专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5182284A Piperazine compounds, processes for preparation thereof and medical uses thereof 失效
标题翻译：哌嗪化合物，其制备方法及其医疗用途
公开(公告)号：US5182284A
公开(公告)日：1993-01-26
申请号：US761974
申请日：1991-09-25
申请人： Masahiro Suzuki , Kenji Nozaki , Makoto Kajitani , Mitsugi Yasumoto , Naohiko Ono , Takashi Shindo
发明人： Masahiro Suzuki , Kenji Nozaki , Makoto Kajitani , Mitsugi Yasumoto , Naohiko Ono , Takashi Shindo
IPC分类号： C07D295/084 , C07D295/125 , C07D295/13 , C07D295/185 , C07D317/60 , C07F9/6509
CPC分类号： C07D295/185 , C07D295/092 , C07D295/125 , C07D295/13 , C07D317/60 , C07F9/650958
摘要： Disclosed are a piperazine compound of the formula below or a pharmaceutically acceptable salt thereof, medical uses thereof, and processes for preparing the same: ##STR1## wherein each of R and R' is --OH, a lower alkoxy, a halo, H, a di(lower alkyl) hydrogenphosphate residue or a group --OR" (R" is an aralkyl group, etc.), etc., Y is --CH.dbd.CH-- or --(CH.sub.2).sub.m -- (m is 0, 1 or 2), and Y.sub.1 is a group of the formula ##STR2## (wherein A is --NH-- or --O--, A.sub.1 is a methylene or a carbonyl, n is 6-20, X is --OH, H or a lower alkoxycarbonyl, and X.sub.1 is an optionally halo-substituted phenyl or H) or a group of the formula ##STR3## (wherein X and n are as defined above), provided that when Y.sub.1 is the group of the formula (3), each of R and R' is an --OH group.

2. 发明授权

US4946951A 2'-deoxy-5-fluorouridine derivatives 失效
标题翻译： 2'-脱氧-5-氟尿苷衍生物
公开(公告)号：US4946951A
公开(公告)日：1990-08-07
申请号：US225984
申请日：1988-07-29
申请人： Yukio Tada , Atsuhiko Uemura , Mitsugi Yasumoto , Setsuo Takeda , Hitoshi Saito , Norio Unemi
发明人： Yukio Tada , Atsuhiko Uemura , Mitsugi Yasumoto , Setsuo Takeda , Hitoshi Saito , Norio Unemi
IPC分类号： B09B3/00 , A61K31/70 , B02C18/00 , C07H19/06 , C07H19/073
CPC分类号： C07H19/06
摘要： Disclosed is a 2'-deoxy-5-fluorouridine derivative of the formula ##STR1## wherein one of R.sub.1 and R.sub.2 is a benzyl group which may optionally have substituent selected from the group consisting of C.sub.1 -C.sub.6 alkyl group, C.sub.1 -C.sub.6 alkoxy group, C.sub.1 -C.sub.3 halogenated alkyl group, halogen atom, hydroxyl group and nitro group on the phenyl ring, and the other constitutes an amino acid residue, or a salt thereof. The compounds are useful for treating cancer.
摘要翻译：公开了式（CHEM）2分钟的脱氧-5-氟尿苷衍生物，其中R 1和R 2之一是可以任选具有选自C 1 -C 6烷基，C 1 -C 6烷氧基的取代基的苄基苯基环上的C1-C3卤代烷基，卤原子，羟基和硝基，另一个构成氨基酸残基或其盐。该化合物可用于治疗癌症。

