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    • 5. 发明申请
    • Hyaluronic acid modification products and drug carrier therefrom
    • 透明质酸改性产品和药物载体
    • US20070031503A1
    • 2007-02-08
    • US10571005
    • 2004-09-08
    • Tai HirakuraTeruo Nakamura
    • Tai HirakuraTeruo Nakamura
    • A61K9/50C08B37/00C08G63/91A61K9/16
    • A61K9/5153A61K9/5161C08B37/0072C08G63/912
    • There is provided a drug carrier which has solved the problems of conventional drug carriers, which can encapsulate a low molecular drug efficiently, which can control a sustained release period for a long term, which can control blood residence, which has high dispersibility in an aqueous solution, and which is not problematical in safety. A drug carrier, which comprises injectable fine particles minimal in agglomeration between the particles, and which has excellent biocompatibility, is also provided. A hyaluronic acid modification product comprising hyaluronic acid or its derivative, and a polymer bonded together, the polymer being selected from polylactic acid, polyglycolic acid and lactic acid-glycolic acid copolymer, according to the present invention, provides a drug carrier which encapsulates a low molecular drug efficiently, which can control a sustained release period for a long term, which can control blood residence, which is well dispersible in an aqueous solution, and which is not problematical in safety. The hyaluronic acid modification product of the present invention also provides a drug carrier comprising injectable fine particles minimal in agglomeration between the particles, and having excellent biocompatibility.
    • 提供了能够有效地包封低分子药物的常规药物载体的问题的药物载体,其可以长期控制持续释放时间,其可以控制血液存留,其在水性中具有高分散性 解决方案,这在安全性上没有问题。 还提供了一种药物载体,其包含颗粒之间附聚最少的可注射的微粒,并且其具有优异的生物相容性。 根据本发明的包含透明质酸或其衍生物的透明质酸改性产品和结合在一起的聚合物,聚合物选自聚乳酸,聚乙醇酸和乳酸 - 乙醇酸共聚物,提供了一种药物载体,其包封低 分子药物有效地控制长期的持续释放期,其可以控制在水溶液中良好分散的血液停留,并且这在安全性方面没有问题。 本发明的透明质酸改性产品还提供了一种药物载体,其包含颗粒之间最少聚集的可注射的微粒,并且具有优异的生物相容性。
    • 7. 发明授权
    • Vane compressor with vane back pressure adjustment
    • 叶片压缩机带叶片背压调节
    • US4717321A
    • 1988-01-05
    • US874555
    • 1986-06-16
    • Tsunenori ShibuyaYutaka IshizukaHaruhiko TakadaTeruo NakamuraHidehiko Takayama
    • Tsunenori ShibuyaYutaka IshizukaHaruhiko TakadaTeruo NakamuraHidehiko Takayama
    • F04C18/344F01C21/08F04C29/02
    • F01C21/0872
    • A vane compressor has a vane back pressure adjustment device including back-pressure chambers defined in a vane-supporting rotor and surrounded by vanes and side blocks secured to axial ends of a cylinder. The back-pressure chamber has axial ends disposed to follow a path against each of the side blocks when the rotor rotates. The path is divided into at least one high-pressure zone in which the vanes move across a pump outlet defined in the cylinder, and at least one normal-pressure zone which is the remainder of the path. In the normal-pressure zone, oil grooves defined in surfaces of the side blocks which face the rotor and supplied with oil from an oil sump in the vane compressor are in communication with the back-pressure chambers, to thereby maintain the oil pressure in the back-pressure chambers at a pressure level in the oil sump. In the high-pressure zone, the back-pressure chambers are out of communication with the oil grooves so that the oil fed into the back-pressure chambers is confined therein, except through a restrictor means. When the vanes move across the pump outlet, the vanes enter the high-pressure zone to trap oil in the back-pressure chambers to thereby elevate the oil pressure in the back-pressure chambers to a high level. Therefore, the vanes are prevented from being retracted deeply into vane slits in the rotor and then popping out into hitting engagement with the cylinder.
