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1. 发明授权

US4190656A Uracil derivatives and production thereof 失效
标题翻译：尿嘧啶衍生物及其生产
公开(公告)号：US4190656A
公开(公告)日：1980-02-26
申请号：US944769
申请日：1978-09-22
申请人： Koichi Matsumura , Osamu Miyashita , Hiroshi Shimadzu , Naoto Hashimoto
发明人： Koichi Matsumura , Osamu Miyashita , Hiroshi Shimadzu , Naoto Hashimoto
IPC分类号： A61K31/505 , A61P31/12 , A61P35/00 , A61P35/02 , C07D233/90 , C07D239/22 , C07D333/00 , C07D401/12 , C07D405/12 , C07D409/12 , C07D239/10
CPC分类号： C07D239/22 , Y10S514/908
摘要： New compounds of the formula ##STR1## (wherein R.sub.1 represents a lower alkyl group: and ##STR2## represents an alkylidene radical in which at least one of R.sub.2 and R.sub.3 is a lower alkyl which may optionally be substituted by phenyl, phenyl or a 5- or 6-membered aromatic ring including S, N or O, and the remainder, if any, is hydrogen; ora cycloalkylidene radical of up to six carbon atoms, to which a benzene ring may optionally be fused).These compounds are produced by reacting the corresponding 6-acyloxy compounds with a compound of the formula ##STR3## The new compounds have antiviral activity and are useful to prolong the life spans of tumor-bearing animals.
摘要翻译：式（IMAGE）的新化合物（其中R 1表示低级烷基：＆lt; IMAGE＆gt;代表亚烷基，其中R 2和R 3中的至少一个为可任意被苯基，苯基或5 - 或6元芳环，其余的（如果有的话）是氢;或至多6个碳原子的亚环烷基，苯环可以任选地被稠合）。这些化合物通过使相应的6-酰氧基化合物与下式化合物反应来制备。新化合物具有抗病毒活性并且可用于延长荷瘤动物的寿命。

2. 发明授权

US4329460A Uracil derivatives and production thereof 失效
标题翻译：尿嘧啶衍生物及其生产
公开(公告)号：US4329460A
公开(公告)日：1982-05-11
申请号：US48169
申请日：1979-06-13
申请人： Osamu Miyashita , Koichi Matsumura , Hiroshi Shimadzu , Naoto Hashimoto
发明人： Osamu Miyashita , Koichi Matsumura , Hiroshi Shimadzu , Naoto Hashimoto
IPC分类号： A61K31/513 , A61P35/00 , C07C273/18 , C07C275/20 , C07C275/50 , C07D239/22 , C07D239/54 , C07D239/553 , C07D239/557 , C07D405/04 , C07F7/18 , A61K31/515 , C07D401/04 , C07D401/06
CPC分类号： C07F7/1856 , C07C273/1854 , C07D239/22 , C07D239/553 , C07D239/557
摘要： New derivatives of the formula: ##STR1## (wherein X is O or NH; R.sub.1 is --OH which may optionally be etherified or esterified, etherified mercapto or --NH.sub.2 which may optionally be substituted; R.sub.2 and R.sub.3, respectively, mean H, lower alkyl or ##STR2## and Y is an esterified or amidated carboxyl group, or CN). These derivatives are produced, by fluorination of corresponding 1,2,3,4-tetrahydro-2,4-dioxopyrimidine compounds and can be converted into 5-fluorouracil derivatives under hydrolytic conditions. The new derivatives are able to prolong the lives of animals having carcinomas or have antiviral activity.
摘要翻译：式中的新衍生物：其中X为O或NH; R 1为-OH，其可任选被醚化或酯化，醚化巯基或可任选被取代的-NH 2; R 2和R 3分别表示H，低级烷基或，Y是酯化或酰胺化的羧基，或CN）。这些衍生物通过相应的1,2,3,4-四氢-2,4-二氧嘧啶化合物的氟化生产，并且可以在水解条件下转化为5-氟尿嘧啶衍生物。新的衍生物能够延长具有癌症或具有抗病毒活性的动物的生命。

3. 发明授权

US4207324A 1,2-Di-Substituted-4-haloimidazole-5-acetic acid derivatives and their use 失效
标题翻译： 1,2-二取代-4-卤代咪唑-5-乙酸衍生物及其用途
公开(公告)号：US4207324A
公开(公告)日：1980-06-10
申请号：US36645
申请日：1979-05-07
申请人： Koichi Matsumura , Naoto Hashimoto , Yoshiyasu Furukawa
发明人： Koichi Matsumura , Naoto Hashimoto , Yoshiyasu Furukawa
IPC分类号： A61K31/415 , A61P7/10 , A61P9/12 , C07D233/68 , C07D333/00 , C07D405/04 , C07D409/04
CPC分类号： C07D233/68 , Y10S514/87
摘要： Novel imidazole derivatives of the formula ##STR1## wherein R.sup.1 is hydrogen, nitro or amino, R.sup.2 is a phenyl, furyl or thieyl group which may be substituted by halogen, lower alkyl, lower alkoxy or di-lower-alkylamino, R.sup.3 is hydrogen or lower alkyl and X is halogen, and their physiologically acceptable salts, have excellent diuretic and hypotensive actions.
摘要翻译：其中R 1为氢，硝基或氨基，R 2为可被卤素，低级烷基，低级烷氧基或二低级烷基氨基取代的苯基，呋喃基或甲硫基，R3为氢或低级烷基，X为卤素，其生理学上可接受的盐具有优异的利尿和降血压作用。

