专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07593617B2 Optical waveguide 失效
标题翻译：光波导
公开(公告)号：US07593617B2
公开(公告)日：2009-09-22
申请号：US11816291
申请日：2006-02-15
申请人： Derk J. W. Klunder , Bernardus H. W. Hendriks , Stein Kuiper
发明人： Derk J. W. Klunder , Bernardus H. W. Hendriks , Stein Kuiper
IPC分类号： G02B6/00
CPC分类号： G02B6/3538 , G02B6/122 , G02B6/3594 , G02B6/3596 , G02B2006/0325
摘要： An optical waveguide comprises a body (13), the body including an entrance window (9) and an exit window (11) defining an optical path (13) through a cavity. The cavity contains a first fluid (A) and a second fluid (B), with an interface between the first fluid and the second fluid defined by a meniscus. The meniscus lies longitudinally along the optical path. Means for adjusting the meniscus are provided, for example a voltage source and at least two electrodes. Electrowetting can be used for influencing the fluids.
摘要翻译：光波导包括主体（13），主体包括通过空腔限定光路（13）的入口窗（9）和出口窗（11）。空腔包含第一流体（A）和第二流体（B），在第一流体和由弯月面限定的第二流体之间具有界面。弯液面沿光路纵向延伸。提供了用于调节弯液面的装置，例如电压源和至少两个电极。电润湿可用于影响流体。

2. 发明授权

US08039818B2 Sub wavelength aperture 有权
标题翻译：子波长孔径
公开(公告)号：US08039818B2
公开(公告)日：2011-10-18
申请号：US12519800
申请日：2007-12-18
申请人： Maarten M. J. W. Van Herpen , Derk J. W. Klunder
发明人： Maarten M. J. W. Van Herpen , Derk J. W. Klunder
IPC分类号： G01N21/64
CPC分类号： G01N21/64 , G01N21/6445
摘要： There is provided a method of detecting a presence of a luminophore in a detection volume comprising providing excitation radiation in said detection volume. A luminophore is provided in said detection volume being excitable by said excitation radiation. The luminescent radiation is detected to identify the presence of said luminophore in said detection volume. In one aspect of the invention, said luminophore is selected to emit luminescent radiation having a wavelength in said medium that is larger than twice said smallest dimension; and wherein said luminophore is selected to be excitable by excitation radiation having a wavelength in said medium that is smaller than twice said smallest dimension. Accordingly, luminescent radiation is blocked from entering the detector but for the portion present on an interface of the aperture.
摘要翻译：提供了一种检测检测体积中的发光体的存在的方法，包括在所述检测体积中提供激发辐射。在所述检测体积中提供发光体，所述发光体可被所述激发辐射激发。检测发光辐射以识别所述检测体积中所述发光体的存在。在本发明的一个方面，所述发光体选择为发射具有大于所述最小尺寸的两倍的所述介质中的波长的发光辐射; 并且其中所述发光体被选择为通过所述介质中具有小于所述最小尺寸的两倍的波长的激发辐射来激发。因此，阻挡发光辐射进入检测器，但是阻挡存在于孔的界面上的部分。

3. 发明授权

US08158398B2 Microelectronic sensor device 有权
标题翻译：微电子传感器装置
公开(公告)号：US08158398B2
公开(公告)日：2012-04-17
申请号：US12810022
申请日：2008-12-18
申请人： Derk J. W. Klunder
发明人： Derk J. W. Klunder
IPC分类号： G01N21/31 , G01N21/64 , G02B27/56
CPC分类号： G01N21/553 , G01N21/648
摘要： An optical device provides evanescent radiation, in response to incident radiation, in a detection volume for containing a target component in a medium. The detection volume has at least one in-plane dimension (W1) smaller than a diffraction limit. The diffraction limit is defined by the radiation wavelength and the medium. The evanescent radiation is provided by aperture defining structures having a smallest in plane aperture dimension (W1) smaller than the diffraction limit. The detection volume is provided between the aperture defining structures. The aperture defining structures further define a largest in plane aperture dimension (W2). The largest in plane aperture dimension is larger than the diffraction limit. A source is provided for emitting a beam of radiation having a wavelength incident at the optical device and having a direction of incidence non parallel to an out of plane normal direction, for providing the evanescent radiation in the detection volume, in response to the radiation incident at the optical device. The plane of incidence may be parallel to the largest in plane aperture dimension.
摘要翻译：光学装置响应于入射辐射，在用于在介质中容纳目标成分的检测体积中提供ev逝辐射。检测体积具有小于衍射极限的至少一个面内尺寸（W1）。衍射极限由辐射波长和介质决定。 ev逝辐射由具有小于衍射极限的最小平面孔径尺寸（W1）的孔限定结构提供。检测体积设置在孔限定结构之间。孔限定结构还限定最大的平面孔径尺寸（W2）。平面孔径尺寸最大，大于衍射极限。提供源，用于发射具有入射在光学装置处的波长并具有不平行于平面外法线方向的入射方向的辐射束，用于响应于辐射入射而提供检测体积中的ev逝辐射在光学装置。入射平面可以平行于最大的平面孔径尺寸。

