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1. 发明申请

US20070077555A1 Adsorption system for the removal of viruses and viral components from fluids, in particular blood and blood plasma 审中-公开
标题翻译：用于从流体，特别是血液和血浆中去除病毒和病毒组分的吸附系统
公开(公告)号：US20070077555A1
公开(公告)日：2007-04-05
申请号：US11326639
申请日：2006-01-06
申请人： Gotz Nowak , Elke Bucha , Ute Lange , Sven Zeeb , Alrun Schumann
发明人： Gotz Nowak , Elke Bucha , Ute Lange , Sven Zeeb , Alrun Schumann
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： A61M1/3679 , B01D15/00 , B01J20/26 , B01J20/28004 , B01J20/28019 , B01J20/28069 , B01J20/28078
摘要： The present invention relates to an adsorption system for the removal of viruses and viral components, in particular hepatitis C viruses, from physiological fluids, in particular whole blood or blood plasma, by means of extracorporeal adsorption processes, as well as to an adsorber material for use in the adsorption system of the present invention.
摘要翻译：本发明涉及通过体外吸附方法从生理液体，特别是全血或血浆中除去病毒和病毒组分，特别是丙型肝炎病毒的吸附系统，以及吸附系统用于本发明的吸附系统中。

2. 发明申请

US20080138843A1 Method For Determining the Total Clotting Activity of a Blood or Plasma Sample 失效
标题翻译：确定血液或血浆样品总凝血活性的方法
公开(公告)号：US20080138843A1
公开(公告)日：2008-06-12
申请号：US11884988
申请日：2006-02-17
申请人： Gotz Nowak , Elke Bucha , Ute Lange
发明人： Gotz Nowak , Elke Bucha , Ute Lange
IPC分类号： C12Q1/56
CPC分类号： G01N33/86 , G01N2333/811 , G01N2333/815 , G01N2333/974
摘要： The invention relates to a method for determining the total clotting activity of a blood or plasma sample, characterized in that a highly specific, not irreversible thrombin inhibitor is added to a blood or plasma sample in a defined amount, the clotting of the blood or plasma sample is induced and, after a defined period of time, the consumed amount of the added thrombin inhibitor is determined in a per se known manner, as well as to a kit for obtaining information about the state of coagulation of a blood sample.
摘要翻译：本发明涉及一种用于确定血液或血浆样品的总凝血活性的方法，其特征在于将高度特异性的，不可逆的凝血酶抑制剂以规定的量加入到血液或血浆样品中，血液或血浆的凝血诱导样品，并且在限定的时间段之后，以本身已知的方式确定所加入的凝血酶抑制剂的消耗量，以及用于获得关于血液样品凝固状态的信息的试剂盒。

3. 发明授权

US07223532B1 Blood compatible polymer surfaces 失效
标题翻译：血液相容的聚合物表面
公开(公告)号：US07223532B1
公开(公告)日：2007-05-29
申请号：US10130616
申请日：2000-11-14
申请人： Gotz Nowak , Elke Bucha
发明人： Gotz Nowak , Elke Bucha
IPC分类号： A01N1/02 , A61F2/00 , C12Q1/00 , C12N11/08 , C12M1/00
CPC分类号： G01N33/545 , A61L27/28 , A61L29/08 , A61L31/08 , A61L33/0029 , A61L33/068 , C08L83/04
摘要： The invention relates to a blood-compatible surface comprising a polymer surface and a plurality of conjugates made of linkers and active agents immobilized thereon. The polymer surface contains similar or different structural units that carry carbonyl groups. The linkers contain a structural element that is able to form a hydrogen bridge bond. A polyorganosiloxane acting as the active agent is linked to the linkers.
摘要翻译：本发明涉及包含聚合物表面和由其上固定有接头和活性剂制成的多个缀合物的血液兼容表面。聚合物表面含有携带羰基的相似或不同的结构单元。连接体含有能够形成氢桥键的结构元素。作为活性剂的聚有机硅氧烷与接头连接。

4. 发明申请

US20050070479A1 Oligo or polyalkylene glycol-coupled thrombin inhibitors 失效
标题翻译：寡聚或聚亚烷基二醇偶联的凝血酶抑制剂
公开(公告)号：US20050070479A1
公开(公告)日：2005-03-31
申请号：US10344722
申请日：2002-01-23
申请人： Torsten Steinmetzer , Gotz Nowak
发明人： Torsten Steinmetzer , Gotz Nowak
IPC分类号： A61K38/00 , A61K47/48 , A61P7/02 , C07K5/062 , C07K5/065 , C07K5/072 , C08G65/329 , C08G65/333 , C08G65/334 , A61K38/05 , A61K38/04 , C07K5/06 , C07D41/02 , C07D43/02
CPC分类号： C08G65/329 , A61K47/60
摘要： The present invention relates to novel covalent oligo and polyalkylene glycol conjugates with synthetic inhibitors of trypsin-type serine proteases, in particular inhibitors of the hemocoagulation protease thrombin, synthetic intermediates stages required in their production and their use for producing active ingredients for the treatment or prophylaxis of thrombotic complications.
摘要翻译：本发明涉及具有胰蛋白酶型丝氨酸蛋白酶的合成抑制剂的新型共价寡聚和聚亚烷基二醇缀合物，特别是血液凝固蛋白酶凝血酶的抑制剂，其生产所需的合成中间体阶段及其用于治疗或预防活性成分的用途的血栓并发症。

