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1. 发明授权

US07623903B2 Double contrast technique for MRI-guided vascular interventions 有权
标题翻译：用于MRI引导血管干预的双重对比技术
公开(公告)号：US07623903B2
公开(公告)日：2009-11-24
申请号：US10441235
申请日：2003-05-19
申请人： Frank K. Wacker , Jeffrey L. Duerk , Jonathan S. Lewin , Robbert M. Maes
发明人： Frank K. Wacker , Jeffrey L. Duerk , Jonathan S. Lewin , Robbert M. Maes
IPC分类号： A61B5/05
CPC分类号： G01R33/5601 , G01R33/286
摘要： A method to detect the location of a catheter relative to a targeted location in a blood vessel is provided. One example method includes acquiring and displaying magnetic resonance (MR) images while a first MR contrast agent is present and while the operation of that first MR contrast agent is counter-acted by a second MR contrast agent. Both MR contrast agents may be introduced into a blood vessel by the catheter whose position is to be detected.
摘要翻译：提供了一种用于检测导管相对于血管中的目标位置的位置的方法。一种示例性方法包括在第一MR造影剂存在的同时获取并显示磁共振（MR）图像，同时该第一MR造影剂的操作由第二MR造影剂反作用。可以通过要检测其位置的导管将两个MR造影剂引入血管。

2. 发明授权

US07996062B2 Double-contrast technique for MRI-guided vascular interventions 有权
标题翻译：用于MRI引导血管干预的双重对比技术
公开(公告)号：US07996062B2
公开(公告)日：2011-08-09
申请号：US12577805
申请日：2009-10-13
申请人： Frank K. Wacker , Jeffrey L. Duerk , Jonathan S. Lewin , Robbert M. Maes
发明人： Frank K. Wacker , Jeffrey L. Duerk , Jonathan S. Lewin , Robbert M. Maes
IPC分类号： A61B5/05
CPC分类号： G01R33/5601 , G01R33/286
摘要： Methods for confirming location of a catheter tip relative to a targeted location in a blood vessel of a subject and improving visualization of the blood vessels downstream of the catheter tip are provided. The methods comprise acquiring and displaying a first modified MR image of the subject's blood vessels between an insertion site for the catheter and the targeted location; acquiring and displaying a sequence of modified MR images of the blood vessels to monitor advancement of an inserted catheter from the insertion site to an intraluminal stop site at or near the targeted location; delivering a bolus of a magnetic resonance contrast agent through the tip of the catheter and to the intraluminal stop site, wherein the magnetic contrast agent alters the first modified MR image of the subject's blood vessels; acquiring and displaying an updated second MR modified image of the blood vessels at and downstream of the tip of the catheter. Systems and computer readable medium storing computer executable instructions operable to perform computer executable aspects of the present methods are also provided.
摘要翻译：提供了用于确认导管尖端相对于受试者的血管中的目标位置的位置并改善导管末端下游的血管的可视化的方法。所述方法包括在导管的插入位置和目标位置之间获取和显示受试者的血管的第一修改的MR图像; 获取和显示所述血管的修改的MR图像的序列，以监测插入的导管从所述插入位置到目标位置处或附近的管腔内停止部位的进展; 通过导管的尖端和腔内停止部位递送大量的磁共振造影剂，其中磁性造影剂改变受试者的血管的第一改良的MR图像; 获取和显示在导管末端和下游的血管的更新的第二MR修改图像。还提供了可操作以执行本方法的计算机可执行方面的存储计算机可执行指令的系统和计算机可读介质。