4. 发明授权

US3959345A Production of maleonitrile 失效
标题翻译：生产马来腈
公开(公告)号：US3959345A
公开(公告)日：1976-05-25
申请号：US545395
申请日：1975-01-30
申请人： Katsura Morita , Naoto Hashimoto , Koichi Matsumura
发明人： Katsura Morita , Naoto Hashimoto , Koichi Matsumura
IPC分类号： C07C255/09 , C07C20060101 , C07C67/00 , C07C253/00 , C07C120/00
CPC分类号： C07C253/10
摘要： Maleonitrile is obtained as a dominant product of the reaction between cyanoacetylene and hydrogen cyanide. The yield of maleonitrile is remarkably higher than that in any of known processes.
摘要翻译：获得了作为氰乙炔和氰化氢反应的主要产物的马来腈。马来腈的产率明显高于任何已知方法。

5. 发明授权

US4424219A 9-Thiomaytansinoids and their pharmaceutical compositions and use 失效
标题翻译： 9-Thiomaytansinoids及其药物组合物和用途
公开(公告)号：US4424219A
公开(公告)日：1984-01-03
申请号：US374158
申请日：1982-05-03
申请人： Naoto Hashimoto , Hiroshi Shimadzu
发明人： Naoto Hashimoto , Hiroshi Shimadzu
IPC分类号： A01N43/90 , A61K31/535 , A61P31/04 , A61P33/02 , A61P35/00 , C07D498/18 , C07D498/06
CPC分类号： C07D498/18 , Y10S514/908
摘要： This invention relates to 9-thiomaytansinoid compounds represented by the formula ##STR1## wherein R is hydrogen or acyl derived from a carboxylic acid, X is chlorine or hydrogen, Y is hydrogen, lower alkylsulfonyl, or alkyl or aralkyl which are unsubstituted or substituted, and methods of producing the same. The compounds are useful as antitumor, antiprotozoal and antifungal agents.
摘要翻译：本发明涉及由下式表示的9-硫代麦芽糖类化合物：其中R为氢或衍生自羧酸的酰基，X为氯或氢，Y为氢，低级烷基磺酰基或未取代或取代的烷基或芳烷基，及其制造方法。该化合物可用作抗肿瘤剂，抗原生动物剂和抗真菌剂。

6. 发明授权

US4914206A Lankacidin derivatives and production thereof 失效
标题翻译：兰卡杀菌素衍生物及其制备
公开(公告)号：US4914206A
公开(公告)日：1990-04-03
申请号：US285302
申请日：1988-12-15
申请人： Isao Minamida , Naoto Hashimoto
发明人： Isao Minamida , Naoto Hashimoto
IPC分类号： C07D493/08 , C07D405/04
CPC分类号： C07D493/08
摘要： The present invention provides lankacidin derivatives of the formula ##STR1## and procedures for the production thereof. The lankacidin derivatives [1] show excellent antimicrobial activities and thus can be used for prophylaxis and treatment of infectious disease in animals.
摘要翻译：本发明提供式[1]的兰卡一啶衍生物及其生产方法。兰卡杀菌素衍生物[1]显示出优异的抗菌活性，因此可用于预防和治疗动物感染性疾病。

7. 发明授权

US5272180A Cell proliferation inhibitor 失效
标题翻译：细胞增殖抑制剂
公开(公告)号：US5272180A
公开(公告)日：1993-12-21
申请号：US906304
申请日：1992-05-08
申请人： Naoto Hashimoto , Kaneyoshi Kato , Yoshio Kozai
发明人： Naoto Hashimoto , Kaneyoshi Kato , Yoshio Kozai
IPC分类号： A61K31/165 , A61K31/38 , C07D333/24 , A61K31/19
CPC分类号： A61K31/165 , A61K31/38 , C07D333/24
摘要： A compound of the formula: ##STR1## wherein, R.sup.1 and R.sup.2 are the same or different/representing methyl or methoxy groups, or form --CH.dbd.CH--CH.dbd.CH-- by binding to each other; R.sup.3 is an aromatic group or a heterocyclic group which may be substituted; and n is an integer of 2 to 8, shows inhibitory effect of cell proliferation and is useful as cell proliferation inhibitor.
摘要翻译：下式的化合物：其中，R1和R2相同或不同，表示甲基或甲氧基，或通过彼此结合形成-CH = CH-CH = CH-; R3是可以被取代的芳基或杂环基; n为2〜8的整数，显示细胞增殖的抑制作用，可用作细胞增殖抑制剂。

