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1. 发明授权

US5026905A Fluorescent dyes 失效
标题翻译：荧光染料
公开(公告)号：US5026905A
公开(公告)日：1991-06-25
申请号：US234361
申请日：1988-08-19
申请人： Thomas L. Tarnowski , Mae W. Hu , Maureen Laney , John S. Pease , Vartan Ghazarossian
发明人： Thomas L. Tarnowski , Mae W. Hu , Maureen Laney , John S. Pease , Vartan Ghazarossian
IPC分类号： G01N33/53 , C09B23/00 , C09B57/00 , G01N1/30 , G01N33/50 , G01N33/533 , G01N33/542 , G01N33/555 , G01N33/80
CPC分类号： G01N1/30 , C09B57/007 , G01N33/5094 , G01N33/533 , G01N33/542 , G01N33/555 , G01N33/80
摘要： The present invention describes a class of dyes for use in staining cell samples and methods of making such dyes. A preferred class of dyes known as detergent dyes which possess the ability to stain cells in whole blood and are only slowly leached or lost from the stained cells over time are described. The present invention has application, for example, to blood typing for the determination of the presence of blood group antigens A, B, AB, O, and D (Rh.sub.o) and antibodies to such antigens.
摘要翻译：本发明描述了一类用于染色细胞样品的染料和制备这种染料的方法。已知洗涤剂染料的一类优选的染料，其具有在全血中染色细胞并随时间缓慢浸出或从染色的细胞中丢失的能力。本发明例如可用于血型分析，用于确定血型抗原A，B，AB，O和D（Rho）的存在以及对这些抗原的抗体。

2. 发明授权

US6008411A Nortriptyline conjugates to antigenic proteins and enzymes 失效
标题翻译： Nortriptyline与抗原蛋白和酶结合
公开(公告)号：US6008411A
公开(公告)日：1999-12-28
申请号：US480633
申请日：1995-06-07
申请人： Mae W. Hu , Prithipal Singh
发明人： Mae W. Hu , Prithipal Singh
IPC分类号： G01N33/531 , G01N33/94 , C07C233/00
CPC分类号： G01N33/531 , G01N33/9466
摘要： Nortriptyline functionalized compounds are provided for conjugation to antigenic compositions, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies, which find use in immunoassays for the determination of nortriptyline in a sample, while the enzyme conjugates find use in an enzyme assay for the determination of nortriptyline in a sample.
摘要翻译：提供了Nortriptyline官能化化合物用于与抗原组合物，特别是聚（氨基酸）和酶缀合。抗体结合物用于生产抗体，其用于免疫测定用于测定样品中的去甲替林，而酶缀合物可用于测定样品中去甲替林的酶测定。

3. 发明授权

US4230805A Theophylline antigens and antibodies 失效
标题翻译：茶碱抗原和抗体
公开(公告)号：US4230805A
公开(公告)日：1980-10-28
申请号：US2527
申请日：1979-01-11
申请人： Prithipal Singh , Mae W. Hu
发明人： Prithipal Singh , Mae W. Hu
IPC分类号： C07D473/04 , G01N33/94 , C07G7/00 , C07G7/02
CPC分类号： C07D473/04 , G01N33/94 , Y10S435/961 , Y10S435/964 , Y10S530/806
摘要： Theophylline derivatives are provided for preparing reagents for use in competitive protein binding assays and for use as reagents in competitive protein binding assays. Theophylline is substituted at the 3 position and conjugated to antigens for production of antibodies which specifically recognize theophylline as distinct from structurally similar analogs such as caffeine. Enzyme conjugates are provided which find use for measuring the amount of theophylline in a sample suspected of containing theophylline. A method is provided employing the reagents for the determination of theophylline.
摘要翻译：提供茶碱衍生物用于制备用于竞争性蛋白质结合测定的试剂，并用作竞争性蛋白质结合测定中的试剂。茶碱在3位被取代并与抗原结合，用于产生特异性识别茶碱与结构上类似的类似物如咖啡因不同的抗体。提供了酶缀合物，其用于测量怀疑含有茶碱的样品中茶碱的量。提供了用于测定茶碱的试剂的方法。

