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1. 发明申请

US20110306557A1 NEURAL REGENERATION PEPTIDES AND METHODS FOR THEIR USE IN TREATMENT OF BRAIN DAMAGE 审中-公开
标题翻译：神经再生肽及其用于治疗脑损伤的方法
公开(公告)号：US20110306557A1
公开(公告)日：2011-12-15
申请号：US12849681
申请日：2010-08-03
申请人： Frank Sieg , Paul Hughes
发明人： Frank Sieg , Paul Hughes
IPC分类号： A61K38/02 , C07K7/08 , C07K14/47 , C07K14/05 , C07K7/06 , C07H21/04 , C07K14/35 , C12N5/0793 , C12N15/63 , C12N1/00 , C12N5/10 , A61P25/28 , C12Q1/02 , G01N33/566 , A61P25/00 , A61P25/16 , C07K2/00
CPC分类号： C07K14/4756 , A61K38/00
摘要： The invention discloses a family of neuronal migration-inducing, proliferation-promoting and neurite outgrowth promoting factors, termed NRP compounds, and provides compositions and methods for the use of NRP compounds in the treatment of brain injury and neurodegenerative disease. NRP-1 compounds induce neurons and neuroblasts to proliferate and migrate into areas of damage caused by acute brain injury or chronic neurodegenerative disease, such as stroke, trauma, nervous system infections, demyelinating diseases, dementias, and metabolic disorders. NRP compounds may be administered directly to a subject or to a subject's cells by a variety of means including orally, intraperitoneally, intravascularly, and directly into the nervous system of a patient.
摘要翻译：本发明公开了一种称为NRP化合物的神经元迁移诱导，增殖促进因子和神经突促生长因子，并提供了使用NRP化合物治疗脑损伤和神经变性疾病的组合物和方法。 NRP-1化合物诱导神经元和成神经细胞增殖并迁移到由急性脑损伤或慢性神经变性疾病如中风，创伤，神经系统感染，脱髓鞘疾病，痴呆和代谢紊乱引起的损伤区域中。 NRP化合物可以通过包括口服，腹膜内，血管内和直接进入患者的神经系统的多种方式直接施用于受试者或受试者的细胞。

2. 发明授权

US07767786B2 Neural regeneration peptides and methods for their use in treatment of neural injury or degeneration 有权
标题翻译：神经再生肽及其用于治疗神经损伤或退化的方法
公开(公告)号：US07767786B2
公开(公告)日：2010-08-03
申请号：US10225838
申请日：2002-08-22
申请人： Frank Sieg , Paul Hughes
发明人： Frank Sieg , Paul Hughes
IPC分类号： C07K2/00 , C07K4/00 , C07K7/00 , C07K14/00 , C12P21/00
CPC分类号： C07K14/4756 , A61K38/00
摘要： The invention discloses a family of neuronal migration-inducing, proliferation-promoting and neurite outgrowth promoting factors, termed NRP compounds, and provides compositions and methods for the use of NRP compounds in the treatment of brain injury and neurodegenerative disease. NRP compounds induce neurons and neuroblasts to proliferate and migrate into areas of damage caused by acute brain injury or chronic neurodegenerative disease, such as stroke, trauma, nervous system infections, demyelinating diseases, dementias, and metabolic disorders. NRP compounds may be administered directly to a subject or to a subject's cells by a variety of means including orally, intraperitoneally, intravascularly, and directly into the nervous system of a patient.
摘要翻译：本发明公开了一种称为NRP化合物的神经元迁移诱导，增殖促进因子和神经突促生长因子，并提供了使用NRP化合物治疗脑损伤和神经变性疾病的组合物和方法。 NRP化合物诱导神经元和神经母细胞增殖并迁移到由急性脑损伤或慢性神经变性疾病如中风，创伤，神经系统感染，脱髓鞘疾病，痴呆和代谢紊乱引起的损伤区域中。 NRP化合物可以通过包括口服，腹膜内，血管内和直接进入患者的神经系统的多种方式直接施用于受试者或受试者的细胞。

