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1. 发明授权

US4479819A Infrared polarizing glasses 失效
标题翻译：红外偏光眼镜
公开(公告)号：US4479819A
公开(公告)日：1984-10-30
申请号：US427732
申请日：1982-09-29
申请人： Nicholas F. Borelli , Frank Coppola , David L. Morse , Daniel A. Nolan , Thomas P. Seward, III
发明人： Nicholas F. Borelli , Frank Coppola , David L. Morse , Daniel A. Nolan , Thomas P. Seward, III
IPC分类号： C03B17/02 , C03B23/037 , C03B32/00 , C03C3/064 , C03C3/091 , C03C4/06 , G02B5/30 , C03C3/26 , C03B19/00 , C03C23/00
CPC分类号： C03B32/00 , C03B17/02 , C03B23/037 , C03C3/064 , C03C3/091 , C03C4/06 , G02B5/3058 , Y10S430/165
摘要： The instant invention is directed to the preparation of glass articles exhibiting excellent polarization in the infrared portion of the spectrum from glasses characterized as containing silver halide particles therein selected from the group of AgCl, AgBr, AgI. The inventive method comprises four general steps:(a) a batch for a glass containing silver and at least one halide selected from the group of chloride, bromide, and iodide is melted and the melt shaped into a glass body of a desired geometry;(b) the glass body is subjected to a heat treatment at least above the strain point but not in excess of 50.degree. C. above the softening point of the glass for a period of time adequate to cause the generation of AgCl and/or AgBr and/or AgI particles therein, said particles ranging in size between 200-5000 .ANG.;(c) the glass body is elongated under stress at temperatures above the annealing point, but below that where said glass exhibits a viscosity of about 10.sup.8 poises, such that the particles are elongated to an aspect ratio of at least 5:1; and(d) the elongated glass body is exposed to a reducing environment at temperatures between 250.degree. C. and about 25.degree. above the annealing point of the glass to reduce the silver halide particles in the glass to metallic silver which is deposited in and/or upon the elongated particles.
摘要翻译：本发明涉及从其中选择AgCl，AgBr，AgI中含有卤化银颗粒的玻璃的红外线部分的红外部分显示优异的玻璃制品的制备。本发明的方法包括四个一般步骤：（a）用于含有银的玻璃和选自氯化物，溴化物和碘化物中的至少一种卤化物的批料熔化并将其熔化成具有所需几何形状的玻璃体; （b）将玻璃体至少高于应变点，但不超过玻璃软化点50℃以上的热处理足以导致产生AgCl和/或AgBr的时间和/或AgI颗粒，所述颗粒的尺寸范围为200-5000安培; （c）玻璃体在高于退火点的温度下在应力下伸长，但低于所述玻璃呈现约108泊的粘度，使得该颗粒伸长至至少5:1的纵横比; 和（d）细长玻璃体在比玻璃退火点高250℃至25℃的温度下暴露于还原环境中，以将玻璃中的卤化银颗粒还原为金属银，其沉积在和/ 或在细长的颗粒上。

