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1. 发明申请

US20110257709A1 METHOD AND APPARATUS FOR MODIFYING NEUROSTIMULATION LINEAR LEAD SHAPE TO CORRECT LEAD MIGRATION 审中-公开
标题翻译：修改神经线性铅形状以修正铅迁移的方法和装置
公开(公告)号：US20110257709A1
公开(公告)日：2011-10-20
申请号：US13090810
申请日：2011-04-20
申请人： Douglas Michael Ackermann , Anne Margaret Pianca , Michael Adam Moffitt
发明人： Douglas Michael Ackermann , Anne Margaret Pianca , Michael Adam Moffitt
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/36125 , A61N1/0551 , A61N1/0558 , A61N1/3605
摘要： A neurostimulation system comprises an implantable neurostimulation lead, an implantable neurostimulator configured for delivering stimulation energy to the implantable neurostimulation lead, an actuating device configured for modifying a linear shape of the lead after it has migrated from a baseline position, memory configured for storing a threshold value, and a processor configured for determining a magnitude at which the lead has migrated from the baseline position, comparing the determined magnitude to the threshold value, and prompting the actuating device to modify the linear shape of the lead based on the comparison. A method of correcting the migration of a neurostimulation lead implanted within the patient comprises determining a magnitude at which the implanted lead has migrated from a baseline position, comparing the determined magnitude to a threshold value, and modifying the linear shape of the lead based on the comparison.
摘要翻译：神经刺激系统包括可植入神经刺激引线，被配置为将刺激能量递送到可植入神经刺激引线的可植入神经刺激器，构造成在引线从基线位置迁移之后修改引线的线性形状的致动器件，配置用于存储阈值的存储器值，以及配置用于确定所述引线已经从所述基准位置迁移的幅度的处理器，将所确定的幅度与所述阈值进行比较，并且基于所述比较提示所述致动装置修改所述引线的线性形状。校正植入在患者体内的神经刺激引线的迁移的方法包括确定植入引线已经从基线位置迁移的大小，将所确定的量值与阈值进行比较，以及基于所述阈值修正引线的线性形状比较。

2. 发明申请

US20120143296A1 PERCUTANEOUSLY IMPLANTABLE PADDLE-TYPE LEAD AND METHODS AND DEVICES FOR DEPLOYMENT 有权
标题翻译： PERCUTANEOUSLY IMPLANTABLE PADDLE-TYPE LEAD AND METHODS AND DEVICES FOR DDPLOY
公开(公告)号：US20120143296A1
公开(公告)日：2012-06-07
申请号：US13299725
申请日：2011-11-18
申请人： Anne Margaret Pianca , Douglas Michael Ackermann
发明人： Anne Margaret Pianca , Douglas Michael Ackermann
IPC分类号： A61N1/05
CPC分类号： A61N1/0553 , A61N1/0558
摘要： A percutaneously implantable paddle lead includes an elongated lead body having a proximal portion and a distal portion; a plurality of terminals disposed on the proximal portion of the lead; a flexible paddle body coupled to the distal portion of the lead; and a plurality of electrodes disposed in the paddle body and electrically coupled to the terminals on the proximal portion of the lead. The percutaneously implantable paddle lead also includes a bonding material in contact with the paddle body and holding the paddle body in a compacted form prior to, and during, insertion into a percutaneous implantation tool. The bonding material is configured and arranged to release the paddle body during or soon after implantation into a patient so that the paddle body can deploy into its paddle-like form. Alternatively, at least one current-degradable fastener can be used instead of the binding material.
摘要翻译：经皮植入式桨引线包括具有近端部分和远端部分的细长引线体; 设置在所述引线的近端部分上的多个端子; 耦合到所述引线的远端部分的柔性桨状体; 以及设置在所述桨体中并与所述引线的近端部分上的端子电耦合的多个电极。经皮植入式桨引线还包括与桨体接触的接合材料，并且在插入到经皮植入工具之前和期间将桨体保持为压实形式。接合材料被配置和布置成在植入患者期间或之后即将释放桨体，使得桨体能够部署成其桨状形式。或者，可以使用至少一种电流可降解的紧固件代替粘结材料。