3. 发明申请

US20050131212A1 Neural regeneration peptides and methods for their use in treatment of brain damage 有权
标题翻译：神经再生肽及其用于治疗脑损伤的方法
公开(公告)号：US20050131212A1
公开(公告)日：2005-06-16
申请号：US10976699
申请日：2004-10-29
申请人： Frank Sieg , Paul Hughes , Thorsten Gorba
发明人： Frank Sieg , Paul Hughes , Thorsten Gorba
IPC分类号： A61K38/17 , A61K48/00 , C07H21/04 , C07K14/705 , C12N5/08 , C12Q1/68
CPC分类号： A61K38/17 , A61K48/00 , C07H21/04 , C07K14/705 , C12Q1/68
摘要： The invention discloses a family of peptides termed NRP compounds or NRPs that can promote neuronal migration, neurite outgrowth, neuronal proliferation, neural differentiation and/or neuronal survival, and provides compositions and methods for the use of NRPs in the treatment of brain injury and neurodegenerative disease. NRP compounds can induce neurons and neuroblasts to proliferate and migrate into areas of damage caused by acute brain injury or chronic neurodegenerative disease, such as exposure to toxins, stroke, trauma, nervous system infections, demyelinating diseases, dementias, and metabolic disorders. NRP compounds may be administered directly to a subject or to a subject's cells by a variety of means including orally, intraperitoneally, intravascularly, and directly into the nervous system of a patient. NRP compounds can be formulated into pharmaceutically acceptable dose forms for therapeutic use. Methods for detecting neural regeneration, neural proliferation, neural differentiation, neurite outgrowth and neural survival can be used to develop other neurally active agents.
摘要翻译：本发明公开了一种称为NRP化合物或NRP的肽，可以促进神经元迁移，神经突生长，神经元增殖，神经分化和/或神经元存活，并提供使用NRP治疗脑损伤和神经变性的组合物和方法疾病。 NRP化合物可以诱导神经元和成神经细胞增殖并迁移到由急性脑损伤或慢性神经变性疾病（例如暴露于毒素，中风，创伤，神经系统感染，脱髓鞘疾病，痴呆和代谢性疾病）引起的损伤区域中。 NRP化合物可以通过包括口服，腹膜内，血管内和直接进入患者的神经系统的多种方式直接施用于受试者或受试者的细胞。 NRP化合物可以配制成用于治疗用途的药学上可接受的剂型。用于检测神经再生，神经增生，神经分化，神经突生长和神经存活的方法可用于开发其他神经活性剂。

4. 发明申请

US20090184303A1 BALUSTRADING 审中-公开
公开(公告)号：US20090184303A1
公开(公告)日：2009-07-23
申请号：US12280421
申请日：2007-02-23
申请人： Anthony Jones , Paul Hughes
发明人： Anthony Jones , Paul Hughes
IPC分类号： E04F11/18 , E04H17/00 , E04H17/14
CPC分类号： E04F11/181
摘要： A kit of parts for assembly into a balustrade (1), the kit comprising rails (3), baluster brackets (6), posts (2), connectors (5) for connecting the posts (2) to the rails (3) and rail-to-rail connectors (8) for connecting two rails (3A, 3B) in a parallel and spaced apart relationship. The baluster brackets (6) and/or the rails (3) are shaped so as to ensure that each bracket (6) is engagable with a rail (3) in a desired configuration. There is further disclosed a balustrade incorporating one or more of the above parts and a method of installing a balustrade (1) on a substrate (5).
摘要翻译：用于组装到栏杆（1）中的一组零件，该套件包括轨道（3），栏杆支架（6），柱（2），用于将柱（2）连接到轨道（3）的连接器（5）轨到轨连接器（8），用于以平行和间隔的关系连接两个导轨（3A，3B）。栏杆支架（6）和/或轨道（3）成形为确保每个支架（6）能够以期望的配置与导轨（3）接合。还公开了一种结合上述部分中的一个或多个的栏杆以及在基板（5）上安装栏杆（1）的方法。