4. 发明授权

US5256575A Geminal diphenyl derivatives and their use in immunoassays 失效
标题翻译： Geminal二苯衍生物及其在免疫测定中的应用
公开(公告)号：US5256575A
公开(公告)日：1993-10-26
申请号：US755203
申请日：1991-09-04
申请人： Mae W. Hu , Kirk Schulkamp , Cheng-I Lin , Edwin F. Ullman
发明人： Mae W. Hu , Kirk Schulkamp , Cheng-I Lin , Edwin F. Ullman
IPC分类号： C07C235/34 , C07C235/52 , C07C259/10 , C07C309/15 , G01N33/53 , G01N33/78 , G01N33/94 , G01N33/566
CPC分类号： C07C309/15 , C07C235/34 , C07C235/52 , C07C259/10 , G01N33/5306 , G01N33/78 , G01N33/94 , Y10S435/962 , Y10S435/975 , Y10S436/825
摘要： A kit for inactivating interfering binding proteins in a immunoassay for a member of a specific binding pair (sbp). The method comprises including in an assay medium containing a sample suspected of containing an sbp member and an interfering binding protein an effective amount of a water soluble compound having two substituted or unsubstituted phenyl groups linked to a common atom. When the sbp member or its sbp partner has two phenyl groups linked to a common atom, the compound has a number of-groups other than hydrogen attached to the phenyl groups and the atom that differs by at least two from the number of such groups on the sbp member. When the sbp member or its sbp partner has two phenyl groups linked to a common atom and the binding protein is not an antibody, the compound has only one group other than hydrogen attached to a phenyl group or the common atom. The methods have particular application in avoiding-cross-reactivity of non-analyte materials in a sample with immunachemical reagents used in such assay. The methods-have application also in disrupting complexer between an analyte to be determined and other materials to that one can accurately determine the amount of an analyte in a sample.
摘要翻译：用于在特异性结合对（sbp）的成员的免疫测定中灭活干扰结合蛋白的试剂盒。该方法包括在含有疑似含有sbp成员和干扰结合蛋白的样品的测定培养基中包含有效量的具有两个与常见原子连接的取代或未取代的苯基的水溶性化合物。当sbp成员或其sbp伴侣具有连接到共同原子的两个苯基时，该化合物具有与苯基连接的氢以外的多个基团，并且与该基团的数目不同的至少两个的原子在 sbp成员。当sbp成员或其sbp伴侣具有连接到共同原子的两个苯基并且结合蛋白不是抗体时，该化合物除了连接到苯基或共同原子上的氢以外仅具有一个基团。该方法特别适用于避免样品中非分析物质与这种测定中使用的免疫化学试剂的交叉反应。所述方法还应用于破坏要测定的待分析物与其他材料之间的复合物，以使得可以准确地确定样品中分析物的量。

5. 发明授权

US4223013A Amitriptyline conjugates to antigenic proteins and enzymes 失效
标题翻译：阿米替林与抗原蛋白和酶结合
公开(公告)号：US4223013A
公开(公告)日：1980-09-16
申请号：US974294
申请日：1978-12-29
申请人： Mae W. Hu , Prithipal Singh
发明人： Mae W. Hu , Prithipal Singh
IPC分类号： C07K16/44 , G01N33/531 , G01N33/535 , A61K39/00 , A61K45/02
CPC分类号： C07K16/44 , G01N33/531 , G01N33/535 , Y10S436/815 , Y10S436/823 , Y10S530/806 , Y10S530/812
摘要： Amitriptyline functionalized compounds are provided for conjugation to antigenic compositions, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies, which find particular use in immunoassays for the determination of amitriptyline, while the enzyme conjugate finds use in a homogeneous enzyme immunoassay for the determination of amitriptyline.
摘要翻译：提供阿米替林官能化化合物用于与抗原组合物，特别是聚（氨基酸）和酶的缀合。抗体结合物用于产生抗体，其在免疫测定中特别用于测定阿米替林，而酶缀合物可用于均相酶免疫测定中用于测定阿米替林。

6. 发明授权

US4307245A Amitriptyline conjugates to antigenic proteins and enzymes 失效
标题翻译：阿米替林与抗原蛋白和酶结合
公开(公告)号：US4307245A
公开(公告)日：1981-12-22
申请号：US137658
申请日：1980-04-07
申请人： Mae W. Hu , Prithipal Singh
发明人： Mae W. Hu , Prithipal Singh
IPC分类号： C07K16/44 , G01N33/531 , C07C87/459 , C07C101/28 , C07C101/34
CPC分类号： G01N33/531 , C07K16/44 , Y10S436/823
摘要： Amitriptyline functionalized compounds are provided for conjugation to antigenic compositions, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies, which find particular use in immunoassays for the determination of amitriptyline, while the enzyme conjugate finds use in a homogeneous enzyme immunoassay for the determination of amitriptyline.
摘要翻译：提供阿米替林官能化化合物用于与抗原组合物，特别是聚（氨基酸）和酶缀合。抗体结合物用于产生抗体，其在免疫测定中特别用于测定阿米替林，而酶缀合物可用于均相酶免疫测定中用于测定阿米替林。

