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1. 发明申请

US20060030584A1 2,8-Disubstituted naphthyridine derivatives 失效
标题翻译： 2,8-二取代的萘啶衍生物
公开(公告)号：US20060030584A1
公开(公告)日：2006-02-09
申请号：US11196532
申请日：2005-08-03
申请人： Gunnar Hanson , Roy Ware , Thomas Barta , He Huang
发明人： Gunnar Hanson , Roy Ware , Thomas Barta , He Huang
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D471/04 , C07D405/14
摘要： Disclosed are compounds of formula A: and pharmaceutically acceptable salts thereof, wherein R1, R2, R2′, R3, R21, A1, A2, X, and Z are as defined herein. Compounds of formula A are useful in the treatment of diseases and/or conditions related to cell differentiation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译：公开了式A的化合物及其药学上可接受的盐，其中R 1，R 2，R 2，R 3， R 21，A 1，A 2，X和Z如本文所定义。式A的化合物可用于治疗与细胞分化相关的疾病和/或病症，例如癌症，炎症，关节炎，血管生成等。还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。

2. 发明申请

US20080032991A1 2, 8-disubstituted Naphthyridine Derivatives 审中-公开
标题翻译： 2,8-二取代的萘啶衍生物
公开(公告)号：US20080032991A1
公开(公告)日：2008-02-07
申请号：US11872471
申请日：2007-10-15
申请人： Gunnar Hanson , Roy Ware , Thomas Barta , He Huang
发明人： Gunnar Hanson , Roy Ware , Thomas Barta , He Huang
IPC分类号： A61K31/4375 , A61K31/4545 , A61K31/496 , A61P19/02 , A61P29/00 , A61P35/00 , C07D471/04
CPC分类号： C07D471/04 , C07D405/14
摘要： Disclosed are compounds of formula A: and pharmaceutically acceptable salts thereof, wherein R1, R2, R2′, R3, R21, A1, A2, X, and Z are as defined herein. Compounds of formula A are useful in the treatment of diseases and/or conditions related to cell differentiation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译：公开了式A的化合物及其药学上可接受的盐，其中R 1，R 2，R 2，R 3， R 21，A 1，A 2，X和Z如本文所定义。式A的化合物可用于治疗与细胞分化相关的疾病和/或病症，例如癌症，炎症，关节炎，血管生成等。还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。

3. 发明申请

US20070078146A1 Substituted pyrazoles as p38 kinase inhibitors 失效
标题翻译：取代的吡唑作为p38激酶抑制剂
公开(公告)号：US20070078146A1
公开(公告)日：2007-04-05
申请号：US10840734
申请日：2004-05-05
申请人： Ashok Naraian , Michael Clare , Paul Collins , Joyce Crich , Rajesh Devraj , Daniel Flynn , Lifeng Geng , Matthew Graneto , Cathleen Hanau , Gunnar Hanson , Susan Hartmann , Michael Hepperle , He Huang , Ish Khanna , Francis Koszyk , Shuyuan Liao , Suzanne Metz , Win Naing , Richard Partis , Thao Perry , Shashidhar Rao , Shaun Selness , Michael South , Michael Stealey , John Talley , Michael Vazquez , John Walker , Richard Weier , Xiangdong Xu , Syaulan Yang , Yi Yu
发明人： Ashok Naraian , Michael Clare , Paul Collins , Joyce Crich , Rajesh Devraj , Daniel Flynn , Lifeng Geng , Matthew Graneto , Cathleen Hanau , Gunnar Hanson , Susan Hartmann , Michael Hepperle , He Huang , Ish Khanna , Francis Koszyk , Shuyuan Liao , Suzanne Metz , Win Naing , Richard Partis , Thao Perry , Shashidhar Rao , Shaun Selness , Michael South , Michael Stealey , John Talley , Michael Vazquez , John Walker , Richard Weier , Xiangdong Xu , Syaulan Yang , Yi Yu
IPC分类号： A61K31/506 , A61K31/4439 , C07D43/02
CPC分类号： C07D401/14 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D473/00 , C07D487/04 , C07D491/10 , C07D495/04
摘要： A class of pyrazole derivatives is described for use in treating p38 kinase medicated disorders. Compounds of particular interest are defined by Formula IA wherein R1, R2, R3 and R4 are as described in the specification.
摘要翻译：描述了一类吡唑衍生物用于治疗p38激酶药物障碍。特别感兴趣的化合物由式IA定义，其中R 1，R 2，R 3和R 4是如说明书中所述。