3. 发明申请

US20100106007A1 DOUBLE-CONTRAST TECHNIQUE FOR MRI-GUIDED VASCULAR INTERVENTIONS 有权
标题翻译：用于MRI引导的血管干预的双对比技术
公开(公告)号：US20100106007A1
公开(公告)日：2010-04-29
申请号：US12577805
申请日：2009-10-13
申请人： Frank K. Wacker , Jeffrey L. Duerk , Jonathan S. Lewin , Robbert M. Maes
发明人： Frank K. Wacker , Jeffrey L. Duerk , Jonathan S. Lewin , Robbert M. Maes
IPC分类号： A61B5/055
CPC分类号： G01R33/5601 , G01R33/286
摘要： Methods for confirming location of a catheter tip relative to a targeted location in a blood vessel of a subject and improving visualization of the blood vessels downstream of the catheter tip are provided. The methods comprise acquiring and displaying a first modified MR image of the subject's blood vessels between an insertion site for the catheter and the targeted location; acquiring and displaying a sequence of modified MR images of the blood vessels to monitor advancement of an inserted catheter from the insertion site to an intraluminal stop site at or near the targeted location; delivering a bolus of a magnetic resonance contrast agent through the tip of the catheter and to the intraluminal stop site, wherein the magnetic contrast agent alters the first modified MR image of the subject's blood vessels; acquiring and displaying an updated second MR modified image of the blood vessels at and downstream of the tip of the catheter. Systems and computer readable medium storing computer executable instructions operable to perform computer executable aspects of the present methods are also provided.
摘要翻译：提供了用于确认导管尖端相对于受试者的血管中的目标位置的位置并改善导管末端下游的血管的可视化的方法。所述方法包括在导管的插入位置和目标位置之间获取和显示受试者的血管的第一修改的MR图像; 获取和显示所述血管的修改的MR图像的序列，以监测插入的导管从所述插入位置到目标位置处或附近的管腔内停止部位的进展; 通过导管的尖端和管腔内止血部位输送大量的磁共振造影剂，其中磁性造影剂改变受试者的血管的第一修改的MR图像; 获取和显示在导管末端和下游的血管的更新的第二MR修改图像。还提供了可操作以执行本方法的计算机可执行方面的存储计算机可执行指令的系统和计算机可读介质。

4. 发明授权

US07835780B1 MR invasive device and method for active MR guidance of invasive devices with target navigation 有权
标题翻译：用于目标导航的侵入性装置的主动MR引导的MR侵入性装置和方法
公开(公告)号：US07835780B1
公开(公告)日：2010-11-16
申请号：US10240219
申请日：2001-03-30
申请人： Jeffrey L. Duerk , Qiang Zhang , Michael Wendt , Yiu-Cho Chung , Jonathan S. Lewin , Elmar M. Merkle
发明人： Jeffrey L. Duerk , Qiang Zhang , Michael Wendt , Yiu-Cho Chung , Jonathan S. Lewin , Elmar M. Merkle
IPC分类号： A61B5/05
CPC分类号： G01R33/287 , G01R33/34084
摘要： An invasive device having an inductive coupling element. One embodiment of the invasive device includes a plurality of receive coils inductively coupled to a communicating coil. The receive coils are selectively tuned and detuned to receive MR signals for providing coordinate information used for device tracking. A second embodiment of the invasive device includes a receive coil having a plurality of winding elements separated from each other by different distances. A method of rapidly acquiring both the invasive device orientation and position information to dynamically adapt MR scan planes to continuously follow the invasive device relative to a target is provided. The target-navigation technique automatically defines the MR scan plane and a time domain multiplexing technique is applied for MR imaging and device tracking. Using these techniques, the acquired MR images shows both the invasive device and the target tissue.
摘要翻译：一种具有感应耦合元件的侵入性装置。侵入性装置的一个实施例包括感应耦合到通信线圈的多个接收线圈。接收线圈被选择性地调谐和失谐以接收用于提供用于设备跟踪的坐标信息的MR信号。侵入性装置的第二实施例包括具有彼此以不同距离分开的多个绕组元件的接收线圈。提供了一种快速获取入侵设备取向和位置信息以便动态地适应MR扫描平面以相对于目标连续跟随侵入性设备的方法。目标导航技术自动定义MR扫描平面，并应用时域复用技术进行MR成像和设备跟踪。使用这些技术，获得的MR图像显示侵入性装置和目标组织。

5. 发明授权

US07830144B2 Reducing effects of rotational motion 有权
标题翻译：减少旋转运动的影响
公开(公告)号：US07830144B2
公开(公告)日：2010-11-09
申请号：US11224822
申请日：2005-09-13
申请人： Jeffrey L. Duerk , Ajit Shankaranarayanan , Michael Wendt , Jonathan S. Lewin
发明人： Jeffrey L. Duerk , Ajit Shankaranarayanan , Michael Wendt , Jonathan S. Lewin
IPC分类号： G01V3/00
CPC分类号： A61B5/055 , A61B5/7207 , G01R33/56509
摘要： A method and system for improving image quality by correcting errors introduced by rotational motion of an object being imaged is provided. The object is associated with a fiducial mark. The method provides a computer executable methodology for detecting a rotation and selectively reordering, deleting and/or reacquiring projection data.
摘要翻译：提供了一种通过校正由成像对象的旋转运动引入的误差来提高图像质量的方法和系统。对象与基准标记相关联。该方法提供了用于检测旋转和选择性重排序，删除和/或重新获取投影数据的计算机可执行方法。

