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1. 发明授权

US10596260B2 Reoviruses having modified sequences 有权
公开(公告)号：US10596260B2
公开(公告)日：2020-03-24
申请号：US16027206
申请日：2018-07-03
申请人： Oncolytics Biotech Inc.
发明人： Matthew C. Coffey
IPC分类号： A61K35/766 , C12N7/00 , A61K45/06 , C07K14/005 , A61K35/765 , A61K35/13
摘要： The invention provides for modified reovirus nucleic acid sequences and modified reovirus polypeptide sequences as well as reoviruses containing such modified nucleic acid or polypeptide sequences. The invention also provides for pharmaceutical compositions that include reoviruses having a modified sequence as well as methods of making and using such reoviruses.

2. 发明申请

US20140178969A1 VIRAL PURIFICATION METHODS 审中-公开
标题翻译：病毒纯化方法
公开(公告)号：US20140178969A1
公开(公告)日：2014-06-26
申请号：US14175214
申请日：2014-02-07
申请人： Oncolytics Biotech Inc.
发明人： Matthew C. Coffey
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , A61K39/12 , A61K39/15 , C07K14/005 , C12N2720/12051 , C12N2720/12222 , C12N2720/12234 , C12N2720/12251
摘要： The present invention is directed to an improved method of purifying virus, particularly reovirus. Infectious virus can be extracted from a cell culture with a detergent to produce high titers of virus, and the virus can then be purified by simple steps such as filtration and column chromatography. Viruses and compositions comprising the viruses prepared according to the present invention are also provided.
摘要翻译：本发明涉及一种纯化病毒，特别是呼肠弧病毒的改进方法。可以用洗涤剂从细胞培养物中提取传染病毒以产生高滴度的病毒，然后可以通过简单的步骤如过滤和柱层析纯化病毒。还提供了包含根据本发明制备的病毒的病毒和组合物。

3. 发明申请

US20040091458A1 Method for reducing pain using oncolytic viruses 审中-公开
标题翻译：使用溶瘤病毒减轻疼痛的方法
公开(公告)号：US20040091458A1
公开(公告)日：2004-05-13
申请号：US10431580
申请日：2003-05-08
申请人： Oncolytics Biotech Inc.
发明人： Donald Morris , Matthew C. Coffey , Bradley G. Thompson
IPC分类号： A61K048/00 , A61K031/485
CPC分类号： A61K35/765 , A61K45/06 , C12N2720/12232 , A61K2300/00
摘要： The present invention provides a method for reducing pain associated with neoplasms in a mammal, comprising administering an effective amount of one or more oncolytic viruses. Preferably, the mammal also receives an analgesic, and the amount of analgesic required by the mammal is reduced when the oncolytic virus is administered. The oncolytic virus is preferably reovirus. The mammal may be additionally subject to other therapies, such as chemotherapy, immunotherapy, hormonal and/or radiation therapy.
摘要翻译：本发明提供了减少与哺乳动物赘生物相关的疼痛的方法，包括施用有效量的一种或多种溶瘤病毒。优选地，哺乳动物还接受止痛剂，并且当施用溶瘤病毒时，哺乳动物所需的止痛剂的量减少。溶瘤病毒优选为呼肠孤病毒。哺乳动物可以另外进行其他治疗，例如化学疗法，免疫治疗，激素和/或放射治疗。

4. 发明授权

US11246930B2 Reoviruses having modified sequences 有权
公开(公告)号：US11246930B2
公开(公告)日：2022-02-15
申请号：US16790114
申请日：2020-02-13
申请人： Oncolytics Biotech Inc.
发明人： Matthew C. Coffey
IPC分类号： A61K35/765 , C12N7/00 , A61K45/06 , C07K14/005 , A61K35/13
摘要： The invention provides for modified reovirus nucleic acid sequences and modified reovirus polypeptide sequences as well as reoviruses containing such modified nucleic acid or polypeptide sequences. The invention also provides for pharmaceutical compositions that include reoviruses having a modified sequence as well as methods of making and using such reoviruses.

5. 发明申请

US20200237917A1 REOVIRUSES HAVING MODIFIED SEQUENCES 审中-公开
公开(公告)号：US20200237917A1
公开(公告)日：2020-07-30
申请号：US16790114
申请日：2020-02-13
申请人： Oncolytics Biotech Inc.
发明人： Matthew C. Coffey
IPC分类号： A61K45/06 , C07K14/005 , C12N7/00 , A61K35/765
摘要： The invention provides for modified reovirus nucleic acid sequences and modified reovirus polypeptide sequences as well as reoviruses containing such modified nucleic acid or polypeptide sequences. The invention also provides for pharmaceutical compositions that include reoviruses having a modified sequence as well as methods of making and using such reoviruses.

