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1. 发明授权

US5658888A Erythromycin derivatives 失效
标题翻译：红霉素衍生物
公开(公告)号：US5658888A
公开(公告)日：1997-08-19
申请号：US318814
申请日：1994-10-19
申请人： Hiroshi Koga , Tsutomu Sato , Hisanori Takanashi
发明人： Hiroshi Koga , Tsutomu Sato , Hisanori Takanashi
IPC分类号： C07D407/00 , C07H17/08 , A61K31/00 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P1/00 , A61P1/12 , A61P43/00 , C07M17/08
CPC分类号： C07H17/08
摘要： Compounds represented by the general formula: ##STR1## wherein R.sub.1 is a hydrogen atom or an acyl group; R.sub.2 and R.sub.3 may be the same or different, and each represents a hydrogen atom, hydroxyl group, acyloxy group or amino group, or, in combination, they represent .dbd.O or .dbd.NOR.sub.10, where R.sub.10 represents a hydrogen atom or lower alkyl group;R.sub.4 represents a hydrogen atom or lower alkyl group; andY represents --NR.sub.5 R.sub.6 or --N.sup.+ R.sub.7 R.sub.8 R.sub.9 X.sup.-, where R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.9 may be the same or different, and each represents a hydrogen atom or an unsubstituted or substituted lower alkyl group, lower alkenyl group, lower alkinyl group, cycloalkyl group or 3-7-membered heterocyclic group comprising an oxygen atom, nitrogen atom or sulphur atom as an heteroatom, and X represents an anion, where R.sub.5 and R.sub.6, or R.sub.7 and R.sub.8 may form an azacycloalkyl group together with the neighboring nitrogen atom, respectively, and salts thereof.These compounds and their salts are subject to a remarkably lower degree of decomposition by gastric acid than are the publicly known erythromycin derivatives of the prior art, and have an excellent enterolinesis stimulating action.
摘要翻译： PCT No.PCT / JP93 / 00702 Sec。 371日期：1994年10月19日 102（e）日期1994年10月19日PCT提交1993年5月26日PCT公布。出版物WO93 / 24509 日期1993年12月9日化合物由通式表示的化合物：酰基; R2和R3可以相同或不同，各自表示氢原子，羟基，酰氧基或氨基，或者组合表示= O或= NOR10，其中R10表示氢原子或低级烷基; R4代表氢原子或低级烷基; 并且Y表示-NR5R6或-N + R7R8R9X-，其中R5，R6，R7，R8和R9可以相同或不同，并且各自表示氢原子或未取代或取代的低级烷基，低级烯基，低级炔基基团，环烷基或包含氧原子，氮原子或硫原子作为杂原子的3-7元杂环基，X表示阴离子，其中R 5和R 6或R 7和R 8可以与相邻的基团一起形成氮杂环烷基氮原子及其盐。与现有技术中公知的红霉素衍生物相比，这些化合物及其盐受胃酸分解程度明显降低，具有优异的肠溶激素作用。

2. 发明授权

US06255285B1 Phenethylamine derivatives 失效
标题翻译：苯乙胺衍生物
公开(公告)号：US06255285B1
公开(公告)日：2001-07-03
申请号：US09485620
申请日：2000-02-15
申请人： Ken-ichiro Kotake , Toshiro Kozono , Tsutomu Sato , Hisanori Takanashi
发明人： Ken-ichiro Kotake , Toshiro Kozono , Tsutomu Sato , Hisanori Takanashi
IPC分类号： A61K3805
CPC分类号： C07K5/0815 , A61K38/00 , C07K5/0202 , C07K5/06034 , C07K5/06078 , C07K5/0802 , C07K5/0812 , C07K5/0819 , C07K5/0821
摘要： The present invention has as its object providing phenethylamine derivatives that typically function as a motilin receptor antagonist and which are useful as medicines. The invention provides compounds represented by the general formula (1): (wherein A is typically an amino acid residue, R1 is typically R6—CO—, R2 is typically a hydrogen atom, R3 is typically —CO—R7, R4 is typically an alkyl group, R5 is typically a hydroxyl group, R6 is typically an alkyl group, and R7 is typically an amino group).
摘要翻译：本发明的目的是提供通常用作胃动素受体拮抗剂并且可用作药物的苯乙胺衍生物。本发明提供由通式（1）表示的化合物:(其中A通常为氨基酸残基，R 1通常为R 6 -CO-，R 2通常为氢原子，R 3通常为-CO-R 7，R 4通常为烷基，R 5通常是羟基，R 6通常是烷基，R 7通常是氨基）。