6. 发明申请

US20080221428A1 Chemical Shift Markers for Improved Wireless Fiducial Marker Tracking 有权
标题翻译：用于改进无线基准标记跟踪的化学位移标记
公开(公告)号：US20080221428A1
公开(公告)日：2008-09-11
申请号：US10514307
申请日：2003-05-15
申请人： Christopher A. Flask , Jonathan S. Lewin , Daniel R. Elgort , Ken-Pin Hwang , Eddy Y. Wong , Jeffrey L. Duerk
发明人： Christopher A. Flask , Jonathan S. Lewin , Daniel R. Elgort , Ken-Pin Hwang , Eddy Y. Wong , Jeffrey L. Duerk
IPC分类号： A61B5/055
CPC分类号： G01R33/285 , A61B5/055 , A61B5/06 , A61B90/39 , A61B2090/3954
摘要： A new and improved method for tracking and/or spatial localization of an invasive device in Magnetic Resonance Imaging (MRI) is provided. The invention includes providing an invasive device including a marker having a chemically shifted signal source with a resonant frequency different from the chemical species of the subject to be imaged, applying a pulse sequence, detecting the resulting RF magnetic resonance signals, and determining the 3D coordinates of the marker. The invention also includes generating scan planes and reconstructing an image from the detected signals to generate an image having the marker contrasted from the subject. The invasive device includes a marker having a chemically shifted signal source which has a resonant frequency different from the chemical species of the subject to be imaged for use in tracking the device during imaging.
摘要翻译：提供了一种用于磁共振成像（MRI）中的侵入性装置的跟踪和/或空间定位的新的和改进的方法。本发明包括提供一种侵入性装置，其包括具有化学位移信号源的标记物，其具有不同于待成像对象的化学物质的共振频率，应用脉冲序列，检测所得到的RF磁共振信号，以及确定3D坐标的标记。本发明还包括产生扫描平面并从检测到的信号重建图像以产生具有与被摄体对比的标记的图像。侵入性装置包括具有化学位移信号源的标记，其具有与被成像对象的化学物种不同的共振频率，以用于在成像期间跟踪装置。

7. 发明授权

US07359745B2 Method to correct magnetic field/phase variations in proton resonance frequency shift thermometry in magnetic resonance imaging 有权
标题翻译：磁共振成像中质子共振频移温度测量中磁场/相位变化的校正方法
公开(公告)号：US07359745B2
公开(公告)日：2008-04-15
申请号：US10437662
申请日：2003-05-14
申请人： Jonathan S. Lewin , Jeffrey L. Duerk , Kestutis J. Barkauskas
发明人： Jonathan S. Lewin , Jeffrey L. Duerk , Kestutis J. Barkauskas
IPC分类号： A61B5/05
CPC分类号： G01R33/022 , G01R33/4804 , G01R33/565 , G01R33/56563
摘要： PRF shift MRI data is acquired. The PRF shift MRI data may include signals affected by both a desired PRF shift and an undesired PRF shift. Thus, example systems and methods describe manipulating the PRF shift MR! data to make it substantially free of the effects of the undesired PRF shift, which facilitates displaying certain MRI images based on the desired PRF shift.
摘要翻译：获取PRF位移MRI数据。 PRF移位MRI数据可以包括受期望的PRF偏移和不期望的PRF偏移影响的信号。因此，示例系统和方法描述了操纵PRF移位MRI数据以使其基本上不受不期望的PRF偏移的影响，这有助于基于期望的PRF偏移来显示某些MRI图像。

