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1. 发明申请

US20080280891A1 Anti-cancer agents and uses thereof 审中-公开
标题翻译：抗癌剂及其用途
公开(公告)号：US20080280891A1
公开(公告)日：2008-11-13
申请号：US11819494
申请日：2007-06-27
申请人： Martha Kelly , Younghee Lee , Bin Liu , Ted Fujimoto , Joel Freundlich , Bruce D. Dorsey , Gary A. Flynn , Arifa Husain , William R. Moore, Jr.
发明人： Martha Kelly , Younghee Lee , Bin Liu , Ted Fujimoto , Joel Freundlich , Bruce D. Dorsey , Gary A. Flynn , Arifa Husain , William R. Moore, Jr.
IPC分类号： A61K31/541 , A61K31/404 , C07D209/42 , C07D401/02 , C07D417/14 , A61K31/44 , A61P35/00 , A61K31/4439 , A61K31/5377 , C07D413/14
CPC分类号： A61K31/404 , A61K31/44 , A61K31/4439 , A61K31/5377 , A61K31/541 , C07D213/74 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/10 , C07D413/12 , C07D498/04
摘要： The present invention is in the area of novel compounds and salts thereof, their syntheses, and their use as anti-cancer agents. The compounds include compounds of Formula I: and solvates, hydrates and pharmaceutically-acceptable salts thereof, wherein A1 is N or CR1; A3 is N or CR3; A5 is N or CR5; R1, R3-R6 and L are defined in the specification; n is 0 or 1; and X is an optionally-substituted aryl group having 6-10 carbons in the ring portion, an optionally-substituted 6-membered heteroaryl group having 1-3 nitrogen atoms in the ring portion, an optionally-substituted 5-membered heteroaryl group having 0-4 nitrogen atoms in the ring portion and optionally having 1 sulfur atom or 1 oxygen atom in the ring portion, or an optionally-substituted heteroaryl group in which a 6-membered ring is fused either to a 5-membered ring or to a 6-membered ring, wherein in each case 1, 2, 3 or 4 ring atoms are heteroatoms independently selected from nitrogen, oxygen and sulfur. They are effective against a broad range of cancers, especially leukemia, prostate, non-small cell lung and colon. They are additionally useful in the treatment of proliferative retinopathies such as diabetic neuropathy and macular degeneration.
摘要翻译：本发明涉及新型化合物及其盐，其合成及其作为抗癌剂的用途。化合物包括式I化合物及其溶剂合物，水合物及其药学上可接受的盐，其中A 1是N或CR 1; N 3或N 3是N或CR 3; A <5>为N或CR 5; 在说明书中定义了R 1，R 3，R 6和L 6; n为0或1; 并且X是在环部分中具有6-10个碳的任选取代的芳基，在环部分中具有1-3个氮原子的任选取代的6元杂芳基，任选取代的5元杂芳基具有0 -4个氮原子，并且在环部分中任选具有1个硫原子或1个氧原子，或任选取代的杂芳基，其中6元环稠合到5元环或6元环其中在每种情况下，1,2,3或4个环原子是独立地选自氮，氧和硫的杂原子。它们对广泛的癌症尤其是白血病，前列腺，非小细胞肺和结肠有效。它们还可用于治疗增殖性视网膜病变，例如糖尿病性神经病变和黄斑变性。

2. 发明申请

US20060270686A1 Anti-cancer agents and uses thereof 失效
标题翻译：抗癌剂及其用途
公开(公告)号：US20060270686A1
公开(公告)日：2006-11-30
申请号：US10928401
申请日：2004-08-30
申请人： Martha Kelly , Younghee Lee , Bin Liu , Ted Fujimoto , Joel Freundlich , Bruce Dorsey , Gary Flynn , Arifa Husain
发明人： Martha Kelly , Younghee Lee , Bin Liu , Ted Fujimoto , Joel Freundlich , Bruce Dorsey , Gary Flynn , Arifa Husain
IPC分类号： A61K31/497 , A61K31/44 , C07D403/02
CPC分类号： C07D209/08 , C07D213/74 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/10
摘要： The present invention is in the area of novel compounds and salts thereof, their syntheses, and their use as anti-cancer agents. The compounds include compounds of Formula I: and solvates, hydrates and pharmaceutically-acceptable salts thereof, wherein A1 is N or CR1; A3 is N or CR3; A5 is N or CR5; R1, R3—R6 and L are defined in the specification; n is 0 or 1; and X is an optionally-substituted aryl group having 6-10 carbons in the ring portion, an optionally-substituted 6-membered heteroaryl group having 1-3 nitrogen atoms in the ring portion, an optionally-substituted 5-membered heteroaryl group having 0-4 nitrogen atoms in the ring portion and optionally having 1 sulfur atom or 1 oxygen atom in the ring portion, or an optionally-substituted heteroaryl group in which a 6-membered ring is fused either to a 5-membered ring or to a 6-membered ring, wherein in each case 1, 2, 3 or 4 ring atoms are heteroatoms independently selected from nitrogen, oxygen and sulfur. They are effective against a broad range of cancers, especially leukemia, non-small cell lung and colon.
摘要翻译：本发明涉及新型化合物及其盐，其合成及其作为抗癌剂的用途。化合物包括式I化合物及其溶剂合物，水合物及其药学上可接受的盐，其中A 1是N或CR 1; N 3或N 3是N或CR 3; A <5>为N或CR 5; 在说明书中定义了R 1，R 3，R 6和L 6; n为0或1; 并且X是在环部分中具有6-10个碳的任选取代的芳基，在环部分中具有1-3个氮原子的任选取代的6元杂芳基，任选取代的5元杂芳基具有0 -4个氮原子，并且在环部分中任选具有1个硫原子或1个氧原子，或任选取代的杂芳基，其中6元环稠合到5元环或6元环其中在每种情况下，1,2,3或4个环原子是独立地选自氮，氧和硫的杂原子。它们对广泛的癌症尤其是白血病，非小细胞肺和结肠有效。

