance frequency quickly, at low cost, reversibly, and with high precision and at the same time the dielectric strength of the resonator system is increased.
摘要翻译：特别是用于磁共振（MR）探针的射频（RF）谐振器系统，其包括具有衬底的至少一个RF谐振器，其上施加导电结构，其中导电结构包括电容和电感的区域元件的特征在于，导电结构至少在电容元件的区域中涂覆有至少一个电介质层，至少部分地覆盖电容元件的区域，其中至少一个电介质层的局部厚度依赖于未涂覆的RF谐振器的谐振频率，一旦涂覆了谐振器的谐振频率，就定义在基底的介电常数和电介质层材料的介电常数上。本发明的谐振器系统可以以低成本，可逆地并且以高精度快速地设置为所需的谐振频率，并且同时增加了谐振器系统的介电强度。

94. 发明授权

US07501822B2 Cooled NMR probe head with flexible cooled connecting conduit 有权
标题翻译：冷却的NMR探头具有柔性冷却连接导管
公开(公告)号：US07501822B2
公开(公告)日：2009-03-10
申请号：US11730765
申请日：2007-04-04
申请人： Marco Sacher , Daniel Marek , Tobias Leutenegger , Daniel Guy Baumann , Ralf Haueisen
发明人： Marco Sacher , Daniel Marek , Tobias Leutenegger , Daniel Guy Baumann , Ralf Haueisen
IPC分类号： G01V3/00
CPC分类号： G01R33/34046 , G01R33/30 , G01R33/34015 , G01R33/34092 , G01R33/3415
摘要： A magnetic resonance (MR) probe head comprises a detecting device with at least one antenna system which is cryogenically cooled by a cooling device, and a cooled preamplifier in a preamplifier housing which is spatially separated from the detecting device, and a thermally insulating connecting means via which the detecting device and the preamplifier housing are connected, wherein the connecting means comprises at least one cooling line for supplying and/or returning a cooling fluid, and with at least one RF line for transmitting the electric signals. The connecting means is implemented as a mechanically flexible connecting line with mechanically flexible RF lines and cooling lines disposed therein. The MR probe head is easy to handle and can be highly sensitive, wherein the detecting device can be quickly installed, removed and put into operation.
摘要翻译：磁共振（MR）探针头包括具有至少一个由冷却装置低温冷却的天线系统的检测装置，以及在与检测装置空间上分离的前置放大器壳体中的冷却前置放大器，以及隔热连接装置检测装置和前置放大器壳体通过其连接，其中连接装置包括用于供应和/或返回冷却流体的至少一条冷却管线，以及用于传输电信号的至少一条RF线。连接装置实现为机械柔性的连接线，其中机械地柔性RF线路和冷却线路设置在其中。 MR探头易于处理，可灵敏度高，可快速安装，拆卸和投入使用。

95. 发明授权

US07408353B2 Cooled NMR probe head which can be coupled 有权
标题翻译：冷却的NMR探头可以耦合
公开(公告)号：US07408353B2
公开(公告)日：2008-08-05
申请号：US11727670
申请日：2007-03-28
申请人： Daniel Marek , Marco Sacher , Tobias Leutenegger
发明人： Daniel Marek , Marco Sacher , Tobias Leutenegger
IPC分类号： G01V3/00
CPC分类号： G01R33/34046 , G01R33/30 , G01R33/302 , G01R33/34092 , G01R33/3415
摘要： A magnetic resonance (MR) probe head comprises a detecting device (3) with at least one antenna system which is cryogenically cooled by a cooling device, a cooled preamplifier (16) in a preamplifier housing (15a, 15b) which is spatially separated from the detecting device (3), and a thermally insulating connecting means via which the detecting device (3) and the preamplifier housing (15a, 15b) are connected, wherein the connecting means (15c) comprises at least one cooling line (9a, 9b, 53a, 53b) for supplying and/or returning a cooling fluid, and at least one RF line (10, 52) for transmitting electric signals. The connecting means (15c), including its RF and cooling lines (10, 52, 9a, 9b, 53a, 53b), can be separated from the preamplifier housing (15a, 15b) by a coupling. The MR probe head is an open system which can be used in a universal fashion through use of different measuring inserts. The system can be expanded for further measuring configurations at little cost and can be easily handled in a time-saving fashion with an optional arrangement having a flexible connecting line.
摘要翻译：磁共振（MR）探头包括具有至少一个由冷却装置低温冷却的天线系统的检测装置（3），在空间上的前置放大器壳体（15a，15b）中的冷却前置放大器（16）与所述检测装置（3）分离，以及隔热连接装置，所述检测装置（3）和所述前置放大器壳体（15a，15b）经由所述隔热连接装置连接，其中所述连接装置（15c）包括至少一个冷却用于供应和/或返回冷却流体的线路（9a，9b，53a，53b）以及用于传输电信号的至少一个RF线路（10,52）。包括其RF和冷却管线（10,52,99a，9b，53a，53b）的连接装置（15c）可以通过联接与前置放大器壳体（15a，15b）分离。 MR探头是一种开放系统，可以通过使用不同的测量插件以通用方式使用。该系统可以以较少的成本进行扩展，用于进一步的测量配置，并且可以以具有柔性连接线的可选布置以节省时间方式容易地处理。

