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1. 发明授权

US06683303B2 Ion trap mass spectrometer and spectrometry 失效
标题翻译：离子阱质谱仪和光谱仪
公开(公告)号：US06683303B2
公开(公告)日：2004-01-27
申请号：US10087743
申请日：2002-03-05
申请人： Kiyomi Yoshinari , Yoshiaki Kato , Tadao Mimura , Shinji Nagai
发明人： Kiyomi Yoshinari , Yoshiaki Kato , Tadao Mimura , Shinji Nagai
IPC分类号： H01J4942
CPC分类号： H01J49/424 , H01J49/0063
摘要： An ion trap mass spectrometer and spectrometry capable of dissociating ions to be dissociated efficiently regardless of ionic species without useless time and performing high-sensitive MS/MS spectrometry, lengthens a period for applying a CID voltage in accordance with a mass number or characteristics of ions to be dissociated in proportion to a mass-to-charge ratio of ions to be dissociated to thereby optimize the application period of the supplementary AC voltage applied in superposition manner in order to dissociate specific ionic species, so that ions to be dissociated are dissociated efficiently and high-sensitive analysis of dissociated ions can be attained without useless time.
摘要翻译：离子阱质谱仪和光谱测定能够离子离子有效解离而无需离子物质无需时间，并进行高灵敏度的MS / MS光谱测定，延长了根据离子的质量数或特征施加CID电压的时间要与待离解的离子的质荷比成比例地离解，从而优化以叠加方式施加的辅助AC电压的施加周期，以便解离特定的离子物质，使得要解离的离子有效解离并且可以在没有无用的时间的情况下获得离解离子的高灵敏度分析。

2. 发明授权

US06759652B2 Ion trap mass analyzing apparatus 有权
标题翻译：离子阱质量分析仪
公开(公告)号：US06759652B2
公开(公告)日：2004-07-06
申请号：US10252699
申请日：2002-09-24
申请人： Kiyomi Yoshinari , Yoshiaki Kato , Tadao Mimura , Masaru Tomioka
发明人： Kiyomi Yoshinari , Yoshiaki Kato , Tadao Mimura , Masaru Tomioka
IPC分类号： H01J4942
CPC分类号： H01J49/424 , H01J49/4255
摘要： An ion-trap mass analyzing apparatus having means for generating ion-capture electric fields asymmetrical with respect to a reference plane containing a central point of a ring electrode and perpendicular to a central axis of the ring electrode in the inside of an ion trap to resonantly amplify ions rapidly to emit the ions from the ion trap in a short time to thereby permit high-sensitive high-accurate mass analysis stably regardless of the structural stability of ions as a subject of analysis.
摘要翻译：一种离子阱质量分析装置，具有用于产生相对于包含环形电极的中心点并垂直于离子阱内部的环形电极的中心轴的参考平面不对称的离子捕获电场的装置，以共振地在短时间内快速放大离子以从离子阱发射离子，从而允许高灵敏度的高精确质量分析，而不管作为分析对象的离子的结构稳定性如何。

3. 发明授权

US06977373B2 Ion trap mass analyzing apparatus 有权
标题翻译：离子阱质量分析仪
公开(公告)号：US06977373B2
公开(公告)日：2005-12-20
申请号：US10846529
申请日：2004-05-17
申请人： Kiyomi Yoshinari , Yoshiaki Kato , Tadao Mimura , Masaru Tomioka
发明人： Kiyomi Yoshinari , Yoshiaki Kato , Tadao Mimura , Masaru Tomioka
IPC分类号： G01N27/62 , H01J49/40 , H01J49/42
CPC分类号： H01J49/424 , H01J49/4255
摘要： An ion-trap mass analyzing apparatus having means for generating ion-capture electric fields asymmetrical with respect to a reference plane containing a central point of a ring electrode and perpendicular to a central axis of the ring electrode in the inside of an ion trap to resonantly amplify ions rapidly to emit the ions from the ion trap in a short time to thereby permit high-sensitive high-accurate mass analysis stably regardless of the structural stability of ions as a subject of analysis.
摘要翻译：一种离子阱质量分析装置，具有用于产生相对于包含环形电极的中心点并垂直于离子阱内部的环形电极的中心轴的参考平面不对称的离子捕获电场的装置，以共振地在短时间内快速放大离子以从离子阱发射离子，从而允许高灵敏度的高精确质量分析，而不管作为分析对象的离子的结构稳定性如何。

