专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070275086A1 Use of Increased Molecular-Weight Hirudin as an Anticoagulant in Extracorporeal Kidney Replace Therapy 审中-公开
标题翻译：在体外肾脏替代疗法中使用增加的分子量水蛭素作为抗凝血剂
公开(公告)号：US20070275086A1
公开(公告)日：2007-11-29
申请号：US11782365
申请日：2007-07-24
申请人： Gotz Nowak , Elke Bucha
发明人： Gotz Nowak , Elke Bucha
IPC分类号： A61K35/62 , A61P13/12
CPC分类号： A61K9/0019 , A61K38/58 , A61K47/60
摘要： The invention relates to the use of increased-molecular-weight hirudin for the manufacture of an anticoagulant for extracorporeal renal replacement therapy which does not induce an autoimmune disease and which does not cross react with autoimmune antibodies. In particular, the use according to the invention does not induce type II thrombocytopenia (HIT II), and no cross reactivity occurs with antibodies to platelet-factor-4-heparin complexes.
摘要翻译：本发明涉及增加分子量的水蛭素用于制造体外肾替代疗法的抗凝血剂，其不诱导自身免疫疾病并且不与自身免疫抗体交叉反应。特别地，根据本发明的用途不会引起II型血小板减少症（HIT II），并且与血小板因子-β-肝素复合物的抗体不发生交叉反应。

2. 发明申请

US20070077555A1 Adsorption system for the removal of viruses and viral components from fluids, in particular blood and blood plasma 审中-公开
标题翻译：用于从流体，特别是血液和血浆中去除病毒和病毒组分的吸附系统
公开(公告)号：US20070077555A1
公开(公告)日：2007-04-05
申请号：US11326639
申请日：2006-01-06
申请人： Gotz Nowak , Elke Bucha , Ute Lange , Sven Zeeb , Alrun Schumann
发明人： Gotz Nowak , Elke Bucha , Ute Lange , Sven Zeeb , Alrun Schumann
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： A61M1/3679 , B01D15/00 , B01J20/26 , B01J20/28004 , B01J20/28019 , B01J20/28069 , B01J20/28078
摘要： The present invention relates to an adsorption system for the removal of viruses and viral components, in particular hepatitis C viruses, from physiological fluids, in particular whole blood or blood plasma, by means of extracorporeal adsorption processes, as well as to an adsorber material for use in the adsorption system of the present invention.
摘要翻译：本发明涉及通过体外吸附方法从生理液体，特别是全血或血浆中除去病毒和病毒组分，特别是丙型肝炎病毒的吸附系统，以及吸附系统用于本发明的吸附系统中。

3. 发明授权

US08163513B2 Method for determining the total clotting activity of a blood or plasma sample 失效
标题翻译：确定血液或血浆样品的总凝血活性的方法
公开(公告)号：US08163513B2
公开(公告)日：2012-04-24
申请号：US11884988
申请日：2006-02-17
申请人： Götz Nowak , Elke Bucha , Ute Lange
发明人： Götz Nowak , Elke Bucha , Ute Lange
IPC分类号： C12Q1/56
CPC分类号： G01N33/86 , G01N2333/811 , G01N2333/815 , G01N2333/974
摘要： The invention relates to a method for determining the total clotting activity of a blood or plasma sample, characterized in that a highly specific, reversible thrombin inhibitor is added to a blood or plasma sample in a defined amount, the clotting of the blood or plasma sample is induced and, after a defined period of time, the consumed amount of the added thrombin inhibitor is determined in a per se known manner, as well as to a kit for obtaining information about the state of coagulation of a blood sample.
摘要翻译：本发明涉及一种用于确定血液或血浆样品的总凝血活性的方法，其特征在于将高度特异性的可逆凝血酶抑制剂以规定的量加入到血液或血浆样品中，血液或血浆样品的凝血并且在规定的时间段之后，以本身已知的方式确定所加入的凝血酶抑制剂的消耗量，以及用于获得关于血液样品凝固状态的信息的试剂盒。

