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1. 发明授权

US5535752A Implantable capacitive absolute pressure and temperature monitor system 失效
标题翻译：可植入电容绝对压力和温度监控系统
公开(公告)号：US5535752A
公开(公告)日：1996-07-16
申请号：US394860
申请日：1995-02-27
申请人： Louis E. Halperin , Brian B. Lee , Glenn M. Roline , Anthony J. Varrichio
发明人： Louis E. Halperin , Brian B. Lee , Glenn M. Roline , Anthony J. Varrichio
IPC分类号： A61B5/00 , A61B5/01 , A61B5/0215 , A61N1/08 , A61N1/365 , A61N1/362
CPC分类号： A61B5/0215 , A61N1/08 , A61N1/3655 , A61N1/36564 , A61B2560/0257 , Y10S977/90 , Y10S977/905
摘要： A capacitive pressure and temperature sensing system for providing signals representative of the magnitude of body fluid absolute pressure at a selected site and ambient operating conditions, including body temperature, at the site. An implantable lead having a sensor module formed in its distal end is coupled to a monitor that powers a sensor circuit in the sensor module and demodulates and stores absolute pressure and temperature data derived from signals generated by the sensor circuit. The sensor module is formed with a pickoff capacitor that changes capacitance with pressure changes and a reference capacitor that is relatively insensitive to pressure changes. The sensor circuit provides charge current that changes with temperature variation at the implant site, alternately charges and discharges the two capacitors, and provides timing pulses having distinguishable parameters at the end of each charge cycle that are transmitted to the demodulator. The demodulator detects and synchronizes the timing pulses and derives pressure and temperature analog voltage values representative of the intervals between the timing pulses which are digitized and stored in the monitor. The monitor may also be coupled with other sensors for measuring and storing related patient body parameters, e.g. blood gas, EGM, and patient activity.
摘要翻译：一种电容式压力和温度感测系统，用于提供代表在现场的所选位置和环境操作条件（包括体温）的体液绝对压力的大小的信号。具有形成在其远端的传感器模块的可植入引线被耦合到对传感器模块中的传感器电路供电的监视器，并且解调并存储由传感器电路产生的信号导出的绝对压力和温度数据。传感器模块形成有一个传感器电容器，可以改变压力变化的电容和对压力变化相对不敏感的参考电容。传感器电路提供随着植入部位温度变化而变化的充电电流，交替地对两个电容器进行充电和放电，并且在每个充电周期结束时提供定时脉冲，其在每个充电周期结束时被传送到解调器。解调器检测并同步定时脉冲，并导出代表数字化和存储在监视器中的定时脉冲之间的间隔的压力和温度模拟电压值。监视器还可以与其他传感器耦合，用于测量和存储相关的患者身体参数，例如，血气，EGM和患者活动。