3. 发明申请

US20110257710A1 METHOD AND APPARATUS FOR ALERTING A USER OF NEUROSTIMULATION LEAD MIGRATION 审中-公开
标题翻译：用于警告神经细胞移植用户的方法和装置
公开(公告)号：US20110257710A1
公开(公告)日：2011-10-20
申请号：US13090692
申请日：2011-04-20
申请人： Douglas Michael Ackermann , Anne Margaret Pianca
发明人： Douglas Michael Ackermann , Anne Margaret Pianca
IPC分类号： A61N1/36
CPC分类号： A61N1/36125 , A61N1/0551 , A61N1/0558 , A61N1/3605
摘要： A neurostimulation system comprises an implantable neurostimulation lead, an implantable neurostimulator configured for delivering stimulation energy to the lead, an indicator configured for outputting a user-discernible alert signal indicating that the lead has migrated from a baseline position, memory configured for storing a threshold value, and a processor configured for determining a magnitude at which the lead has migrated from the baseline position, comparing the determined magnitude to the threshold value, and prompting the indicator to output the alert signal based on the comparison. A method of alerting a user to the migration of a neurostimulation lead implanted within the user comprises determining a magnitude at which an implanted neurostimulation lead has migrated from a baseline position, comparing the determined magnitude to a threshold value, and outputting a user-discernible alert signal indicating that the implanted lead has migrated based on the comparison.
摘要翻译：神经刺激系统包括可植入神经刺激引线，被配置为将刺激能量传递到引线的可植入神经刺激器，被配置为输出指示引线已经从基线位置迁移的用户可识别警报信号的指示符，所述指示器被配置用于存储阈值以及处理器，被配置为用于确定所述引线已经从所述基准位置迁移的幅度，将所确定的幅度与所述阈值进行比较，并且基于所述比较提示所述指示符输出所述警报信号。提醒用户对植入在使用者内的神经刺激引线的迁移的方法包括确定植入的神经刺激引线已经从基线位置迁移的大小，将所确定的量值与阈值进行比较，以及输出用户可识别的警报指示植入的引线基于比较而迁移的信号。

4. 发明授权

US09265934B2 Percutaneously implantable paddle-type lead and methods and devices for deployment 有权
标题翻译：经皮植入式桨式引线及其部署方法和装置
公开(公告)号：US09265934B2
公开(公告)日：2016-02-23
申请号：US13299725
申请日：2011-11-18
申请人： Anne Margaret Pianca , Douglas Michael Ackermann
发明人： Anne Margaret Pianca , Douglas Michael Ackermann
IPC分类号： A61N1/00 , A61N1/05
CPC分类号： A61N1/0553 , A61N1/0558
摘要： A percutaneously implantable paddle lead includes an elongated lead body having a proximal portion and a distal portion; a plurality of terminals disposed on the proximal portion of the lead; a flexible paddle body coupled to the distal portion of the lead; and a plurality of electrodes disposed in the paddle body and electrically coupled to the terminals on the proximal portion of the lead. The percutaneously implantable paddle lead also includes a bonding material in contact with the paddle body and holding the paddle body in a compacted form prior to, and during, insertion into a percutaneous implantation tool. The bonding material is configured and arranged to release the paddle body during or soon after implantation into a patient so that the paddle body can deploy into its paddle-like form. Alternatively, at least one current-degradable fastener can be used instead of the binding material.
摘要翻译：经皮可植入的桨引线包括具有近端部分和远端部分的细长引线体; 设置在所述引线的近端部分上的多个端子; 耦合到所述引线的远端部分的柔性桨状体; 以及设置在所述桨体中并与所述引线的近端部分上的端子电耦合的多个电极。经皮植入式桨引线还包括与桨体接触的接合材料，并且在插入到经皮植入工具之前和期间将桨体保持为压实形式。接合材料被配置和布置成在植入患者期间或之后即将释放桨体，使得桨体能够部署成其桨状形式。或者，可以使用至少一种电流可降解的紧固件代替粘结材料。

5. 发明申请

US20120130398A1 SYSTEMS AND METHODS FOR TREATMENT OF DRY EYE 有权
标题翻译：用于治疗干眼症的系统和方法
公开(公告)号：US20120130398A1
公开(公告)日：2012-05-24
申请号：US13298042
申请日：2011-11-16
申请人： Douglas Michael Ackermann , Daniel Palanker , James Donald Loudin , Garrett Cale Smith , Victor Wayne McCray , Brandon McNary Felkins
发明人： Douglas Michael Ackermann , Daniel Palanker , James Donald Loudin , Garrett Cale Smith , Victor Wayne McCray , Brandon McNary Felkins
IPC分类号： A61N1/36 , A61B19/00
CPC分类号： A61N1/37205 , A61N1/36046 , A61N1/36057 , A61N1/3606 , A61N1/36142 , A61N1/37211 , A61N1/3756 , A61N1/3787
摘要： A stimulation system stimulates anatomical targets in a patient for treatment of dry eye. The system may include a controller and a microstimulator. The controller may be implemented externally to or internally within the microstimulator. The components of the controller and microstimulator may be implemented in a single unit or in separate devices. When implemented separately, the controller and microstimulator may communicate wirelessly or via a wired connection. The microstimulator may generate pulses from a controller signal and apply the signal via one or more electrodes to an anatomical target. The microstimulator may not have any intelligence or logic to shape or modify a signal. The microstimulator may be a passive device configured to generate a pulse based on a signal received from the controller. The microstimulator may shape or modify a signal. Waveforms having different frequency, amplitude and period characteristics may stimulate different anatomical targets in a patient.
摘要翻译：刺激系统刺激患者的解剖目标以治疗干眼症。该系统可以包括控制器和微型激励器。控制器可以在微型激励器外部或内部实现。控制器和微型激励器的组件可以在单个单元中或在单独的设备中实现。当单独实现时，控制器和微型激励器可以无线地或经由有线连接进行通信。微型激励器可以从控制器信号产生脉冲，并通过一个或多个电极将信号施加到解剖靶。微型激励器可能没有任何智能或逻辑来塑造或修改信号。微型激励器可以是被配置为基于从控制器接收的信号产生脉冲的无源器件。微型激励器可以形成或修改信号。具有不同频率，幅度和周期特征的波形可以刺激患者中不同的解剖目标。

