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1. 发明授权

US07153846B2 Bengamide derivatives, process for preparing them, and their use 失效
标题翻译：孟加拉胺衍生物，其制备方法及其用途
公开(公告)号：US07153846B2
公开(公告)日：2006-12-26
申请号：US10971228
申请日：2004-10-22
申请人： Holger Hoffmann , Sabine Haag-Richter , Michael Kurz , Heiko Tietgen
发明人： Holger Hoffmann , Sabine Haag-Richter , Michael Kurz , Heiko Tietgen
IPC分类号： C07D223/12 , A61K31/55 , A61P35/00
CPC分类号： C12R1/01 , C07D223/12 , C12P17/10
摘要： The present invention relates to bengamide derivatives which are formed, during fermentation, by the microorganism Myxococcus virescens ST200611 (DSM 15898), to their use for treating cancer diseases, to pharmaceuticals which comprise bengamide derivatives, to a process for preparing bengamides of the formula (V) and to the microorganism Myxococcus virescens ST200611 (DSM 15898)
摘要翻译：本发明涉及在发酵期间由微生物粘球菌ST200611（DSM15898）在治疗癌症疾病中用于治疗癌症疾病的孟加拉酰胺衍生物，涉及制备式（b）的班格酰胺的方法， V）和微生物粘液菌（Myxococcus virescens）ST200611（DSM 15898）

2. 发明申请

US20050171089A1 Bengamide derivatives, process for preparing them, and their use 失效
标题翻译：孟加拉胺衍生物，其制备方法及其用途
公开(公告)号：US20050171089A1
公开(公告)日：2005-08-04
申请号：US10971228
申请日：2004-10-22
申请人： Holger Hoffmann , Sabine Haag-Richter , Michael Kurz , Heiko Tietgen
发明人： Holger Hoffmann , Sabine Haag-Richter , Michael Kurz , Heiko Tietgen
IPC分类号： C07D223/12 , C12P17/10 , A61K31/55
CPC分类号： C12R1/01 , C07D223/12 , C12P17/10
摘要： The present invention relates to bengamide derivatives which are formed, during fermentation, by the microorganism Myxococcus virescens ST200611 (DSM 15898), to their use for treating cancer diseases, to pharmaceuticals which comprise bengamide derivatives, to a process for preparing bengamides of the formula (V) and to the microorganism Myxococcus virescens ST200611 (DSM 15898).
摘要翻译：本发明涉及在发酵期间由微生物粘球菌ST200611（DSM15898）在治疗癌症疾病中用于治疗癌症疾病的孟加拉酰胺衍生物，涉及制备式（b）的班格酰胺的方法， V）和微生物粘液菌（Myxococcus virescens）ST200611（DSM 15898）。

3. 发明申请

US20070065932A1 BENGAMIDE DERIVATIVES, PROCESS FOR PREPARING THEM, AND THEIR USE 失效
标题翻译：孟加玛衍生物，制备它们的方法及其使用
公开(公告)号：US20070065932A1
公开(公告)日：2007-03-22
申请号：US11555809
申请日：2006-11-02
申请人： Holger HOFFMANN , Sabine HAAG-RICHTER , Michael Kurz , Heiko Tietgen
发明人： Holger HOFFMANN , Sabine HAAG-RICHTER , Michael Kurz , Heiko Tietgen
IPC分类号： C12N1/20
CPC分类号： C12R1/01 , C07D223/12 , C12P17/10
摘要： The present invention relates to bengamide derivatives which are formed, during fermentation, by the microorganism Myxococcus virescens ST200611 (DSM 15898), to their use for treating cancer diseases, to pharmaceuticals which comprise bengamide derivatives, to a process for preparing bengamides of the formula (V) and to the microorganism Myxococcus virescens ST200611 (DSM 15898).
摘要翻译：本发明涉及在发酵期间由微生物粘球菌ST200611（DSM15898）在治疗癌症疾病中用于治疗癌症疾病的孟加拉酰胺衍生物，涉及制备式（b）的班格酰胺的方法， V）和微生物粘液菌（Myxococcus virescens）ST200611（DSM 15898）。