4. 发明申请

US20050256180A1 Substituted pyrazolyl compounds for the treatment of inflammation 失效
标题翻译：用于治疗炎症的取代的吡唑基化合物
公开(公告)号：US20050256180A1
公开(公告)日：2005-11-17
申请号：US11113926
申请日：2005-04-25
申请人： Arija Bergmanis , Michael Clare , Joyce Crich , Lifeng Geng , Timothy Hagen , Gunnar Hanson , Stephen Houdek , He Huang , Donna Iula , Francis Koszyk , Shuyuan Liao , Scott Mohler , Maria Nguyen , Richard Partis , Michael Stealey , Michael Tollefson , Richard Weier , Xiangdong Xu , Dominique Bonafoux , Theresa Fletcher , Bruce Hamper , Patrick Lennon , Subo Liao , Suzanne Metz , David Oburn , Thomas Owen , Angela Scates , Michael Vazquez , Serge Wolfson
发明人： Arija Bergmanis , Michael Clare , Joyce Crich , Lifeng Geng , Timothy Hagen , Gunnar Hanson , Stephen Houdek , He Huang , Donna Iula , Francis Koszyk , Shuyuan Liao , Scott Mohler , Maria Nguyen , Richard Partis , Michael Stealey , Michael Tollefson , Richard Weier , Xiangdong Xu , Dominique Bonafoux , Theresa Fletcher , Bruce Hamper , Patrick Lennon , Subo Liao , Suzanne Metz , David Oburn , Thomas Owen , Angela Scates , Michael Vazquez , Serge Wolfson
IPC分类号： A61K31/416 , A61K31/4178 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/551 , A61P19/02 , A61P25/04 , A61P29/00 , A61P35/00 , C07D231/54 , C07D333/62 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , A61K31/4162
CPC分类号： C07D403/12 , C07D231/54 , C07D333/62 , C07D401/12 , C07D401/14 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The present invention relates to substituted pyrazolyl derivatives, compositions comprising such, intermediates, methods of making substituted pyrazolyl derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.
摘要翻译：本发明涉及取代的吡唑基衍生物，包含这些的组合物，中间体，制备取代的吡唑基衍生物的方法，以及用于治疗癌症，炎症和炎症相关疾病如关节炎的方法。

5. 发明申请

US20050197338A1 Substituted pyrazole urea compounds for the treatment of inflammation 审中-公开
标题翻译：用于治疗炎症的取代的吡唑脲化合物
公开(公告)号：US20050197338A1
公开(公告)日：2005-09-08
申请号：US10970769
申请日：2004-10-21
申请人： He Huang , Michael Stealey , Gunnar Hanson , Patrick Lennon , Bruce Hamper , Jin Xie , David Oburn , Serge Wolfson , Theresa Fletcher , Richard Heier , Matthew Reding , Michael Clare
发明人： He Huang , Michael Stealey , Gunnar Hanson , Patrick Lennon , Bruce Hamper , Jin Xie , David Oburn , Serge Wolfson , Theresa Fletcher , Richard Heier , Matthew Reding , Michael Clare
IPC分类号： A61K31/415 , A61K31/416 , A61K31/422 , A61K31/427 , A61K31/454 , A61K31/4709 , A61K31/497 , A61K31/506 , A61K31/53 , C07D231/38 , C07D231/40 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10
CPC分类号： C07D403/10 , C04B35/632 , C07D231/38 , C07D401/12 , C07D403/04 , C07D405/10 , C07D409/10 , C07D413/10
摘要： Compounds of Formula I: wherein X1, X2, L1, A, R, L2, R1, R12, R12a, R13, R14 and R14a are as defined herein, are disclosed.
摘要翻译：式I的化合物：其中X 1，X 2，L 1，A，R，L 2， R 1，R 12，R 12，R 13，R 14和R 14，和 R 14a如本文所定义。