3. 发明授权

US09301917B2 Sustained-release pharmaceutical composition 有权
标题翻译：持续释放药物组合物
公开(公告)号：US09301917B2
公开(公告)日：2016-04-05
申请号：US13824598
申请日：2011-10-14
申请人： Masanori Fukushima , Hiroaki Matsubara , Satoaki Matoba , Shigeki Hijikata , Yu Aso , Tsutomu Sato
发明人： Masanori Fukushima , Hiroaki Matsubara , Satoaki Matoba , Shigeki Hijikata , Yu Aso , Tsutomu Sato
IPC分类号： A61K38/00 , A61K9/00 , A61K31/7004 , A61K31/7008 , A61K45/06 , A61K38/39 , A61K9/51 , A61K47/26 , A61K47/42 , A61K38/27 , A61K38/18
CPC分类号： A61K9/0002 , A61K9/0024 , A61K9/5123 , A61K31/7004 , A61K31/7008 , A61K38/1808 , A61K38/1816 , A61K38/1825 , A61K38/1858 , A61K38/27 , A61K38/39 , A61K45/06 , A61K47/26 , A61K47/42 , A61K2300/00
摘要： Provided is a pharmaceutical composition, including a drug and a collagen, in which the composition is satisfactory in handleability and has sustained-release property. The sustained-release pharmaceutical composition includes: a drug; a collagen; and at least one kind of sugar selected from monosaccharides, disaccharides, trisaccharides, and tetrasaccharides. The inventors of the present invention have found that the in vivo administration of a collagen solution containing a sugar results in the gelation of a collagen. Based on this finding, the inventors have found that a composition containing a drug, a collagen, and a sugar can control the release rate of the drug, and such composition can be used as a sustained-release pharmaceutical composition.
摘要翻译：本发明提供包含药物和胶原的药物组合物，其组合物的操作性良好且具有缓释性。缓释药物组合物包括：药物; 胶原蛋白和选自单糖，二糖，三糖和四糖中的至少一种糖。本发明的发明人已经发现，含有糖的胶原溶液的体内施用导致胶原蛋白的凝胶化。基于该发现，本发明人发现含有药物，胶原和糖的组合物可以控制药物的释放速度，并且这种组合物可以用作缓释药物组合物。

4. 发明申请

US20130034371A1 TONER CARTRIDGE 有权
公开(公告)号：US20130034371A1
公开(公告)日：2013-02-07
申请号：US13650620
申请日：2012-10-12
申请人： Tsutomu Sato
发明人： Tsutomu Sato
IPC分类号： G03G15/08
CPC分类号： G03G15/0889 , G03G15/0863 , G03G15/0865 , G03G15/087 , G03G15/0875 , G03G15/0877 , G03G21/1647 , G03G21/1676 , G03G2215/0695 , G03G2221/163 , G03G2221/1657
摘要： A toner cartridge comprises a toner container which contains toner, a driving member which rotationally drives a conveying member, an agitating member which agitates a toner in the toner container while being rotated, a driven member which rotates in association with the driving member which is for rotationally driving the agitating member, and a rotational body which rotates according to rotation of the driven member, has a plurality of slits in rotational circumference for identifying a type of the toner cartridge, and has 1/K or more of the slits when a ratio of a rotational speed R1 (rad/s) of the driving member and a rotational speed R2 (rad/s) of the driven member is K=R2/R1.