7. 发明授权

US4156081A Theophylline antigens and antibodies 失效
标题翻译：茶碱抗原和抗体
公开(公告)号：US4156081A
公开(公告)日：1979-05-22
申请号：US787829
申请日：1977-04-15
申请人： Prithipal Singh , Mae W. Hu
发明人： Prithipal Singh , Mae W. Hu
IPC分类号： C07D473/06 , C07D473/04 , C07K14/00 , C07K16/00 , C12N9/00 , C12N9/06 , C12N9/14 , C12N9/24 , G01N33/53 , G01N33/94
CPC分类号： C07D473/04 , G01N33/94 , Y10S435/961 , Y10S435/964 , Y10S530/807
摘要： Theophylline derivatives are provided for preparing reagents for use in competitive protein binding assays and for use as reagents in competitive protein binding assays. Theophylline is substituted at the 3 position and conjugated to antigens for production of antibodies which specifically recognize theophylline as distinct from structurally similar analogs such as caffeine. Enzyme conjugates are provided which find use for measuring the amount of theophylline in a sample suspected of containing theophylline. A method is provided employing the reagents for the determination of theophylline.
摘要翻译：提供茶碱衍生物用于制备用于竞争性蛋白质结合测定的试剂，并用作竞争性蛋白质结合测定中的试剂。茶碱在3位被取代并与抗原结合，用于产生特异性识别茶碱与结构上类似的类似物如咖啡因不同的抗体。提供了酶缀合物，其用于测量怀疑含有茶碱的样品中茶碱的量。提供了用于测定茶碱的试剂的方法。

8. 发明申请

US20140213646A1 Sustained Release Formulations for the Treatment of Intraocular Pressure or Glaucoma 有权
标题翻译：用于治疗眼内压或青光眼的持续释放制剂
公开(公告)号：US20140213646A1
公开(公告)日：2014-07-31
申请号：US14168139
申请日：2014-01-30
申请人： Vernon G. Wong , Mae W. Hu , Glenn T. Huang
发明人： Vernon G. Wong , Mae W. Hu , Glenn T. Huang
IPC分类号： A61K31/216
CPC分类号： A61K31/5575 , A61K9/0019 , A61K9/0048 , A61K47/14
摘要： The present embodiments provide for methods of treating elevated intraocular pressure or glaucoma using a sustained release medicament consisting of prostaglandin in benzyl benzoate that is injected intraocularly no more frequently than once every two months.
摘要翻译：本实施例提供了使用由前列腺素组成的持续释放药物治疗眼内压或青光眼的方法，所述缓释药物由苯甲酸苄酯组成，其眼内注射的频率不得超过每两个月一次。

9. 发明申请

US20140180245A1 DOSE GUIDES FOR INJECTION SYRINGE 有权
标题翻译：注射器剂量指导
公开(公告)号：US20140180245A1
公开(公告)日：2014-06-26
申请号：US14113803
申请日：2012-04-25
申请人： Vernon G. Wong , Tan Pham , William S. White , Glenn T. Huang , Mae W. Hu
发明人： Vernon G. Wong , Tan Pham , William S. White , Glenn T. Huang , Mae W. Hu
IPC分类号： A61M5/315
CPC分类号： A61M5/31536 , A61M5/315 , A61M5/3156 , A61M5/31591
摘要： Devices that guide the accurate loading and dispensing of predetermined doses of fluid from injection syringes are disclosed.
摘要翻译：公开了引导从注射器精确加载和分配预定剂量的流体的装置。

10. 发明授权

US4795822A Nortriptyline conjugates to antigenic proteins and enzymes 失效
标题翻译： Nortriptyline与抗原蛋白和酶结合
公开(公告)号：US4795822A
公开(公告)日：1989-01-03
申请号：US613709
申请日：1984-05-23
申请人： Mae W. Hu , Prithipal Singh
发明人： Mae W. Hu , Prithipal Singh
IPC分类号： C07C45/00 , C07C49/675 , C07C67/00 , C07C69/738 , C07C69/76 , C07C209/00 , C07C209/36 , C07C211/32 , C07C213/00 , C07C215/70 , C07C225/22 , C07C313/00 , C07C323/60 , C07D207/452 , C07K1/04 , C07K1/113 , C07K14/00 , C07K14/415 , C07K14/76 , C07K16/00 , G01N30/34 , G01N30/88 , G01N33/53 , G01N33/531 , G01N33/94 , C07C149/40 , C07C149/23
CPC分类号： G01N33/9466 , G01N33/531
摘要： Nortriptyline functionalized compounds are provided for conjugation to antigenic compositions, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies, which find use in immunoassays for the determination of nortriptyline in a sample, while the enzyme conjugates find use in an enzyme assay for the determination of nortriptyline in a sample.
摘要翻译：提供了Nortriptyline官能化化合物用于与抗原组合物，特别是聚（氨基酸）和酶缀合。抗体结合物用于生产抗体，其用于免疫测定用于测定样品中的去甲替林，而酶缀合物可用于测定样品中去甲替林的酶测定。

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