3. 发明授权

US07504401B2 Anti-cancer agents and uses thereof 失效
标题翻译：抗癌剂及其用途
公开(公告)号：US07504401B2
公开(公告)日：2009-03-17
申请号：US10928401
申请日：2004-08-30
申请人： Martha Kelly , Bruce D. Dorsey , Gary A. Flynn
发明人： Martha Kelly , Bruce D. Dorsey , Gary A. Flynn
IPC分类号： A61K31/497 , A61K31/4439 , A61K31/421 , A61K31/404 , C07D401/10 , C07D403/10 , C07D413/10
CPC分类号： C07D209/08 , C07D213/74 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/10
摘要： The present invention is in the area of novel compounds and salts thereof, their syntheses, and their use as anti-cancer agents. The compounds include compounds of Formula I: and solvates, hydrates and pharmaceutically-acceptable salts thereof, wherein A1 is N or CR1; A3 is N or CR3; A5 is N or CR5; R1, R3-R6 and L are defined in the specification; n is 0 or 1; and X is an optionally-substituted aryl group having 6-10 carbons in the ring portion, an optionally-substituted 6-membered heteroaryl group having 1-3 nitrogen atoms in the ring portion, an optionally-substituted 5-membered heteroaryl group having 0-4 nitrogen atoms in the ring portion and optionally having 1 sulfur atom or 1 oxygen atom in the ring portion, or an optionally-substituted heteroaryl group in which a 6-membered ring is fused either to a 5-membered ring or to a 6-membered ring, wherein in each case 1, 2, 3 or 4 ring atoms are heteroatoms independently selected from nitrogen, oxygen and sulfur. They are effective against a broad range of cancers, especially leukemia, non-small cell lung and colon.
摘要翻译：本发明涉及新型化合物及其盐，其合成及其作为抗癌剂的用途。化合物包括式I化合物及其溶剂合物，水合物及其药学上可接受的盐，其中A1为N或CR1; A3是N或CR3; A5为N或CR5; R1，R3-R6和L在说明书中定义; n为0或1; 并且X是在环部分中具有6-10个碳的任选取代的芳基，在环部分中具有1-3个氮原子的任选取代的6元杂芳基，任选取代的5元杂芳基具有0 -4个氮原子，并且在环部分中任选具有1个硫原子或1个氧原子，或任选取代的杂芳基，其中6元环稠合到5元环或6元环其中在每种情况下，1,2,3或4个环原子是独立地选自氮，氧和硫的杂原子。它们对广泛的癌症尤其是白血病，非小细胞肺和结肠有效。

4. 发明申请

US20050288189A1 Method for treating plants or plant parts 失效
标题翻译：处理植物或植物部位的方法
公开(公告)号：US20050288189A1
公开(公告)日：2005-12-29
申请号：US11157107
申请日：2005-06-20
申请人： Richard Jacobson , Martha Kelly , Fiona Wehmeyer
发明人： Richard Jacobson , Martha Kelly , Fiona Wehmeyer
IPC分类号： A01N3/02 , A01N27/00 , A01N29/00 , A01N31/00 , A01N35/06 , A01N35/10
CPC分类号： A01N35/06 , A01N27/00 , A01N35/10
摘要： The present invention generally relates to a method of treating plants or plant parts comprising the step of contacting said plants or plant parts with at least one composition comprising at least one double bond adducted cyclopropene compound.
摘要翻译：本发明一般涉及一种处理植物或植物部分的方法，包括使所述植物或植物部分与至少一种包含至少一种双键加合的环丙烯化合物的组合物接触的步骤。