5. 发明授权

US07407982B2 Oligo or polyalkylene glycol-coupled thrombin inhibitors 失效
标题翻译：寡聚或聚亚烷基二醇偶联的凝血酶抑制剂
公开(公告)号：US07407982B2
公开(公告)日：2008-08-05
申请号：US10344722
申请日：2002-01-23
申请人： Torsten Steinmetzer , Götz Nowak
发明人： Torsten Steinmetzer , Götz Nowak
IPC分类号： A61K31/40 , C07D209/54
CPC分类号： C08G65/329 , A61K47/60
摘要： The present invention relates to novel covalent oligo and polyalkylene glycol conjugates with synthetic inhibitors of trypsin-type serine proteases, in particular inhibitors of the hemocoagulation protease thrombin, synthetic intermediates stages required in their production and their use for producing active ingredients for the treatment or prophylaxis of thrombotic complications.
摘要翻译：本发明涉及具有胰蛋白酶型丝氨酸蛋白酶合成抑制剂的新型共价寡聚和聚亚烷基二醇缀合物，特别是血液凝固蛋白酶凝血酶的抑制剂，其生产所需的合成中间体阶段及其用于治疗或预防活性成分的用途的血栓并发症。

6. 发明授权

US07172878B1 Method for determining the concentration of thrombin inhibitors and kits therefor 有权
标题翻译：确定凝血酶抑制剂浓度的方法及其试剂盒
公开(公告)号：US07172878B1
公开(公告)日：2007-02-06
申请号：US09890654
申请日：2000-01-28
申请人： Gotz Nowak , Elke Bucha
发明人： Gotz Nowak , Elke Bucha
IPC分类号： C12Q1/56
CPC分类号： C12Q1/56
摘要： The invention relates to a method for determining the concentration of thrombin inhibitors in a non-turbid body liquid or a non-turbid extract from a body liquid. It comprises the following steps. The body liquid is taken from a living body, and the body liquid is subjected to a separation from the turbid matter, if necessary. To the non-turbid body liquid thus obtained are added a coagulation-inhibiting substance not interfering in the transformation prothrombin/active meizothrombin or Mtdesfgl, resp., a chromogenic or fluorogenic substrate not dissociable by active meizothrombin or Mtdesfgl, resp., and a substance dissociating prothrombin into meizothrombin or Mtdesfgl, resp., and as an optional prothrobmin. The thus obtained solution or mixture, resp., is subjected to a wavelength-selective light absorption or light emission measurement as a function of the time. From the reduction of the light absorption or light emission per time unit is determined the amount of the thrombin inhibitor included in the body liquid by comparison to previously determined standard curves.
摘要翻译：本发明涉及一种用于测定来自人体液体的非浑浊体液或非混浊提取物中凝血酶抑制剂的浓度的方法。它包括以下步骤。如果需要，从生物体取出体液，使体液与浑浊物分离。向非混浊体液中加入不干扰转化凝血酶原/活性成胶体凝胶酶或Mtdesfgl的凝血抑制物质，分别是不能通过活性迷迭香素或Mtdesfgl分解的显色或荧光底物，以及物质将凝血酶原分解成迷迭香素或Mtdesfgl，以及作为任选的prothrobmin。将如此获得的溶液或混合物作为时间的函数进行波长选择性光吸收或发光测量。通过与预先确定的标准曲线相比，从每时间单位的光吸收或发光的减少确定包含在体液中的凝血酶抑制剂的量。

7. 发明授权

US06861052B1 Separation process 失效
标题翻译：分离过程
公开(公告)号：US06861052B1
公开(公告)日：2005-03-01
申请号：US09517863
申请日：2000-03-03
申请人： Götz Nowak , Elke Bucha
发明人： Götz Nowak , Elke Bucha
IPC分类号： C08J7/00 , C07K1/12 , C07K1/14 , A61K31/74 , A61K9/14 , A61K9/16
CPC分类号： C07K1/12
摘要： The present invention relates to a process for separating substances, which are bonded to a polymer surface via a linker, by adding a polar organic solvent.
摘要翻译：本发明涉及通过添加极性有机溶剂来分离通过接头与聚合物表面结合的物质的方法。

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