4. 发明申请

US20080138843A1 Method For Determining the Total Clotting Activity of a Blood or Plasma Sample 失效
标题翻译：确定血液或血浆样品总凝血活性的方法
公开(公告)号：US20080138843A1
公开(公告)日：2008-06-12
申请号：US11884988
申请日：2006-02-17
申请人： Gotz Nowak , Elke Bucha , Ute Lange
发明人： Gotz Nowak , Elke Bucha , Ute Lange
IPC分类号： C12Q1/56
CPC分类号： G01N33/86 , G01N2333/811 , G01N2333/815 , G01N2333/974
摘要： The invention relates to a method for determining the total clotting activity of a blood or plasma sample, characterized in that a highly specific, not irreversible thrombin inhibitor is added to a blood or plasma sample in a defined amount, the clotting of the blood or plasma sample is induced and, after a defined period of time, the consumed amount of the added thrombin inhibitor is determined in a per se known manner, as well as to a kit for obtaining information about the state of coagulation of a blood sample.
摘要翻译：本发明涉及一种用于确定血液或血浆样品的总凝血活性的方法，其特征在于将高度特异性的，不可逆的凝血酶抑制剂以规定的量加入到血液或血浆样品中，血液或血浆的凝血诱导样品，并且在限定的时间段之后，以本身已知的方式确定所加入的凝血酶抑制剂的消耗量，以及用于获得关于血液样品凝固状态的信息的试剂盒。

5. 发明申请

US20050239131A1 Interactive system for presenting and eliminating substances 失效
标题翻译：提供和消除物质的互动系统
公开(公告)号：US20050239131A1
公开(公告)日：2005-10-27
申请号：US11170666
申请日：2005-06-29
申请人： Elke Bucha , Gotz Nowak
发明人： Elke Bucha , Gotz Nowak
IPC分类号： A23L33/00 , A61F2/06 , A61F2/30 , A61K9/00 , A61K31/74 , A61K38/00 , A61K45/00 , A61K47/32 , A61K47/48 , A61L27/00 , A61L29/00 , A61M1/16 , A61P3/00 , A61P7/02 , A61P31/04 , A61P31/10 , A61P33/00 , A61P35/00 , B01D67/00 , B01D69/14 , B01D71/40 , C07K16/24 , C08F8/00 , C08G65/00 , C08G85/00 , C12N11/08 , C12Q1/68 , C12M1/34 , G01N33/53 , G01N33/537 , G01N33/543
CPC分类号： B01D67/0093 , A61K31/74 , A61M1/16 , B01D69/141 , B01D71/40 , C07K16/241 , C08G81/02 , C12N11/08 , Y10T436/25125 , Y10T436/255
摘要： An interactive system is provided with at least one active surface of plastic from monomers containing at least one structural element derived from a carbon dioxide (A), and at least one substance associated to a linker with at least one structural element (B) capable of establishing a hydrogen bond, and involving an interaction between the structural elements (A) and (B). The interactive system is suitable for presenting and eliminating substances in liquids.
摘要翻译：交互式系统提供有至少一种含有至少一种衍生自二氧化碳（A）的结构元件的单体的塑料活性表面，以及至少一种与具有至少一种能够具有建立氢键，并涉及结构元件（A）和（B）之间的相互作用。交互式系统适用于呈现和消除液体中的物质。