6. 发明授权

US09047186B2 Allocation method and apparatus of moderate memory 有权
标题翻译：中度记忆的分配方法和装置
公开(公告)号：US09047186B2
公开(公告)日：2015-06-02
申请号：US13341256
申请日：2011-12-30
申请人： Qinghua Fan , He Huang , Guoping Li
发明人： Qinghua Fan , He Huang , Guoping Li
IPC分类号： G06F12/02 , G06F11/07 , G11C8/06 , G11C29/44 , G06F11/00 , G11C16/34
CPC分类号： G06F11/073 , G06F11/008 , G06F11/076 , G06F11/0793 , G11C8/06 , G11C16/349 , G11C29/44 , G11C2029/4402
摘要： An allocation method comprises: partitioning moderate memory into a plurality of physical memory pages having predetermined page size according to the predetermined page size; scanning the moderate memory using the predetermined page size and recording the physical address and damage degree of each physical memory page; obtaining the allocation information of the physical memory pages when a memory request is received and allocating physical memory to the request based on the recorded physical address and damage degree of each physical memory page and the obtained allocation information. A moderate memory is scanned and the physical address and damage degree of each physical memory page are recorded, then the physical memory is allocated based on the recorded physical address and damage degree of each physical memory page and the obtained allocation information.
摘要翻译：分配方法包括：根据预定页面大小将中等存储器分配成具有预定页面大小的多个物理存储器页面; 使用预定页面尺寸扫描中等记忆体并记录每个物理存储器页面的物理地址和损坏程度; 在接收到存储器请求时获取物理存储器页的分配信息，并且基于所记录的物理地址和每个物理存储器页面的损坏程度以及所获得的分配信息，为该请求分配物理存储器。扫描中等存储器并记录每个物理存储器页面的物理地址和损坏程度，然后基于所记录的物理地址和每个物理存储器页面的损坏程度以及所获得的分配信息来分配物理存储器。

7. 发明申请

US20120258513A1 Selective Neuronal Nitric Oxide Synthase Inhibitors 有权
标题翻译：选择性神经元一氧化氮合酶抑制剂
公开(公告)号：US20120258513A1
公开(公告)日：2012-10-11
申请号：US13441683
申请日：2012-04-06
申请人： Richard B. Silverman , Haitao Ji , He Huang
发明人： Richard B. Silverman , Haitao Ji , He Huang
IPC分类号： C12N9/99 , C07D401/14 , C07D401/06
CPC分类号： C12N9/0073 , C07D401/06 , C07D401/14
摘要： Compounds and related methods for selective inhibition of neuronal nitric oxide synthase over inducible and endothelial isoforms, such compounds as can provide reduced cationic character and enhanced bioavailability.
摘要翻译：用于选择性抑制神经元一氧化氮合酶对诱导型和内皮同种型的化合物和相关方法，可提供降低的阳离子特征和增强的生物利用度。

8. 发明授权

US08150795B2 Methods and devices for analysis of clustered data, in particular action potentials (i.e. neuron firing signals in the brain) 有权
标题翻译：用于分析聚类数据的方法和装置，特别是动作电位（即脑中的神经元激发信号）
公开(公告)号：US08150795B2
公开(公告)日：2012-04-03
申请号：US11722229
申请日：2005-12-22
申请人： Erwin B. Montgomery, Jr. , He Huang , Amir H. Assadi
发明人： Erwin B. Montgomery, Jr. , He Huang , Amir H. Assadi
IPC分类号： G06F15/00 , G06F15/18
CPC分类号： G06K9/0057
摘要： Methods for clustering of multi-dimensional data allow unsupervised grouping of multi-dimensional data points into clusters having like characteristics. The methods may be usefully applied to extracellular action potentials (neuronal spikes) measured from the brain, whereby spike data may be grouped in accordance with dimensions such as spike period, spike shape, etc., to assist in identification and location of individual neurons and/or regions of the brain.
摘要翻译：用于多维数据聚类的方法允许多维数据点的无监督分组成为具有相似特征的簇。这些方法可能有用地应用于从脑测量的细胞外动作电位（神经元峰值），由此尖峰数据可以根据诸如尖峰周期，尖峰形状等的尺寸进行分组，以帮助识别和定位个体神经元， /或大脑的区域。

