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1. 发明申请

US20180209905A1 SUPER-RESOLUTION MICROSCOPE 审中-公开
公开(公告)号：US20180209905A1
公开(公告)日：2018-07-26
申请号：US15834230
申请日：2017-12-07
申请人： OLYMPUS CORPORATION , UNIVERSITY OF TSUKUBA
发明人： Yoshinori IKETAKI , Hideaki KANOU
IPC分类号： G01N21/63 , G02B21/00 , G02B6/42 , G02B27/58 , G01N21/65
CPC分类号： G01N21/636 , G01N21/65 , G01N2021/637 , G01N2021/653 , G01N2021/655 , G02B6/0006 , G02B6/06 , G02B6/4298 , G02B21/0032 , G02B21/0048 , G02B21/0076 , G02B21/14 , G02B27/58
摘要： A super-resolution microscope includes an illuminator that irradiates illumination beams of colors of different wavelengths through an objective lens onto a sample while causing the illumination beams to overlap at least spatially and a detector that detects a signal beam generated by the sample through irradiation with the illumination beams. As the illumination beams, the illuminator irradiates first and second illumination beams onto the sample from the same direction. The first illumination beam includes multiple wavelengths or monochromatic light for inducing a nonlinear optical effect in the sample. The second illumination beam has a different wavefront distribution on a converging surface of the objective lens or a different spatial distribution of an electrical field vector than the first illumination beam and suppresses induction of the nonlinear optical effect. The detector detects a signal beam generated by the sample as a result of the nonlinear optical effect.

2. 发明授权

US11913881B2 Bond-selective intensity diffraction tomography and uses thereof 有权
$Bond-selective intensity diffraction tomography and uses thereof$
公开(公告)号：US11913881B2
公开(公告)日：2024-02-27
申请号：US18100347
申请日：2023-01-23
申请人： Trustees of Boston University
发明人： Ji-Xin Cheng , JIan Zhao , Lei Tian , Alex Matlock
IPC分类号： G01N21/63 , G01N21/65
CPC分类号： G01N21/636 , G01N2021/637 , G01N2021/655
摘要： An example microscope includes a pump laser for providing a first illumination to a sample. A laser array provides a second illumination to the sample. The laser array may include a plurality of laser elements, each providing oblique illuminations to the sample. An illumination collecting source collects the first illumination and the second illumination from the sample. The illumination collecting source may capture transient 3D refractive index (RI) variations in the sample due to the first illumination and second illumination.

3. 发明申请

US20060092402A1 Laser crystal evaluating system 审中-公开
标题翻译：激光晶体评估系统
公开(公告)号：US20060092402A1
公开(公告)日：2006-05-04
申请号：US11205340
申请日：2005-08-17
申请人： Yoshiaki Goto , Masayuki Momiuchi , Taizo Eno
发明人： Yoshiaki Goto , Masayuki Momiuchi , Taizo Eno
IPC分类号： G01N21/00
CPC分类号： G01N21/958 , G01N2021/637
摘要： A laser crystal evaluating system, comprising a light emitting source for emitting an excitation light, a laser crystal support base for supporting a laser crystal, a photodetection unit for receiving a laser beam emitted from the laser crystal, a moving device for relatively moving the light emitting source and the laser crystal in parallel to an end surface of the laser crystal, and an arithmetic operation control device for acquiring an amount of relative movement from the moving device and a result of photodetection from the photodetection unit, wherein a position in the end surface of the laser crystal where the excitation light enters is moved by the moving device, and the arithmetic operation control device obtains output distribution within the end surface of the laser crystal based on the incident position of the excitation light and on the result of photodetection.
摘要翻译：一种激光晶体评估系统，包括用于发射激发光的发光源，用于支撑激光晶体的激光晶体支撑基座，用于接收从激光晶体发射的激光束的光电检测单元，用于相对移动光的移动装置发光源和激光晶体平行于激光晶体的端面;以及算术运算控制装置，用于获取来自移动装置的相对移动量和来自光电检测单元的光检测结果，其中，位置在末端激发光进入的激光晶体的表面由移动装置移动，并且算术运算控制装置基于激发光的入射位置和光电检测结果获得激光晶体的端面内的输出分布。