2. 发明授权

US5564434A Implantable capacitive absolute pressure and temperature sensor 失效
标题翻译：可植入电容绝对压力和温度传感器
公开(公告)号：US5564434A
公开(公告)日：1996-10-15
申请号：US394870
申请日：1995-02-27
申请人： Louis E. Halperin , Keith A. Miesel , Keith A. Ufford , James R. Svensk , Timothy Patrick , Beth A. Hassler , Anthony J. Varrichio
发明人： Louis E. Halperin , Keith A. Miesel , Keith A. Ufford , James R. Svensk , Timothy Patrick , Beth A. Hassler , Anthony J. Varrichio
IPC分类号： G01L9/12 , A61B5/00 , A61N1/365 , G01K5/32
CPC分类号： A61B5/0031 , A61N1/3655 , A61N1/36564 , A61B2560/0257 , A61B2562/0247 , A61B5/7217 , Y10S977/90 , Y10S977/905
摘要： An endocardial lead for implantation in a right heart chamber for responding to blood pressure and temperature and providing modulated pressure and temperature related signals to an implanted or external hemodynamic monitor and/or cardiac pacemaker or pacemaker/cardioverter/defibrillator. The lead has a sensor module formed in its distal end and is coupled to a monitor that powers a sensor circuit in the sensor module. The sensor module is formed with a pickoff capacitor that changes capacitance with pressure changes and a reference capacitor that is relatively insensitive to pressure changes. The sensor circuit provides charge current that changes with temperature variation at the implant site, alternately charges and discharges the two capacitors, and provides timing pulses having distinguishable parameters at the end of each charge cycle that are transmitted to the demodulator. The demodulator detects and synchronizes the timing pulses and derives pressure and temperature analog voltage values representative of the intervals between the timing pulses which are digitized and stored in the monitor. The monitor may also be coupled with other sensors for measuring and storing related patient body parameters, e.g. blood gas, EGM, and patient activity.
摘要翻译：用于植入在右心室中以响应血压和温度并且向植入或外部血液动力学监测器和/或心脏起搏器或起搏器/心律转复器/除颤器提供调制的压力和温度相关信号的心内膜引线。引线具有在其远端形成的传感器模块，并且耦合到对传感器模块中的传感器电路供电的监视器。传感器模块形成有一个传感器电容器，可以改变压力变化的电容和对压力变化相对不敏感的参考电容。传感器电路提供随着植入部位温度变化而变化的充电电流，交替地对两个电容器进行充电和放电，并且在每个充电周期结束时提供定时脉冲，其在每个充电周期结束时被传送到解调器。解调器检测并同步定时脉冲，并导出代表数字化和存储在监视器中的定时脉冲之间的间隔的压力和温度模拟电压值。监视器还可以与其他传感器耦合，用于测量和存储相关的患者身体参数，例如，血气，EGM和患者活动。

3. 发明授权

US5987352A Minimally invasive implantable device for monitoring physiologic events 失效
标题翻译：用于监测生理事件的微创植入式装置
公开(公告)号：US5987352A
公开(公告)日：1999-11-16
申请号：US33678
申请日：1998-03-03
申请人： George J. Klein , Dwight H. Warkentin , Kenneth M. Riff , Brian B. Lee , James K. Carney , Gregg Turi , Anthony J. Varrichio
发明人： George J. Klein , Dwight H. Warkentin , Kenneth M. Riff , Brian B. Lee , James K. Carney , Gregg Turi , Anthony J. Varrichio
IPC分类号： A61B5/0492 , A61B5/0404 , A61B5/0408 , A61B5/0478 , A61N1/375 , A61B5/0402
CPC分类号： A61N1/375
摘要： A minimally invasive implant, means for insertion, and description of how to most efficiently use it are described n several embodiments. This implant preferably has a segmented looping memory for storing triggered physiologic events. Preferred events for setting autotriggers to record physiologic signals occurring during events include arrhythmias and syncopal events. Preferably the device can function without a microprocessor. An outside device or other patient activated manual trigger is included. Auto triggers and manually set triggers may be of different sizes. The preferred physiologic events are ECG signals. Electrode spacing can be critical. Additional sensors may be provided to the device. Preferred communications with the device is through telemetry such as is used for pacemakers and other implanted devices.
摘要翻译：在几个实施例中描述了微创植入物，用于插入的手段和如何最有效地使用它的描述。该植入物优选地具有用于存储触发的生理事件的分段循环存储器。设置自动跟踪器记录事件中发生的生理信号的首选事件包括心律失常和晕厥事件。优选地，该装置可以在没有微处理器的情况下工作。包括外部设备或其他患者激活的手动触发器。自动触发器和手动设置触发器可能具有不同的大小。优选的生理事件是ECG信号。电极间距可能很重要。可以向设备提供附加的传感器。与设备的首选通信是通过诸如用于起搏器和其他植入设备的遥测。