5. 发明授权

US08048897B2 Cyclohexane derivative, prodrug thereof and salt thereof, and therapeutic agent containing the same for diabetes 有权
标题翻译：环己烷衍生物，其前药及其盐，以及含有其的用于糖尿病的治疗剂
公开(公告)号：US08048897B2
公开(公告)日：2011-11-01
申请号：US11658400
申请日：2005-07-26
申请人： Hiroharu Matsuoka , Tsutomu Sato , Masahiro Nishimoto , Nobuo Shimma
发明人： Hiroharu Matsuoka , Tsutomu Sato , Masahiro Nishimoto , Nobuo Shimma
IPC分类号： A61K31/7028 , A61K31/403 , A61P3/10 , C07C63/00 , C07D209/04 , C07D213/62 , C07D231/14 , C07D307/79 , C07D317/48 , C07D333/34 , C07D333/56
CPC分类号： C07D333/32 , C07C35/14 , C07C35/48 , C07C43/23 , C07C43/253 , C07C69/94 , C07C217/58 , C07C235/46 , C07C255/54 , C07C317/22 , C07C323/18 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/16 , C07D209/12 , C07D213/64 , C07D231/12 , C07D307/80 , C07D317/54 , C07D333/56 , C07H15/203 , C07H17/00 , C07H17/02
摘要： A cyclohexane derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug activity, metabolic stability, and safety; and a medicinal composition for use in the prevention or treatment of diseases attributable to hyperglycemia, such as diabetes, e.g., insulin dependent diabetes mellitus (type 1 diabetes) or noninsulin-dependent diabetes mellitus (type 2 diabetes), complications of diabetes, and obesity. The derivative is a compound represented by the formula (I): (wherein A is —O—, —CH2—, or —NH—; n is an integer selected between 0 and 1; R6 and R7 each independently is hydrogen or C1-6 alkyl; m is an integer selected among 1-3; Q is selected among the following formulae Q1 to Q5; Ar1 is optionally substituted arylene or optionally substituted heteroarylene, provided that the heteroarylene may be bonded to an aromatic carbocycle or aromatic heterocycle to form a fused ring; and Ar2 is optionally substituted aryl or optionally substituted heteroaryl), a prodrug of the compound, or a pharmaceutically acceptable salt of either. Also provided are a medicine, a medicinal composition, or the like each containing the compound.
摘要翻译：具有降低血糖水平并且具有药物所需的优选性能的持久性药物活性，代谢稳定性和安全性的环己烷衍生物; 以及用于预防或治疗高血糖疾病（例如糖尿病，例如胰岛素依赖性糖尿病（1型糖尿病）或非胰岛素依赖性糖尿病（2型糖尿病）），糖尿病并发症和肥胖症的药物组合物。该衍生物是由式（I）表示的化合物：其中A是-O-，-CH2-或-NH-; n是选自0和1之间的整数; R6和R7各自独立地是氢或C1- 6烷基; m是选自1-3中的整数; Q选自下式Q1至Q5; Ar1是任选取代的亚芳基或任选取代的亚杂芳基，条件是杂亚芳基可以键合到芳族碳环或芳族杂环以形成稠合环; Ar 2是任选取代的芳基或任选取代的杂芳基），化合物的前药或其药学上可接受的盐。还提供含有化合物的药物，药物组合物等。

