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1. 发明授权

US06848462B2 Adhesiveless microfluidic device fabrication 有权
标题翻译：无粘性微流体装置制造
公开(公告)号：US06848462B2
公开(公告)日：2005-02-01
申请号：US10313231
申请日：2002-12-06
申请人： Joseph F. Covington , Steven E. Hobbs , Jeffrey A. Koehler , Paren P. Patel , Marci Pezzuto , Mark S. Scheib
发明人： Joseph F. Covington , Steven E. Hobbs , Jeffrey A. Koehler , Paren P. Patel , Marci Pezzuto , Mark S. Scheib
IPC分类号： B01L3/00 , B29C65/00 , B29C65/18 , B32B37/08 , B81C1/00 , G01N27/447 , F15C1/06
CPC分类号： B01L3/502707 , B01J2219/00783 , B01J2219/00833 , B01J2219/00835 , B01J2219/00891 , B01J2219/00952 , B01L3/502738 , B01L3/502746 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/0681 , B01L2300/0874 , B01L2300/0887 , B01L2300/14 , B29C65/18 , B29C66/02 , B29C66/026 , B29C66/1122 , B29C66/45 , B29C66/71 , B29C66/727 , B29C66/73112 , B29C66/8322 , B29C66/91212 , B29C66/91213 , B29C66/91216 , B29C66/91221 , B29C66/91231 , B29C66/91411 , B29C66/91445 , B29C66/91645 , B29C66/92445 , B29C66/929 , B29C66/961 , B29K2023/00 , B29K2023/12 , B29L2031/756 , B32B37/0023 , B32B37/08 , B32B37/10 , B32B38/004 , B32B41/00 , B32B2037/0092 , B32B2038/166 , B32B2309/02 , B32B2309/022 , B32B2309/12 , B32B2310/024 , B81B2201/058 , B81C1/00119 , B81C3/008 , B81C2201/019 , G01N27/44791 , G01N30/6095 , Y10T29/49002 , Y10T137/0402 , Y10T137/2224 , Y10T137/598 , B29C2035/0827 , B29K2067/00
摘要： A method for fabricating a microfluidic device where first and second substantially flat platens are provided. Multiple substantially planar, substantially metal-free, adhesiveless polymer device layers, the device layers including a first cover layer, second cover layer, and at least one stencil layer defining a microfluidic channel penetrating through the entire thickness of the stencil layer also are provided. Each stencil layer is disposed between other device layers such that the channel is bounded laterally by a stencil layer, and bounded from above and below by surrounding device layers to define an upper channel surface and a lower channel surface. The device layers are stacked between the first platen and the second platen. The stacked device layers are controllably heated according to a heating profile adapted to form a substantially sealed adhesiveless microfluidic device wherein each upper channel surface remains distinct from its corresponding lower channel surface. The resulting microfluidic device has high inter-layer bond strength while preserving the integrity of the channel(s) defined in the stencil layer(s).
摘要翻译：一种制造微流体装置的方法，其中设置有第一和第二基本平坦的压板。还提供了多个基本平坦的，基本上无金属的无粘合剂聚合物器件层，所述器件层包括第一覆盖层，第二覆盖层和限定穿透模板层的整个厚度的微流体通道的至少一个模板层。每个模版层设置在其它装置层之间，使得通道被模板层横向限定，并且由周围装置层从上方和下方界定，以限定上通道表面和下通道表面。装置层堆叠在第一压板和第二压板之间。根据适于形成基本上密封的无粘合微流体装置的加热轮廓可控制地加热堆叠的装置层，其中每个上部通道表面保持与其相应的下部通道表面不同。所得到的微流体装置具有高的层间结合强度，同时保持在模版层中定义的通道的完整性。

