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1. 发明授权

US10596260B2 Reoviruses having modified sequences 有权
公开(公告)号：US10596260B2
公开(公告)日：2020-03-24
申请号：US16027206
申请日：2018-07-03
申请人： Oncolytics Biotech Inc.
发明人： Matthew C. Coffey
IPC分类号： A61K35/766 , C12N7/00 , A61K45/06 , C07K14/005 , A61K35/765 , A61K35/13
摘要： The invention provides for modified reovirus nucleic acid sequences and modified reovirus polypeptide sequences as well as reoviruses containing such modified nucleic acid or polypeptide sequences. The invention also provides for pharmaceutical compositions that include reoviruses having a modified sequence as well as methods of making and using such reoviruses.

2. 发明申请

US20140178969A1 VIRAL PURIFICATION METHODS 审中-公开
标题翻译：病毒纯化方法
公开(公告)号：US20140178969A1
公开(公告)日：2014-06-26
申请号：US14175214
申请日：2014-02-07
申请人： Oncolytics Biotech Inc.
发明人： Matthew C. Coffey
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , A61K39/12 , A61K39/15 , C07K14/005 , C12N2720/12051 , C12N2720/12222 , C12N2720/12234 , C12N2720/12251
摘要： The present invention is directed to an improved method of purifying virus, particularly reovirus. Infectious virus can be extracted from a cell culture with a detergent to produce high titers of virus, and the virus can then be purified by simple steps such as filtration and column chromatography. Viruses and compositions comprising the viruses prepared according to the present invention are also provided.
摘要翻译：本发明涉及一种纯化病毒，特别是呼肠弧病毒的改进方法。可以用洗涤剂从细胞培养物中提取传染病毒以产生高滴度的病毒，然后可以通过简单的步骤如过滤和柱层析纯化病毒。还提供了包含根据本发明制备的病毒的病毒和组合物。

3. 发明授权

US08685734B2 Viral purification methods 有权
标题翻译：病毒纯化方法
公开(公告)号：US08685734B2
公开(公告)日：2014-04-01
申请号：US11736479
申请日：2007-04-17
申请人： Matthew C. Coffey
发明人： Matthew C. Coffey
IPC分类号： C12N5/00 , C12N7/00 , C12N7/02 , C12N1/02 , C12Q1/70 , C12N5/02
CPC分类号： C12N7/00 , A61K39/12 , A61K39/15 , C07K14/005 , C12N2720/12051 , C12N2720/12222 , C12N2720/12234 , C12N2720/12251
摘要： The present invention is directed to an improved method of purifying virus, particularly reovirus. Infectious virus can be extracted from a cell culture with a detergent to produce high titers of virus, and the virus can then be purified by simple steps such as filtration and column chromatography. Viruses and compositions comprising the viruses prepared according to the present invention are also provided.
摘要翻译：本发明涉及一种纯化病毒，特别是呼肠弧病毒的改进方法。可以用洗涤剂从细胞培养物中提取传染病毒以产生高滴度的病毒，然后可以通过简单的步骤如过滤和柱层析纯化病毒。还提供了包含根据本发明制备的病毒的病毒和组合物。

4. 发明申请

US20130273012A1 VIRUS CLEARANCE OF NEOPLASTIC CELLS FROM MIXED CELLULAR COMPOSITIONS 有权
标题翻译：来自混合细胞组成的神经细胞的病毒清除
公开(公告)号：US20130273012A1
公开(公告)日：2013-10-17
申请号：US13903236
申请日：2013-05-28
申请人： Donald Morris , Bradley G. Thompson , Matthew C. Coffey
发明人： Donald Morris , Bradley G. Thompson , Matthew C. Coffey
IPC分类号： C12N5/078
CPC分类号： C12N5/0634 , A61K35/28 , A61K35/761 , A61K35/768 , C12N2720/12032
摘要： The present invention relates to a method for removing neoplastic cells from a mixed cellular composition, which is outside of a living organism, by using a virus which selectively infect and kill neoplastic cell. A variety of viruses can be used in this method to remove neoplastic cells for different purposes, for example, to purge hematopoietic stem cells prior to transplantation. Also provided are compositions prepared according to this method, and kits comprising a combination of viruses which are useful in this invention.
摘要翻译：本发明涉及通过使用选择性感染和杀死肿瘤细胞的病毒，从活体外部的混合细胞组合物中去除肿瘤细胞的方法。在该方法中可以使用各种病毒以除去不同目的的肿瘤细胞，例如在移植前清除造血干细胞。还提供了根据该方法制备的组合物，以及包含可用于本发明的病毒组合的试剂盒。