5. 发明申请

US20050065033A1 Method to inhibit ethylene responses in plants 审中-公开
标题翻译：抑制植物乙烯反应的方法
公开(公告)号：US20050065033A1
公开(公告)日：2005-03-24
申请号：US10645431
申请日：2003-08-21
申请人： Richard Jacobson , Martha Kelly , Fiona Wehmeyer , Karen Evans
发明人： Richard Jacobson , Martha Kelly , Fiona Wehmeyer , Karen Evans
IPC分类号： A01N27/00 , A01N29/04 , A01N31/14 , A01N33/06 , A01N37/10 , A01N37/18 , A01N37/42 , A01N41/04 , A01N43/08 , A01N43/10 , A01N43/12 , A01N43/32 , A01N43/36 , A01N43/40 , A01N43/50 , A01N43/54 , A01N43/56 , A01N43/60 , A01N43/653 , A01N43/80 , A01N43/82 , A01N55/00 , A01N55/08 , A01N55/10 , A01N57/12 , C07C13/04 , C07C17/00 , C07C17/23 , C07C17/25 , C07C17/26 , C07C17/275 , C07C17/278 , C07C23/18 , C07C43/215 , C07C43/225 , C07C43/23 , C07C45/00 , C07C45/29 , C07C211/55 , C07C309/73 , C07C321/10 , C07C323/09 , C07D207/16 , C07D213/70 , C07D231/16 , C07D233/54 , C07D237/14 , C07D249/12 , C07D307/68 , C07D317/12 , C07D333/08 , C07F7/08 , C07F7/18 , C07F9/177 , A01N25/26 , A01N47/40 , A01N35/00 , A01N35/10
CPC分类号： C07D213/70 , A01N27/00 , A01N29/04 , A01N31/14 , A01N33/06 , A01N37/10 , A01N37/18 , A01N37/42 , A01N41/04 , A01N43/08 , A01N43/10 , A01N43/12 , A01N43/32 , A01N43/36 , A01N43/40 , A01N43/50 , A01N43/54 , A01N43/56 , A01N43/60 , A01N43/653 , A01N43/80 , A01N43/82 , A01N55/00 , A01N55/08 , A01N57/12 , C07C13/04 , C07C17/00 , C07C17/23 , C07C17/25 , C07C17/263 , C07C17/2632 , C07C17/275 , C07C17/278 , C07C23/18 , C07C43/215 , C07C43/225 , C07C43/23 , C07C45/00 , C07C45/29 , C07C211/55 , C07C309/73 , C07C321/10 , C07C323/09 , C07C2601/02 , C07D207/16 , C07D231/16 , C07D233/54 , C07D237/14 , C07D249/12 , C07D307/68 , C07D317/12 , C07D333/08 , C07F7/0805 , C07F7/1804 , C07F9/177 , C07C22/04 , C07C23/04 , C07C21/14 , C07C25/24 , C07C49/213 , C07C47/225
摘要： The present invention generally relates to methods of inhibiting ethylene responses in plants and plant materials, and particularly relates to methods of inhibiting various ethylene responses including plant maturation and degradation, by exposing plants to cyclopropene derivatives and compositions thereof wherein: 1) at least one substituent on the cyclopropene ring contains a carbocyclic or heterocyclic ring, or 2) . a substituent contains silicon, sulfur, phosphorous, or boron, or 3) least one substituent contains from one to four non-hydrogen atoms and at least one substituent contains more than four non-hydrogen atoms.
摘要翻译：本发明一般涉及在植物和植物材料中抑制乙烯应答的方法，特别涉及通过将植物暴露于环丙烯衍生物及其组合物来抑制各种乙烯应答（包括植物成熟和降解）的方法，其中：1）至少一个取代基在环丙烯环上含有碳环或杂环，或2）。取代基含有硅，硫，磷或硼，或3）至少一个取代基含有一至四个非氢原子，至少一个取代基含有四个以上的非氢原子。