3. 发明授权

US4886877A Novel 2'-deoxy-5-substituted uridine derivatives, processes for preparing the same and antitumor agent containing the same 失效
标题翻译：新的2'-脱氧-5-取代的尿苷衍生物，其制备方法和含有它们的抗肿瘤剂
公开(公告)号：US4886877A
公开(公告)日：1989-12-12
申请号：US163237
申请日：1988-02-26
申请人： Setsuro Fujii , Jun-ichi Yamashita , Hiroshi Matsumoto , Setsuo Takeda , Tadafumi Terada , Mitsugi Yasumoto , Norio Unemi
发明人： Setsuro Fujii , Jun-ichi Yamashita , Hiroshi Matsumoto , Setsuo Takeda , Tadafumi Terada , Mitsugi Yasumoto , Norio Unemi
IPC分类号： C07D405/04 , C07H19/06
CPC分类号： C07H19/06
摘要： Novel 2'-deoxy-5-substituted uridine derivative represented by the general formula, ##STR1## wherein R.sub.1 is a hydrogen atom, a benzoyl group or a tetrahydrofuranyl group; R.sub.2 is a fluorine atom or a trifluoromethyl group; and any one of R.sub.3 and R.sub.4 is a hydrogen atom and the other one is an alkyl group having 1 to 10 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, a benzyl group having as the substituents selected from the group consisting of a halogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms and a nitro group, or an alkyl group having 1 to 3 carbon atoms having one or two phenyl groups as the substituents.The novel 2'-deoxy-5-substituteduridine derivative possesses excellent antitumor activity with less toxicity, thus it is useful as antitumor agent.
摘要翻译：由通式表示的新型2'-脱氧-5-取代的尿苷衍生物，其中R1是氢原子，苯甲酰基或四氢呋喃基; R2是氟原子或三氟甲基; R 3和R 4中的任一个为氢原子，另一个为碳原子数1〜10的烷基，碳原子数为2〜6的烯基，作为取代基的苄基，选自卤原子，碳原子数为1〜4的烷基，碳原子数为1〜4的烷氧基，硝基，碳原子数为1〜3的烷基，具有一个或两个苯基作为取代基。新型2'-脱氧-5-取代尿苷衍生物具有优异的抗肿瘤活性，毒性低，因此可用作抗肿瘤剂。

4. 发明授权

US4581372A Sulfonium compounds 失效
标题翻译：锍化合物
公开(公告)号：US4581372A
公开(公告)日：1986-04-08
申请号：US541799
申请日：1983-10-14
申请人： Akihide Koda , Mikio Hori , Mitsugi Yasumoto , Ichiro Yamawaki , Yuji Yamada , Katsuo Takikawa
发明人： Akihide Koda , Mikio Hori , Mitsugi Yasumoto , Ichiro Yamawaki , Yuji Yamada , Katsuo Takikawa
IPC分类号： A61K31/34 , A61K31/341 , A61K31/35 , A61K31/351 , A61P35/00 , A61P37/04 , C07D307/10 , C07D309/04
CPC分类号： C07D307/10 , C07D309/04
摘要： Sulfonium compounds represented by the formula ##STR1## having immunostimulant activity and useful as the active components of drugs and agricultural chemicals.
摘要翻译：由式（I）表示的具有免疫刺激活性并可用作药物和农药活性成分的锍化合物。

5. 发明授权

US5206261A Oxindole derivative 失效
标题翻译： OXINDOLE DERIVATIVE
公开(公告)号：US5206261A
公开(公告)日：1993-04-27
申请号：US663960
申请日：1991-03-20
申请人： Akihiro Kawaguchi , Atsushi Sato , Makoto Kajitani , Mitsugi Yasumoto , Junji Yamamoto
发明人： Akihiro Kawaguchi , Atsushi Sato , Makoto Kajitani , Mitsugi Yasumoto , Junji Yamamoto
IPC分类号： A61K31/40 , A61K31/44 , C07D209/34 , C07D401/06 , C07D405/06
CPC分类号： C07D401/06 , C07D209/34 , C07D405/06
摘要： The present invention provides an oxindole derivative which has the following formula and is useful as medicaments for treating senile dementia, i.e., as cerebral function improving agents and cerebral metabolism activators or anoxic brain damage protectives ##STR1## wherein R.sup.1 is hydrogen atom, halogen atom, lower alkyl group or lower alkoxyl group, R.sup.2 is hydrogen atom or lower alkyl group, R.sup.3 is --CH.sub.2 --R.sup.5 group (R.sup.5 being alkyl group which may form a ring; benzodioxanyl group; or phenyl group which may have plural substituents selected from among halogen atom, lower alkyl group, lower alkoxyl group, hydroxyl group, diethylamino group, trifluoromethyl group, nitrile group, nitro group and benzyloxy group), R.sup.2 and R.sup.3 may form together .dbd.CH--R.sup.5 (R.sup.5 being same as above), R.sup.4 is 1-propylbutyl group; pyridyl group; or phenyl group which may be substituted by lower alkoxyl group, halogen atom, diethylamino group, benzyloxy group, trifluoromethyl group, nitrile group, nitro group or lower alkyl group.

