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1. 发明授权

US6110967A Epoxysuccinamide derivative or salt thereof 失效
标题翻译：环氧琥珀酰胺衍生物或其盐
公开(公告)号：US6110967A
公开(公告)日：2000-08-29
申请号：US202607
申请日：1998-12-17
申请人： Tetsuji Asao , Tomohiro Yamashita , Yoshimitsu Suda , Shigeo Okajima , Yukio Tada , Nobuhiko Katsunuma , Shozo Yamada , Kazuhiko Shigeno , Atsuhiko Uemura
发明人： Tetsuji Asao , Tomohiro Yamashita , Yoshimitsu Suda , Shigeo Okajima , Yukio Tada , Nobuhiko Katsunuma , Shozo Yamada , Kazuhiko Shigeno , Atsuhiko Uemura
IPC分类号： C07D303/40 , C07D303/48 , A61K31/495 , A61K31/41 , A61K31/435
CPC分类号： C07D303/48
摘要： The invention relates an epoxysuccinamide derivative represented by a formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom, an alkyl or aminoalkyl group, R.sup.2 represents an aminoalkyl group which May be substituted, an aryl group which may be substituted, a heterocyclic group which may be substituted, an aralkyl group which may be substituted, or an alkyl group substituted by a heterocyclic ring which may be substituted, or R.sup.1 and R.sup.2 may form a nitrogen-containing heterocyclic ring, which may be substituted, together with the adjacent nitrogen atoms, and R.sup.3 and R.sup.4 are the same or different from each other and independently represent a hydrogen atom, or an alkyl or aralkyl group, or a salt thereof, a preparation process thereof, and a medicine comprising such a derivative or salt as an active ingredient. This compound has a specific inhibitory activity for cathepsin L and family enzymes thereof, and is useful as an agent for preventing and treating metabolic osteopathy such as osteoporosis and hypercalcemia.
摘要翻译： PCT No.PCT / JP98 / 01778 Sec。 371日期1998年12月17日第 102（e）1998年12月17日日期PCT提交1998年4月17日PCT公布。第WO98 / 47887号公报日期：1998年10月29日本发明涉及由式（I）表示的环氧琥珀酰胺衍生物：其中R1表示氢原子，烷基或氨基烷基，R2表示可以被取代的氨基烷基，可以被取代的芳基，可以被取代的杂环基，可以被取代的芳烷基或被可被取代的杂环取代的烷基，或者可以被R 1和R 2形成可以被取代的含氮杂环，和相邻的氮原子和R3和R4彼此相同或不同，并且独立地表示氢原子或烷基或芳烷基或其盐，其制备方法和包含这种衍生物或盐的药物作为活性成分。该化合物对组织蛋白酶L及其家族酶具有特异性抑制活性，可用作预防和治疗代谢性骨病如骨质疏松症和高钙血症的药剂。