5. 发明授权

US08491886B2 Viruses for the treatment of cellular proliferative disorders 有权
标题翻译：用于治疗细胞增殖性疾病的病毒
公开(公告)号：US08491886B2
公开(公告)日：2013-07-23
申请号：US13297384
申请日：2011-11-16
申请人： Matthew C. Coffey , Bradley G. Thompson
发明人： Matthew C. Coffey , Bradley G. Thompson
IPC分类号： A61K39/00 , A61K38/00
CPC分类号： A61K35/76 , A61K35/13 , C12N2710/10032
摘要： Methods for treating cell proliferative disorders by administering virus to proliferating cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras-pathway. Proliferative disorders include but are not limited to neoplasms. The virus is selected from modified adenovirus, modified HSV, modified vaccinia virus and modified parapoxvirus orf virus. Also disclosed are methods for treating cell proliferative disorders by further administering an immunosuppressive agent.
摘要翻译：公开了通过向具有活化的Ras通路的增殖细胞施用病毒来治疗细胞增殖障碍的方法。施用病毒使得其最终直接接触具有活化的Ras途径的增殖细胞。增生性疾病包括但不限于赘生物。病毒选自修饰的腺病毒，修饰的HSV，修饰的痘苗病毒和修饰的副痘病毒或病毒。还公开了通过进一步施用免疫抑制剂来治疗细胞增殖性疾病的方法。

6. 发明授权

US08066985B2 Reovirus for the treatment of cellular proliferative disorders 有权
标题翻译：用于治疗细胞增殖性疾病的呼肠孤病毒
公开(公告)号：US08066985B2
公开(公告)日：2011-11-29
申请号：US12323223
申请日：2008-11-25
申请人： Patrick W. K. Lee , James Strong , Matthew C. Coffey
发明人： Patrick W. K. Lee , James Strong , Matthew C. Coffey
IPC分类号： A61K49/00 , A61K39/15
CPC分类号： A61K9/0019 , A61K35/765 , C12N2720/12032 , C12N2720/12232
摘要： Methods for treating proliferative disorders, by administering reovirus to a Ras-mediated proliferative disorder, are disclosed. The reovirus is administered so that it ultimately directly contacts ras-mediated proliferating cells. Proliferative disorders include but are not limited to neoplasms. Human reovirus, non-human mammalian reovirus, and/or avian reovirus can be used. If the reovirus is human reovirus, serotype 1 (e.g., strain Lang), serotype 2 (e.g., strain Jones), serotype 3 (e.g., strain Dearing or strain Abney), as well as other serotypes or strains of reovirus can be used. Combinations of more than one type and/or strain of reovirus can be used, as can reovirus from different species of animal. Either solid neoplasms or hematopoietic neoplasms can be treated.
摘要翻译：公开了通过向Ras介导的增殖性病症施用呼肠孤病毒来治疗增殖性疾病的方法。施用呼肠孤病毒使其最终直接接触ras介导的增殖细胞。增生性疾病包括但不限于赘生物。可以使用人呼肠病毒，非人哺乳动物呼肠病毒和/或禽呼肠孤病毒。如果呼肠孤病毒是人呼肠病毒，则可以使用血清型1（例如，菌株Lang），血清型2（例如菌株琼斯），血清型3（例如，菌株Dearing或菌株Abney）以及呼肠孤病毒的其它血清型或菌株。可以使用多于一种类型和/或菌株的呼肠病病毒的组合，以及来自不同动物种类的呼肠弧病毒。可以治疗实体肿瘤或造血赘生物。

7. 发明授权

US07964186B2 Viruses for the treatment of cellular proliferative disorders 有权
公开(公告)号：US07964186B2
公开(公告)日：2011-06-21
申请号：US11807920
申请日：2007-05-30
申请人： Matthew C. Coffey , Bradley G. Thompson
发明人： Matthew C. Coffey , Bradley G. Thompson
IPC分类号： A61K31/15 , C12N15/63
CPC分类号： A61K35/761 , A61K38/13 , A61K45/06 , C12N2710/10032 , C12N2710/24132 , A61K2300/00
摘要： Methods for treating cell proliferative disorders by administering virus to proliferating cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras-pathway. Proliferative disorders include but are not limited to neoplasms. The virus is selected from modified adenovirus, modified HSV, modified vaccinia virus and modified parapoxvirus orf virus. Also disclosed are methods for treating cell proliferative disorders by further administering an immunosuppressive agent.