    • 叶片式压缩机具有叶片背压调节装置,该叶片背压调节装置包括限定在叶片支承转子中的背压室,并被固定在气缸的轴向端部的叶片和侧块包围。 背压室具有轴向端部,当转子旋转时,轴向端部设置成沿着每个侧块的路径。 该路径被分成至少一个高压区域,在该高压区域中,叶片移动通过限定在气缸中的泵出口,以及作为路径的剩余部分的至少一个正常压力区域。 在正常压力区域中,限定在面向转子并且从叶片式压缩机中的油底壳供给油的侧块的表面中的油槽与背压室连通,从而将油压保持在 在油底壳中处于压力水平的背压室。 在高压区域中,背压室与油槽不连通,除了通过限流装置之外,供给到背压室的油被限制在其中。 当叶片移动穿过泵出口时,叶片进入高压区以捕获背压室中的油,从而将背压室中的油压提升到高水平。 因此,防止叶片深深地缩回到转子中的叶片狭缝中,然后弹出与滚筒的接合。
    • 8. 发明授权
    • Heat-sensitive recording materials
    • 热敏记录材料
    • US4420538A
    • 1983-12-13
    • US336174
    • 1981-12-31
    • Teruo NakamuraNaoto Arai
    • Teruo NakamuraNaoto Arai
    • B41M5/337B41M5/30B41M5/333B41M5/18
    • B41M5/3335B41M5/3336Y10S428/913
    • A heat-sensitive recording material is described comprising a support having a recording layer provided thereon, said recording layer containing (1) at least one colorless or pale-colored basic dye, (2) hydroquinone monobenzyl ether, and (3) at least one compound selected from compounds represented by the formulae (I) to (IV): ##STR1## wherein X and Y are each a chlorine atom, an alkyl group having 1 to 7 carbon atoms, a phenyl group or a benzyl group; m and n are each an integer of 0 to 3; and R.sub.1 and R.sub.2 are each a hydrogen atom, an alkyl group having 1 to 7 carbon atoms, a phenyl group or a benzyl group, or R.sub.1 and R.sub.2 may jointly form a cyclohexane ring. The heat-sensitive recording material is suitable for use in high-speed recording, e.g., high-speed facsimiles.
    • 描述了一种热敏记录材料,其包括其上设置有记录层的载体,所述记录层含有(1)至少一种无色或浅色碱性染料,(2)氢醌单苄醚,和(3)至少一种 (Ⅰ)至(IV)表示的化合物的化合物:其中X和Y各自为氯原子, 具有1至7个碳原子的烷基,苯基或苄基; m和n分别为0〜3的整数, R 1和R 2各自为氢原子,具有1〜7个碳原子的烷基,苯基或苄基,或者R 1和R 2可共同形成环己烷环。 热敏记录材料适用于高速记录,例如高速传真机。
    • 9. 发明授权
    • Main memory control system
    • 主内存控制系统
    • US4414627A
    • 1983-11-08
    • US296978
    • 1981-08-27
    • Teruo Nakamura
    • Teruo Nakamura
    • G06F12/16G06F12/06G06F13/00
    • G06F12/0653
    • A main memory control system reconstructs the main memory following DP system failure to ensure continuous logical address to operative physical memory mapping so that the DP system can be restarted using a rescue type initial program load. An address converting table has word registers addressable by logical address for storing the respective preassigned physical unit memory addresses and corresponding flags to indicate whether the unit memories are operative. Prior to DP system restart, the words of the address converting table are shifted among the registers to reallocate the real addresses of nonfunctioning unit memories to the read address of functioning unit memories.
    • 主存储器控制系统重建DP系统故障后的主存储器,以确保连续的逻辑地址到可操作的物理存储器映射,以便DP系统可以使用救援类型的初始程序加载重新启动。 地址转换表具有可通过逻辑地址寻址的字寄存器,用于存储相应的预分配的物理单元存储器地址和相应的标志,以指示单元存储器是否可操作。 在DP系统重启之前,地址转换表的字在寄存器之间移位,以将非功能单元存储器的实际地址重新分配到功能单元存储器的读地址。