2. 发明授权

US5883121A Epoxysuccinamide derivative or salt thereof, and medicine comprising the same 失效
标题翻译：环氧琥珀酰胺衍生物或其盐，以及含有它们的药物
公开(公告)号：US5883121A
公开(公告)日：1999-03-16
申请号：US894050
申请日：1997-08-12
申请人： Tomohiro Yamashita , Yoshimitsu Suda , Yukio Tada , Nobuhiko Katunuma , Tetsuji Asao
发明人： Tomohiro Yamashita , Yoshimitsu Suda , Yukio Tada , Nobuhiko Katunuma , Tetsuji Asao
IPC分类号： C07D303/48 , A61K31/335 , C07D303/46
CPC分类号： C07D303/48
摘要： The invention relates an epoxysuccinamide derivative represented by the general formula (1) ##STR1## wherein R.sup.1 and R.sup.2 are the same or different from each other and independently represent H or an aromatic hydrocarbon group or aralkyl group which may be substituted, or R.sup.1 and R.sup.2 may form a nitrogen-containing heterocyclic ring together with the adjacent nitrogen atoms, R.sup.3 is H or an acyl group, R.sup.4 is H or an aralkyl group, and R.sup.5 is an aromatic hydrocarbon group or aralkyl group which may be substituted, or R.sup.5 may form an amino acid residue, which may be protected, together with the adjacent nitrogen atom, or a salt thereof, and a medicine comprising the derivative as an active ingredient; and this compound has an inhibiting activity against cathepsin, and particularly, specifically inhibits cathepsin L and is hence useful for prevention and treatment of osteopathy such as osteoporosis.
摘要翻译： PCT No.PCT / JP96 / 03603 Sec。 371日期：1997年8月12日 102（e）日期1997年8月12日PCT 1996年12月10日PCT PCT。出版物WO97 / 21694 日期：1996年6月19日本发明涉及由通式（1）表示的环氧琥珀酰胺衍生物彼此不同，独立地表示H或可被取代的芳香族烃基或芳烷基，或者R 1和R 2可以形成含氮杂环与相邻的氮原子一起，R3是H或酰基，R4是H或芳烷基，R5是可被取代的芳族烃基或芳烷基，或R5可以形成氨基酸残基，其中可以与相邻的氮原子或其盐一起保护，以及包含该衍生物作为活性成分的药物; 并且该化合物对组织蛋白酶具有抑制活性，特别是抑制组织蛋白酶L，因此可用于预防和治疗骨质疏松症等骨病。

3. 发明授权

US4946951A 2'-deoxy-5-fluorouridine derivatives 失效
标题翻译： 2'-脱氧-5-氟尿苷衍生物
公开(公告)号：US4946951A
公开(公告)日：1990-08-07
申请号：US225984
申请日：1988-07-29
申请人： Yukio Tada , Atsuhiko Uemura , Mitsugi Yasumoto , Setsuo Takeda , Hitoshi Saito , Norio Unemi
发明人： Yukio Tada , Atsuhiko Uemura , Mitsugi Yasumoto , Setsuo Takeda , Hitoshi Saito , Norio Unemi
IPC分类号： B09B3/00 , A61K31/70 , B02C18/00 , C07H19/06 , C07H19/073
CPC分类号： C07H19/06
摘要： Disclosed is a 2'-deoxy-5-fluorouridine derivative of the formula ##STR1## wherein one of R.sub.1 and R.sub.2 is a benzyl group which may optionally have substituent selected from the group consisting of C.sub.1 -C.sub.6 alkyl group, C.sub.1 -C.sub.6 alkoxy group, C.sub.1 -C.sub.3 halogenated alkyl group, halogen atom, hydroxyl group and nitro group on the phenyl ring, and the other constitutes an amino acid residue, or a salt thereof. The compounds are useful for treating cancer.
摘要翻译：公开了式（CHEM）2分钟的脱氧-5-氟尿苷衍生物，其中R 1和R 2之一是可以任选具有选自C 1 -C 6烷基，C 1 -C 6烷氧基的取代基的苄基苯基环上的C1-C3卤代烷基，卤原子，羟基和硝基，另一个构成氨基酸残基或其盐。该化合物可用于治疗癌症。

4. 发明授权

US06294535B1 Uracil derivatives and antitumor effect potentiator and antitumor agent containing the same 有权
标题翻译：尿嘧啶衍生物和抗肿瘤作用增强剂和抗肿瘤药含有相同的作用
公开(公告)号：US06294535B1
公开(公告)日：2001-09-25
申请号：US09457668
申请日：1999-12-09
申请人： Shingo Yano , Yukio Tada , Hideki Kazuno , Tsutomu Sato , Junichi Yamashita , Norihiko Suzuki , Tomohiro Emura , Masakazu Fukushima , Tetsuji Asao
发明人： Shingo Yano , Yukio Tada , Hideki Kazuno , Tsutomu Sato , Junichi Yamashita , Norihiko Suzuki , Tomohiro Emura , Masakazu Fukushima , Tetsuji Asao
IPC分类号： A61K31535
CPC分类号： C07D239/54 , C07D231/12 , C07D233/56 , C07D239/553 , C07D249/08 , C07D403/06 , C07D403/12
摘要： The invention relates to novel uracil derivatives having excellent inhibiting effects on human derived thymidine phosphorylates and anti-tumor activity. The pharmaceutical compositions, anti-tumor potentiators and antitumor agents containing such novel compounds, and a process for their preparation and use are described. The novel uracil derivative compounds are represented by the general formula (1′):
摘要翻译：本发明涉及对人衍生的胸苷磷酸酯具有优异抑制作用的新型尿嘧啶衍生物和抗肿瘤活性。描述了含有这些新化合物的药物组合物，抗肿瘤增强剂和抗肿瘤剂及其制备和使用方法。新型尿嘧啶衍生物化合物由通式（1'）表示：