4. 发明授权

US5532483A Mass spectrometer and ion source 失效
标题翻译：质谱仪和离子源
公开(公告)号：US5532483A
公开(公告)日：1996-07-02
申请号：US403980
申请日：1995-03-15
申请人： Yoichi Ose , Kiyomi Yoshinari , Masayoshi Yano , Tadao Mimura
发明人： Yoichi Ose , Kiyomi Yoshinari , Masayoshi Yano , Tadao Mimura
IPC分类号： H01J49/06 , H01J49/10
CPC分类号： H01J49/10 , H01J49/06
摘要： An ion beam having a good converging property and a good quality is provided by satisfying the limitations controlling both angle of dispersion and the width of beam at the same time. The voltage 12d of a repeller electrode 1f in an ion source of electron bombardment type is input to an ion source state monitor 11 and the ion source state monitor 11 output a predicted value 12e of the voltage applied to an extractor electrode 1g to an extractor power source 9. As for the extractor electrode system, the width of a slit in the acceleration electrode 1b is made larger than the width of a slit of the extractor electrode 1g, and the extractor electrode 1g is set in a position apart from the acceleration electrode 1b by the distance nearly equal to the distance between the acceleration electrode 1b and the ion generating region 2a. By doing so, the electric field leaked from the slit of the acceleration electrode 1b to the inside of the ionization chamber 1a expands to the vicinity of the ion generating region. As the result, the ion beam 2 is effectively extracted to pass through the slits in the acceleration electrode 1b and the extractor 1g. The amount of the current passing through the slits is measured with an ion current monitor 8a and the voltage 12f of a converging electrode 1d is adjusted so that the value of the current becomes the maximum.
摘要翻译：通过满足同时控制分散角和宽度的限制来提供具有良好的会聚特性和良好质量的离子束。电子轰击型离子源中的斥极电极1f的电压12d被输入到离子源状态监视器11，离子源状态监视器11将施加到抽出电极1g的电压的预测值12e输出到提取电力对于提取器电极系统，使加速电极1b中的狭缝的宽度大于提取电极1g的狭缝的宽度，并且将提取电极1g设置在离开加速电极1的位置 1b的距离几乎等于加速电极1b和离子产生区域2a之间的距离。通过这样做，从加速电极1b的狭缝向电离室1a的内部泄漏的电场扩大到离子产生区域附近。结果，有效地提取离子束2以通过加速电极1b和提取器1g中的狭缝。通过离子电流监视器8a测量通过狭缝的电流量，调节会聚电极1d的电压12f，使得电流值变为最大值。

5. 发明授权

US5789746A Liquid chromatograph mass spectrometry and liquid chromatograph mass spectrometer 失效
标题翻译：液相色谱质谱和液相色谱质谱仪
公开(公告)号：US5789746A
公开(公告)日：1998-08-04
申请号：US886465
申请日：1997-07-01
申请人： Yoshiaki Kato , Tadao Mimura
发明人： Yoshiaki Kato , Tadao Mimura
IPC分类号： G01N27/62 , G01N30/62 , G01N30/72 , G01N30/74 , G01N30/78 , G01N30/86 , H01J49/04 , H01J49/26 , H01J49/00
CPC分类号： G01N30/7233 , G01N2030/625 , G01N30/74
摘要： An eluant is supplied to an analyzer column, a sample solution is supplied through a sample inlet. The analyzer column separates the components of the sample solution. The separated components are eluted by the analyzer column, the eluted components are detected by an eluted component detector, the results of detection provided by the eluted component detector is processed by a data processor to produce a liquid chromatogram having peaks indicating the components of the sample. The components of the sample is supplied through a capillary pipe to an ion source and the ion source ionizes the components of the sample. A mass spectrometer subjects the ions produced by the ion source to mass analysis, an ion detector detects the ions included in a mass spectrum to produce an ion chromatogram having peaks. A time difference between the chromatograms is determined beforehand through an experiment using a standard sample, and the liquid chromatogram is shifted on its time axis by the time difference.
摘要翻译：将洗脱液供应到分析器柱，通过样品入口提供样品溶液。分析仪柱分离样品溶液的组分。分离的组分被分析器柱洗脱，洗脱组分由洗脱组分检测器检测，由洗脱组分检测器提供的检测结果由数据处理器处理，以产生具有表示样品成分的峰的液相色谱图。样品的组分通过毛细管供给到离子源，离子源将样品的组分电离。质谱仪将由离子源产生的离子进行质量分析，离子检测器检测质谱中包含的离子，产生具有峰值的离子色谱图。通过使用标准样品的实验预先确定色谱图之间的时间差，并且液相色谱在其时间轴上偏移时间差。