6. 发明授权

US08013398B2 Semiconductor device 有权
标题翻译：半导体器件
公开(公告)号：US08013398B2
公开(公告)日：2011-09-06
申请号：US12056909
申请日：2008-03-27
申请人： Shinji Mori , Tsutomu Sato , Koji Matsuo
发明人： Shinji Mori , Tsutomu Sato , Koji Matsuo
IPC分类号： H01L29/78
CPC分类号： H01L29/772 , H01L21/823807 , H01L21/823814 , H01L21/823842 , H01L29/66636 , H01L29/7848
摘要： A semiconductor device includes a first pMISFET region having an Si channel, a second pMISFET region having an Si channel and an nMISFET region having an Si channel. First SiGe layers which apply first compression strain to the Si channel are embedded and formed in the first pMISFET region to sandwich the Si channel thereof and second SiGe layers which apply second compression strain different from the first compression strain to the Si channel are embedded and formed in the second pMISFET region to sandwich the Si channel thereof.
摘要翻译：半导体器件包括具有Si沟道的第一pMISFET区，具有Si沟道的第二pMISFET区和具有Si沟道的nMISFET区。将第一压缩应变施加到Si沟道的第一SiGe层嵌入并形成在第一pMISFET区域中以夹持其Si沟道，并且将施加与第一压缩应变不同的第二压缩应变的第二SiGe层嵌入并形成在第二pMISFET区域夹持其Si通道。

7. 发明授权

US07957680B2 Toner cartridge 有权
标题翻译：墨粉盒
公开(公告)号：US07957680B2
公开(公告)日：2011-06-07
申请号：US11749280
申请日：2007-05-16
申请人： Tsutomu Sato
发明人： Tsutomu Sato
IPC分类号： G03G15/08 , B01F7/02
CPC分类号： G03G15/0875 , G03G15/0877 , G03G2215/0802
摘要： A toner cartridge inserted in an image forming apparatus and supplying toner to the image forming apparatus comprises a container which contains the toner and provided with a discharging opening for discharging the contained toner, the container having a shape with a predetermined curvature at a bottom part, a conveying member which conveys the toner in the container to the discharging opening, an agitating member which rotates centering on a rotational axis in the container, and agitates the toner contained in the container and a sheet member provided in the agitating member such that a front edge part abuts the bottom part of the container, the sheet member having the front edge part which is formed with a part having substantially the same curvature as the bottom part of the container.
摘要翻译：插入图像形成装置中并且向成像装置供应调色剂的调色剂盒包括容纳调色剂并且设置有用于排出所容纳的调色剂的排出口的容器，所述容器在底部具有预定曲率的形状，输送构件，其将容器中的调色剂输送到排出口，搅拌构件，其以容器中的旋转轴线为中心旋转，并且搅拌容纳在容器中的调色剂和设置在搅拌构件中的片材构件，边缘部分邻接容器的底部，片状构件具有形成有与容器的底部基本相同曲率的部分的前边缘部分。

8. 发明申请

US20100322641A1 TONER CARTRIDGE 有权
标题翻译：墨粉盒
公开(公告)号：US20100322641A1
公开(公告)日：2010-12-23
申请号：US12850794
申请日：2010-08-05
申请人： Tsutomu Sato
发明人： Tsutomu Sato
IPC分类号： G03G15/08
CPC分类号： G03G15/0889 , G03G15/0863 , G03G15/0865 , G03G15/087 , G03G15/0875 , G03G15/0877 , G03G21/1647 , G03G21/1676 , G03G2215/0695 , G03G2221/163 , G03G2221/1657
摘要： A toner cartridge comprises a toner container which contains toner, a driving member which rotationally drives a conveying member, an agitating member which agitates a toner in the toner container while being rotated, a driven member which rotates in association with the driving member which is for rotationally driving the agitating member, and a rotational body which rotates according to rotation of the driven member, has a plurality of slits in rotational circumference for identifying a type of the toner cartridge, and has 1/K or more of the slits when a ratio of a rotational speed R1 (rad/s) of the driving member and a rotational speed R2 (rad/s) of the driven member is K=R2/R1.
摘要翻译：调色剂盒包括一个容纳调色剂的调色剂容器，一个旋转地驱动传送部件的驱动部件，一个搅拌部件，其在旋转时搅拌调色剂容器中的调色剂;与驱动部件相关联地旋转的从动部件，旋转地驱动搅拌构件，以及根据从动构件的旋转而旋转的旋转体，具有旋转周向的多个狭缝，用于识别调色剂盒的类型，并且当比例为1 / K以上时，驱动构件的转速R1（rad / s）和从动构件的转速R2（rad / s）为K = R2 / R1。