5. 发明授权

US6159969A Uracil derivatives, and antitumor effect potentiator and antitumor agent containing the same 失效
标题翻译：尿嘧啶衍生物，抗肿瘤效果增强剂和抗肿瘤药含有相同的作用
公开(公告)号：US6159969A
公开(公告)日：2000-12-12
申请号：US6009
申请日：1998-01-12
申请人： Shingo Yano , Yukio Tada , Hideki Kazuno , Tsutomu Sato , Junichi Yamashita , Norihiko Suzuki , Tomohiro Emura , Masakazu Fukushima , Tetsuji Asao
发明人： Shingo Yano , Yukio Tada , Hideki Kazuno , Tsutomu Sato , Junichi Yamashita , Norihiko Suzuki , Tomohiro Emura , Masakazu Fukushima , Tetsuji Asao
IPC分类号： C07D239/54 , C07D239/553 , C07D403/06 , C07D403/12 , C07D521/00 , A61K31/535 , C07D239/02 , C07D401/00 , C07D413/00
CPC分类号： C07D239/54 , C07D231/12 , C07D233/56 , C07D239/553 , C07D249/08 , C07D403/06 , C07D403/12
摘要： The invention relates to novel uracil derivatives having excellent inhibiting effects of human derived thymidine phosphorylase and anti-tumor activity. The pharmaceutical compositions, anti-tumor potentiators, antitumor agents containing such novel compounds, and a process for their preparation and use is described. The novel compounds satisfy the general formula (1): ##STR1##
摘要翻译：本发明涉及具有优异的人衍生胸苷磷酸化酶抑制作用的新型尿嘧啶衍生物和抗肿瘤活性。描述了药物组合物，抗肿瘤增强剂，含有这些新化合物的抗肿瘤剂及其制备和使用方法。新化合物满足通式（1）：

6. 发明授权

US5744475A Uracil derivatives, and antitumor effect potentiator and antitumor agent containing the same 失效
标题翻译：尿嘧啶衍生物，抗肿瘤效果增强剂和抗肿瘤药含有相同的作用
公开(公告)号：US5744475A
公开(公告)日：1998-04-28
申请号：US737677
申请日：1996-11-21
申请人： Shingo Yano , Yukio Tada , Hideki Kazuno , Tsutomu Sato , Junichi Yamashita , Norihiko Suzuki , Tomohiro Emura , Masakazu Fukushima , Tetsuji Asao
发明人： Shingo Yano , Yukio Tada , Hideki Kazuno , Tsutomu Sato , Junichi Yamashita , Norihiko Suzuki , Tomohiro Emura , Masakazu Fukushima , Tetsuji Asao
IPC分类号： C07D239/54 , C07D239/553 , C07D403/06 , C07D403/12 , C07D521/00 , A01N43/54 , A01N43/64 , C07D239/00 , C07D239/02
CPC分类号： C07D239/54 , C07D231/12 , C07D233/56 , C07D239/553 , C07D249/08 , C07D403/06 , C07D403/12
摘要： The invention relates to novel uracil derivatives having excellent inhibiting effects of human derived thymidine phosphorylase and anti-tumor activity. The pharmaceutical compositions, anti-tumor potentiators, antitumor agents containing such novel compounds, and a process for their preparation and use is described. The novel compounds satisfy the general formula (1): ##STR1##
摘要翻译： PCT No.PCT / JP96 / 00828 Sec。 371日期：1996年11月21日 102（e）1996年11月21日PCT PCT 1996年3月28日PCT公布。公开号WO96 / 30346 日期：1996年10月3日本发明涉及具有优异的人衍生胸苷磷酸化酶抑制作用的新型尿嘧啶衍生物和抗肿瘤活性。描述了药物组合物，抗肿瘤增强剂，含有这些新化合物的抗肿瘤剂及其制备和使用方法。新化合物满足通式（1）：（1）