8. 发明授权

US10792588B2 Organic material production system using biomass material and method 有权
公开(公告)号：US10792588B2
公开(公告)日：2020-10-06
申请号：US12865273
申请日：2008-09-19
申请人： Minoru Genta , Ryosuke Uehara , Kinya Fujita , Tsuyoshi Sakaki , Noriyuki Yamada , Katsuichi Saito , Naoto Hashimoto , Yasuhiro Hasa
发明人： Minoru Genta , Ryosuke Uehara , Kinya Fujita , Tsuyoshi Sakaki , Noriyuki Yamada , Katsuichi Saito , Naoto Hashimoto , Yasuhiro Hasa
IPC分类号： B01D11/02 , C08H8/00 , C08B37/00 , B09B3/00 , C12P7/10 , C12M1/00
摘要： An organic material production system includes: a pretreatment device (12) that pulverizes a biomass material (11); a hydrothermal decomposition apparatus (14) that hydrothermally decomposes a pulverized biomass (13) by causing it to countercurrently contact with hot compressed water (15), elutes lignin components and hemicellulose components into the hot compressed water (15), and separates the lignin components and the hemicellulose components from a biomass solid residue; a first enzymatic hydrolysis device (19-1) that treats cellulose in a biomass solid residue (17), discharged from the hydrothermal decomposition apparatus, with an enzyme (18) to enzymatically hydrolyze it to a sugar solution containing hexose; a fermenter (21) that produces ethanol by fermentation using a sugar solution (20) obtained by the first enzymatic hydrolysis device (19-1); and a refiner 25 that refines an alcohol fermentation liquid (22), so as to separate it into ethanol (23) and a residue (24).

9. 发明授权

US08305865B2 Optical information recording/reproducing optical system and optical information recording/reproducing apparatus 失效
标题翻译：光信息记录/再现光学系统和光信息记录/重放装置
公开(公告)号：US08305865B2
公开(公告)日：2012-11-06
申请号：US12893268
申请日：2010-09-29
申请人： Satoshi Inoue , Yuta Yoshida , Naoto Hashimoto , Suguru Takishima
发明人： Satoshi Inoue , Yuta Yoshida , Naoto Hashimoto , Suguru Takishima
IPC分类号： G11B7/135
CPC分类号： G11B7/1374
摘要： An objective lens for an optical information recording/reproducing optical system for an optical disc letting a laser beam impinge on a recording layer of the optical disc, and wherein a center wavelength λ (unit: nm) of the laser beam is in a range defined by a condition: 390≦λ≦420, a base material of the objective lens is made of resin, the resin has a glass transition temperature Tg and light transmissivity T (unit: %) per a path length of 3 mm at a wavelength of 406 nm defined by conditions: Tg≧115° C., 85≦T≦90, same antireflection films or different types of antireflection films are respectively formed on optical surfaces of the objective lens, and each of the antireflection films formed on the objective lens has a thickness of 100 nm or more in a vicinity of an optical axis of the objective lens.
摘要翻译：一种用于光盘的光学信息记录/再现光学系统的物镜，其使激光束照射在光盘的记录层上，并且其中激光束的中心波长λ（单位：nm）在限定的范围内通过条件：390＆nlE;λ＆nlE; 420，物镜的基材由树脂制成，树脂的玻璃化转变温度Tg和光透射率T（单位：％），每个路径长度为3mm，波长为由条件限定的406nm：Tg≥115℃，85＆lt; NE; T＆lt; NE; 90，在物镜的光学表面上分别形成相同的防反射膜或不同类型的抗反射膜，并且形成在物镜上的每个防反射膜在物镜的光轴附近具有100nm以上的厚度。

10. 发明授权

US4826834A Cephem compounds 失效
标题翻译：头孢烯化合物
公开(公告)号：US4826834A
公开(公告)日：1989-05-02
申请号：US909942
申请日：1986-09-22
申请人： Yoshinobu Yoshimura , Naoto Hashimoto , Shoji Kishimoto
发明人： Yoshinobu Yoshimura , Naoto Hashimoto , Shoji Kishimoto
IPC分类号： C07D519/00 , A61K31/545
CPC分类号： C07D519/00 , Y02P20/55
摘要： A compound having the general formula ##STR1## wherein, R.sup.0 is a hydrogen atom, a nitrogen-containing heterocyclic group, an acyl group or an amino-protective group; Z is S, S.fwdarw.O,O or CH.sub.2 ; R.sup.4 is a hydrogen atom, a methoxy group, or a formamide group; R.sup.13 is a hydrogen atom, a methyl group, a hydroxyl group, or a halogen atom; A.sym. is a condensed triazolio group which may be substituted, or a pharmaceutically acceptable salt or ester thereof is novel and has an excellent antibacterial activity.
摘要翻译：具有通式的化合物，其中R 0是氢原子，含氮杂环基，酰基或氨基保护基; Z是S，S-> O，O或CH 2; R4是氢原子，甲氧基或甲酰胺基; R 13是氢原子，甲基，羟基或卤素原子; A（+）是可被取代的缩合的三唑基，或其药学上可接受的盐或酯是新颖的，具有优异的抗菌活性。

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