6. 发明授权

US07161141B2 Ion trap/time-of-flight mass spectrometer and method of measuring ion accurate mass 有权
公开(公告)号：US07161141B2
公开(公告)日：2007-01-09
申请号：US11128261
申请日：2005-05-13
申请人： Tadao Mimura , Yoshiaki Kato , Toyoharu Okumoto
发明人： Tadao Mimura , Yoshiaki Kato , Toyoharu Okumoto
IPC分类号： B01D59/44 , H01J49/00 , G01D18/00 , G12B13/00
CPC分类号： H01J49/42 , H01J49/0009 , H01J49/004 , H01J49/40
摘要： An ion trap/time-of-flight mass spectrometer, which can perform accurate mass measurement of a product ion based on MS/MS and MSn has an ion source for ionizing a sample, an ion trap capable of temporarily trapping ions, and a time-of-flight mass spectrometer. The ion source produces ions of the sample as a measurement target and ions of a reference sample each having a known mass value. A precursor ion is selected from among the ions of the measurement target sample, and the selected precursor ion is excited and fragmented in the ion trap to produce a product ion. The reference sample ions are introduced to and trapped in the ion trap. The trapped product ion and reference sample ions are expelled out of the ion trap and introduced to the time-of-flight mass spectrometer, thereby obtaining a mass spectrum.

7. 发明授权

US06339218B1 Method and apparatus for direct coupling of liquid chromatograph and mass spectrometer, liquid chromatography—mass spectrometry, and liquid chromatograph mass spectrometer 失效
标题翻译：液相色谱仪和质谱仪直接耦合的方法和装置，液相色谱 - 质谱仪和液相色谱质谱仪
公开(公告)号：US06339218B1
公开(公告)日：2002-01-15
申请号：US09440474
申请日：1999-11-15
申请人： Yoshiaki Kato , Tadao Mimura
发明人： Yoshiaki Kato , Tadao Mimura
IPC分类号： B01D5944
CPC分类号： H01J49/145 , G01N30/7246 , G01N30/7273 , H01J49/045 , H01J49/049
摘要： A nebulized jet from a nebulizer is subjected to mechanical agitation and stirring to render the mists uniform and fine, then the droplets of the mists thus rendered uniform and fine are ionized. By accelerative collision of the resulting ions in a medium pressure chamber it is made possible to effect desolvation efficiently. Consequently, chemical noises caused by cluster ions can be greatly diminished and it is possible to attain high sensitive measurement of a sample in atmospheric pressure ionizations LC/MS.
摘要翻译：将来自喷雾器的喷雾喷雾器进行机械搅拌和搅拌以使雾化均匀且细微，从而雾化的液滴均匀且细小。通过所得到的离子在中压室中的加速碰撞，可以有效地实现去溶剂化。因此，可以大大减少由簇离子引起的化学噪声，并且可以在大气压离子化LC / MS中获得样品的高灵敏度测量。