9. 发明授权

US08122184B2 Methods for managing blocks in flash memories 有权
标题翻译：用于管理闪存中的块的方法
公开(公告)号：US08122184B2
公开(公告)日：2012-02-21
申请号：US12497368
申请日：2009-07-02
申请人： He Huang
发明人： He Huang
IPC分类号： G06F12/10 , G06F12/16
CPC分类号： G06F12/0246 , G06F2212/1016 , G06F2212/1036 , G06F2212/7201 , G06F2212/7211
摘要： A method for managing blocks in a flash memory is provided, which includes dynamic and static block managing methods. In the dynamic block managing method, a blank block is selected as a swap block for write operation. During each write operation, new data and/or original data in an object block to be operated are written into the swap block, and the object block is erased. Then, a logical address of the object block is changed to be a logical address of the swap block, so that the object block served as the swap block for a next write operation. In the static block managing method, a variable seed parameter is set. Different values of the seed parameter are each associated with a logical address of a respective flash memory block. When the value of the seed parameter varies, data in the flash memory block and the swap block associated to the value of the seed parameter are exchanged, so that the flash memory block associated to the value of the seed parameter becomes the swap block for the next write operation.
摘要翻译：提供了一种用于管理闪存中的块的方法，其包括动态和静态块管理方法。在动态块管理方法中，选择空白块作为写操作的交换块。在每个写入操作期间，将要操作的对象块中的新数据和/或原始数据写入交换块，并且擦除对象块。然后，将对象块的逻辑地址改变为交换块的逻辑地址，使得对象块用作下一个写入操作的交换块。在静态块管理方法中，设置变量种子参数。种子参数的不同值各自与相应闪存块的逻辑地址相关联。当种子参数的值变化时，交换闪存块和与种子参数的值相关联的交换块中的数据，使得与种子参数的值相关联的闪存块成为用于下一个写操作。

10. 发明申请

US20110140307A1 METHOD OF MAKING POLYLACTIC ACID AND ITS PRODUCTS 有权
标题翻译：制备聚酯酸及其产品的方法
公开(公告)号：US20110140307A1
公开(公告)日：2011-06-16
申请号：US13034030
申请日：2011-02-24
申请人： Zhenjiang Li , Pingkai Ouyang , He Huang
发明人： Zhenjiang Li , Pingkai Ouyang , He Huang
IPC分类号： B29C47/40 , C08G63/08 , C08G73/06 , C08G75/32
CPC分类号： C08G63/823 , B29C47/0004 , B29C47/0021 , B29C47/40 , B29C47/662 , B29C47/767 , B29C47/827 , B29C67/246 , B29C2947/92704 , B29C2947/92895 , B29K2067/046 , B29K2995/006 , C08G63/08 , C08G63/785
摘要： The present disclosure provides a method for preparing polylactic acid and its products using a twin-screw extruder, comprising the step of mixing carbon dioxide adducts of carbene and lactide, and obtaining polylactic acid and its products via reactive extrusion using a twin-screw extruder. Some of the carbon dioxide adducts or carbene have the following general formula:
摘要翻译：本公开内容提供了使用双螺杆挤出机制备聚乳酸及其产品的方法，其包括将卡宾和丙交酯的二氧化碳加合物混合，并使用双螺杆挤出机通过反应性挤出获得聚乳酸及其产物的步骤。一些二氧化碳加合物或卡宾具有以下通式：

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