2. 发明授权

US07261812B1 Multi-column separation devices and methods 有权
标题翻译：多柱分离装置和方法
公开(公告)号：US07261812B1
公开(公告)日：2007-08-28
申请号：US10638258
申请日：2003-08-07
申请人： Christoph D. Karp , Joseph F. Covington , Matthew M. Gregori , Steven E. Hobbs , Jeffrey A. Koehler , Stephen D. O'Connor , Paren P. Patel , Scott G. Beach
发明人： Christoph D. Karp , Joseph F. Covington , Matthew M. Gregori , Steven E. Hobbs , Jeffrey A. Koehler , Stephen D. O'Connor , Paren P. Patel , Scott G. Beach
IPC分类号： B01D15/08
CPC分类号： B01D15/1864 , B01D15/1885 , G01N30/603 , G01N30/6043 , G01N30/6091 , G01N30/6095
摘要： Chromatographic separation devices include multiple batch-processed columns joined by a body structure and adapted to perform parallel analyses. Both slurry-packed and monolithic column embodiments are provided. One or more liquid-permeable frits of various types may be used to retain stationary phase material within columns. A fluidic distribution network may be used to distribute stationary phase material and/or mobile phase solvents to multiple columns. Separation devices, including microfluidic embodiments, may be fabricated with various materials including polymers. Multi-column fabrication and separation methods are provided.
摘要翻译：色谱分离装置包括由身体结构连接并适于执行平行分析的多个批处理柱。提供浆料包装和整体柱实施例。可以使用一种或多种各种类型的透液性玻璃料将固定相材料保持在塔内。可以使用流体分配网络将固定相材料和/或流动相溶剂分配到多个塔。包括微流体实施例的分离装置可以用包括聚合物的各种材料制成。提供了多列制造和分离方法。

3. 发明授权

US07153421B2 Frit material and bonding method for microfluidic separation devices 失效
标题翻译：微流体分离装置的玻璃料和粘合方法
公开(公告)号：US07153421B2
公开(公告)日：2006-12-26
申请号：US10916565
申请日：2004-08-10
申请人： Jeffrey A. Koehler , Paren P. Patel
发明人： Jeffrey A. Koehler , Paren P. Patel
IPC分类号： B01D15/08
CPC分类号： B01D61/18 , B01D61/20 , B01D63/081 , B01D63/087 , B01D63/088 , B01D65/003 , B01F13/0059 , B01F15/0264 , B01J19/0093 , B01L3/502707 , B01L3/502753 , B01L2200/10 , B01L2200/12 , B01L2300/0681 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2300/0887 , B01L2300/14 , B01L2400/0406 , B01L2400/0688 , B29C59/14 , B29C59/16 , B29C65/18 , B29C66/02 , B29C66/026 , B29C66/1122 , B29C66/45 , B29C66/71 , B29C66/727 , B29C66/73161 , B29C66/81812 , B29C66/92441 , B29C66/929 , B29C2035/0827 , B29K2023/00 , B29K2023/06 , B29K2023/12 , B29K2071/00 , B29L2031/756 , B32B38/0008 , B32B38/10 , B32B2037/0092 , B32B2309/02 , B32B2309/12 , B81B2201/058 , B81C3/008 , G01N27/44791 , G01N30/6095 , G01N2030/565
摘要： A multi-layer microfluidic separation device comprises a polymeric membrane frit that may be securely bonded within the device and minimizes lateral wicking. Stationary phase material having an average particle size is retained by a frit having an average pore size that is smaller than the average particle size. In one embodiment, a secure bond is ensured by treating the polymer to match its surface energy to that of the materials to which it is bound. Treatments include plasma treatment, irradiation and the application of acids.
摘要翻译：多层微流体分离装置包括聚合物膜玻璃料，其可以牢固地结合在装置内并使侧向芯吸最小化。具有平均粒径的平均粒径的平均粒径的平均粒径保持在平均粒径小于平均粒径的玻璃料。在一个实施方案中，通过处理聚合物以将其表面能与其所结合的材料的表面能相匹配来确保安全的结合。处理包括等离子体处理，照射和酸的应用。