6. 发明授权

US07494824B2 Interactive system for presenting and eliminating substances 失效
标题翻译：提供和消除物质的互动系统
公开(公告)号：US07494824B2
公开(公告)日：2009-02-24
申请号：US11170666
申请日：2005-06-29
申请人： Elke Bucha , Götz Nowak
发明人： Elke Bucha , Götz Nowak
IPC分类号： G01N33/545
CPC分类号： B01D67/0093 , A61K31/74 , A61M1/16 , B01D69/141 , B01D71/40 , C07K16/241 , C08G81/02 , C12N11/08 , Y10T436/25125 , Y10T436/255
摘要： An interactive system is provided with at least one active surface of plastic from monomers containing at least one structural element derived from a carbon dioxide (A), and at least one substance associated to a linker with at least one structural element (B) capable of establishing a hydrogen bond, and involving an interaction between the structural elements (A) and (B). The interactive system is suitable for presenting and eliminating substances in liquids.
摘要翻译：交互式系统提供有至少一种含有至少一种衍生自二氧化碳（A）的结构元件的单体的塑料活性表面，以及至少一种与具有至少一种能够具有建立氢键，并涉及结构元件（A）和（B）之间的相互作用。交互式系统适用于呈现和消除液体中的物质。

7. 发明授权

US07223532B1 Blood compatible polymer surfaces 失效
标题翻译：血液相容的聚合物表面
公开(公告)号：US07223532B1
公开(公告)日：2007-05-29
申请号：US10130616
申请日：2000-11-14
申请人： Gotz Nowak , Elke Bucha
发明人： Gotz Nowak , Elke Bucha
IPC分类号： A01N1/02 , A61F2/00 , C12Q1/00 , C12N11/08 , C12M1/00
CPC分类号： G01N33/545 , A61L27/28 , A61L29/08 , A61L31/08 , A61L33/0029 , A61L33/068 , C08L83/04
摘要： The invention relates to a blood-compatible surface comprising a polymer surface and a plurality of conjugates made of linkers and active agents immobilized thereon. The polymer surface contains similar or different structural units that carry carbonyl groups. The linkers contain a structural element that is able to form a hydrogen bridge bond. A polyorganosiloxane acting as the active agent is linked to the linkers.
摘要翻译：本发明涉及包含聚合物表面和由其上固定有接头和活性剂制成的多个缀合物的血液兼容表面。聚合物表面含有携带羰基的相似或不同的结构单元。连接体含有能够形成氢桥键的结构元素。作为活性剂的聚有机硅氧烷与接头连接。

8. 发明授权

US06929955B2 Interactive system for presenting and eliminating substances 失效
标题翻译：提供和消除物质的互动系统
公开(公告)号：US06929955B2
公开(公告)日：2005-08-16
申请号：US09417534
申请日：1999-10-14
申请人： Elke Bucha , Götz Nowak
发明人： Elke Bucha , Götz Nowak
IPC分类号： A23L33/00 , A61F2/06 , A61F2/30 , A61K9/00 , A61K31/74 , A61K38/00 , A61K45/00 , A61K47/32 , A61K47/48 , A61L27/00 , A61L29/00 , A61M1/16 , A61P3/00 , A61P7/02 , A61P31/04 , A61P31/10 , A61P33/00 , A61P35/00 , B01D67/00 , B01D69/14 , B01D71/40 , C07K16/24 , C08F8/00 , C08G65/00 , C08G85/00 , C12N11/08 , G01N33/545
CPC分类号： B01D67/0093 , A61K31/74 , A61M1/16 , B01D69/141 , B01D71/40 , C07K16/241 , C08G81/02 , C12N11/08 , Y10T436/25125 , Y10T436/255
摘要： The present invention relates to an interactive system comprising at least one active surface of plastic from monomers containing at least one structural element derived from a carbon dioxide (A), and at least one substance associated to a linker with at least one structural element (B) capable of establishing a hydrogen bond, and involving an interaction between the structural elements (A) and (B). That interactive system is suitable for presenting and eliminating substances in liquids.
摘要翻译：本发明涉及一种交互式系统，其包括至少一种包含至少一种衍生自二氧化碳（A）的结构元件的单体的塑料活性表面，以及至少一种与至少一种结构元件（B ）能够建立氢键，并涉及结构元件（A）和（B）之间的相互作用。该互动系统适用于呈现和消除液体中的物质。