8. 发明授权

US5668370A Automatic ionization mass spectrometer with a plurality of atmospheric ionization sources 失效
标题翻译：具有多个大气电离源的自动电离质谱仪
公开(公告)号：US5668370A
公开(公告)日：1997-09-16
申请号：US683347
申请日：1996-07-18
申请人： Masayoshi Yano , Tadao Mimura , Yoshiaki Kato
发明人： Masayoshi Yano , Tadao Mimura , Yoshiaki Kato
IPC分类号： G01N30/72 , H01J49/04 , H01J49/26
CPC分类号： H01J49/165 , H01J49/107 , H01J49/168 , G01N30/7233
摘要： An LC-MS is provided with a plurality of ion sources which can be quickly and selectively disposed at a fixed working position, and capable of analyzing a large variety of substances. An APCI unit (1) and an ESI unit (2) are fixedly mounted on a rotating table (11) or a sliding carriage (19). The rotating table (11) is held for rotation on a base (13) with a holding ring (12), and the sliding carriage (19) is held for linear sliding movement on a bearing (22) on a base (21) with a holding member (20) and is moved by a feed screw (23). Either the APCI unit (1) or the ESI unit (2) is selectively disposed at a fixed working position opposite to a first aperture (16), a second aperture (17) and a mass spectrometric unit (18) to ionize a substance for mass spectrometry. The plurality of ion sources can be set at the fixed working position by a simple setting operation, increases the variety of substances which can be analyzed, and enables the LC-MS to produce a plurality of mass spectra for a single substance to facilitate the analysis and the like of the molecular structure of the substance.
摘要翻译： LC-MS设有多个离子源，可以快速，有选择地设置在固定的工作位置，能够分析各种物质。 APCI单元（1）和ESI单元（2）固定地安装在旋转台（11）或滑动滑架（19）上。旋转台（11）被保持以在具有保持环（12）的基座（13）上旋转，并且滑动滑架（19）被保持用于在基座（21）上的轴承（22）上的直线滑动运动，保持构件（20），并通过进给螺杆（23）移动。 APCI单元（1）或ESI单元（2）选择性地设置在与第一孔（16）相对的固定工作位置，第二孔（17）和质谱单元（18）上，以将物质离子化质谱。可以通过简单的设定操作将多个离子源设置在固定工作位置，增加可分析的物质的种类，并使LC-MS能够为单一物质产生多个质谱，以方便分析等等物质的分子结构。

9. 发明授权

US5567938A Mass spectrometer 失效
标题翻译：质谱仪
公开(公告)号：US5567938A
公开(公告)日：1996-10-22
申请号：US191919
申请日：1994-02-04
申请人： Tadao Mimura , Yoshiaki Kato , Kazumi Matsumura
发明人： Tadao Mimura , Yoshiaki Kato , Kazumi Matsumura
IPC分类号： G01N27/62 , G01N30/72 , H01J49/04 , H01J49/10
CPC分类号： H01J49/0404 , G01N30/7266 , G01N30/7293 , H01J49/0468 , H01J49/165
摘要： Ions generated by an ES ion supply are introduced into a mass spectrometer portion through a small hole in a second electrode after passing through a small hole in a heated first electrode, and are analyzed by a mass spectrometer. Corresponding to heating of the first electrode, a length of the small hole in the first electrode is determined to a predetermined adequate value.
摘要翻译：通过ES离子源产生的离子通过第一电极中的小孔后通过第二电极中的小孔引入质谱仪部分，并通过质谱仪进行分析。对应于第一电极的加热，将第一电极中的小孔的长度确定为预定的适当值。

10. 发明申请

US20070069121A1 Ion trap/time-of-flight mass spectrometer and method of measuring ion accurate mass 审中-公开
标题翻译：离子阱/飞行时间质谱仪和离子精确质量的测量方法
公开(公告)号：US20070069121A1
公开(公告)日：2007-03-29
申请号：US11606046
申请日：2006-11-30
申请人： Tadao Mimura , Yoshiaki Kato , Toyoharu Okumoto
发明人： Tadao Mimura , Yoshiaki Kato , Toyoharu Okumoto
IPC分类号： H01J49/00
CPC分类号： H01J49/42 , H01J49/0009 , H01J49/004 , H01J49/40
摘要： An ion trap/time-of-flight mass spectrometer, which can perform accurate mass measurement of a product ion based on MS/MS and MSn has an ion source for ionizing a sample, an ion trap capable of temporarily trapping ions, and a time-of-flight mass spectrometer. The ion source produces ions of the sample as a measurement target and ions of a reference sample each having a known mass value. A precursor ion is selected from among the ions of the measurement target sample, and the selected precursor ion is excited and fragmented in the ion trap to produce a product ion. The reference sample ions are introduced to and trapped in the ion trap. The trapped product ion and reference sample ions are expelled out of the ion trap and introduced to the time-of-flight mass spectrometer, thereby obtaining a mass spectrum.
摘要翻译：离子阱/飞行时间质谱仪可以基于MS / MS和MS进行产物离子的精确质量测量具有离子源，用于离子化样品，离子阱能力暂时捕获离子和飞行时间质谱仪。离子源产生样品的离子作为测量对象，每个参考样品的离子具有已知的质量值。从测量对象样品的离子中选择前体离子，并且将所选择的前体离子在离子阱中激发并碎裂以产生产物离子。将参考样品离子引入并捕获在离子阱中。捕获的产物离子和参考样品离子从离子阱中排出并引入飞行时间质谱仪，从而获得质谱。

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