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    • 9. 发明授权
    • Production of dyed polymer microparticles
    • 染色聚合物微粒的生产
    • US06964747B2
    • 2005-11-15
    • US10348123
    • 2003-01-21
    • Sukanta BanerjeeCecilia GeorgescuEric S. DanielsVictoria L. DimonieMichael Seul
    • Sukanta BanerjeeCecilia GeorgescuEric S. DanielsVictoria L. DimonieMichael Seul
    • B01J13/02D06P3/52
    • D06P1/90C08J3/215D06P1/908D06P1/92D06P1/922D06P1/924D06P1/926D06P1/928Y10T428/2987Y10T428/2989
    • A dye, such as a fluorescent dye, is incorporated into polymer microparticles using a solvent system composed of a first solvent in which the dye and the microparticle polymer are soluble, a second solvent in which the dye and the microparticle polymer are not or only weakly soluble, and a third solvent in which the dye and the microparticle polymer are not or only weakly soluble. The first and second solvents are immiscible with each other, or at most partially miscible. The third solvent is miscible with the first and second solvents. The formulation provides substantially complete partitioning of the dye to the microparticles. The method may be used to obtain dyed polymer microparticle formed of cross-linked or non-cross-linked polymers. Libraries are provided comprising two or more sets of microparticles of different dye loadings. Fluorescent core-shell microparticles are produced from a mixture of microparticle cores incorporating one or more fluorescent dyes, a polymerization mixture comprising at least one polymerizable shell monomer, at least one free radical polymerization initiator comprising a water-insoluble oxidizing agent, and at least one water-soluble reducing agent.
    • 使用由可溶于染料和微粒聚合物的第一溶剂构成的溶剂体系将染料,例如荧光染料引入聚合物微粒中,染料和微粒聚合物不是或仅仅是弱的第二溶剂 和其中染料和微粒聚合物不是或仅仅是弱溶解的第三溶剂。 第一和第二溶剂彼此不混溶,或最多部分混溶。 第三溶剂与第一溶剂和第二溶剂混溶。 该制剂提供染料基本上完全分配到微粒。 该方法可用于获得由交联或非交联聚合物形成的染色聚合物微粒。 提供包括两组或更多组不同染料负载的微粒子的文库。 荧光核壳微粒由掺入一种或多种荧光染料的微粒核心,包含至少一种可聚合壳单体的聚合混合物,至少一种包含水不溶性氧化剂的自由基聚合引发剂和至少一种 水溶性还原剂。
    • 10. 发明申请
    • Method for controlling solute loading of polymer microparticles
    • 控制聚合物微粒溶质负载的方法
    • US20050246844A1
    • 2005-11-10
    • US11179135
    • 2005-07-12
    • Sukanta BanerjeeCecilia GeorgescuMichael Seul
    • Sukanta BanerjeeCecilia GeorgescuMichael Seul
    • C08J3/215A61K7/021A61K9/16A61K9/50
    • C08J3/212C08J3/215C08J3/22C08J2325/08
    • Solute-loaded polymer microparticles are obtained by immersing microparticles in a bath comprising a selected solute dissolved in a ternary solvent system. A first solvent of the ternary system is a strong solvent for both the solute and the polymer from which the microparticle was formed. A second solvent is a weak solvent or non-solvent for the solute and the polymer (tuning solvent). A third solvent is a weak solvent or non-solvent for the solute and polymer, but serves as a co-solvent with respect to the first and second solvents in that it is miscible with both the first and second solvents. The amount of solute incorporated into the microparticles is controlled by adjusting the ratio of solute with respect to the microparticle polymer, and by adjusting the composition of the ternary solvent system, principally the amount of tuning solvent. The method is particularly useful for providing libraries of combinatorially encoded microparticles containing distinguishable dye loadings, particularly distinguishable fluorescent dye loadings.
    • 通过将微粒浸入包含溶解在三元溶剂系统中的选定溶质的浴中来获得溶质负载的聚合物微粒。 三元体系的第一溶剂是溶质和形成微粒的聚合物的强溶剂。 第二溶剂是用于溶质和聚合物(调谐溶剂)的弱溶剂或非溶剂。 第三溶剂是用于溶质和聚合物的弱溶剂或非溶剂,但是作为相对于第一和第二溶剂的共溶剂,因为其可与第一溶剂和第二溶剂混溶。 通过调节溶质相对于微粒聚合物的比例,调节三元溶剂体系的组成,主要是调谐溶剂的量来控制掺入到微粒中的溶质的量。 该方法对于提供包含可区分的染料负载,特别是可区分的荧光染料负载的组合编码的微粒的文库是特别有用的。