4. 发明授权

US08125627B2 Laser spectroscopy system 有权
标题翻译：激光光谱系统
公开(公告)号：US08125627B2
公开(公告)日：2012-02-28
申请号：US12597761
申请日：2008-04-28
申请人： Ed Dottery , Rob Waterbury , Chris Stefano , Roy Walters , Jeremy Rose , Frank Vilardi
发明人： Ed Dottery , Rob Waterbury , Chris Stefano , Roy Walters , Jeremy Rose , Frank Vilardi
IPC分类号： G01N21/00
CPC分类号： G01N21/65 , G01J3/443 , G01N21/718 , G01N2021/1793 , G01N2021/637 , G01N2021/655
摘要： A spectroscopy system including first and second lasers. The first laser is triggered to induce a plasma, such as on a surface of a target at a stand-off distance from the target. The second laser stimulates amplified emissions from the plasma detected by one or more spectroscopes. The gain induced by the second laser detects traces of explosives and other substances on surfaces at stand-off distances. The spectroscopy systems use the same telescopic optics to collect emissions from the detection surface and activated at or just before the peak emission intensity useful for detecting element signatures and intensity ratios from the trace elements in the plasma.
摘要翻译：包括第一和第二激光的光谱系统。触发第一激光以诱导等离子体，例如在与目标的隔离距离处的靶的表面上。第二激光器刺激由一个或多个分光镜检测到的等离子体的放大发射。由第二台激光器引起的增益在距离距离处检测表面上的爆炸物和其他物质的痕迹。光谱系统使用相同的伸缩光学器件来收集来自检测表面的发射，并且在用于检测来自等离子体中的微量元素的元件特征和强度比的峰值发射强度之前或之前激活。

5. 发明授权

US5469255A Method and apparatus for spectrometric measurement of particulate surfaces 失效
标题翻译：颗粒表面光谱测量方法和装置
公开(公告)号：US5469255A
公开(公告)日：1995-11-21
申请号：US186991
申请日：1994-01-27
申请人： Kenji Kamada , Keiji Sasaki , Noboru Kitamura , Hiroshi Masuhara
发明人： Kenji Kamada , Keiji Sasaki , Noboru Kitamura , Hiroshi Masuhara
IPC分类号： G01N15/00 , G01N21/63 , G01J3/42 , G01J3/443
CPC分类号： G01N21/636 , G01N15/00 , G01N2021/637
摘要： A method of spectrometry is disclosed for measuring transient absorbance and transient absorption spectrum of a substance to be measured at interfaces in liquid phase of particulates containing a fluorescent pigment and the substance to be measured by the utilization of optical resonance phenomenon. An apparatus for carrying out the method is also disclosed and comprises: (a) a pulse laser oscillator for exciting the fluorescent pigment and the substance to be measured, respectively; (b) an optical delay device for causing delay of any one of pulse laser beams of two kinds of wavelengths generated by the pulse laser oscillator; (c) a microscope system for condensing laser beams generated by the pulse laser oscillator and irradiating the condensed beams to the sample; and (d) a detector for detecting light emission of the sample. According to the method of the present invention, it is possible to measure transient absorbance and transient absorption spectrum at a high sensitivity even when particulates containing the substance to be measured in liquid phase are present.
摘要翻译：公开了一种用于测量在含有荧光颜料的微粒的液相界面处的物质的瞬时吸光度和瞬时吸收光谱的方法，以及通过利用光学共振现象来测量的物质。还公开了一种用于实施该方法的装置，包括：（a）分别激发荧光颜料和待测物质的脉冲激光振荡器; （b）用于使由脉冲激光振荡器产生的两种波长的脉冲激光束中的任一种延迟的光延迟装置; （c）用于聚集由脉冲激光振荡器产生的激光束并将聚光束照射到样品的显微镜系统; 和（d）用于检测样品的光发射的检测器。根据本发明的方法，即使存在含有在液相中待测物质的微粒，也能以高灵敏度测定瞬时吸光度和瞬时吸收光谱。

6. 发明申请

US20180120227A1 METHODS AND SYSTEMS FOR INCORPORATING BIO-SENSORS IN DRONES TO WIRELESSLY DETECT BIOLOGICAL MOLECULES AND HAZARDS 审中-公开
公开(公告)号：US20180120227A1
公开(公告)日：2018-05-03
申请号：US15801296
申请日：2017-11-01
申请人： The United States of America as represented by the Secretary of the Navy
发明人： Kin Chiu Ng , Subrata Sanyal
IPC分类号： G01N21/63 , B64C39/02 , G08G5/00 , G01D21/02 , G01N21/64
CPC分类号： G01N21/636 , B64C39/024 , B64C2201/027 , B64C2201/126 , G01D21/02 , G01N21/645 , G01N21/6454 , G01N2021/637 , G01N2021/6415 , G01N2021/6421 , G01N2021/6491 , G01N2201/0214 , G08G5/0013 , G08G5/0056 , G08G5/0069 , G08G5/0073 , G08G5/0086
摘要： Exemplary methods and systems for incorporating bio-sensors in drones to wirelessly detect biological molecules and hazards without exposing an operator to harmful contaminants or conditions. Bio-sensors can incorporate simultaneous dual-detection methods to ensure accuracy of measurements. Methods of operation include registering blank and safe air profiles for comparison against unknown air profiles to accurately determine the presence of bio-contaminants in unknown air.

