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1. 发明申请

US20070259116A1 Partially coated workpiece and method of making same 审中-公开
标题翻译：部分涂层工件及其制作方法
公开(公告)号：US20070259116A1
公开(公告)日：2007-11-08
申请号：US11415111
申请日：2006-05-02
申请人： Robert Nolan , Dave McMorrow , Timothy O'Connor , Barry Heaney , Aiden Flanagan , Anthony Malone , James McGovern
发明人： Robert Nolan , Dave McMorrow , Timothy O'Connor , Barry Heaney , Aiden Flanagan , Anthony Malone , James McGovern
IPC分类号： B05D1/32
CPC分类号： B05D1/32 , B05D7/22 , B05D2254/02 , B05D2254/04 , B05D2254/06 , B05D2258/00 , B05D2701/00
摘要： The present invention is directed to methods and processes for coating portions of a workpiece as well as to workpieces that have themselves been coated with one or more of these processes. Under these methods and processes a masking material may be positioned over a portion of a workpiece prior to applying coating to the workpiece. Once the coating is applied this masking may be removed to expose a portion of the workpiece that has not been coated.
摘要翻译：本发明涉及用于涂覆工件的部分以及已经用这些工艺中的一种或多种涂覆的工件的方法和工艺。在这些方法和方法下，在将涂层施加到工件之前，掩模材料可以被定位在工件的一部分上方。一旦施加涂层，可以去除该掩模以暴露未被涂覆的工件的一部分。

2. 发明申请

US20070259114A1 Partially coated workpieces and method and system for making the same 审中-公开
标题翻译：部分涂层工件及其制造方法和系统
公开(公告)号：US20070259114A1
公开(公告)日：2007-11-08
申请号：US11415109
申请日：2006-05-02
申请人： Anthony Malone , Dave McMorrow , Barry Heaney , Timothy O'Connor , Aiden Flanagan
发明人： Anthony Malone , Dave McMorrow , Barry Heaney , Timothy O'Connor , Aiden Flanagan
IPC分类号： A61L33/00 , B05D3/12 , B05D3/00 , B05D3/10
CPC分类号： B05D1/002 , A61L31/16 , A61L2300/606 , A61L2420/02 , B05D1/32 , B05D3/101 , B05D3/102 , B05D3/104 , B05D3/12 , B05D3/14
摘要： The present invention is directed to methods, processes, and systems for coating portions of a workpiece as well as to workpieces that have themselves been coated in accord with the invention. Under these methods and processes of the invention, a workpiece may be rotated to drive coating away from a non-target surface. In some embodiments, surfaces of the workpiece may be pre-treated. Still further, in accord with the embodiments of the present invention, the workpiece may be positioned in a treatment chamber. In still other embodiments, the workpiece may be an implantable medical device and the coating may include a therapeutic.
摘要翻译：本发明涉及用于涂覆工件的部分以及本身已经根据本发明进行了涂覆的工件的方法，工艺和系统。在本发明的这些方法和方法下，可以旋转工件以驱动涂层远离非目标表面。在一些实施例中，可以对工件的表面进行预处理。此外，根据本发明的实施例，工件可以位于处理室中。在其它实施例中，工件可以是可植入医疗装置，并且涂层可以包括治疗剂。

3. 发明授权

US08182859B2 Using magnetism to prepare a medical device 失效
标题翻译：用磁性制备医疗器械
公开(公告)号：US08182859B2
公开(公告)日：2012-05-22
申请号：US12057135
申请日：2008-03-27
申请人： Liliana Atanasoska , Aiden Flanagan , Timothy O'Connor , David McMorrow , Robert Nolan , Anthony Malone , Jan Weber
发明人： Liliana Atanasoska , Aiden Flanagan , Timothy O'Connor , David McMorrow , Robert Nolan , Anthony Malone , Jan Weber
IPC分类号： A61L33/00
CPC分类号： B05B5/00 , A61F2/91 , A61F2210/009 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/60 , A61L2300/62 , B05C3/09 , B05D1/18 , B05D1/32 , B05D3/207 , B05D2401/32
摘要： The present invention is directed to methods, processes, and systems for delivering therapeutic agent to a medical device. Under some methods, processes, and systems of the invention, particles including a magnetic material and a therapeutic agent may be directed towards a medical device via magnetic attraction. In another embodiment particles including a magnetic material may force a therapeutic agent/solvent solution into porous matrix by using a magnetic attraction. In still another embodiment, a medical device having at least a portion thereof including a magnetic material is used to attract and adhere particles comprising magnetic material and therapeutic agent to a target surface of the medical device, wherein the particles are fused to the target surface.
摘要翻译：本发明涉及将治疗剂递送到医疗装置的方法，过程和系统。在一些方法下，本发明的方法和系统，包括磁性材料和治疗剂的颗粒可以通过磁吸引而引向医疗装置。在另一个实施方案中，包括磁性材料的颗粒可以通过使用磁吸引剂将治疗剂/溶剂溶液强制成多孔基质。在另一个实施例中，使用包括磁性材料的至少其一部分的医疗装置将包含磁性材料和治疗剂的颗粒吸附并附着到医疗装置的靶表面上，其中所述颗粒与目标表面融合。

