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1. 发明授权

US09489474B2 Model and methods for identifying points of action in electrically active cells 有权
标题翻译：用于识别电活动细胞中的作用点的模型和方法
公开(公告)号：US09489474B2
公开(公告)日：2016-11-08
申请号：US13576442
申请日：2011-02-07
申请人： James Hickman , Peter Molnar , Frank Sommerhage , Jonathan Ernest Hood , Jerry Jenkins
发明人： James Hickman , Peter Molnar , Frank Sommerhage , Jonathan Ernest Hood , Jerry Jenkins
IPC分类号： G01N33/48 , G06F17/50 , G01N33/50 , G06F19/12 , G06G7/58
CPC分类号： G06F17/5009 , G01N33/5058 , G06F19/12
摘要： The invention provides a model for generating predicted action potentials of an electrically active cell. The disclosed model includes three operatively coupled submodels. A first submodel contains Hodgkin-Huxley elements generating action potentials based on electrical equivalent circuits. A second submodel is based on reaction kinetics of cell metabolism and is operatively coupled with the first submodel. A third submodel is based on Boolean dynamics representing signaling and associated cellular processes and is operatively coupled with the first and second submodels. The invention includes storing a library of calculated action potentials and associated cellular parameters generated by the model, applying a stimulus to the electrically active cell in vitro so that the cell generates an action potential; and comparing the cell-generated action potential with those stored in the library, wherein a match is predictive of the cellular point of action of the applied stimulus according to the parameters stored.
摘要翻译：本发明提供了一种用于产生电活性电池的预测动作电位的模型。所公开的模型包括三个可操作耦合的子模型。第一个子模型包含Hodgkin-Huxley元素，其基于电等效电路产生动作电位。第二子模型基于细胞代谢的反应动力学，并且与第一子模型操作性耦合。第三子模型基于表示信令和相关联的细胞过程的布尔动力学，并且与第一和第二子模型可操作地耦合。本发明包括存储由模型产生的计算的动作电位和相关联的细胞参数的文库，在体外对电活性细胞施加刺激，使得细胞产生动作电位; 以及将细胞产生的动作电位与库中存储的动作电位进行比较，其中匹配是根据所存储的参数来预测所施加的刺激的细胞作用点。

2. 发明申请

US20130096888A1 Model and Methods for Identifying Points of Action in Electrically Active Cells 有权
标题翻译：识别电活动细胞中的作用点的模型和方法
公开(公告)号：US20130096888A1
公开(公告)日：2013-04-18
申请号：US13576442
申请日：2011-02-07
申请人： James Hickman , Peter Molnar , Frank Sommerhage , Jonathan Hood , Jerry Jenkins
发明人： James Hickman , Peter Molnar , Frank Sommerhage , Jonathan Hood , Jerry Jenkins
IPC分类号： G06F17/50
CPC分类号： G06F17/5009 , G01N33/5058 , G06F19/12
摘要： The invention provides a model for generating predicted action potentials of an electrically active cell. The disclosed model includes three operatively coupled submodels. A first submodel contains Hodgkin-Huxley elements generating action potentials based on electrical equivalent circuits. A second submodel is based on reaction kinetics of cell metabolism and is operatively coupled with the first submodel. A third submodel is based on Boolean dynamics representing signaling and associated cellular processes and is operatively coupled with the first and second submodels. The invention includes storing a library of calculated action potentials and associated cellular parameters generated by the model, applying a stimulus to the electrically active cell in vitro so that the cell generates an action potential; and comparing the cell-generated action potential with those stored in the library, wherein a match is predictive of the cellular point of action of the applied stimulus according to the parameters stored.
摘要翻译：本发明提供了一种用于产生电活性电池的预测动作电位的模型。所公开的模型包括三个可操作耦合的子模型。第一个子模型包含Hodgkin-Huxley元素，其基于电等效电路产生动作电位。第二子模型基于细胞代谢的反应动力学，并且与第一子模型操作性耦合。第三子模型基于表示信令和相关联的细胞过程的布尔动力学，并且与第一和第二子模型可操作地耦合。本发明包括存储由模型产生的计算的动作电位和相关联的细胞参数的文库，在体外对电活性细胞施加刺激，使得细胞产生动作电位; 以及将细胞产生的动作电位与库中存储的动作电位进行比较，其中匹配是根据所存储的参数来预测所施加的刺激的细胞作用点。