8. 发明申请

US20100248205A1 Reovirus Clearance of Ras-Mediated Neoplastic Cells from Mixed Cellular Compositions 有权
标题翻译：来自混合细胞组合物的Ras介导的肿瘤细胞的呼肠孤病毒清除
公开(公告)号：US20100248205A1
公开(公告)日：2010-09-30
申请号：US12726002
申请日：2010-03-17
申请人： Donald Morris , Bradley G. Thompson , Matthew C. Coffey
发明人： Donald Morris , Bradley G. Thompson , Matthew C. Coffey
IPC分类号： A01N1/02 , C12N5/02
CPC分类号： C12N5/0093 , A61K35/28 , A61K35/765 , A61K48/00 , A61L2/00 , C12N5/0693 , C12N7/00 , C12N15/86 , C12N2720/12032 , C12N2720/12211 , C12N2720/12232 , C12N2720/12243 , Y10T436/25
摘要： Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient.
摘要翻译：呼肠病毒可用于从细胞组合物中选择性地除去ras介导的肿瘤细胞。特别值得注意的是，将携带呼吸病毒的肿瘤细胞移植到接受者之前清除携带肿瘤细胞的亲本，从而降低将肿瘤细胞引入或重新引入接受者的风险。

9. 发明申请

US20100105122A1 Oncolytic Viruses as Phenotyping Agents for Neoplasms 有权
标题翻译：溶瘤病毒作为肿瘤表型剂
公开(公告)号：US20100105122A1
公开(公告)日：2010-04-29
申请号：US12652289
申请日：2010-01-05
申请人： Bradley G. Thompson , Matthew C. Coffey
发明人： Bradley G. Thompson , Matthew C. Coffey
IPC分类号： C12N7/00
CPC分类号： G01N33/574 , G01N33/5748 , G01N2333/14 , Y10S435/975
摘要： The present invention provides a method of diagnosing neoplasms having a particular phenotype by using oncolytic viruses that selectively replicate in neoplasms having the particular phenotype. For example, reovirus does not replicate in normal cells. However, reovirus selectively replicate in cells with an activated ras pathway, which leads to death of these cells. Therefore, a cell which becomes neoplastic due to, at least in part, elevated ras pathway activities can be diagnosed by its susceptibility to reovirus replication. This invention can further be applied, using other oncolytic viruses, to the diagnosis and/or treatment of other tumors, such as interferon-sensitive tumors, p53-deficient tumors and Rb-deficient tumors. Kits useful in the diagnosis or treatment disclosed herein are also provided.
摘要翻译：本发明提供了通过使用在具有特定表型的肿瘤中选择性复制的溶瘤病毒来诊断具有特定表型的赘生物的方法。例如，呼肠孤病毒不会在正常细胞中复制。然而，呼肠孤病毒在具有活化的ras途径的细胞中选择性复制，这导致这些细胞的死亡。因此，由于至少部分地升高的ras途径活性而变得肿瘤的细胞可以通过其对呼肠孤病毒复制的易感性来诊断。本发明还可以使用其他溶瘤病毒来应用于其它肿瘤如干扰素敏感性肿瘤，p53缺陷型肿瘤和Rb缺陷型肿瘤的诊断和/或治疗。还提供了在本文公开的诊断或治疗中有用的试剂盒。

10. 发明授权

US07608257B2 Sensitization of chemotherapeutic agent resistant neoplastic cells with a virus 有权
公开(公告)号：US07608257B2
公开(公告)日：2009-10-27
申请号：US11809293
申请日：2007-05-31
申请人： Matthew C. Coffey , Bradley G. Thompson
发明人： Matthew C. Coffey , Bradley G. Thompson
IPC分类号： A61K39/15 , C12N15/18
CPC分类号： A61K33/24 , A61K35/765 , A61K45/06 , C12N2720/12232 , A61K2300/00
摘要： The present invention relates to a method of increasing the sensitivity of neoplastic cells to chemotherapeutic agents by using a virus, a method of treating proliferative disorders with a virus and chemotherapeutic agents, and a method for preventing a neoplasm from developing drug resistance to chemotherapeutic agents. The virus is preferably a reovirus.

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