6. 发明授权

US5447944A Carbamoyl-2-pyrrolidinone compounds 失效
标题翻译：氨基甲酰基-2-吡咯烷酮化合物
公开(公告)号：US5447944A
公开(公告)日：1995-09-05
申请号：US216244
申请日：1994-03-22
申请人： Makoto Kajitani , Etsuo Hasegawa , Akihiro Kawaguchi , Junji Yamamoto , Katsuo Toide , Takaji Honna , Mitsugi Yasumoto , Nobuo Kasahara
发明人： Makoto Kajitani , Etsuo Hasegawa , Akihiro Kawaguchi , Junji Yamamoto , Katsuo Toide , Takaji Honna , Mitsugi Yasumoto , Nobuo Kasahara
IPC分类号： C07D207/26 , C07D207/263 , C07D207/273 , C07D401/12 , C07D417/12 , A61K31/425 , A61K31/40 , A61K31/44 , C07D207/12
CPC分类号： C07D207/27 , C07D207/26 , C07D207/273 , C07D401/12 , C07D417/12
摘要： The present invention provides carbamoyl-2 -pyrrolidinone compounds useful as medicaments for improving cerebral functions and activating cerebral metabolism or protecting against anoxic brain damage.
摘要翻译：本发明提供了用作改善脑功能和激活脑代谢或防止缺氧性脑损伤的药物的氨基甲酰基-2-吡咯烷酮化合物。

7. 发明授权

US5318970A Isoxazole compounds, pharmaceutically acceptable salts thereof and medical uses thereof 失效
标题翻译：异恶唑化合物，其药学上可接受的盐及其医疗用途
公开(公告)号：US5318970A
公开(公告)日：1994-06-07
申请号：US844561
申请日：1993-03-17
申请人： Masahiro Suzuki , Kenji Nozaki , Makoto Kajitani , Mitsugi Yasumoto , Naohiko Ono , Takashi Shindo
发明人： Masahiro Suzuki , Kenji Nozaki , Makoto Kajitani , Mitsugi Yasumoto , Naohiko Ono , Takashi Shindo
IPC分类号： A61K31/42 , A61P29/00 , A61P37/08 , A61P43/00 , C07D261/08 , C07D413/12 , A61K31/495 , C07D413/06 , C07D413/14
CPC分类号： C07D413/10 , C07D261/08
摘要： A isoxazole compound represented by the formula (1): ##STR1## wherein R represents a hydrogen atom or a lower alkoxy group, R.sub.1 is a group represented by the formula (2): ##STR2## (wherein A represents --NH-- or --O--, B represents a methylene group or a carbonyl group, m is 0 or 1, n is an integer of 1 to 12, X represents a hydrogen atom, a hydroxy group or a lower alkoxycarbonyl group, Y represents a phenyl group which can be substituted with one or more halogen atoms, or a hydrogen atom), a group represented by the formula (3): ##STR3## (wherein Z represents a pyrimidinyl group), or a group represented by the formula (4): ##STR4## (wherein R.sub.2 represents a styryl group which can be substituted with one or more hydroxy groups); a pharmaceutically acceptable salt thereof; or a medical use thereof in a method of inhibiting lipoxygenase, inhibiting 5-lipoxygenase or inhibiting cyclooxygenase.
摘要翻译： PCT No.PCT / JP91 / 01253第 371日期1993年3月17日 102（e）1993年3月17日PCT PCT 1991年9月20日PCT公布。出版物WO92 / 05162 （1）表示的异恶唑化合物：其中R表示氢原子或低级烷氧基，R1表示式（2）表示的基团：（2）（其中A表示-NH-或-O-，B表示亚甲基或羰基，m表示0或1，n表示1〜12的整数，X表示氢原子，羟基或低级烷氧基羰基，Y表示可以被一个或多个卤素原子取代的苯基或氢原子），由式（3）表示的基团：其中Z表示嘧啶基基团）或由式（4）表示的基团：其中R 2表示可以被一个或多个羟基取代的苯乙烯基; 其药学上可接受的盐; 或其在抑制脂肪氧合酶，抑制5-脂肪氧合酶或抑制环加氧酶的方法中的医疗用途。