6. 发明申请

US20200253723A1 PUPILLARY ACCOMMODATING INTRAOCULAR LENS 审中-公开
公开(公告)号：US20200253723A1
公开(公告)日：2020-08-13
申请号：US16635530
申请日：2018-07-27
申请人： Douglas Michael Ackermann , Anand Doraiswamy
发明人： Douglas Michael Ackermann , Anand Doraiswamy
IPC分类号： A61F2/16
摘要： Systems and methods can advantageously leverage the pupillary accommodation reflex to provide improved quality of vision throughout the range of focus distances. As such, some embodiments include an accommodating pupillary lens (APL) that sits at least partially within the pupil and/or is partially or fully attached, adhered, or otherwise held in place with respect to the iris, and/or is anchored in the sulcus and/or elsewhere in the eye. The optical power of the lens can be configured to change with changes in pupil diameter.

7. 发明授权

US08918181B2 Systems and methods for treatment of dry eye 有权
标题翻译：用于治疗干眼症的系统和方法
公开(公告)号：US08918181B2
公开(公告)日：2014-12-23
申请号：US13298042
申请日：2011-11-16
申请人： Douglas Michael Ackermann , Daniel Palanker , James Donald Loudin , Garrett Cale Smith , Victor Wayne McCray , Brandon McNary Felkins
发明人： Douglas Michael Ackermann , Daniel Palanker , James Donald Loudin , Garrett Cale Smith , Victor Wayne McCray , Brandon McNary Felkins
IPC分类号： A61N1/36 , A61N1/372 , A61N1/378 , A61N1/375
CPC分类号： A61N1/37205 , A61N1/36046 , A61N1/36057 , A61N1/3606 , A61N1/36142 , A61N1/37211 , A61N1/3756 , A61N1/3787
摘要： A stimulation system stimulates anatomical targets in a patient for treatment of dry eye. The system may include a controller and a microstimulator. The controller may be implemented externally to or internally within the microstimulator. The components of the controller and microstimulator may be implemented in a single unit or in separate devices. When implemented separately, the controller and microstimulator may communicate wirelessly or via a wired connection. The microstimulator may generate pulses from a controller signal and apply the signal via one or more electrodes to an anatomical target. The microstimulator may not have any intelligence or logic to shape or modify a signal. The microstimulator may be a passive device configured to generate a pulse based on a signal received from the controller. The microstimulator may shape or modify a signal. Waveforms having different frequency, amplitude and period characteristics may stimulate different anatomical targets in a patient.
摘要翻译：刺激系统刺激患者的解剖目标以治疗干眼症。该系统可以包括控制器和微型激励器。控制器可以在微型激励器外部或内部实现。控制器和微型激励器的组件可以在单个单元中或在单独的设备中实现。当单独实现时，控制器和微型激励器可以无线地或经由有线连接进行通信。微型激励器可以从控制器信号产生脉冲，并通过一个或多个电极将信号施加到解剖靶。微型激励器可能没有任何智能或逻辑来塑造或修改信号。微型激励器可以是被配置为基于从控制器接收的信号产生脉冲的无源器件。微型激励器可以形成或修改信号。具有不同频率，幅度和周期特征的波形可以刺激患者中不同的解剖目标。

8. 发明申请

US20210236809A1 NASAL STIMULATION DEVICES AND METHODS FOR TREATING DRY EYE 有权
公开(公告)号：US20210236809A1
公开(公告)日：2021-08-05
申请号：US17222578
申请日：2021-04-05
申请人： Douglas Michael Ackermann
发明人： Douglas Michael Ackermann , James Donald Loudin
IPC分类号： A61N1/05 , A61N1/36 , A61H1/00 , A61F7/12 , A61H9/00 , A61H21/00 , A61H23/02 , A61N1/378 , H02J7/00 , A61N1/04 , A61N7/00
摘要： Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.