4. 发明申请

US20090204160A1 PULSE GENERATOR HAVING AN EFFICIENT FRACTIONAL VOLTAGE CONVERTER AND METHOD OF USE 有权
标题翻译：具有有效的电压转换器的脉冲发生器及其使用方法
公开(公告)号：US20090204160A1
公开(公告)日：2009-08-13
申请号：US12426053
申请日：2009-04-17
申请人： Benjamin A. Tranchina , John H. Erickson , Anthony J. Varrichio
发明人： Benjamin A. Tranchina , John H. Erickson , Anthony J. Varrichio
IPC分类号： A61N1/02
CPC分类号： A61N1/025 , H02M3/07
摘要： Disclosed are systems and methods which provide voltage conversion in increments less than integer multiples of a power supply (e.g., battery) voltage. A representative embodiment provides power supply voltage multipliers in a binary ladder distribution to provide a desired number of output voltage steps using a relatively uncomplicated circuit design. By using different sources in various combinations and/or by “stacking” different sources in various ways, the voltage multiplier circuit may be used to provide desired voltages. In order to minimize the number of components used in a voltage converter of an embodiment, a capacitive voltage converter circuit uses one or more storage capacitors in place of pump capacitors in a voltage generation cycle. Also, certain embodiments do not operate to generate an output voltage until the time that voltage is needed.
摘要翻译：公开了以小于电源（例如，电池）电压的整数倍的增量提供电压转换的系统和方法。代表性的实施例提供二进制梯形分布中的电源电压倍增器，以使用相对简单的电路设计提供期望数量的输出电压步长。通过以各种方式使用不同的源和/或以不同的方式“堆叠”不同的源，可以使用电压倍增器电路来提供期望的电压。为了最小化实施例的电压转换器中使用的部件的数量，电容性电压转换器电路在电压产生循环中使用一个或多个存储电容器代替泵电容器。而且，某些实施例在直到需要电压的时间之前不会产生输出电压。

5. 发明授权

US07571007B2 Systems and methods for use in pulse generation 有权
标题翻译：用于脉冲发生的系统和方法
公开(公告)号：US07571007B2
公开(公告)日：2009-08-04
申请号：US11420670
申请日：2006-05-26
申请人： John H. Erickson , Anthony J. Varrichio , Benjamin A. Tranchina
发明人： John H. Erickson , Anthony J. Varrichio , Benjamin A. Tranchina
IPC分类号： A61N1/378
CPC分类号： A61N1/3787
摘要： In one embodiment, an implantable medical device comprises: a rechargeable battery for powering the implantable medical device; an antenna for receiving RF power; and circuitry for charging the rechargeable battery using power received via the antenna, wherein the circuitry for charging comprises control circuitry that causes the circuitry for charging to recharge the rechargeable battery using multiple current levels applied in succession, and wherein the circuitry for charging switches from at least one of the current levels to another current level when a charging voltage of the rechargeable battery reaches a threshold value that is varied by the control circuitry over a lifespan of the rechargeable battery.
摘要翻译：在一个实施例中，可植入医疗装置包括：用于为可植入医疗装置供电的可再充电电池; 用于接收RF功率的天线; 以及用于通过天线接收的功率对可再充电电池充电的电路，其中用于充电的电路包括控制电路，其使所述电路进行充电以使用连续施加的多个电流电平对所述可充电电池进行再充电，并且其中所述用于从当可再充电电池的充电电压达到在可再充电电池的寿命期间由控制电路改变的阈值时，当前电平中的至少一个电平达到另一电流水平。