8. 发明授权

US5250673A 2'-deoxy-5-substituted uridine derivatives 失效
标题翻译： 2'-脱氧-5-取代的尿苷衍生物
公开(公告)号：US5250673A
公开(公告)日：1993-10-05
申请号：US422721
申请日：1989-10-17
申请人： Setsuro Fujii , Jun-ichi Yamashita , Hiroshi Matsumoto , Setsuo Takeda , Tadafumi Terada , Mitsugi Yasumoto , Norio Unemi
发明人： Setsuro Fujii , Jun-ichi Yamashita , Hiroshi Matsumoto , Setsuo Takeda , Tadafumi Terada , Mitsugi Yasumoto , Norio Unemi
IPC分类号： C07H19/06 , C07H19/073
CPC分类号： C07H19/06
摘要： Novel 2'-deoxy-5-substituted uridine derivative represented by the general formula, ##STR1## wherein R.sub.1 is a hydrogen atom, a benzoyl group or a tetrahydrofuranyl group; R.sub.2 is a fluorine atom or a trifluoromethyl group; and any one of R.sub.3 and R.sub.4 is a hydrogen atom and the other one is an alkyl group having 1 to 10 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, a benzyl group having as the substituents selected from the group consisting of a halogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms and a nitro group, or an alkyl group having 1 to 3 carbon atoms having one or two phenyl groups as the substituents.The novel 2'-deoxy-5-substituteduridine derivative possesses excellent antitumor activity with less toxicity, thus it is useful as antitumor agent.
摘要翻译：由通式表示的新型2'-脱氧-5-取代的尿苷衍生物，其中R1是氢原子，苯甲酰基或四氢呋喃基; R2是氟原子或三氟甲基; R 3和R 4中的任一个为氢原子，另一个为碳原子数1〜10的烷基，碳原子数为2〜6的烯基，作为取代基的苄基，选自卤原子，碳原子数为1〜4的烷基，碳原子数为1〜4的烷氧基，硝基，碳原子数为1〜3的烷基，具有一个或两个苯基作为取代基。新型2'-脱氧-5-取代尿苷衍生物具有优异的抗肿瘤活性，毒性低，因此可用作抗肿瘤剂。