3. 发明授权

US09404140B1 Patterned cardiomyocyte culture on microelectrode array 有权
标题翻译：图案化心肌细胞培养在微电极阵列上
公开(公告)号：US09404140B1
公开(公告)日：2016-08-02
申请号：US12938701
申请日：2010-11-03
申请人： Peter Molnar , Anupama Natarajan , Maria Stancescu , James Hickman
发明人： Peter Molnar , Anupama Natarajan , Maria Stancescu , James Hickman
IPC分类号： C12Q1/02 , C12Q1/04 , G01N33/50
CPC分类号： G01N33/4836 , C12N5/0657 , C12N2533/30 , C12N2535/10 , C12Q1/02 , C12Q1/04 , G01N33/48728 , G01N33/5008 , G01N33/5061
摘要： The invention provides a culture of patterned cardiomyocytes, the culture including a support substrate bearing a multielectrode array, a negative surface resistant to cell attachment and deposited on the support substrate covering the multi-electrode array, a pattern ablated on the negative surface, a positive surface promoting cell attachment deposited on the pattern ablated on the negative surface; and cardiomyocytes adherent to the positive surface and growing aligned along the pattern ablated on the negative surface. The invention also includes a method of making the culture of patterned cardiomyocytes and a method of in vitro method of testing the effect of a compound on cardiac function by measuring electrical output from the patterned cardiomyocytes.
摘要翻译：本发明提供了一种图案化心肌细胞的培养物，其培养物包括支持多电极阵列的支撑基底，抵抗细胞附着并沉积在覆盖多电极阵列的支撑基底上的负表面，在负表面上烧蚀的图案，阳性沉积在图案上的表面促进细胞附着物消融在负面上; 并且附着在阳性表面上的生长对准的心肌细胞沿消融在阴性表面上的图案生长。本发明还包括使图案化心肌细胞培养的方法和通过测量来自图案化心肌细胞的电输出来测试化合物对心脏功能的影响的体外方法。

4. 发明申请

US20070010413A1 Automotive cleaning compound for plastic lens 审中-公开
标题翻译：汽车清洁复合塑料镜片
公开(公告)号：US20070010413A1
公开(公告)日：2007-01-11
申请号：US11175359
申请日：2005-07-07
申请人： Peter Molnar
发明人： Peter Molnar
IPC分类号： C11D3/37
CPC分类号： C11D11/0035 , C11D1/04 , C11D3/1213 , C11D3/18 , C11D17/0013
摘要： An automotive cleaning compound for a plastic lens having a cleaning compound, hydrocarbons, water, ammonia, stabilizing material, and waxy material.
摘要翻译：一种用于具有清洁化合物，碳氢化合物，水，氨，稳定材料和蜡质材料的塑料透镜的汽车清洁化合物。

5. 发明授权

US5992241A Method and device for determining the neutral temperature of welded tracks 失效
标题翻译：用于确定焊接轨迹的中性温度的方法和装置
公开(公告)号：US5992241A
公开(公告)日：1999-11-30
申请号：US945985
申请日：1998-01-26
申请人： Gyorgy Posgay , Peter Molnar , Ferenc Varga , Tibor Zsakai , Alfonz Szamos , Janos Beli , Jozsef Vegi
发明人： Gyorgy Posgay , Peter Molnar , Ferenc Varga , Tibor Zsakai , Alfonz Szamos , Janos Beli , Jozsef Vegi
IPC分类号： G01N27/72 , G01B7/24
CPC分类号： G01N27/725
摘要： A method for determining the longitudinal loading acting on a beam, such as a rail of a railway track subjected to longitudinal loading and, in particular, for determining the neutral temperature of railway tracks. The beam is energized longitudinally in the acoustic frequency range, and the level of magnetic Barkhausen noise at the surface of the energized region is measured. Measurements of the magnetic Barkhausen noise are taken for different longitudinal stress states and used for plotting the calibration curve of the magnetic Barkhausen noise as a function of longitudinal stress, the Barkhausen noise being measured at least at three points on the face of the built-in beam, and the calibration curve is used for determining the longitudinal loading on the cross-section in question using weighted averaging. The neutral temperature of the railway track is then calculated considering the modulus of elasticity, coefficient of thermal expansion and temperature of the rail.
摘要翻译： PCT No.PCT / HU96 / 00027 Sec。 371日期1998年1月26日 102（e）1998年1月26日PCT PCT 1996年5月9日PCT公布。第WO96 / 35947号公报日期1996年11月14日一种用于确定作用在梁（例如经受纵向载荷的铁路轨道的轨道）上的纵向载荷的方法，特别是用于确定铁路轨道的中性温度。光束在声频范围内纵向通电，并测量通电区域表面的磁性Barkhausen噪声水平。采用不同纵向应力状态测量磁性Barkhausen噪声，并用于绘制磁性Barkhausen噪声的校准曲线作为纵向应力的函数，巴克豪森噪声至少在内置的三个点上测量光束，并且校准曲线用于使用加权平均来确定所讨论的横截面上的纵向载荷。考虑到弹性模量，热膨胀系数和轨道温度，计算出铁路轨道的中性温度。