4. 发明授权

US08263171B2 Methods for making drug-eluting medical devices 失效
标题翻译：药物洗脱医疗器械的制备方法
公开(公告)号：US08263171B2
公开(公告)日：2012-09-11
申请号：US12170889
申请日：2008-07-10
申请人： John T. Clarke , Timothy O'Connor
发明人： John T. Clarke , Timothy O'Connor
IPC分类号： A61L27/54
CPC分类号： B05D5/00 , A61F2/91 , A61F2210/0076 , A61F2240/001 , A61F2250/0023 , A61F2250/0067
摘要： The present invention is directed to medical implants that are configured to controllably release therapeutic agent to a target site of a patient and methods of making these implants. Embodiments of the present invention may include a method comprising the steps of providing a tube having a wall with inner and outer surfaces and defining a passageway, forming an opening through the wall of the tube, applying a porous coating layer to at least one of the inner and outer surfaces of the tube, and loading a therapeutic agent solution into the passageway so that therapeutic agent passes through the opening and into the porous coating layer. The method may also include removing portions of the tube to form the implantable medical device, which may be a stent.
摘要翻译：本发明涉及被配置为将治疗剂可控地释放到患者的靶位点的医疗植入物和制造这些植入物的方法。本发明的实施例可以包括一种方法，包括以下步骤：提供具有内壁和外表面的壁的管，并限定通道，形成穿过管壁的开口，将多孔涂层施加到至少一个管的内表面和外表面，并将治疗剂溶液装载到通道中，使得治疗剂通过开口并进入多孔涂层。该方法还可以包括去除管的部分以形成可植入的医疗装置，其可以是支架。

5. 发明申请

US20090017188A1 METHODS FOR MAKING DRUG-ELUTING MEDICAL DEVICES 失效
标题翻译：制造药物治疗设备的方法
公开(公告)号：US20090017188A1
公开(公告)日：2009-01-15
申请号：US12170889
申请日：2008-07-10
申请人： John T. Clarke , Timothy O'Connor
发明人： John T. Clarke , Timothy O'Connor
IPC分类号： A61L27/54
CPC分类号： B05D5/00 , A61F2/91 , A61F2210/0076 , A61F2240/001 , A61F2250/0023 , A61F2250/0067
摘要： The present invention is directed to medical implants that are configured to controllably release therapeutic agent to a target site of a patient and methods of making these implants. Embodiments of the present invention may include a method comprising the steps of providing a tube having a wall with inner and outer surfaces and defining a passageway, forming an opening through the wall of the tube, applying a porous coating layer to at least one of the inner and outer surfaces of the tube, and loading a therapeutic agent solution into the passageway so that therapeutic agent passes through the opening and into the porous coating layer. The method may also include removing portions of the tube to form the implantable medical device, which may be a stent.
摘要翻译：本发明涉及被配置为将治疗剂可控地释放到患者的靶位点的医疗植入物和制造这些植入物的方法。本发明的实施例可以包括一种方法，包括以下步骤：提供具有内壁和外表面的壁的管，并限定通道，形成穿过管壁的开口，将多孔涂层施加到至少一个管的内表面和外表面，并将治疗剂溶液装载到通道中，使得治疗剂通过开口并进入多孔涂层。该方法还可以包括去除管的部分以形成可植入的医疗装置，其可以是支架。

6. 发明申请

US20070281072A1 Coating a workpiece using a metering device and workpieces coated with this metering device 审中-公开
标题翻译：使用计量装置和涂有该计量装置的工件涂覆工件
公开(公告)号：US20070281072A1
公开(公告)日：2007-12-06
申请号：US11447175
申请日：2006-06-06
申请人： Timothy O'Connor , Gabriel Sobrino , Liam Ward
发明人： Timothy O'Connor , Gabriel Sobrino , Liam Ward
IPC分类号： A61L33/00 , B05D3/12
CPC分类号： B05D1/28 , B05C11/025 , B05D1/002
摘要： The present invention is directed to methods, processes, and systems for selectively coating portions of a workpiece as well as to workpieces that have themselves been coated in accord with the invention. Under methods and processes of the invention, a target surface of a workpiece may be positioned in contact with a roller to coat a target surface of the workpiece. In some embodiments, the roller may also be positioned in contact with a metering device during portions or all of the treating and coating process. The workpiece may be an implantable medical device and the coating may include therapeutic, the workpiece may be other devices as well.
摘要翻译：本发明涉及用于选择性地涂覆工件的部分以及本身已经根据本发明进行了涂覆的工件的方法，工艺和系统。在本发明的方法和方法下，工件的目标表面可以定位成与辊接触以涂覆工件的目标表面。在一些实施例中，在处理和涂覆过程的部分或全部期间，辊也可以定位成与计量装置接触。工件可以是可植入医疗装置，并且涂层可以包括治疗剂，工件也可以是其它装置。