4. 发明授权

US06956061B2 Polyisoprenylbenzophenone derivatives, processes for their preparation and use thereof 有权
标题翻译：聚异戊二烯基二苯甲酮衍生物，其制备方法和用途
公开(公告)号：US06956061B2
公开(公告)日：2005-10-18
申请号：US10632064
申请日：2003-07-31
申请人： Matthias Schiell , Michael Kurz , Sabine Haag-Richter
发明人： Matthias Schiell , Michael Kurz , Sabine Haag-Richter
IPC分类号： C07C45/78 , C07C49/835 , C07C49/84 , A61K31/12 , A61P31/00 , C07C49/115
CPC分类号： C07C45/78 , C07C49/835 , C07C49/84
摘要： The present invention relates to compounds of the formula (I): which are produced by the plant Garcinia punctata, chemical derivatives derived therefrom, a process for their preparation, and their use as pharmaceuticals, in particular for the treatment and/or prophylaxis of bacterial infectious diseases.
摘要翻译：本发明涉及式（I）化合物：其由植物藤黄，由其衍生的化学衍生物，其制备方法及其作为药物的用途，特别是用于治疗和/或预防细菌传染性疾病。

5. 发明授权

US08875241B2 Optical media protection driver 有权
标题翻译：光媒体保护驱动
公开(公告)号：US08875241B2
公开(公告)日：2014-10-28
申请号：US10552288
申请日：2004-03-25
申请人： Andreas Winter , Michael Kurz
发明人： Andreas Winter , Michael Kurz
IPC分类号： G06F17/30 , G11B20/00 , G06F21/10
CPC分类号： G06F21/10 , G06F2221/0744 , G06F2221/2153 , G11B20/00086 , G11B20/00173 , G11B20/00202 , G11B20/00659 , G11B20/00688 , G11B20/00695 , G11B20/00884 , G11B20/00927
摘要： A method to protect content within protected data areas on a target optical record carrier against unauthorized reading and/or copying with a computer, comprises the steps of—determining whether a target optical record carrier or a non-target optical record carrier is inserted into a drive of the computer, and—in case a target optical record carrier is inserted into the drive of the computer—modifying read requests to the protected data areas so that no data is read or the read data is useless, and/or—modifying write commands in respect to the data within the protected data areas to a recordable record carrier or other storage so that the written data is useless.
摘要翻译：一种用于保护目标光学记录载体上的受保护数据区域内的内容以防止未经授权的读取和/或与计算机复制的方法包括以下步骤：确定目标光学记录载体或非目标光学记录载体是否被插入到并且在目标光学记录载体被插入计算机修改读取请求的驱动器到受保护数据区域的情况下，使得没有数据被读取或读取数据是无用的，和/或修改写入关于受保护数据区域内的数据到可记录记录载体或其他存储器的命令，使得写入的数据是无用的。

6. 发明授权

US07148254B2 2-Phenylbenzofuran derivatives, a process for preparing them, and their use 有权
标题翻译： 2-苯基苯并呋喃衍生物，其制备方法及其应用
公开(公告)号：US07148254B2
公开(公告)日：2006-12-12
申请号：US10972546
申请日：2004-10-25
申请人： Laszlo Vertesy , Michael Kurz , Astrid Markus-Erb , Luigi Toti
发明人： Laszlo Vertesy , Michael Kurz , Astrid Markus-Erb , Luigi Toti
IPC分类号： A61K31/34 , C07D307/86 , C12P17/04 , C12N1/18
CPC分类号： C12R1/66 , C07D307/86 , C12P17/04
摘要： The present invention relates to 2-phenylbenzofurans of formula (I) which are formed, during fermentation, by the microorganism Aspergillus flavipes ST003878 (DSM 15290), to a process for preparing them and to their use as pharmaceuticals for the treatment and/or prophylaxis of bacterial infectious diseases or mycoses.
摘要翻译：本发明涉及式（I）的2-苯基苯并呋喃，其在发酵过程中由微生物黄曲霉ST003878（DSM15290）制成，涉及其制备方法及其作为药物用于治疗和/或预防的用途的细菌感染性疾病或真菌病。