6. 发明申请

US20050058115A1 Method and apparatus for data allocation in an overlapenable communication system 有权
标题翻译：用于可重叠通信系统中的数据分配的方法和装置
公开(公告)号：US20050058115A1
公开(公告)日：2005-03-17
申请号：US10958039
申请日：2004-10-04
申请人： Howard Levin , Kenneth Cavanaugh , Jeffrey Gleason , Peter Molnar
发明人： Howard Levin , Kenneth Cavanaugh , Jeffrey Gleason , Peter Molnar
IPC分类号： H04J11/00 , H04L5/06 , H04L5/14 , H04L27/26 , H04L29/02 , H04L29/08 , H04B7/208
CPC分类号： H04L5/0064 , H04L5/0007 , H04L5/0046 , H04L5/006 , H04L5/06 , H04L5/143
摘要： A communication system is dynamically configured to use some or all of the communication channel bandwidth. Regions of the communication channel are prioritized, and bandwidth is allocated in accordance with priorities and requested data rate.
摘要翻译：动态配置通信系统以使用部分或全部通信信道带宽。优先考虑通信信道的区域，并根据优先级和请求的数据速率分配带宽。

7. 发明授权

US08583984B2 Method and apparatus for increasing data reliability for raid operations 有权
标题翻译：提高袭击操作数据可靠性的方法和装置
公开(公告)号：US08583984B2
公开(公告)日：2013-11-12
申请号：US12976247
申请日：2010-12-22
申请人： Mark A. Schmisseur , Sivakumar Radhakrishnan , Pankaj Kumar , Marc A. Goldschmidt , Peter Molnar
发明人： Mark A. Schmisseur , Sivakumar Radhakrishnan , Pankaj Kumar , Marc A. Goldschmidt , Peter Molnar
IPC分类号： H03M13/00
CPC分类号： G06F11/1076
摘要： A method and apparatus to enable data integrity checking of a block of data while the block of data is being transferred from a volatile memory to a non-volatile storage device is provided. The data integrity checking is performed in conjunction with Direct Memory Access operations and Redundant Array of Independent Disk (RAID) operations. In addition, data integrity checking of syndrome blocks in the RAID is performed during transfers to/from the storage devices in the RAID system and during RAID update and RAID data reconstruction operations.
摘要翻译：提供了一种方法和装置，用于在数据块从易失性存储器传输到非易失性存储装置的同时使数据块的数据完整性检查得以实现。数据完整性检查与直接内存访问操作和独立磁盘冗余阵列（RAID）操作一起执行。此外，在向RAID系统的存储设备传输期间以及在RAID更新和RAID数据重建操作期间执行RAID中的校验块的数据完整性检查。

8. 发明申请

US20120166909A1 METHOD AND APPARATUS FOR INCREASING DATA RELIABILITY FOR RAID OPERATIONS 有权
标题翻译：增加RAID操作数据可靠性的方法和装置
公开(公告)号：US20120166909A1
公开(公告)日：2012-06-28
申请号：US12976247
申请日：2010-12-22
申请人： Mark A. Schmisseur , Sivakumar Radhakrishnan , Pankaj Kumar , Marc A. Goldschmidt , Peter Molnar
发明人： Mark A. Schmisseur , Sivakumar Radhakrishnan , Pankaj Kumar , Marc A. Goldschmidt , Peter Molnar
IPC分类号： G11C29/00
CPC分类号： G06F11/1076
摘要： A method and apparatus to enable data integrity checking of a block of data while the block of data is being transferred from a volatile memory to a non-volatile storage device is provided. The data integrity checking is performed in conjunction with Direct Memory Access operations and Redundant Array of Independent Disk (RAID) operations. In addition, data integrity checking of syndrome blocks in the RAID is performed during transfers to/from the storage devices in the RAID system and during RAID update and RAID data reconstruction operations.
摘要翻译：提供了一种方法和装置，用于在数据块从易失性存储器传输到非易失性存储装置的同时使数据块的数据完整性检查得以实现。数据完整性检查与直接内存访问操作和独立磁盘冗余阵列（RAID）操作一起执行。此外，在向RAID系统的存储设备传输期间以及在RAID更新和RAID数据重建操作期间执行RAID中的校验块的数据完整性检查。