6. 发明申请

US20180344853A1 REOVIRUSES HAVING MODIFIED SEQUENCES 审中-公开
公开(公告)号：US20180344853A1
公开(公告)日：2018-12-06
申请号：US16027206
申请日：2018-07-03
申请人： Oncolytics Biotech Inc.
发明人： Matthew C. Coffey
IPC分类号： A61K45/06 , C12N7/00 , A61K35/765
CPC分类号： A61K45/06 , A61K35/13 , A61K35/765 , C07K14/005 , C12N7/00 , C12N2720/12221 , C12N2720/12222
摘要： The invention provides for modified reovirus nucleic acid sequences and modified reovirus polypeptide sequences as well as reoviruses containing such modified nucleic acid or polypeptide sequences. The invention also provides for pharmaceutical compositions that include reoviruses having a modified sequence as well as methods of making and using such reoviruses.

7. 发明授权

US10039827B2 Reoviruses having modified sequences 有权
公开(公告)号：US10039827B2
公开(公告)日：2018-08-07
申请号：US14179840
申请日：2014-02-13
申请人： Oncolytics Biotech Inc.
发明人： Matthew C. Coffey
IPC分类号： A61K45/06 , C07K14/005 , C12N7/00 , A61K35/765 , A61K35/13
摘要： The invention provides for modified reovirus nucleic acid sequences and modified reovirus polypeptide sequences as well as reoviruses containing such modified nucleic acid or polypeptide sequences. The invention also provides for pharmaceutical compositions that include reoviruses having a modified sequence as well as methods of making and using such reoviruses.

8. 发明授权

US09365823B2 Virus clearance of neoplastic cells from mixed cellular compositions 有权
公开(公告)号：US09365823B2
公开(公告)日：2016-06-14
申请号：US13903236
申请日：2013-05-28
申请人： Oncolytics Biotech Inc.
发明人： Donald Morris , Bradley G. Thompson , Matthew C. Coffey
IPC分类号： A61K35/761 , A61K35/768 , C12N5/078 , A61K35/28 , C12N15/64
CPC分类号： C12N5/0634 , A61K35/28 , A61K35/761 , A61K35/768 , C12N2720/12032
摘要： The present invention relates to a method for removing neoplastic cells from a mixed cellular composition, which is outside of a living organism, by using a virus which selectively infect and kill neoplastic cell. A variety of viruses can be used in this method to remove neoplastic cells for different purposes, for example, to purge hematopoietic stem cells prior to transplantation. Also provided are compositions prepared according to this method, and kits comprising a combination of viruses which are useful in this invention.

9. 发明申请

US20040029112A1 Oncolytic viruses as phenotyping agents for neoplasms 有权
标题翻译：肿瘤溶解病毒作为肿瘤的表型剂
公开(公告)号：US20040029112A1
公开(公告)日：2004-02-12
申请号：US10602024
申请日：2003-06-24
申请人： Oncolytics Biotech Inc.
发明人： Bradley G. Thompson , Matthew C. Coffey
IPC分类号： C12Q001/70
CPC分类号： G01N33/574 , G01N33/5748 , G01N2333/14 , Y10S435/975
摘要： The present invention provides a method of diagnosing neoplasms having a particular phenotype by using oncolytic viruses that selectively replicate in neoplasms having the particular phenotype. For example, reovirus does not replicate in normal cells. However, reovirus selectively replicate in cells with an activated ras pathway, which leads to death of these cells. Therefore, a cell which becomes neoplastic due to, at least in part, elevated ras pathway activities can be diagnosed by its susceptibility to reovirus replication. This invention can further be applied, using other oncolytic viruses, to the diagnosis and/or treatment of other tumors, such as interferon-sensitive tumors, p53-deficient tumors and Rb-deficient tumors. Kits useful in the diagnosis or treatment disclosed herein are also provided.
摘要翻译：本发明提供了通过使用在具有特定表型的肿瘤中选择性复制的溶瘤病毒来诊断具有特定表型的赘生物的方法。例如，呼肠孤病毒不会在正常细胞中复制。然而，呼肠孤病毒在具有活化的ras途径的细胞中选择性复制，这导致这些细胞的死亡。因此，由于至少部分地升高的ras途径活性而变得肿瘤的细胞可以通过其对呼肠孤病毒复制的易感性来诊断。本发明还可以使用其他溶瘤病毒来应用于其它肿瘤如干扰素敏感性肿瘤，p53缺陷型肿瘤和Rb缺陷型肿瘤的诊断和/或治疗。还提供了在本文公开的诊断或治疗中有用的试剂盒。

10. 发明申请

US20040005546A1 Use of ribozymes in the detection of adventitious agents 审中-公开
标题翻译：使用核酶检测外来因子
公开(公告)号：US20040005546A1
公开(公告)日：2004-01-08
申请号：US10375700
申请日：2003-02-26
申请人： Oncolytics Biotech Inc.
发明人： Matthew C. Coffey
IPC分类号： C12Q001/70
CPC分类号： C12Q1/04 , C12N15/1131 , C12N2310/121 , C12Q1/701 , C12Q2521/337
摘要： The present invention provides a method of detecting adventitious agents in a composition comprising a microorganism by using ribozyme-expressing indicator cells, as well as indicator cells useful in such detection.
摘要翻译：本发明提供了通过使用表达核酶的指示剂细胞以及用于这种检测的指示细胞来检测包含微生物的组合物中的外来物质的方法。

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