96. 发明授权

US07397246B2 Electrically symmetric NMR coils with a plurality of windings connected in series 有权
标题翻译：具有串联连接的多个绕组的电对称NMR线圈
公开(公告)号：US07397246B2
公开(公告)日：2008-07-08
申请号：US11540577
申请日：2006-10-02
申请人： Nicolas Freytag , Daniel Marek , Alia Hassan , Stephan Graf , Peter Scheuzger
发明人： Nicolas Freytag , Daniel Marek , Alia Hassan , Stephan Graf , Peter Scheuzger
IPC分类号： G01V3/00
CPC分类号： G01R33/34069 , G01R33/34092 , G01R33/3635
摘要： A nuclear magnetic resonance probe head comprising at least two orthogonal coil/resonator configurations A1 and A2 having different resonance frequencies, wherein at feast one of the coil/resonator configurations A1 has two saddle-shaped coils S1 and S2, wherein each coil has a window about which N windings are disposed which are connected in series, wherein N≧2. Each coil S1 and S2 is formed mirror-symmetrically relative to a central plane of the respective coil, which is perpendicular to the window of the respective coil, wherein the central planes of the coils S1 and S2 are identical to minimize the electromagnetic coupling between the two coil/resonator configurations A1 and A2 at the resonance frequency of A2. The NMR probe head reduces coupling between the two coil/resonator configurations.
摘要翻译：包括具有不同谐振频率的至少两个正交线圈/谐振器配置A 1和A 2的核磁共振探头，其中在线圈/谐振器配置A 1中的一个具有两个鞍形线圈S 1和S 2，其中每个线圈具有围绕N个绕组串列连接的窗口，其中N≥2。每个线圈S 1和S 2相对于垂直于相应线圈的窗口的相应线圈的中心平面镜对称地形成，其中线圈S1和S2的中心平面相同，以使谐振频率为A 2的两个线圈/谐振器配置A 1和A 2之间的电磁耦合。 NMR探头降低了两个线圈/谐振器配置之间的耦合。

97. 发明申请

US20070257675A1 Cooled NMR probe head which can be coupled 有权
标题翻译：冷却的NMR探头可以耦合
公开(公告)号：US20070257675A1
公开(公告)日：2007-11-08
申请号：US11727670
申请日：2007-03-28
申请人： Daniel Marek , Marco Sacher , Tobias Leutenegger
发明人： Daniel Marek , Marco Sacher , Tobias Leutenegger
IPC分类号： G01V3/00
CPC分类号： G01R33/34046 , G01R33/30 , G01R33/302 , G01R33/34092 , G01R33/3415
摘要： A magnetic resonance (MR) probe head comprises a detecting device (3) with at least one antenna system which is cryogenically cooled by a cooling device, a cooled preamplifier (16) in a preamplifier housing (15a, 15b) which is spatially separated from the detecting device (3), and a thermally insulating connecting means via which the detecting device (3) and the preamplifier housing (15a, 15b) are connected, wherein the connecting means (15c) comprises at least one cooling line (9a, 9b, 53a, 53b) for supplying and/or returning a cooling fluid, and at least one RF line (10, 52) for transmitting electric signals. The connecting means (15c), including its RF and cooling lines (10, 52, 9a, 9b, 53a, 53b), can be separated from the preamplifier housing (15a, 15b) by a coupling. The MR probe head is an open system which can be used in a universal fashion through use of different measuring inserts. The system can be expanded for further measuring configurations at little cost and can be easily handled in a time-saving fashion with an optional arrangement having a flexible connecting line.
摘要翻译：磁共振（MR）探头包括具有至少一个由冷却装置低温冷却的天线系统的检测装置（3），在空间上的前置放大器壳体（15a，15b）中的冷却前置放大器（16）与所述检测装置（3）分离，以及隔热连接装置，所述检测装置（3）和所述前置放大器壳体（15a，15b）经由所述隔热连接装置连接，其中所述连接装置（15c）包括至少一个冷却用于供应和/或返回冷却流体的线路（9a，9b，53a，53b）以及用于传输电信号的至少一个RF线路（10,52）。包括其RF和冷却管线（10,52,99a，9b，53a，53b）的连接装置（15c）可以通过联接与前置放大器壳体（15a，15b）分离。 MR探头是一种开放系统，可以通过使用不同的测量插件以通用方式使用。该系统可以以较少的成本进行扩展，用于进一步的测量配置，并且可以以具有柔性连接线的可选布置以节省时间方式容易地处理。