4. 发明授权

US06923907B2 Separation column devices and fabrication methods 有权
标题翻译：分离柱装置和制造方法
公开(公告)号：US06923907B2
公开(公告)日：2005-08-02
申请号：US10366985
申请日：2003-02-13
申请人： Steven E. Hobbs , Matthew M. Gregori , Christoph D. Karp , Jeffrey A. Koehler , Paren P. Patel , Joseph F. Covington
发明人： Steven E. Hobbs , Matthew M. Gregori , Christoph D. Karp , Jeffrey A. Koehler , Paren P. Patel , Joseph F. Covington
IPC分类号： B01D15/08 , B01F13/00 , B01J19/00 , B01J20/281 , B01J20/283 , B01J20/285 , B01L3/00 , B29C65/00 , G01N30/26 , G01N30/46 , G01N30/56 , G01N30/60 , G01N30/74 , G01N30/78 , G01N30/88
CPC分类号： B01F13/0059 , B01F15/0264 , B01J19/0093 , B01L3/502707 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L2300/0681 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2300/0887 , B01L2300/14 , B01L2400/0406 , B01L2400/0688 , B29C65/02 , B29C66/02 , B29C66/026 , B29C66/71 , B29C66/727 , B29K2023/00 , B29K2023/12 , B29L2031/756 , B81B2201/058 , B81C3/008 , G01N30/6095 , G01N2030/565 , B29C2035/0827
摘要： Pressure-driven microfluidic separation devices, such as may be used for performing high performance liquid chromatography, are provided. Multiple separation columns may be defined in a single device and packed with stationary phase material retained by porous frits. One or more splitters may be provided to distribute slurry and/or mobile phase among multiple separation columns. In one embodiment, separation devices are substantially planar and fabricated with multiple device layers. Systems and methods employing slurry for packing separation devices are also provided.
摘要翻译：提供压力驱动的微流体分离装置，例如可用于执行高效液相色谱。多个分离柱可以在单个装置中定义并且填充有被多孔玻璃料保留的固定相材料。可以提供一个或多个分离器以在多个分离柱之间分配淤浆和/或流动相。在一个实施例中，分离装置基本上是平面的并且用多个装置层制造。还提供了使用用于包装分离装置的浆料的系统和方法。

5. 发明授权

US06814859B2 Frit material and bonding method for microfluidic separation devices 失效
标题翻译：微流体分离装置的玻璃料和粘合方法
公开(公告)号：US06814859B2
公开(公告)日：2004-11-09
申请号：US10256505
申请日：2002-09-27
申请人： Jeffrey A. Koehler , Paren P. Patel
发明人： Jeffrey A. Koehler , Paren P. Patel
IPC分类号： B01D1508
CPC分类号： B01D61/18 , B01D61/20 , B01D63/081 , B01D63/087 , B01D63/088 , B01D65/003 , B01F13/0059 , B01F15/0264 , B01J19/0093 , B01L3/502707 , B01L3/502753 , B01L2200/10 , B01L2200/12 , B01L2300/0681 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2300/0887 , B01L2300/14 , B01L2400/0406 , B01L2400/0688 , B29C59/14 , B29C59/16 , B29C65/18 , B29C66/02 , B29C66/026 , B29C66/1122 , B29C66/45 , B29C66/71 , B29C66/727 , B29C66/73161 , B29C66/81812 , B29C66/92441 , B29C66/929 , B29C2035/0827 , B29K2023/00 , B29K2023/06 , B29K2023/12 , B29K2071/00 , B29L2031/756 , B32B38/0008 , B32B38/10 , B32B2037/0092 , B32B2309/02 , B32B2309/12 , B81B2201/058 , B81C3/008 , G01N27/44791 , G01N30/6095 , G01N2030/565
摘要： A frit for use in multi-layer microfluidic separation devices is provided. The frit comprises a polymeric membrane that may be securely bonded within the device and minimizes lateral wicking. A secure bond is ensured by treating the polymer to match its surface energy to that of the materials to which it is bound. Treatments include plasma treatment, irradiation and the application of acids.
摘要翻译：提供了用于多层微流体分离装置的玻璃料。玻璃料包括聚合物膜，其可以牢固地结合在装置内并使侧向芯吸最小化。通过处理聚合物使其表面能与其所结合的材料的表面能相匹配来确保牢固的粘合。处理包括等离子体处理，照射和酸的应用。