7. 发明授权

US09645045B2 SHG imaging technique for assessing hybrid EO polymer/silicon photonic integrated circuits 有权
公开(公告)号：US09645045B2
公开(公告)日：2017-05-09
申请号：US14437776
申请日：2013-10-22
申请人： The Arizona Board of Regents on Behalf of the University of Arizona
发明人： Robert A. Norwood , Khanh Q. Kieu , Roland Himmelhuber
IPC分类号： G01N21/00 , G01M11/00 , G01N21/63 , G02B21/00 , G01N21/23 , G01N21/21 , G01N21/65
CPC分类号： G01M11/37 , G01N21/23 , G01N21/636 , G01N2021/218 , G01N2021/637 , G01N2021/653 , G02B21/0016 , G02B21/002
摘要： Probe beams are scanned with respect to waveguide substrates to generate optical harmonics. Detection of the optical harmonic radiation is used to image waveguide cores, claddings, or other structures such as electrodes. The detected optical radiation can also be used to provide estimates of linear electrooptic coefficients, or ratios of linear electrooptic coefficients. In some cases, the poling of polymer waveguide structures is monitored during fabrication based on a second harmonic of the probe beam. In some examples, third harmonic generation is used for imaging of conductive layers.

8. 发明申请

US20100085567A1 LASER SPECTROSCOPY SYSTEM 有权
标题翻译：激光光谱系统
公开(公告)号：US20100085567A1
公开(公告)日：2010-04-08
申请号：US12597761
申请日：2008-04-28
申请人： Ed Dottery , Rob Waterbury , Chris Stefano , Roy Walters , Jeremy Rose , Frank Vilardi
发明人： Ed Dottery , Rob Waterbury , Chris Stefano , Roy Walters , Jeremy Rose , Frank Vilardi
IPC分类号： G01J3/30 , G01J3/44
CPC分类号： G01N21/65 , G01J3/443 , G01N21/718 , G01N2021/1793 , G01N2021/637 , G01N2021/655
摘要： A spectroscopy system including first and second lasers. The first laser is triggered to induce a plasma, such as on a surface of a target at a stand-off distance from the target. The second laser stimulates amplified emissions from the plasma detected by one or more spectroscopes. The gain induced by the second laser detects traces of explosives and other substances on surfaces at stand-off distances. The spectroscopy systems use the same telescopic optics to collect emissions from the detection surface and activated at or just before the peak emission intensity useful for detecting element signatures and intensity ratios from the trace elements in the plasma.
摘要翻译：包括第一和第二激光的光谱系统。触发第一激光以诱导等离子体，例如在与目标的隔离距离处的靶的表面上。第二激光器刺激由一个或多个分光镜检测到的等离子体的放大发射。由第二台激光器引起的增益在距离距离处检测表面上的爆炸物和其他物质的痕迹。光谱系统使用相同的伸缩光学器件来收集来自检测表面的发射，并且在用于检测来自等离子体中的微量元素的元件特征和强度比的峰值发射强度之前或之前激活。

9. 发明公开

US20240272074A1 BOND-SELECTIVE INTENSITY DIFFRACTION TOMOGRAPHY AND USES THEREOF 审中-公开
公开(公告)号：US20240272074A1
公开(公告)日：2024-08-15
申请号：US18582748
申请日：2024-02-21
申请人： Trustees of Boston University
发明人： Ji-Xin Cheng , Jian Zhao , Lei Tian , Alex Matlock
IPC分类号： G01N21/63 , G01N21/65
CPC分类号： G01N21/636 , G01N2021/637 , G01N2021/655
摘要： An example microscope includes a pump laser for providing a first illumination to a sample. A laser array provides a second illumination to the sample. The laser array may include a plurality of laser elements, each providing oblique illuminations to the sample. An illumination collecting source collects the first illumination and the second illumination from the sample. The illumination collecting source may capture transient 3D refractive index (RI) variations in the sample due to the first illumination and second illumination.

10. 发明公开

US20240175815A1 APPARATUS FOR QUANTITATIVELY DETECTING ISOTOPOLOGUE OF CARBON DIOXIDE USING DUAL-PHOTON ABSORPTION AND SPECTROMETER 审中-公开
公开(公告)号：US20240175815A1
公开(公告)日：2024-05-30
申请号：US18511664
申请日：2023-11-16
申请人： University of Science and Technology of China , Hefei National Laboratory
发明人： Shuiming Hu , Cunfeng Cheng
IPC分类号： G01N21/63 , G01J3/427 , G01N21/03 , G01N21/31 , G01N21/39
CPC分类号： G01N21/636 , G01J3/427 , G01N21/0332 , G01N21/3151 , G01N21/39 , G01N2021/391 , G01N2021/637
摘要： An apparatus for quantitatively detecting isotopologue of carbon dioxide using dual-photon absorption, comprising a laser source, a laser frequency stabilizer, a sample chamber, a signal detector, and a signal analyzer. The sample chamber comprises an optical resonator and a piezoelectric ceramic. The laser source is configured to output a laser beam. The laser frequency stabilizer is configured to lock the laser beam to a mode frequency of the optical resonator. The piezoelectric ceramic is configured to adjust a length of the optical resonator to alter the mode frequency of the optical resonator to match energy levels of a target molecular isotopologue. The signal detector is configured to detect a transmission intensity of the light beam passing the optical resonator to obtain a dual-photon absorption signal. The signal analyzer is configured to analyze and process the dual-photon absorption signal to obtain a concentration of the target molecular isotopologue.

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