7. 发明授权

US07067112B2 Cephaibols: novel antiparasitics from Acremonium tubakii, process for their production, and use thereof 有权
标题翻译：头孢唑醇：来自Acremonium tubakii的新型抗寄生虫药，其生产方法及其用途
公开(公告)号：US07067112B2
公开(公告)日：2006-06-27
申请号：US10411144
申请日：2003-04-11
申请人： Laszlo Vertesy , Michael Kurz , Matthias Schiell , Joachim Hofmann
发明人： Laszlo Vertesy , Michael Kurz , Matthias Schiell , Joachim Hofmann
IPC分类号： A61K49/00 , A61K38/10 , C07K7/08
CPC分类号： C07K7/08 , A61K38/00
摘要： The invention relates to compounds of the formula I AcPhe-Aib-Aib-Aib-x-w-Leu-y-Aib-Hyp-Gln-z-Hyp-Aib-Pro-R (I) in which R is Phe-ol or Phe-al and w, x, y, and z have the following meanings: a) w is Gly or Ala; x is Aib and y and z are Iva; b) w is Gly; x, y and z are Iva; c) w is Gly; x and z are Aib and y is Iva; d) w is Gly; x, y and z are Aib; or e) w is Gly; x and y are Aib and z is Iva; or of the formula II AcPhe-Iva-Gln-Aib-lle-Thr-Aib-Leu-Aib-x-Gln-Aib-Hyp-Aib-Pro-Phe-Ser, (II) wherein x is Hyp or Pro, which are synthesized by Acremonium tubakii FH 1685 DSM 12774 during fermentation and released into the culture medium, a process for the isolation of the cephaibols from the culture medium, and their purification, and the use of the cephaibols as pharmacologically active compounds, in particular for the control of parasites.
摘要翻译：本发明涉及式I化合物<？in-line-formula description =“In-line Formulas”end =“lead”→AcPhe-Aib-Aib-Aib-xw-Leu-y-Aib-Hyp-Gln -z-Hyp-Aib-Pro-R（I）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中R是Phe-ol或Phe-al，w，x ，y和z具有以下含义：a）w是Gly或Ala; x是Aib，y和z是Iva; b）w是Gly; x，y和z是Iva; c）w是Gly; x和z是Aib，y是Iva; d）w是Gly; x，y和z是Aib; 或e）w是Gly; x和y是Aib，z是Iva; AcPhe-Iva-Gln-Aib-Lle-Thr-Aib-Leu-Aib-x-Gln-Aib，或者式II <？in-line-formula description =“In-line Formulas”end =“lead” -Hyp-Aib-Pro-Phe-Ser，（II）<？在线公式描述=“在线公式”end =“tail”？>其中x是Hyp或Pro，它们是由Acremonium tubakii FH 1685 DSM 12774在发酵过程中释放到培养基中，从培养基中分离头孢胆素的方法及其纯化，以及将头孢唑醇用作药物活性化合物，特别是用于控制寄生虫的方法。

8. 发明授权

US06994280B2 Fuel injection device for internal combustion engines 失效
标题翻译：内燃机燃油喷射装置
公开(公告)号：US06994280B2
公开(公告)日：2006-02-07
申请号：US10296705
申请日：2002-03-22
申请人： Michael Kurz , Gerd Wahr
发明人： Michael Kurz , Gerd Wahr
IPC分类号： F02M59/00 , F02M61/00 , F02M63/00 , F02M47/02 , B05B1/00
CPC分类号： F02M61/168 , F02M61/16
摘要： A fuel injector for internal combustion engines, includes a base body, an injection housing and a fastening device. The fastening device includes at least one lock nut with an annular land and an annular shoulder on the injection housing. By means of the fastening device, the injection housing is braced axially against the base body. A fuel inlet and at least one valve element are also provided. To improve the seal between the base body and the injection housing, the fastening device has at least one annular face which is oriented toward the annular land of the lock nut and is curved convexly in the manner of a spherical-segmental face.
摘要翻译：一种用于内燃机的燃料喷射器，包括基体，注射壳体和紧固装置。紧固装置包括至少一个具有环形接合面的锁紧螺母和注射壳体上的环形肩部。通过紧固装置，注射壳体轴向地支撑在基体上。还提供燃料入口和至少一个阀元件。为了改善基体和注射壳体之间的密封，紧固装置具有至少一个朝向锁定螺母的环形平台的环形面，并且以球形节面的方式凸出地弯曲。