98. 发明申请

US20070159170A1 Electrically symmetric NMR coils with a plurality of windings connected in series 有权
标题翻译：具有串联连接的多个绕组的电对称NMR线圈
公开(公告)号：US20070159170A1
公开(公告)日：2007-07-12
申请号：US11540577
申请日：2006-10-02
申请人： Nicolas Freytag , Daniel Marek , Alia Hassan , Stephen Graf , Peter Scheuzger
发明人： Nicolas Freytag , Daniel Marek , Alia Hassan , Stephen Graf , Peter Scheuzger
IPC分类号： G01V3/00
CPC分类号： G01R33/34069 , G01R33/34092 , G01R33/3635
摘要： A nuclear magnetic resonance probe head comprising at least two coil/resonator configurations A1 and A2, wherein at least one of the coil/resonator configurations A1 has two saddle-shaped coils S1 and S2 (1, 2; 21; 41, 42; 53), wherein each coil (1, 2; 21; 41, 42; 53) has a window (9) about which N windings (3, 4; 26, 28, 30) are disposed which are connected in series, wherein N≧2, wherein the coil/resonator configurations A1 and A2 are aligned perpendicularly to each other, and wherein the coil/resonator configurations A1 and A2 have different resonance frequencies is characterized in that each coil S1 and S2 (1, 2; 21; 41, 42; 53) is formed mirror-symmetrically relative to a central plane (5) of the respective coil (1, 2; 21; 41, 42; 53), which is perpendicular to the window (9) of the respective coil, and wherein the central planes (5) of the coils S1 and S2 are identical to minimize the electromagnetic coupling between the two coil/resonator configurations A1 and A2 at the resonance frequency of A2. The inventive NMR probe head reduces coupling between the two coil/resonator configurations.
摘要翻译：包括至少两个线圈/谐振器构造A 1和A 2的核磁共振探头，其中线圈/谐振器构造A 1中的至少一个具有两个鞍形线圈S 1和S 2（1,2; 21; 41，42; 53），其中每个线圈（1,2; 21; 41,42; 53）具有窗口（9），N个绕组（3,4; 26,28,30）其中N> = 2，其中线圈/谐振器结构A 1和A 2彼此垂直对准，并且其中线圈/谐振器结构A 1和A 2具有不同的谐振频率，其特征在于每个线圈S 1 并且S 2（1,2; 21; 41，42; 53）相对于相应线圈（1,2; 21; 41,42; 53）的中心平面（5）被镜像对称地形成，所述中心平面垂直到相应线圈的窗口（9），并且其中线圈S 1和S 2的中心平面（5）是相同的，以使两个线圈/谐振器构造之间的电磁耦合最小化在A 2的共振频率下的口径A 1和A 2。本发明的NMR探头降低了两个线圈/谐振器配置之间的耦合。