9. 发明申请

US20110201025A1 Polymer-coupled peptidases 有权
标题翻译：聚合物偶联肽酶
公开(公告)号：US20110201025A1
公开(公告)日：2011-08-18
申请号：US13026474
申请日：2011-02-14
申请人： Hans-Jurgen Kolde , Ute Lange , Elke Bucha
发明人： Hans-Jurgen Kolde , Ute Lange , Elke Bucha
IPC分类号： G01N33/53 , C12Q1/37 , C12Q1/56 , C12N9/99
CPC分类号： G01N33/86 , C12N9/6429 , C12N9/647 , C12Y304/21005
摘要： The present invention is directed to a simple process for the modification of the specificity of a peptidase of the hemostatic system by coupling polymers to the peptidase causing it to lose its reactivity in the hemostatic system, but enabling it to continue to react with certain inhibitors, effectors and substrates. The invention is furthermore directed to processes for the detection or quantitative determination of inhibitors of the peptidase in bodily fluids or other samples as well as to processes for their neutralization and/or removal from liquids. Finally, the invention allows the use of a polymer-coupled peptidase as drug and furthermore provides a device which makes use of such a peptidase in the removal of peptidase inhibitors from samples or from the bloodstream of a patient.
摘要翻译：本发明涉及通过将聚合物偶联至肽酶来改变止血系统肽酶的特异性的简单方法，导致其在止血系统中失去其反应性，但使其能够与某些抑制剂继续反应，效应器和基板。本发明还涉及用于检测或定量测定体液或其它样品中肽酶抑制剂的方法，以及其中和和/或从液体中除去的方法。最后，本发明允许使用聚合物偶联的肽酶作为药物，并且还提供一种使用这种肽酶从样品或来自患者的血液中除去肽酶抑制剂的装置。

10. 发明授权

US07803570B2 Method for determining the concentration of thrombin inhibitors 有权
标题翻译：确定凝血酶抑制剂浓度的方法
公开(公告)号：US07803570B2
公开(公告)日：2010-09-28
申请号：US11636438
申请日：2006-12-11
申请人： Gotz Nowak , Elke Bucha
发明人： Gotz Nowak , Elke Bucha
IPC分类号： C12Q1/56
CPC分类号： C12Q1/56
摘要： The invention relates to a method for determining the concentration of thrombin inhibitors in a non-turbid body liquid or a non-turbid extract from a body liquid. It comprises the following steps. The body liquid is taken from a living body, and the body liquid is subjected to a separation from the turbid matter, if necessary. To the non-turbid body liquid thus obtained are added a coagulation-inhibiting substance not interfering in the transformation prothrombin/active meizothrombin or Mtdesfg1, resp., a chromogenic or fluorogenic substrate not dissociable by active meizothrombin or Mtdesfg1, resp., and a substance dissociating prothrombin into meizothrombin or Mtdesfg1, resp., and as an option prothrombin. The thus obtained solution or mixture, resp., is subjected to a wavelength-selective light absorption or light emission measurement as a function of the time. From the reduction of the light absorption or light emission per time unit is determined the amount of the thrombin inhibitor included in the body liquid by comparison to previously determined standard curves.
摘要翻译：本发明涉及一种用于测定来自人体液体的非浑浊体液或非混浊提取物中凝血酶抑制剂的浓度的方法。它包括以下步骤。如果需要，从生物体取出体液，使体液与浑浊物分离。对于这样得到的非混浊体液，添加不干扰转化凝血酶原/活性迷迭香素或Mtdesfg1的凝血抑制物质，分别是不能通过活性迷迭香素或Mtdesfg1分解的显色或荧光底物，将凝血酶原分解成迷迭香素或Mtdesfg1，并作为选择性凝血酶原。将如此获得的溶液或混合物作为时间的函数进行波长选择性光吸收或发光测量。通过与预先确定的标准曲线相比，从每时间单位的光吸收或发光的减少确定包含在体液中的凝血酶抑制剂的量。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式