9. 发明授权

US06624143B1 Calcium salts of lipopeptide antibiotics, method for producing same and their use 有权
标题翻译：脂肽抗生素的钙盐，其制备方法及其用途
公开(公告)号：US06624143B1
公开(公告)日：2003-09-23
申请号：US09623022
申请日：2000-08-25
申请人： Laszló Vértesy , Werner Aretz , Heinrich Decker , Eberhard Ehlers , Michael Kurz , Frank Rainer Schmidt
发明人： Laszló Vértesy , Werner Aretz , Heinrich Decker , Eberhard Ehlers , Michael Kurz , Frank Rainer Schmidt
IPC分类号： A61K3800
CPC分类号： C12R1/045 , A61K38/00 , C07K7/56
摘要： The invention relates to a calcium salt of the compound of formula (II), where R1 is a straight-chain or branched, saturated or unsaturated aliphatic acyl radical having 8 to 22 carbon atoms, which can optionally be interrupted by or linked to one or more phenyl or cycloalkyl groups and optionally interrupted by oxygen. The invention also relates to a method for producing said calcium salt and to its use as a medicine.
摘要翻译：本发明涉及式（II）化合物的钙盐，其中R 1是具有8至22个碳原子的直链或支链，饱和或不饱和的脂族酰基，其可任选地被一个或多个更多的苯基或环烷基并且任选被氧中断。本发明还涉及一种生产所述钙盐和用作药物的方法。

10. 发明授权

US06582949B1 Cephaibols: novel antiparasitics from Acremonium tubakii process for their production, and use thereof 有权
标题翻译： Cephaibols：来自Acremonium tubakii方法的新型抗寄生虫药物的生产及其用途
公开(公告)号：US06582949B1
公开(公告)日：2003-06-24
申请号：US09563505
申请日：2000-05-03
申请人： László Vértesy , Michael Kurz , Matthias Schiell , Joachim Hofmann
发明人： László Vértesy , Michael Kurz , Matthias Schiell , Joachim Hofmann
IPC分类号： C07K708
CPC分类号： C07K7/08 , A61K38/00
摘要： The invention relates to compounds of the formula I AcPhe-Aib-Aib-Aib-x-w-Leu-y-Aib-Hyp-Gln-z-Hyp-Aib-Pro-R (I) in which R is Phe-ol or Phe-al and w, x, y, and z have the following meanings: a) w is Gly or Ala; x is Aib and y and z are Iva; b) w is Gly; x, y and z are va; c) w is Gly; x and z are Aib and y is Iva; d) w is Gly; x, y and z are Aib; or e) w is Gly; x and y are Aib and z is Iva; or of the formula II AcPhe-Iva-Gln-Aib-Ile-Thr-Aib-Leu-Aib-x-Gln-Aib-Hyp-Aib-Pro-Phe-Ser (II), wherein x is Hyp or Pro, which are synthesized by Acremonium tubakii FH 1685 DSM 12774 during fermentation and released into the culture medium, a process for the isolation of the cephaibols from the culture medium, and their purification, and the use of the cephaibols as pharmacologically active compounds, in particular for the control of parasites.
摘要翻译：本发明涉及式Iin化合物，其中R为Phe-ol或Phe-al，w，x，y和z具有以下含义：a）w为Gly或Ala; x是Aib，y和z是Iva; b）w是Gly; x，y和z是va; c）w是Gly; x和z是Aib，y是Iva; d）w是Gly; x，y和z是Aib; 矿石）w是Gly; x和y是Aib，z是Iva;或者其中X是Hyp或Pro的式II，其在发酵过程中被Acremonium tubakii FH 1685 DSM 12774合成并释放到培养基中，从头孢曲松培养基和它们的纯化，以及将头孢吡肟作为药理学活性化合物的用途，特别是用于控制寄生虫。

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