6. 发明授权

US06499499B2 Flow control in multi-stream microfluidic devices 失效
标题翻译：多流微流体装置中的流量控制
公开(公告)号：US06499499B2
公开(公告)日：2002-12-31
申请号：US09962034
申请日：2001-09-25
申请人： Eugene Dantsker , Christoph D. Karp , Marci Pezzuto , Steven E. Hobbs , Paren P. Patel
发明人： Eugene Dantsker , Christoph D. Karp , Marci Pezzuto , Steven E. Hobbs , Paren P. Patel
IPC分类号： F15C106
CPC分类号： F16K99/0025 , B01L3/502707 , B01L3/502738 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2400/0418 , B01L2400/0487 , B01L2400/0688 , B01L2400/084 , F16K99/0001 , F16K99/0028 , F16K99/0036 , F16K99/0057 , F16K2099/0074 , F16K2099/0076 , F16K2099/008 , Y10T137/0318 , Y10T137/206 , Y10T137/2196 , Y10T137/2224
摘要： Microfluidic devices for splitting an established fluidic flow through a microfluidic channel among multiple downstream microfluidic channels include a plurality of elevated flow resistance regions to promote precise and predictable splitting. Each elevated resistance region imparts a flow resistance that is substantially greater than the characteristic resistance to established flow of its associated downstream channel. Elevated flow resistance regions may include one or more porous materials and/or alterations to the channel geometry of at least a portion of a downstream channel.
摘要翻译：用于在多个下游微流体通道之间分离已建立的流体通过微流体通道的微流体装置包括多个升高的流动阻力区域，以促进精确和可预测的分裂。每个升高的电阻区域赋予流动阻力，其明显大于其相关联的下游通道的建立流量的特性阻力。高流动阻力区域可以包括一个或多个多孔材料和/或对下游通道的至少一部分的通道几何形状的改变。

7. 发明授权

US07010964B2 Pressurized microfluidic devices with optical detection regions 失效
标题翻译：具有光学检测区域的加压微流体装置
公开(公告)号：US07010964B2
公开(公告)日：2006-03-14
申请号：US10697923
申请日：2003-10-29
申请人： Christoph D. Karp , Paren P. Patel
发明人： Christoph D. Karp , Paren P. Patel
IPC分类号： G01N30/00
CPC分类号： G01N30/6095 , G01N30/6082 , G01N30/74 , G01N30/466 , G01N30/32
摘要： Microfluidic analytical devices and systems have at least one porous element disposed downstream of one or more optical detection regions in a pressure-based separation system. A porous element elevates the backpressure within an optical detection region, thus suppressing bubble formation and enhancing optical detection. Various types of porous elements include porous membranes, packed particulate material, and polymerized monoliths. Preferred devices may be fabricated with substantially planar device layers, including stencil layers, that are directly bonded without adhesives to form a substantially sealed microstructure suitable for performing pressure-based chromatographic separations at elevated operating pressures and with organic solvents.
摘要翻译：微流体分析装置和系统在基于压力的分离系统中具有至少一个多孔元件，其设置在一个或多个光学检测区域的下游。多孔元件提高光学检测区域内的背压，从而抑制气泡形成和增强光学检测。各种类型的多孔元件包括多孔膜，填充颗粒材料和聚合的整料。优选的器件可以被制造成具有基本上平面的器件层，包括蜡纸层，其直接粘合而没有粘合剂以形成适合于在升高的操作压力下和与有机溶剂进行基于压力的色谱分离的基本上密封的微结构。