5. 发明申请

US20070150771A1 Synchronisation of signals between asynchronous logic 有权
标题翻译：异步逻辑之间的信号同步
公开(公告)号：US20070150771A1
公开(公告)日：2007-06-28
申请号：US11314737
申请日：2005-12-22
申请人： Antony Penton , Vladimir Vasekin , Andrew Rose , Paul Hughes , Christopher Wrigley
发明人： Antony Penton , Vladimir Vasekin , Andrew Rose , Paul Hughes , Christopher Wrigley
IPC分类号： G06F1/12
CPC分类号： G06F1/12
摘要： A data processing apparatus comprising a plurality of data processors, each data processor comprising: first logic operable in a first clock domain and further logic operable in a second clock domain, said first and second clock domains being asynchronous with each other; a synchroniser operable to synchronise a signal processed by said first logic to produce a signal synchronised to said second clock domain; a synchronised signal output operable to export from said data processor said synchronised signal output from said synchroniser; and a signal input operable to import a signal to said data processor, said data processor being operable to route said imported signal to said further logic; wherein said plurality of data processors are arranged to operate in parallel with each other and said data processing apparatus further comprises: combining logic arranged to receive said exported synchronised signals from each of said plurality of data processors and to combine said exported synchronised signals to produce a resultant signal, said resultant signal being routed to each of said signal inputs of said plurality of data processors.
摘要翻译：一种包括多个数据处理器的数据处理装置，每个数据处理器包括：可在第一时钟域中操作的第一逻辑和可在第二时钟域中操作的另外的逻辑，所述第一和第二时钟域彼此异步; 同步器，其可操作以使由所述第一逻辑处理的信号同步，以产生与所述第二时钟域同步的信号; 同步信号输出可操作以从所述数据处理器输出从所述同步器输出的所述同步信号; 以及可操作以将信号导入所述数据处理器的信号输入，所述数据处理器可操作以将所述导入的信号路由到所述另外的逻辑; 其中所述多个数据处理器被布置为彼此并行操作，并且所述数据处理装置还包括：组合逻辑，被布置为从所述多个数据处理器中的每一个接收所述输出的同步信号，并组合所述输出的同步信号以产生所述结果信号被路由到所述多个数据处理器的每个所述信号输入端。

6. 外观设计

USD553956S1 Pivotal bracket for balusters 有权
标题翻译：栏杆支架
公开(公告)号：USD553956S1
公开(公告)日：2007-10-30
申请号：US29245710
申请日：2005-12-28
申请人： Anthony Trevor Jones , Paul Hughes
设计人： Anthony Trevor Jones , Paul Hughes

7. 发明申请

US20060212764A1 Integrated circuit and method for testing memory on the integrated circuit 有权
标题翻译：用于集成电路测试存储器的集成电路和方法
公开(公告)号：US20060212764A1
公开(公告)日：2006-09-21
申请号：US11076020
申请日：2005-03-10
申请人： Richard Slobodnik , Paul Hughes , Frank Frederick , Brandon Backlund
发明人： Richard Slobodnik , Paul Hughes , Frank Frederick , Brandon Backlund
IPC分类号： G11C29/00
CPC分类号： G11C29/16 , G11C29/26 , G11C29/48 , G11C2029/0401 , G11C2029/3602
摘要： An integrated circuit and method for testing memory on that integrated circuit are provided. The integrated circuit comprises processing logic operable to perform data processing operations on data, and a number of memory units operable to store data for access by the processing logic. A memory test controller is also provided which is operable to execute test events in order to seek to detect any memory defects in the number of memory units. The memory test controller comprises a storage operable to store event defining information for each of a plurality of test events forming a sequence of test events to be executed, and an interface which, during a single programming operation, receives the event defining information for each of the plurality of test events and causes that event defining information to be stored in the storage. Event processing logic within the memory test controller is then operable, following the single programming operation, to execute the sequence of test events. This provides an efficient technique for enabling a sequence of test events to be programmed at run time.
摘要翻译：提供了一种用于测试该集成电路上的存储器的集成电路和方法。集成电路包括可操作以对数据执行数据处理操作的处理逻辑，以及可操作以存储用于由处理逻辑进行访问的数据的多个存储单元。还提供了一种存储器测试控制器，其可操作以执行测试事件，以便寻求检测存储器单元数量中的任何存储器缺陷。存储器测试控制器包括可操作以存储形成要执行的测试事件序列的多个测试事件中的每一个的事件定义信息的存储器，以及在单个编程操作期间接收每个测试事件的事件定义信息的接口所述多个测试事件并且使所述事件定义要存储在所述存储器中的信息。然后，在单个编程操作之后，存储器测试控制器内的事件处理逻辑可以执行测试事件的顺序。这提供了一种有效的技术，可以在运行时对一系列测试事件进行编程。