4. 发明申请

US20110039720A1 DEVICE AND METHOD FOR PARALLEL QUANTITATIVE ANALYSIS OF MULTIPLE NUCLEIC ACIDS 审中-公开
标题翻译：用于多个核酸并行定量分析的装置和方法
公开(公告)号：US20110039720A1
公开(公告)日：2011-02-17
申请号：US12809412
申请日：2008-12-16
申请人： Erik R. Vossenaar , Derk J. W. Klunder , Hendrik R. Stapert , Henk Van Houten , Bob Van Gemen , Erik M. H. P. Van Dijk
发明人： Erik R. Vossenaar , Derk J. W. Klunder , Hendrik R. Stapert , Henk Van Houten , Bob Van Gemen , Erik M. H. P. Van Dijk
IPC分类号： C40B30/04 , C40B60/12
CPC分类号： C12Q1/6818 , C12Q1/6851 , C12Q2525/301 , C12Q2565/1015 , C12Q2565/549 , C12Q2561/113
摘要： The present invention relates to a process for conducting real-time PCR, and to a device for conducting the method of the present invention. The invention is especially suited for the simultaneous identification and quantification of nucleic acids present in a sample, e.g. a biological sample. Further, this invention describes a method for simultaneous quantitative analysis of multiple nucleic acid sequences in a single compartment by using an integrated nucleic acid microarray combined with a highly surface-specific readout device. The invention relates to a device wherein a surface which is either part of the chamber surface or a surface that is created in the reaction chamber, such as bead surface, is coated with capture probes and in the same chamber, a PCR reaction takes place.
摘要翻译：本发明涉及一种用于进行实时PCR的方法以及用于实施本发明的方法的装置。本发明特别适用于同时鉴定和定量样品中存在的核酸，例如，生物样品。此外，本发明描述了通过使用与高表面特异性读出装置组合的整合的核酸微阵列来同时定量分析单个隔室中的多个核酸序列的方法。本发明涉及一种装置，其中作为室表面的一部分的表面或在反应室中产生的表面（例如珠粒表面）的表面涂覆有捕获探针，并且在相同的室中进行PCR反应。

5. 发明授权

US09176062B2 Aperture biosensor with trenches 有权
标题翻译：孔径生物传感器与沟槽
公开(公告)号：US09176062B2
公开(公告)日：2015-11-03
申请号：US12519849
申请日：2007-12-17
申请人： Derk J. W. Klunder , Maarten M. J. W. Van Herpen , Hendrik R. Stapert
发明人： Derk J. W. Klunder , Maarten M. J. W. Van Herpen , Hendrik R. Stapert
IPC分类号： G01N27/00 , G01N21/64
CPC分类号： G01N21/648 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L2200/025 , B01L2300/0654 , B01L2300/0816 , B01L2300/0887 , C12Q1/6837 , G01N21/47 , G01N21/554 , G01N21/658 , G01N2021/95676
摘要： A luminescence sensor, comprising a non-transparent substrate structure (2) having at least one aperture (5) intended to comprise an analyte and a transparent substrate structure (3), which is arranged to or adjacent said first structure (2). The aperture has a smallest lateral dimension, which is smaller than half the effective wavelength of an excitation radiation, such as light at a wavelength of 700 nm, resulting in an effective wavelength in water of about 538 nm. The transparent structure has a trench (4) with a surface portion provided with ligands with an affinity towards a target molecule. The trench results in that a luminophore attached to the target molecule will be positioned at the entrance surface of the aperture, where the excitation energy is largest.
摘要翻译：发光传感器，包括具有至少一个孔（5）的非透明衬底结构（2），所述孔旨在包括被分析物和透明衬底结构（3），所述透明衬底结构（3）布置在所述第一结构（2）上或邻近所述第一结构（2）。孔径具有最小的横向尺寸，其小于激发辐射的有效波长的一半，例如波长为700nm的光，导致在约538nm的水中的有效波长。透明结构具有沟槽（4），其表面部分具有对靶分子具有亲和性的配体。沟槽导致连接到靶分子的发光体将位于孔的入射表面处，其中激发能量最大。

6. 发明授权

US09134244B2 Wiregrid monitor device 有权
标题翻译：铁丝网监控设备
公开(公告)号：US09134244B2
公开(公告)日：2015-09-15
申请号：US12526547
申请日：2008-02-12
申请人： Derk J. W. Klunder , Maarten M. J. W. Van Herpen , Hendrik R. Stapert
发明人： Derk J. W. Klunder , Maarten M. J. W. Van Herpen , Hendrik R. Stapert
IPC分类号： G01N21/64 , B82Y15/00
CPC分类号： G01N21/648 , B82Y15/00 , G01N21/6445 , G01N21/6452
摘要： A device for monitoring radiation emitted by luminophores present in an analyte fluid of a wiregrid biosensor. The monitoring device comprises a non-polarized light source (41) for illuminating the wiregrid biosensor for exciting fluorescent labels arranged in the analyte fluid of said biosensor. A detector (71) detects radiation emitted by the labels after excitation. A polarizing filter (53) is arranged in between the transparent substrate and the detector for suppression of background emission radiation from labels positioned outside apertures in the wiregrid, in the analyte fluid.
摘要翻译：用于监测存在于丝网生物传感器的分析物流体中的发光体发射的辐射的装置。监测装置包括用于照亮丝网生物传感器以激发布置在所述生物传感器的分析物流体中的荧光标记的非偏振光源（41）。检测器（71）检测激励后由标签发射的辐射。偏振滤光器（53）布置在透明基板和检测器之间，用于抑制分析物流体中位于线网中的孔外部的标签的背景辐射辐射。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式