99. 发明申请

US20070107445A1 NMR apparatus with commonly cooled probe head and cryogenic container and method for the operation thereof 有权
标题翻译：具有通常冷却的探针头和低温容器的NMR装置及其操作方法
公开(公告)号：US20070107445A1
公开(公告)日：2007-05-17
申请号：US11509778
申请日：2006-08-25
申请人： Johannes Boesel , Agnes Glemot , Daniel Eckert , Daniel Baumann
发明人： Johannes Boesel , Agnes Glemot , Daniel Eckert , Daniel Baumann
IPC分类号： F25B9/00 , F25B19/00 , F25D23/12
CPC分类号： F25D19/006 , F25B9/10 , F25B9/145 , F25B2309/1418 , F25B2400/17 , G01R33/31 , G01R33/3815
摘要： An NMR apparatus comprising an NMR magnet system disposed in a first cryocontainer (2) of a cryostat (9), and an NMR probe head (1), wherein the first cryocontainer (2) is installed in an evacuated outer jacket and is surrounded by a radiation shield (24) and/or a further cryocontainer (3), wherein a cooling device is provided for cooling the NMR probe head (1) and a cryocontainer (2, 3), which comprises a cold head (4, 4a, 4b, 4c) with several cold stages (12a, 12b, 12c, 18a, 18b, 18c, 19a), wherein one cold stage (12a, 12b, 12c, 18a, 18b, 18c, 19a) is connected to a heat-transferring device, and wherein a cooling circuit is provided between the cooling device and the NMR probe head (1), is characterized in that the cooling device is disposed in a separate, evacuated housing (6) which is positioned directly above the cryostat (9), wherein the heat-transferring device is inserted directly into suspension tubes (29a, 29c) of the cryocontainer (2, 3) and/or is in contact with the radiation shield (24). This effects a simple construction that is efficient for cooling an NMR apparatus.
摘要翻译：一种NMR装置，包括设置在低温恒温器（9）的第一低温容器（2）中的NMR磁体系统和NMR探针头（1），其中第一低温容器（2）安装在抽真空的外护套中并被辐射屏蔽（24）和/或另一个低温容器（3），其中提供冷却装置用于冷却NMR探针头（1）和低温容器（2,3），其包括冷头（4,4a ，4b，4c）具有几个冷阶段（12a，12b，12c，18a，18b，18c，19a），其中一个冷阶段（12a，12b，12c，18a ，18b，18c，19a）连接到传热装置，并且其中在所述冷却装置和所述NMR探头（1）之间设置有冷却回路，其特征在于，所述冷却装置设置在位于低温恒温器（9）正上方的独立的抽真空壳体（6），其中传热装置直接插入低温容器（9）的悬挂管（29a，29c）（2,3）和/或与辐射屏蔽（24）接触。这实现了用于冷却NMR装置的有效的简单结构。

100. 发明申请

US20070089432A1 Cryostat configuration with cryocooler 审中-公开
标题翻译：冷冻机配置与低温冷却器
公开(公告)号：US20070089432A1
公开(公告)日：2007-04-26
申请号：US11443268
申请日：2006-05-31
申请人： Johannes Boesel , Urs Meier , Andreas Kraus , Beat Mraz
发明人： Johannes Boesel , Urs Meier , Andreas Kraus , Beat Mraz
IPC分类号： F25B9/00 , F17C5/02 , F25B19/00
CPC分类号： G01R33/3815 , F17C2203/0312 , F17C2203/0629 , F17C2223/0161 , F17C2223/033 , F17C2227/0353 , F17C2227/0372 , F17C2227/0381 , F17C2265/032 , F17C2270/0527 , F25B9/10 , F25B9/145 , F25B2309/1428 , F25B2400/17 , F25D19/006
摘要： A cryostat configuration for keeping cryogenic fluids in at least one cryocontainer, comprising an outer shell and a neck tube containing a cold head of a cryocooler, wherein the coldest cold stage of the cold head is disposed in a contact-free manner relative to the neck tube and the cryocontainer, and wherein a cryogenic fluid is located in the neck tube, is characterized in that the neck tube is disposed between the outer shell and a cryocontainer and/or the radiation shield, the neck tube is closed in a gas-tight manner at the end facing the cryocontainer and/or the radiation shield, the neck tube is coupled to the cryocontainer and/or a radiation shield disposed between the cryocontainers or a cryocontainer and the outer shell, via a connection having a good thermal conductivity, the neck tube comprising a fill-in device at an end located at ambient temperature. This permits efficient heat transfer between the cryocooler and the cryocontainer with little vibration, while simultaneously ensuring great safety during maintenance work without discharging the magnet.
摘要翻译：一种用于将低温液体保持在至少一个低温容器中的低温恒温器构造，其包括外壳和含有低温冷却器冷头的颈管，其中冷头的最冷冷阶段相对于颈部以无接触的方式设置管和低温容器，并且其中低温流体位于颈管中，其特征在于颈管设置在外壳和低温容器和/或辐射屏蔽之间，颈管以气密的方式封闭在靠近低温容器和/或辐射屏蔽的一端的方式，颈管通过具有良好导热性的连接件连接到低温容器和/或设置在低温容器或低温容器和外壳之间的辐射屏蔽，颈管包括位于环境温度下的末端的填充装置。这允许在低温冷却器和低温容器之间几乎没有振动的有效的热传递，同时确保维护工作期间的极大安全性而不排出磁体。

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