7. 发明授权

US08630405B2 Echo removing apparatus 有权
标题翻译：回波消除装置
公开(公告)号：US08630405B2
公开(公告)日：2014-01-14
申请号：US12677200
申请日：2008-09-24
申请人： Yukio Tada
发明人： Yukio Tada
IPC分类号： H04M1/00 , H04M9/00 , H04M9/08
CPC分类号： H04M9/082 , H01L2924/14 , H01L2924/00
摘要： An echo removing apparatus that can remove an echo appropriately if the produced sound volume becomes large although the configuration is simple is provided. A control section 17 switches the operations of an echo suppressor 14 and an echo canceller 15 in response to the volume value input from a volume operation section 18. If the volume value is large, the echo suppressor 14 is operated and an echo is suppressed reliably. If the volume value is small, the echo canceller 15 is operated and double talk is enabled.
摘要翻译：如果产生的音量变大，则尽管配置简单，但是可以适当地去除回声的回波消除装置。控制部分17响应于从音量操作部分18输入的音量值来切换回波抑制器14和回波消除器15的操作。如果音量值大，则回波抑制器14被操作并且可靠地抑制回波。如果音量值较小，则回波消除器15被操作，并且启用双方通话。

8. 发明申请

US20060052411A1 Pyridone derivatives having a binding activity to the cannabinoid type 2 receptor 失效
标题翻译：对大麻素2型受体具有结合活性的吡啶酮衍生物
公开(公告)号：US20060052411A1
公开(公告)日：2006-03-09
申请号：US11168640
申请日：2005-06-29
申请人： Yukio Tada , Yasuyoshi Iso , Kohji Hanasaki
发明人： Yukio Tada , Yasuyoshi Iso , Kohji Hanasaki
IPC分类号： A61K31/4745 , A61K31/4741 , A61K31/4415 , C07D491/02 , C07D487/02
CPC分类号： C07D213/69 , C07D213/70 , C07D213/75 , C07D213/82 , C07D215/227 , C07D215/38 , C07D215/54 , C07D217/22 , C07D217/26 , C07D221/10 , C07D221/16 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D455/02 , C07D455/06 , C07D471/04 , C07D491/04
摘要： It was found that the compound having a binding activity to the cannabinoid type 2 receptor represented by the formula (I): wherein R1 is a group represented by the formula: —Y1—Y2—Y3—Ra wherein Y1 is single bond or the like; Y2 is —C(═O)—NH— or the like; Y3 is optionally substituted aryl or the like; R2 is hydrogen or the like; R3 is alkyl or the like; R4 is alkyl or the like; R5 is optionally substituted alkyl or the like; or R3 and R4 taken together with the adjacent atom form cyclic group or the like.
摘要翻译：发现对由式（I）表示的大麻素2型受体具有结合活性的化合物：