8. 发明授权

US07042215B2 Three point dixon techniques in MRI spiral trajectories with off-resonance correction where each TE is a multiple of 2.2 milliseconds 有权
标题翻译：具有偏共振校正的MRI螺旋轨迹中的三点狄克逊技术，其中每个TE是2.2毫秒的倍数
公开(公告)号：US07042215B2
公开(公告)日：2006-05-09
申请号：US10832659
申请日：2004-04-26
申请人： Hisamoto Moriguchi , Jonathan S. Lewin , Jeffrey L. Duerk
发明人： Hisamoto Moriguchi , Jonathan S. Lewin , Jeffrey L. Duerk
IPC分类号： G01V3/00
CPC分类号： G01R33/565 , G01R33/4828 , G01R33/56563
摘要： Spiral imaging has recently gained acceptance for rapid MR data acquisition. One of the main disadvantages of spiral imaging, however, is blurring artifacts due to off-resonance effects. Dixon techniques have been developed as methods of water-fat signal decomposition in rectilinear sampling schemes, and they can produce unequivocal water-fat signal decomposition even in the presence of B0 inhomogeneity. Three-point and two-point Dixon techniques can be extended to conventional spiral and variable-density spiral data acquisitions for unambiguous water-fat decomposition with off-resonance blurring correction. In the spiral three-point Dixon technique, water-fat signal decomposition and image deblurring are performed based on the frequency maps that are directly derived from the acquired images. In the spiral two-point Dixon technique, several predetermined frequencies are tested to create a frequency map. The techniques can achieve more effective and more uniform fat signal suppression when compared to the conventional spiral acquisition method with SPSP pulses.
摘要翻译：螺旋成像最近已经获得了快速MR数据采集的认可。然而，螺旋成像的主要缺点之一是由于共振效应引起的模糊伪影。已经开发了Dixon技术作为直线抽样方案中水脂信号分解的方法，即使在不均匀性的情况下也能产生明确的水脂信号分解。三点和二点Dixon技术可以扩展到常规螺旋和可变密度螺旋数据采集，用于明确的水分解与非共振模糊校正。在螺旋三点Dixon技术中，基于从所获取的图像直接导出的频率图执行水脂信号分解和图像去模糊。在螺旋二点Dixon技术中，测试了几个预定频率以创建频率图。与使用SPSP脉冲的常规螺旋采集方法相比，该技术可以实现更有效和更均匀的脂肪信号抑制。

9. 发明授权

US5813984A Forensic skull and soft tissue database and on-line facial reconstruction of victims and age progession portrait rendering of missing children through utilization of advance diagnostic radiologic modalities 失效
标题翻译：法医头骨和软组织数据库和在线面部重建的受害者和年龄进展肖像呈现失踪的儿童通过利用先进的诊断放射学模式
公开(公告)号：US5813984A
公开(公告)日：1998-09-29
申请号：US812528
申请日：1997-03-07
申请人： John R. Haaga , David A. Miller , Joseph P. Molter , Jeffrey L. Duerk , Jonathan S. Lewin
发明人： John R. Haaga , David A. Miller , Joseph P. Molter , Jeffrey L. Duerk , Jonathan S. Lewin
IPC分类号： G06T7/60 , G06T15/00 , A61B6/00
CPC分类号： G06T15/00 , G06T7/60
摘要： A method and device for generating a forensic skull and soft tissue database used for the on-line facial reconstruction of victims and age progression portrait rendering of missing children through utilization of advance diagnostic radiologic modalities.
摘要翻译：一种用于产生法医头骨和软组织数据库的方法和装置，用于通过利用先进的诊断放射学模式对受害者的在线面部重建和失踪儿童的年龄进展肖像呈现。

10. 发明授权

US08111068B2 Reducing effects of rotational motion 有权
标题翻译：减少旋转运动的影响
公开(公告)号：US08111068B2
公开(公告)日：2012-02-07
申请号：US12890963
申请日：2010-09-27
申请人： Jeffrey L. Duerk , Ajit Shankaranarayanan , Michael Wendt , Jonathan S. Lewin
发明人： Jeffrey L. Duerk , Ajit Shankaranarayanan , Michael Wendt , Jonathan S. Lewin
IPC分类号： G01V3/00
CPC分类号： A61B5/055 , A61B5/7207 , G01R33/56509
摘要： A method and system for improving image quality by correcting errors introduced by rotational motion of an object being imaged is provided. The object is associated with a fiducial mark. The method provides a computer executable methodology for detecting a rotation and selectively reordering, deleting and/or reacquiring projection data.
摘要翻译：提供了一种通过校正由成像对象的旋转运动引入的误差来提高图像质量的方法和系统。对象与基准标记相关联。该方法提供了用于检测旋转和选择性重排序，删除和/或重新获取投影数据的计算机可执行方法。

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