9. 发明申请

US20120122728A1 Method Of Screening Drugs For Reversal Of Amyloid Beta Neurotoxicity 审中-公开
标题翻译：筛选药物用于反转淀粉样蛋白β神经毒性的方法
公开(公告)号：US20120122728A1
公开(公告)日：2012-05-17
申请号：US13322911
申请日：2010-05-27
申请人： James J. Hickman , Kucku Vaghese , Peter Molnar
发明人： James J. Hickman , Kucku Vaghese , Peter Molnar
IPC分类号： C40B30/06 , C12Q1/02
CPC分类号： C07K14/4711
摘要： A method of screening a compound for effectiveness in treating amyloid beta neurotoxicity comprises culturing mammalian neurons in serum-free defined medium until the neurons are electrically functional, exposing the electrically stable neurons to amyloid beta, monitoring the exposed neurons for impairment of electrical functionality, and treating the exposed neurons with the candidate drug while monitoring their electrical activity for reversal of impairment. The invention also includes a method of identifying a mammalian neuron having a biological marker conferring predisposition to development of Alzheimer's disease, the method comprising culturing the mammalian neuron in serum-free medium until the neuron is electrically functional, exposing the electrically stable neuron to amyloid beta while monitoring for impairment of electrical functionality as an indicator of presence of said biological marker, and verifying presence of the biological marker by treating the impaired neuron with an anti-amyloidogenic compound while monitoring for return of neuron functionality.
摘要翻译：筛选化合物以治疗淀粉样蛋白β神经毒性的有效性的方法包括在无血清定义的培养基中培养哺乳动物神经元，直到神经元具有电功能，将电稳定的神经元暴露于淀粉样蛋白β，监测暴露的神经元以损害电功能，以及用候选药物治疗暴露的神经元，同时监测其电活动以逆转损伤。本发明还包括鉴定具有赋予阿尔茨海默病发展倾向的生物学标记的哺乳动物神经元的方法，所述方法包括在无血清培养基中培养哺乳动物神经元，直到神经元具有电功能，将电稳定的神经元暴露于淀粉样蛋白β 同时监测电功能损伤作为所述生物标志物存在的指标，以及通过用抗淀粉样变性化合物治疗受损神经元同时监测神经元功能的返回来验证生物标志物的存在。

10. 发明授权

US06527193B1 Tracking metallic objects by information incorporated therein 失效
标题翻译：通过内置的信息跟踪金属物体
公开(公告)号：US06527193B1
公开(公告)日：2003-03-04
申请号：US09463608
申请日：2000-03-30
申请人： János Béli , Róbert Keszte , Peter Molnar , Gyorgy Posgay , Alfonz Szamos , János Takács
发明人： János Béli , Róbert Keszte , Peter Molnar , Gyorgy Posgay , Alfonz Szamos , János Takács
IPC分类号： G06K1906
CPC分类号： G06K19/06 , G06K1/126 , G06K1/128
摘要： The subject of the invention is method and device system for entering and retrieving information in the surface layer of objects made of solid matters. The information is entered with a (concentrated) beam directed to the surface and having a power density selected to induce permanent change at least in the surface layer of the material's structure in a way that the power density of the beam is smaller that the power density of the beam causing visible deformation, but bigger than that of the beam that causes (within the order of magnitude of the beam's diameter) inhomogeneities commensurable with the structural inhomogeneities generally present in the material. The invention can be used for all materials, the structure or internal stress of which can be modified with high energy density surface treatment (at the location of the treatment) (specially with the local laser treatment of ferromagnetic material).
摘要翻译：本发明的主题是用于在由固体物体制成的物体的表面层中输入和检索信息的方法和装置系统。信息以指向表面的（集中）光束进入，并且具有选择的功率密度以至少在材料结构的表面层中引起永久变化，使得光束的功率密度小于功率密度的光束引起可见变形，但大于导致材料中通常存在的结构不均匀性（与光束直径的数量级）不均匀性不同的光束。本发明可用于所有材料，其结构或内部应力可以用高能量密度表面处理（处理位置）（特别是用铁磁材料的局部激光处理）进行改性。

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