9. 发明申请

US20140055741A1 CONTACT LENS WITH A HYDROPHILIC LAYER 有权
标题翻译：接触透镜与水泥层
公开(公告)号：US20140055741A1
公开(公告)日：2014-02-27
申请号：US13975868
申请日：2013-08-26
申请人： Karen L. Havenstrite , Victor Wayne McCray , Brandon McNary Felkins , Douglas Michael Ackermann , Garrett Cale Smith , Paul A. Cook , Evan S. Luxon , Andrew A. McGibbon
发明人： Karen L. Havenstrite , Victor Wayne McCray , Brandon McNary Felkins , Douglas Michael Ackermann , Garrett Cale Smith , Paul A. Cook , Evan S. Luxon , Andrew A. McGibbon
IPC分类号： G02B1/04
CPC分类号： G02C7/049 , C08L5/08 , C08L71/00 , C08L2203/02 , C08L2205/025 , C09D105/08 , C09D171/00 , G02B1/043 , G02C2202/16 , C08L101/14
摘要： Embodiments of the technology relate to a contact lens having a core that is covalently coated by a hydrogel layer, and to methods of making such a lens. In one aspect, embodiments provide for a coated contact lens comprising a lens core comprising an outer surface; and a hydrogel layer covalently attached to at least a portion of the outer surface, the hydrogel layer adapted to contact an ophthalmic surface, wherein the hydrogel layer comprises a hydrophilic polymer population having a first PEG species and a second PEG species, the first PEG species being at least partially cross-linked to the second PEG species.
摘要翻译：该技术的实施方案涉及具有由水凝胶层共价涂覆的芯的隐形眼镜以及制造这种透镜的方法。在一个方面，实施例提供了一种涂覆的隐形眼镜，其包括包括外表面的透镜芯; 以及水凝胶层，其共价连接到所述外表面的至少一部分，所述水凝胶层适于接触眼表面，其中所述水凝胶层包含具有第一PEG种类和第二PEG物质的亲水聚合物群体，所述第一PEG种类至少部分地与第二PEG种类交联。

10. 发明申请

US20120215285A1 System for Communication with Implantable Medical Devices Using a Bridge Device 有权
标题翻译：使用桥接器件与植入式医疗设备进行通信的系统
公开(公告)号：US20120215285A1
公开(公告)日：2012-08-23
申请号：US13372177
申请日：2012-02-13
申请人： Samuel Tahmasian , Daniel Aghassian , Douglas Michael Ackermann , Joonho Hyun
发明人： Samuel Tahmasian , Daniel Aghassian , Douglas Michael Ackermann , Joonho Hyun
IPC分类号： A61N1/08 , H04W4/00 , H04B7/14 , H04B7/26 , H04B5/02
CPC分类号： A61N1/37229 , A61N1/36125 , A61N1/37217 , A61N1/37247 , A61N1/37264 , A61N1/37282 , H04B5/0031 , H04B5/0037 , H04B5/0075 , H04W4/80
摘要： A communications bridge device communicates between a consumer electronics device, such as a smart telephone, and an implantable medical device. The bridge forwards instructions and data between the consumer electronics device and the implantable medical device. The bridge contains a first transceiver that operates according to a communication protocol operating in the consumer electronics device (such as Bluetooth®), and second transceiver that operates according to a communications technique operating in the implantable medical device (e.g., Frequency Shift Keying). A software application is installed on the consumer electronics device, which provides a user interface for controlling and reading the implantable medical device. The software application is downloadable using standard cellular means. The bridge is preferably small, and easily and discreetly carried by the implantable medical device patient. The bridge is preferably also simple to operate, and may have only a simple user interface, or no user interface at all.
摘要翻译：通信桥接设备在诸如智能电话的消费电子设备和可植入医疗设备之间进行通信。桥接器在消费电子设备和可植入医疗设备之间转发指令和数据。桥接器包含根据在消费电子设备（例如Bluetooth®）中操作的通信协议进行操作的第一收发器，以及根据在可植入医疗设备中操作的通信技术（例如，频移键控）操作的第二收发器。软件应用程序安装在消费电子设备上，其提供用于控制和读取可植入医疗设备的用户界面。软件应用程序可以使用标准的蜂窝手段下载。该桥优选地是小的，并且容易且谨慎地由可植入医疗装置的患者携带。该桥优选地操作简单，并且可以仅具有简单的用户界面，或者根本没有用户界面。

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