8. 发明申请

US20060046914A1 Reformer exercise apparatus foot bar support 有权
标题翻译：重整器运动器具脚支撑
公开(公告)号：US20060046914A1
公开(公告)日：2006-03-02
申请号：US10933015
申请日：2004-09-01
申请人： Ken Endelman , Paul Hughes
发明人： Ken Endelman , Paul Hughes
IPC分类号： A63B26/00 , A63B23/00
CPC分类号： A63B22/0087 , A63B21/023 , A63B21/0442 , A63B21/068 , A63B23/03525 , A63B23/0405 , A63B2208/0252
摘要： A reformer exercise apparatus has a generally rectangular frame having a head end and a foot end and including a pair of spaced apart parallel track members, a movable carriage mounted on the frame for movement along the track members between said head and foot ends against one or more springs connected between the carriage and the foot end of the frame and an adjustable foot bar assembly mounted at the foot end of the frame. The foot bar assembly includes a foot bar and a foot bar support bar that fits into a pair of support brackets. Each bracket is a generally block shaped body fastened to the foot end of the frame. The bracket has a plurality of vertically spaced, downwardly opening slanted slots therein for receiving the support bar, each slanted slot having an entrance portion extending upward to an enlarged support portion at a base of the slot for retaining the support bar therein. The enlarged support portion forms a pocket to positively retain the support bar. A lock block that removably fastens to the foot bar support bar may be slidably inserted into the support portion of the bracket to lock the support bar in the support portion of the bracket.
摘要翻译：重整器锻炼设备具有大致矩形的框架，其具有头端和脚端，并且包括一对间隔开的平行轨道构件，安装在框架上的可移动滑架，用于沿着位于所述头部和脚部端部之间的轨道构件的一个或多个连接在支架和框架的脚端之间的更多的弹簧和安装在框架的脚端的可调整的脚杆组件。脚杆组件包括一个脚杆和一个安装在一对支撑架上的脚杆支撑杆。每个支架是固定到框架的脚端的大致块状的主体。支架在其中具有多个垂直间隔开的向下开口的倾斜狭槽，用于接收支撑杆，每个倾斜槽具有向上延伸到在槽的基部处的扩大的支撑部分的入口部分，用于将支撑杆保持在其中。扩大的支撑部分形成一个口袋以肯定地保持支撑杆。可拆卸地紧固到脚杆支撑杆的锁块可以可滑动地插入支架的支撑部分中，以将支撑杆锁定在支架的支撑部分中。

9. 发明申请

US20050115911A1 Processes and devices for water and wastewater treatment, including stationary cloth media filtration 有权
公开(公告)号：US20050115911A1
公开(公告)日：2005-06-02
申请号：US11005561
申请日：2004-12-06
申请人： David Smith , Paul Hughes , Lloyd P.E. , Peter P.E.
发明人： David Smith , Paul Hughes , Lloyd P.E. , Peter P.E.
IPC分类号： B01D29/39 , B01D35/30 , B01D29/62
CPC分类号： B01D35/301 , B01D29/39 , B01D29/684 , B01D2201/44
摘要： The present invention relates to stationary cloth media filtration systems and devices, as well as processes and devices for uniform flow distribution and improved cloth media filter backwashing.

10. 发明申请

US20050040604A1 Bushing arrangement for seal cavity protection in rotating fluid equipment 有权
标题翻译：用于旋转流体设备密封腔保护的衬套布置
公开(公告)号：US20050040604A1
公开(公告)日：2005-02-24
申请号：US10483987
申请日：2002-06-26
申请人： Joseph Dunford , Aniko Dunford , Paul Hughes
发明人： Joseph Dunford , Aniko Dunford , Paul Hughes
IPC分类号： F04D7/04 , F04D29/10 , F16J15/18 , F16J15/34 , F16L17/00
CPC分类号： F04D29/106 , F04D7/04 , F16J15/182 , F16J15/3404
摘要： An arrangement (120) of members for a throat bushing for rotary fluid equipment includes a first member (122) that is useful for seal cavities that contain conventional packing, and a second bushing member (132) that will be used in conjunction with the first bushing member if the seal cavity utilize a mechanical seal at the remote end of the cavity. Both bushing members (122, 132) are provided with spiral grooves (140) in a central bore thereof for the removal of contaminants from the seal cavity. The distal end face (124) of the first bushing member is contoured to receive a mating proximal end face (144) of the second bushing member or to also receive the abutting face of a packing ring or a lantern ring. The arrangement of the invention allows an operator to switch between the use of a mechanical seal or conventional packing without having to discard his primary seal cavity protector.
摘要翻译：用于旋转流体设备的喉套管的构件的装置（120）包括可用于包含常规密封件的密封腔的第一构件（122）和将与第一构件（122）结合使用的第二衬套构件（132）如果密封腔在空腔的远端使用机械密封，则衬套构件。两个衬套构件（122,132）在其中心孔中设置有螺旋槽（140），用于从密封腔去除污染物。第一衬套构件的远端面（124）成形为接收第二衬套构件的配合的近端面（144），或者还容纳衬垫环或灯笼环的抵接面。本发明的装置允许操作者在机械密封件或常规包装的使用之间切换，而不必丢弃其主密封腔保护器。

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