7. 发明申请

US20070100428A1 Multiple-wing balloon catheter and membrane to reduce damage to coated expandable medical implants 审中-公开
标题翻译：多翼气囊导管和膜，以减少涂层可扩展医疗植入物的损伤
公开(公告)号：US20070100428A1
公开(公告)日：2007-05-03
申请号：US11634160
申请日：2006-12-06
申请人： Tom Mc Hale , Jan Weber , Timothy O'Connor
发明人： Tom Mc Hale , Jan Weber , Timothy O'Connor
IPC分类号： A61F2/06
CPC分类号： A61M25/1027 , A61F2/958 , A61F2250/0067 , A61M25/1002 , A61M25/1038 , A61M2025/1004
摘要： System for reducing the damage to a coated medical implant during the expansion of the coated implant is provided. The system may include a coated medical implant, a multi-wing balloon catheter having at least four expandable wings, and an expandable membrane positioned between the balloon and the medical implant.
摘要翻译：提供了用于在涂覆的植入物的膨胀期间减少涂覆的医疗植入物的损伤的系统。该系统可以包括涂覆的医疗植入物，具有至少四个可膨胀翼的多翼气囊导管，以及位于球囊和医疗植入物之间的可扩张膜。

8. 发明授权

US6013781A Semaphorin gene family 失效
公开(公告)号：US6013781A
公开(公告)日：2000-01-11
申请号：US833391
申请日：1997-04-08
申请人： Corey S. Goodman , Alex L. Kolodkin , David Matthes , David R. Bentley , Timothy O'Connor
发明人： Corey S. Goodman , Alex L. Kolodkin , David Matthes , David R. Bentley , Timothy O'Connor
IPC分类号： A01K67/027 , A01K67/033 , A61K38/00 , A61K39/395 , A61P25/00 , A61P31/12 , A61P35/00 , A61P37/00 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/07 , C07K14/435 , C07K14/47 , C07K14/705 , C07K16/18 , C12N5/10 , C12N15/09 , C12N15/85 , C12P21/02 , C12Q1/00 , C12Q1/68 , C12R1/91 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , C12N15/11
CPC分类号： C12N15/8509 , A01K67/0339 , C07K14/005 , C07K14/4703 , C07K14/705 , A01K2217/05 , A01K2217/075 , A01K2267/01 , A01K2267/03 , A01K2267/0318 , A61K38/00 , C12N2710/24122
摘要： A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.

9. 发明授权

US5639856A Semaphorin gene family 失效
标题翻译：信号素基因家族
公开(公告)号：US5639856A
公开(公告)日：1997-06-17
申请号：US121713
申请日：1993-09-13
申请人： Corey S. Goodman , Alex L. Kolodkin , David Matthes , David R. Bentley , Timothy O'Connor
发明人： Corey S. Goodman , Alex L. Kolodkin , David Matthes , David R. Bentley , Timothy O'Connor
IPC分类号： A01K67/027 , A01K67/033 , A61K38/00 , A61K39/395 , A61P25/00 , A61P31/12 , A61P35/00 , A61P37/00 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/07 , C07K14/435 , C07K14/47 , C07K14/705 , C07K16/18 , C12N5/10 , C12N15/09 , C12N15/85 , C12P21/02 , C12Q1/00 , C12Q1/68 , C12R1/91 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , A61K38/04 , A61K38/16 , C07K14/005
CPC分类号： C12N15/8509 , A01K67/0339 , C07K14/005 , C07K14/4703 , C07K14/705 , A01K2217/05 , A01K2217/075 , A01K2267/01 , A01K2267/03 , A01K2267/0318 , A61K38/00 , C12N2710/24122
摘要： A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.
摘要翻译：公开了一类新颖的蛋白质，信号素，编码信号素的核酸，信号素肽，以及使用信号素和信号素编码核酸的方法。信号肽和受体激动剂和拮抗剂提供神经细胞生长和再生的有效调节剂。本发明提供药物组合物，用于筛选细胞生长/分化调节物的化学文库的方法; 用于遗传作图的信号素基因衍生的核酸，作为相关基因的探针，以及作为遗传神经疾病的诊断试剂; 特异性细胞和动物系统用于神经疾病治疗的发展。

10. 发明授权

US10152723B2 Methods and systems for identifying new computers and providing matching services 有权
公开(公告)号：US10152723B2
公开(公告)日：2018-12-11
申请号：US13478998
申请日：2012-05-23
申请人： Craig Warner , Timothy O'Connor , Alexander Ross
发明人： Craig Warner , Timothy O'Connor , Alexander Ross
IPC分类号： G06Q30/02
摘要： A method of providing services to computing devices includes establishing a connection over the Internet with a computing device; receiving data from the computing device during the connection; extracting a signal from the data received from the computing device; estimating a relative age of the computing device based on the extracted signal; selecting a service from a plurality of services based on the estimated relative age of the computing device; and providing the selected service to the computing device.

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