9. 发明申请

US20050120865A1 Music session support method, musical instrument for music session, and music session support program 有权
标题翻译：音乐会议支持方式，音乐会乐器和音乐会议支持节目
公开(公告)号：US20050120865A1
公开(公告)日：2005-06-09
申请号：US11002427
申请日：2004-12-02
申请人： Yukio Tada
发明人： Yukio Tada
IPC分类号： G06F15/00 , G10H1/00 , A63F9/24 , A63F13/00 , G06F17/00 , G06F19/00
CPC分类号： G10H1/0058
摘要： A music session support method which enables each of players in a music session which is performed via a network to immediately recognize whether or not the other players are in the state of being able to participate in the session. A session support apparatus 10 transmits sets of status information indicative of whether or not each of players is in a state of being able to participate in a session, and player identification information which identifies the players, to each of session terminals 20. Each of the session terminals 20 which have received the sets of status information and player identification information causes a touch display 24 thereof to display the status information for each of the players. The session support apparatus 10 acquires a set of status transition information indicating that a player of at least one of the session terminals 20 in which the detecting device has detected the performance preparatory operation has gone into the state of being able to participate in a session, and player identification information for a session terminal 20, from the session terminal 20. The session support apparatus 10 transmits the acquired set of status transition information and player identification information to the session terminals 20. Each of the session terminals 20 updates contents displayed on the touch display 24 thereof, based upon the status transition information and player identification information transmitted from the session support apparatus 10.
摘要翻译：一种音乐会话支持方法，其使得经由网络执行的音乐会话中的每个玩家能够立即识别其他玩家是否处于能够参与该会话的状态。会话支持装置10发送指示每个玩家是否处于能够参加会话的状态的状态信息集合以及识别玩家的玩家识别信息给每个会话终端20.每个已经接收到状态信息和玩家识别信息的会话终端20使其触摸显示器24显示每个玩家的状态信息。会话支持装置10获取指示检测装置已经检测到演奏预备操作的会话终端20中的至少一个已经进入能够参加会话的状态的一组状态转换信息，以及来自会话终端20的会话终端20的播放器识别信息。会话支持装置10将获取的一组状态转换信息和玩家识别信息发送到会话终端20.每个会话终端20更新显示在基于从会话支持装置10发送的状态转移信息和玩家识别信息，触摸显示器24。

10. 发明授权

US4570587A Internal combustion engine 失效
标题翻译：内燃机
公开(公告)号：US4570587A
公开(公告)日：1986-02-18
申请号：US594162
申请日：1984-03-28
申请人： Yoshimi Watanabe , Yukio Tada , Takanori Suzuki , Hitoshi Suzuki
发明人： Yoshimi Watanabe , Yukio Tada , Takanori Suzuki , Hitoshi Suzuki
IPC分类号： F02B61/00 , F02B63/02 , F02B75/00 , F02B75/02 , F02B75/16 , F02F7/00 , F01B31/00
CPC分类号： F02B75/007 , F02B61/00 , F02B63/02 , F02B75/16 , F02F7/00 , F02B2075/027 , F02B2275/34 , Y10S123/06
摘要： An internal combustion engine includes a crank shaft having a crank web, a crank pin on one end of the crank web, and a weight on an opposite end of the crank web, a crank case supporting the crank shaft therein, a cylinder, a piston reciprocally fitted in the cylinder, a rod coupled to the piston by a piston pin and connecting the piston to the crank pin for reciprocally moving the piston in the cylinder, the crank case having an opening and extending obliquely to axes of the crank shaft and the cylinder. The cylinder has an end corresponding to a bottom dead center of the piston and having a first recess opening toward the opening, the first recess being of a size allowing the piston pin to pass therethrough when the piston is in the bottom dead center. The weight on the crank web has on one side a second recess of a shape defining with the end of the cylinder a space allowing the piston as disconnected from the rod to pass therethrough.
摘要翻译：一种内燃机，其特征在于，具备曲柄轴，曲柄腹板一端的曲柄销，曲柄腹板的另一端的曲柄轴，支承曲轴的曲轴箱，缸体，活塞往复安装在气缸中，杆通过活塞销连接到活塞，并将活塞连接到曲柄销，以使活塞在气缸中往复运动，曲轴箱具有开口并且倾斜地延伸到曲轴的轴线和圆筒。气缸具有对应于活塞的下死点的端部，并且具有朝向开口的第一凹部开口，当活塞处于下止点时，第一凹部具有允许活塞销穿过的尺寸。曲柄腹板上的重量在一侧具有形状为圆柱体端部的形状的第二凹槽，允许活塞与杆分离的空间通过。

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