6. 再颁专利

USRE35129E Optimization of bone formation at cathodes 失效
标题翻译：阴极骨形成优化
公开(公告)号：USRE35129E
公开(公告)日：1995-12-19
申请号：US138230
申请日：1993-10-15
申请人： Brian A. Pethica , James M. Devine , Anthony J. Varrichio
发明人： Brian A. Pethica , James M. Devine , Anthony J. Varrichio
IPC分类号： A61N1/08 , A61N1/20 , A61N1/32 , A61N1/00
CPC分类号： A61N1/205 , A61N1/08 , A61N1/326
摘要： A method including applying varying signals to a first electrode at the tissue site and a second electrode remote from the tissue site and monitoring the results to determine a distinctive transition in the current-voltage characteristics of the electrode pair. A signal is then selected and applied to the electrodes to operate beyond the transition. Periodically, a varying signal is applied to the electrodes and the monitoring process reperformed to determine a new transition and an appropriate signal is selected to operate beyond the transition.
摘要翻译：一种方法，包括将变化的信号施加到组织部位处的第一电极和远离组织部位的第二电极，并监测结果以确定电极对的电流 - 电压特性的特征性转变。然后选择信号并将其施加到电极以超出转换。周期性地，将改变的信号施加到电极，并且重新执行监视过程以确定新的转变，并且选择适当的信号以超出转换。

7. 发明授权

US5056518A Optimization of bone formation at cathodes 失效
标题翻译：阴极骨形成优化
公开(公告)号：US5056518A
公开(公告)日：1991-10-15
申请号：US547821
申请日：1990-07-02
申请人： Brian A. Pethica , James M. Devine , Anthony J. Varrichio
发明人： Brian A. Pethica , James M. Devine , Anthony J. Varrichio
IPC分类号： A61N1/08 , A61N1/20 , A61N1/32
CPC分类号： A61N1/205 , A61N1/08 , A61N1/326
摘要： A method including applying varying signals to a first electrode at the tissue site and a second electrode remote from the tissue site and monitoring the results to determine a distinctive transition in the current-voltage characteristics of the electrode pair. A signal is then selected and applied to the electrodes to operate beyond the transition. Periodically, a varying signal is applied to the electrodes and the monitoring process reperformed to determine a new transition and an appropriate signal is selected to operate beyond the transition.
摘要翻译：一种方法，包括将变化的信号施加到组织部位处的第一电极和远离组织部位的第二电极，并监测结果以确定电极对的电流 - 电压特性的特征性转变。然后选择信号并将其施加到电极以超出转换。周期性地，将改变的信号施加到电极，并且重新执行监视过程以确定新的转变，并且选择适当的信号以超出转换。

8. 发明申请

US20120286841A1 PULSE GENERATOR HAVING AN EFFICIENT FRACTIONAL VOLTAGE CONVERTER AND METHOD OF USE 有权
标题翻译：具有有效的电压转换器的脉冲发生器及其使用方法
公开(公告)号：US20120286841A1
公开(公告)日：2012-11-15
申请号：US13470764
申请日：2012-05-14
申请人： Benjamin A. Tranchina , John H. Erickson , Anthony J. Varrichio
发明人： Benjamin A. Tranchina , John H. Erickson , Anthony J. Varrichio
IPC分类号： H03K3/02
CPC分类号： A61N1/025 , H02M3/07
摘要： Disclosed are systems and methods which provide voltage conversion in increments less than integer multiples of a power supply (e.g., battery) voltage. A representative embodiment provides power supply voltage multipliers in a binary ladder distribution to provide a desired number of output voltage steps using a relatively uncomplicated circuit design. By using different sources in various combinations and/or by “stacking” different sources in various ways, the voltage multiplier circuit may be used to provide desired voltages. In order to minimize the number of components used in a voltage converter of an embodiment, a capacitive voltage converter circuit uses one or more storage capacitors in place of pump capacitors in a voltage generation cycle. Also, certain embodiments do not operate to generate an output voltage until the time that voltage is needed.
摘要翻译：公开了以小于电源（例如，电池）电压的整数倍的增量提供电压转换的系统和方法。代表性的实施例提供二进制梯形分布中的电源电压倍增器，以使用相对简单的电路设计提供期望数量的输出电压步长。通过以各种组合使用不同的源和/或以各种方式堆叠不同的源，可以使用电压倍增器电路来提供期望的电压。为了最小化实施例的电压转换器中使用的部件的数量，电容性电压转换器电路在电压产生循环中使用一个或多个存储电容器代替泵电容器。而且，某些实施例在直到需要电压的时间之前不会产生输出电压。