8. 发明授权

US06729352B2 Microfluidic synthesis devices and methods 失效
标题翻译：微流控合成装置及方法
公开(公告)号：US06729352B2
公开(公告)日：2004-05-04
申请号：US10165448
申请日：2002-06-07
申请人： Stephen D. O'Connor , Christoph D. Karp , Marci Pezzuto , Paren P. Patel , Steven E. Hobbs , Eugene Dantsker
发明人： Stephen D. O'Connor , Christoph D. Karp , Marci Pezzuto , Paren P. Patel , Steven E. Hobbs , Eugene Dantsker
IPC分类号： F15C114
CPC分类号： B01F5/0471 , B01F5/064 , B01F13/0059 , B01F15/0205 , B01F15/0264 , B01J19/0093 , B01J2219/00783 , B01J2219/00889 , B01L3/5027 , B01L3/502707 , B01L3/502738 , B01L2300/0681 , B01L2300/0864 , B01L2300/0874 , B01L2300/0887 , B01L2400/0406 , B01L2400/0487 , B01L2400/06 , B01L2400/0688 , B82Y30/00 , Y10T137/2164 , Y10T137/2191 , Y10T137/2224 , Y10T137/85938
摘要： A microfluidic reactor for performing chemical and biological synthesis reactions, including chemical and biological syntheses of organic, polymer, inorganic, oligonucleotide, peptide, protein, bacteria, and enzymatic products is provided. Two fluids are input into the device, mixed in a mixing region and provided to a long, composite reaction channel. Fluids flowing through the reaction channel may be diverted at a diversion region into a sample channel. Fluids in the sample channel may be mixed at a second region, with additional reagents.
摘要翻译：提供了用于进行化学和生物合成反应的微流体反应器，包括有机，聚合物，无机，寡核苷酸，肽，蛋白质，细菌和酶产物的化学和生物合成。将两种流体输入到装置中，在混合区域中混合并提供给长的复合反应通道。流过反应通道的流体可以在分流区域被转移到样品通道中。样品通道中的液体可以在第二区域与另外的试剂混合。

9. 发明授权

US06935772B2 Fluidic mixer in microfluidic system 有权
标题翻译：流体混合器在微流体系统中
公开(公告)号：US06935772B2
公开(公告)日：2005-08-30
申请号：US10444041
申请日：2003-05-21
申请人： Christoph D. Karp , Stephen D. O'Connor , Paren P. Patel
发明人： Christoph D. Karp , Stephen D. O'Connor , Paren P. Patel
IPC分类号： B01D17/00 , B01F5/06 , B01F13/00 , B01L3/00 , B81B1/00 , G01N35/00 , G05B7/00
CPC分类号： B01D17/00 , B01D17/0208 , B01D17/08 , B01F5/0604 , B01F13/0059 , B01L3/5027 , B01L3/502707 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2300/0887 , B01L2300/165 , B01L2400/0406 , B01L2400/0487 , B81B1/002 , B81B2201/051 , G01N2035/00237 , G01N2035/00544 , Y10T137/2191 , Y10T137/2224 , Y10T137/8122 , Y10T428/24562 , Y10T428/24744
摘要： Microfluidic devices capable of efficiently mixing two or more fluid are provided. Two or more microfluidic inlet channels defined in different sheets of material meet at an overlap region in fluid communication with an outlet channel. The channels are defined through the entire thickness of stencil sheets. The overlap region may include an aperture-defining spacer layer, and/or an impedance element, such as a porous membrane, adapted to distribute at least one fluid across the entire width of the outlet channel to promote reliable fluid mixing.
摘要翻译：提供能够有效地混合两种或多种流体的微流体装置。限定在不同材料片材中的两个或多个微流体入口通道在与出口通道流体连通的重叠区域相遇。通道是通过蜡纸的整个厚度来定义的。重叠区域可以包括孔隙限定间隔层和/或阻抗元件，例如多孔膜，适于在出口通道的整个宽度上分布至少一种流体，以促进可靠的流体混合。

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