9. 发明授权

US5229402A Carbamoyl-2-pyrrolidinone compounds 失效
标题翻译：卡巴酸-2-吡咯烷酮化合物
公开(公告)号：US5229402A
公开(公告)日：1993-07-20
申请号：US449923
申请日：1989-12-13
申请人： Makoto Kajitani , Etsuo Hasegawa , Akihiro Kawaguchi , Junji Yamamoto , Katsuo Toide , Takaji Honna , Mitsugi Yasumoto , Nobuo Kasahara
发明人： Makoto Kajitani , Etsuo Hasegawa , Akihiro Kawaguchi , Junji Yamamoto , Katsuo Toide , Takaji Honna , Mitsugi Yasumoto , Nobuo Kasahara
IPC分类号： C07D207/26 , C07D207/263 , C07D207/273 , C07D401/12 , C07D417/12
CPC分类号： C07D207/27 , C07D207/26 , C07D207/273 , C07D401/12 , C07D417/12
摘要： The present invention provides a carbamoyl-2-pyrrolidinone compound which has the following formula (2) and is useful as medicaments for treating senile dementia, i.e., as cerebral function improving agents and cerebral metabolism activators or anoxic brain damage protectives ##STR1## wherein R.sup.1 is a hydrogen atom, hydroxyl or lower alkyl substituted or unsubstituted with hydroxyl, and R.sup.3 is phenyl, tetrahydronaphthyl, pyridyl or thiazolyl having or not having lower alkoxyl, lower alkylamino, a halogen atom or halogenomethyl as a substituent.Further, the present invention provides novel carbamoyl-2-pyrrolidinone compounds represented by the formula ##STR2## wherein R.sup.1 is a hydrogen atom, hydroxyl or lower alkyl substituted or unsubstituted with hydroxyl, and R.sup.2 is phenyl, tetrahydronaphthyl, pyridyl or thiazolyl having or not having methoxy or lower alkylamino as a substituent, provided that when R.sup.1 is a hydrogen atom or unsubstituted lower alkyl, R.sup.2 is not unsubstituted phenyl.
摘要翻译： PCT No.PCT / JP89 / 00401 Sec。 371日期1989年12月13日第 102（e）日期1989年12月13日PCT提交1989年4月12日PCT公布。公开号WO89 / 09767 本发明提供具有下式（2）的氨基甲酰基-2-吡咯烷酮化合物，可用作治疗老年痴呆的药物，即作为脑功能改善剂和脑代谢激活剂或缺氧性脑（2）其中R1是氢原子，羟基或被羟基取代或未取代的低级烷基，R3是具有或没有低级烷氧基，低级烷基氨基，卤原子或卤代甲基的苯基，四氢萘基，吡啶基或噻唑基作为取代基。此外，本发明提供由式（1）表示的新型氨基甲酰基-2-吡咯烷酮化合物，其中R 1是氢原子，羟基或被羟基取代或未取代的低级烷基，R 2是苯基，四氢萘基，吡啶基或噻唑基具有或不具有甲氧基或低级烷基氨基作为取代基，条件是当R 1为氢原子或未取代的低级烷基时，R 2为未取代的苯基。

10. 发明授权

US4696929A Derivative of piperazine having anti-allergic and anti-inflammatory action 失效
标题翻译：具有抗过敏和抗炎作用的哌嗪衍生物
公开(公告)号：US4696929A
公开(公告)日：1987-09-29
申请号：US809876
申请日：1985-12-17
申请人： Ichiro Yamawaki , Kazuo Ogawa , Naohiko Ono , Takaji Honna , Sekio Nagayama , Mitsugi Yasumoto
发明人： Ichiro Yamawaki , Kazuo Ogawa , Naohiko Ono , Takaji Honna , Sekio Nagayama , Mitsugi Yasumoto
IPC分类号： C07D405/12 , A61K31/495 , A61P29/00 , A61P37/08 , A61P43/00 , C07D209/28 , C07D403/12 , C07F7/18 , C12N9/99
CPC分类号： C07D209/28 , Y02P20/55
摘要： A piperazine derivative represented by the formula (I) below ##STR1## wherein R.sup.1 is lower alkyl or phenyl, R.sup.2 is hydrogen or lower alkyl, n is an integer of 2 to 10, is useful as an effective component of anti-inflammatory agent or antiallergic agent.
摘要翻译：由下式（I）表示的哌嗪衍生物，其中R 1为低级烷基或苯基，R 2为氢或低级烷基，n为2至10的整数，可用作抗 - 抗炎剂或抗过敏剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式