9. 发明授权

US07180760B2 Method of efficiently performing fractional voltage conversion and system comprising efficient fractional voltage converter circuitry 有权
$Method of efficiently performing fractional voltage conversion and system comprising efficient fractional voltage converter circuitry$
标题翻译：有效执行分数电压转换的方法和包括有效分数电压转换器电路的系统
公开(公告)号：US07180760B2
公开(公告)日：2007-02-20
申请号：US11105332
申请日：2005-04-12
申请人： Anthony J. Varrichio , Benjamin A. Tranchina
发明人： Anthony J. Varrichio , Benjamin A. Tranchina
IPC分类号： H02M3/18 , H02M7/00
CPC分类号： A61N1/36153 , A61N1/36125 , A61N1/3782 , H02M3/07 , H02M2003/072
摘要： Embodiments provide a capacitive voltage multiplier for efficiently producing multiples, including fractional multiples, of a power supply voltage use high, medium and low voltage field effect transistors for switching terminals of various capacitors into and out of connection with power supply or ground voltages in charge mode and with an output or other capacitor terminals for series connection in pump mode. A single non-overlapping clock is level-shifted up to the maximum voltage level required for switching to produce a desired output, then level shifted back down to lower levels with delay added as necessary according to embodiments.
摘要翻译：实施例提供一种用于有效地产生电源电压的倍数（包括分数倍）的电容电压倍增器，其使用高，中和低电压场效应晶体管，用于将各种电容器的端子切换到与电源或充电模式中的接地电压相关联并具有用于泵模式串联连接的输出或其他电容器端子。单个不重叠的时钟被电平移位直到切换产生期望的输出所需的最大电压电平，然后根据实施例根据需要将电平移位回到较低的电平并根据需要进行延迟。

10. 发明授权

US5235980A Implanted apparatus disabling switching regulator operation to allow radio frequency signal reception 失效
标题翻译：植入式装置禁用开关调节器操作以允许射频信号接收
公开(公告)号：US5235980A
公开(公告)日：1993-08-17
申请号：US802736
申请日：1991-12-05
申请人： Anthony J. Varrichio , William L. Winstrom
发明人： Anthony J. Varrichio , William L. Winstrom
IPC分类号： A61N1/36 , G05F1/46
CPC分类号： A61N1/36053 , A61N1/36064 , A61N1/37217 , G05F1/468 , A61N1/025
摘要： An implant for stimulating the vagus nerve receives commands over a radio frequency link. The implant disables a voltage convertor used in providing the stimulation signal at periodic intervals to monitor for communications attempts. The implant provides radio frequency marker pulses before providing stimulation signals of certain frequencies. During the providing of stimulation signals the implant monitors the voltage overhead present between the voltage source and the load and adjusts the overhead to a desired level. The implant changes the voltage applied to certain internal components during stimulation periods to allow full power operation during those intervals and reduced power levels at other intervals. The implant is reset by the placing a magnet in a given location in conjunction with the application of a radio frequency transmission for a given period.
摘要翻译：用于刺激迷走神经的植入物通过射频链路接收命令。植入物禁用用于以周期性间隔提供刺激信号的电压转换器以监视通信尝试。在提供某些频率的刺激信号之前，植入物提供射频标记脉冲。在提供刺激信号期间，植入物监测电压源和负载之间的电压开销，并将开销调整到期望的水平。植入物在刺激期间改变施加到某些内部组件的电压，以允许在这些间隔期间的全功率操作，并且在其它间隔降低功率水平。通过将磁铁放置在给定位置并结合给定时间段的射频传输的应用来重置植入物。

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