9. 发明授权

US07767651B2 Spiroketal derivatives and use thereof as diabetic medicine 有权
标题翻译：螺缩酮衍生物及其作为糖尿病药物的用途
公开(公告)号：US07767651B2
公开(公告)日：2010-08-03
申请号：US11815074
申请日：2006-01-27
申请人： Takamitsu Kobayashi , Tsutomu Sato , Masahiro Nishimoto
发明人： Takamitsu Kobayashi , Tsutomu Sato , Masahiro Nishimoto
IPC分类号： A01N43/04 , C07H1/00 , C07H3/00 , C08B37/00
CPC分类号： C07D311/96 , C07D491/153 , C07D493/10 , C07H19/01
摘要： The present invention provides a compound of Formula (I): wherein R1, R2, R3 and R4 are each independently selected from a hydrogen atom, an optionally substituted C1-C6 alkyl group, an optionally substituted C7-C14 aralkyl group and —C(═O)Rx; Rx represents an optionally substituted C1-C6 alkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted C1-C6 alkoxy group or —NReRf; Ar1 represents an optionally substituted aromatic carbocyclic ring or an optionally mono-substituted aromatic heterocyclic ring; Q represents —(CH2)m-(L)p- or -(L)p-(CH2)m—; m represents an integer selected from 0 to 2, n represents an integer selected from 1 and 2, and p represents an integer selected from 0 and 1; L represents —O—, —S— or —NR5—; and A represents an optionally substituted aryl group or an optionally substituted heteroaryl group, a prodrug thereof and a pharmaceutically acceptable salt thereof, as well as a pharmaceutical preparation or pharmaceutical composition comprising such a compound.
摘要翻译：本发明提供式（I）的化合物：其中R 1，R 2，R 3和R 4各自独立地选自氢原子，任选取代的C 1 -C 6烷基，任选取代的C 7 -C 14芳烷基和-C（ ΟO）Rx; Rx表示任选取代的C 1 -C 6烷基，任选取代的芳基，任选取代的杂芳基，任选取代的C 1 -C 6烷氧基或-NRrf; Ar 1表示任选取代的芳族碳环或任选单取代的芳族杂环; Q表示 - （CH 2）m - （L）p-或 - （L）p-（CH 2）m - ; m表示选自0至2的整数，n表示选自1和2的整数，p表示选自0和1的整数; L表示-O - ， - S-或-NR5-; A表示任选取代的芳基或任选取代的杂芳基，其前药及其药学上可接受的盐，以及包含这种化合物的药物制剂或药物组合物。

10. 发明授权

US07734197B2 Toner cartridge having protrusion to show type of toner cartridge 有权
标题翻译：墨粉盒具有突出以显示墨粉盒的类型
公开(公告)号：US07734197B2
公开(公告)日：2010-06-08
申请号：US11749275
申请日：2007-05-16
申请人： Tsutomu Sato
发明人： Tsutomu Sato
IPC分类号： G03G15/00 , G03G15/08
CPC分类号： G03G15/0875 , G03G15/0863 , G03G15/0877
摘要： A toner cartridge inserted in an image forming apparatus and supplying toner to the image forming apparatus, the cartridge contains a toner container that contains toner, and a protrusion for showing a type of the toner cartridge, wherein the protrusion forms a ramp inclining toward a direction the toner cartridge is inserted in the image forming apparatus.
摘要翻译：一种插入图像形成装置中的调色剂盒，并且向成像装置供应调色剂，盒包括含有调色剂的调色剂容器和用于显示调色剂盒类型的突起，其中突起形成朝向方向倾斜的斜面调色剂盒插入图像形成装置中。

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