6. 发明授权

US08426412B2 2-alkynyl-6-pyridin-2-yl-pyridazinones, 2-alkynyl-6-pyridin-2-yl-dihydropyridazinones, 2-alkynyl-6-pyrimidin-2-yl-pyridazinones and 2-alkynyl-6-pyrimidin-2-yl-dihydropyridazinones and their use as fungicides 失效
标题翻译： 2-炔基-6-吡啶-2-基 - 哒嗪酮，2-炔基-6-吡啶-2-基 - 二氢哒嗪酮，2-炔基-6-嘧啶-2-基 - 哒嗪酮和2-炔基-6-嘧啶-2-基 - 二氢哒嗪酮及其作为杀真菌剂的用途
公开(公告)号：US08426412B2
公开(公告)日：2013-04-23
申请号：US12420081
申请日：2009-04-08
申请人： Martha Kelly , Ronald Ross, Jr. , David H. Young
发明人： Martha Kelly , Ronald Ross, Jr. , David H. Young
IPC分类号： C07D401/04 , C07D403/04 , A61K31/501 , A01N63/00
CPC分类号： C07D401/04 , A01N43/58 , C07D403/04
摘要： This invention relates to certain novel 2-alkynyl-6-pyridin-2-yl-pyridazinones, 2-alkynyl-6-pyridin-2-yl-dihydropyridazinones, 2-alkynyl-6-pyrimidin-2-yl-pyridazinones and 2-alkynyl-6-pyrimidin-2-yl-dihydropyridazinones such as those illustrated in Formula I and to the use of these compounds for control of fungal pathogens of plants and mammals.
摘要翻译：本发明涉及某些新的2-炔基-6-吡啶-2-基 - 哒嗪酮，2-炔基-6-吡啶-2-基 - 二氢哒嗪酮，2-炔基-6-嘧啶-2-基 - 哒嗪酮和2- 炔基-6-嘧啶-2-基 - 二氢哒嗪酮，如式I所示的那些，以及这些化合物用于控制植物和哺乳动物真菌病原体的用途。

7. 发明申请

US20090253708A1 2-ALKYNYL-6-PYRIDIN-2-YL-PYRIDAZINONES, 2-ALKYNYL-6-PYRIDIN-2-YL-DIHYDROPYRIDAZINONES, 2-ALKYNYL-6-PYRIMIDIN-2-YL-PYRIDAZINONES AND 2-ALKYNYL-6-PYRIMIDIN-2-YL-DIHYDROPYRIDAZINONES AND THEIR USE AS FUNGICIDES 失效
标题翻译： 2-烷基-6-吡啶-2-基-2-吡咯烷酮，2-烷基-6-吡啶-2-基-L-二氢吡啶并[2,3-d]吡啶-2-酮，2-烷基-6-吡啶基-2-YL-吡啶二酮和2-烷基-6-吡啶基 - 2-YL-二氢吡啶并嗪及其作为杀真菌剂使用
公开(公告)号：US20090253708A1
公开(公告)日：2009-10-08
申请号：US12420081
申请日：2009-04-08
申请人： Martha Kelly , Ronald Ross, JR. , David H. Young
发明人： Martha Kelly , Ronald Ross, JR. , David H. Young
IPC分类号： A01N43/58 , C07D401/04 , A01P3/00
CPC分类号： C07D401/04 , A01N43/58 , C07D403/04
摘要： This invention relates to certain novel 2-alkynyl-6-pyridin-2-yl-pyridazinones, 2-alkynyl-6-pyridin-2-yl-dihydropyridazinones, 2-alkynyl-6-pyrimidin-2-yl-pyridazinones and 2-alkynyl-6-pyrimidin-2-yl-dihydropyridazinones and to the use of these compounds for control of fungal pathogens of plants and mammals.
摘要翻译：本发明涉及某些新的2-炔基-6-吡啶-2-基 - 哒嗪酮，2-炔基-6-吡啶-2-基 - 二氢哒嗪酮，2-炔基-6-嘧啶-2-基 - 哒嗪酮和2- 炔基-6-嘧啶-2-基 - 二氢哒嗪酮，以及这些化合物用于控制植物和哺乳动物真菌病原体的用途。

8. 发明申请

US20050043179A1 Method to inhibit ethylene responses in plants 失效
标题翻译：抑制植物乙烯反应的方法
公开(公告)号：US20050043179A1
公开(公告)日：2005-02-24
申请号：US10645769
申请日：2003-08-21
申请人： Richard Jacobson , Martha Kelly , Fiona Wehmeyer , Edward Sisler
发明人： Richard Jacobson , Martha Kelly , Fiona Wehmeyer , Edward Sisler
IPC分类号： A01N27/00 , A01N29/00 , A01N35/00 , A01N35/10 , A01N43/24 , A01N43/58 , A01N43/72 , A01N47/40 , A01N55/08
CPC分类号： A01N43/24 , A01N27/00
摘要： The present invention generally relates to methods of inhibiting ethylene responses in plants and plant materials, and particularly relates to methods of inhibiting various ethylene responses including plant maturation and degradation, by exposing plants to cyclopropene derivatives and compositions thereof wherein the cyclopropene is associated with another ring system.
摘要翻译：本发明一般涉及在植物和植物材料中抑制乙烯应答的方法，特别涉及通过将植物暴露于环丙烯衍生物及其组合物来抑制各种乙烯应答（包括植物成熟和降解）的方法，其中环丙烯与另一个环系统。

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