2. 发明授权

US4190451A Photochromic glass 失效
标题翻译：光致变色玻璃
公开(公告)号：US4190451A
公开(公告)日：1980-02-26
申请号：US14981
申请日：1979-02-28
申请人： George B. Hares , David L. Morse , Thomas P. Seward, III , Dennis W. Smith
发明人： George B. Hares , David L. Morse , Thomas P. Seward, III , Dennis W. Smith
IPC分类号： C03C3/064 , C03C3/11 , C03C4/06 , C03C21/00 , G02C7/10 , C03C3/08 , C03C3/26
CPC分类号： C03C4/06 , Y10S501/903
摘要： The instant invention is concerned with transparent photochromic glass compositions which not only exhibit desirably rapid darkening and fading characteristics, but which also demonstrate the other physical and optical properties required for use in ophthalmic applications. Such glasses utilize the presence of silver chloride and/or silver bromide crystals to impart photochromic behavior in a narrowly-defined composition range within the alkali metal aluminoborosilicate base system. Copper ions are also included in the composition to perform as a sensitizing agent. The glasses have the capability of being either thermally tempered or chemically strengthened to comply with the United States Food and Drug Administration regulations for lenses used in ophthalmic applications. Improved independence of temperature effects upon the photochromic properties can be achieved where the copper level, expressed as CuO, is maintained between about 0.004-0.02% by weight, the chloride value, expressed as Cl, is held between about 0.1-0.25% by weight, the silver content, expressed as Ag, is included between about 0.15-0.3% by weight, and the quantity of bromide, expressed as Br, is varied between about 0.1-0.2% by weight. The fading rate of the glasses is enhanced by maintaining the molar ratio of alkali metal oxides to B.sub.2 O.sub.3 between about 0.55-0.85, the molar ratio of alkali metal oxides minus Al.sub.2 O.sub.3 to B.sub.2 O.sub.3 is about 0.25-0.4, and the weight ratio Ag:(Cl+Br) is about 0.65-0.95.
摘要翻译：本发明涉及透明光致变色玻璃组合物，其不仅表现出期望的快速变暗和褪色特性，而且还显示了用于眼科应用所需的其它物理和光学性质。这种玻璃利用氯化银和/或溴化银晶体的存在，以在碱金属铝硼硅酸盐基体系内的窄范围的组成范围内赋予光致变色行为。铜离子也包括在组合物中以用作敏化剂。眼镜具有热回火或化学强化的能力，以符合美国食品和药物管理局对眼科应用中使用的镜片的规定。可以实现温度对光致变色性能的独立性，其中以CuO表示的铜含量维持在约0.004-0.02重量％之间，氯化物值（以Cl表示）保持在约0.1-0.25重量％，以Ag表示的银含量在约0.15-0.3重量％之间，以Br表示的溴的量在约0.1-0.2重量％之间变化。通过将碱金属氧化物与B 2 O 3的摩尔比保持在约0.55-0.85之间，碱金属氧化物减去Al 2 O 3与B 2 O 3的摩尔比为约0.25-0.4，并且重量比Ag Cl + Br）为约0.65-0.95。

3. 发明授权

US4222781A Optically clear copper halide photochromic glass articles 失效
标题翻译：光学透明卤化物光致变色玻璃制品
公开(公告)号：US4222781A
公开(公告)日：1980-09-16
申请号：US66912
申请日：1979-08-16
申请人： David L. Morse , Thomas P. Seward, III
发明人： David L. Morse , Thomas P. Seward, III
IPC分类号： C03C3/11 , C03C3/091 , C03C3/118 , C03C4/06 , C03C3/26 , C03C3/08
CPC分类号： C03C4/065
摘要： Silver-free, cadmium-free, copper halide-based alkali aluminoborosilicate glasses exhibiting good optical clarity and good photochromic darkening and fading are provided by controlling the alkali, Al.sub.2 O.sub.3 and B.sub.2 O.sub.3 concentrations in the base glass and/or adding MoO.sub.3 or WO.sub.3 thereto.
摘要翻译：通过控制基底玻璃中的碱，Al 2 O 3和B 2 O 3浓度和/或向其中添加MoO 3或WO 3，提供了具有良好光学透明度和良好的光致变色变暗和褪色的无银，无卤素，卤化铜基碱性铝硼硅酸盐玻璃。

4. 发明申请

US20140112873A1 MELANOCORTIN 1 RECEPTOR LIGANDS AND METHODS OF USE 有权
标题翻译： MELANOCORTIN 1受体配体及其使用方法
公开(公告)号：US20140112873A1
公开(公告)日：2014-04-24
申请号：US14117949
申请日：2012-05-17
申请人： Robert J. Gillies , David L. Morse , Natalie M. Barkey , Kevin N. Sill , Josef Vagner , Narges K. Tafreshi , Jonathan L. Sessler , Christian Preihs , Victor J. Hruby
发明人： Robert J. Gillies , David L. Morse , Natalie M. Barkey , Kevin N. Sill , Josef Vagner , Narges K. Tafreshi , Jonathan L. Sessler , Christian Preihs , Victor J. Hruby
IPC分类号： C07K7/08 , A61K49/18 , A61K47/48 , A61K49/14 , C07K7/06 , C07K5/117
CPC分类号： C07K5/1024 , A61K38/34 , A61K47/48246 , A61K47/488 , A61K47/64 , A61K47/6907 , A61K49/0056 , A61K49/101 , A61K49/1809 , C07K7/08 , C07K14/68 , C07K14/723
摘要： The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell.
摘要翻译：本发明涉及包含黑皮质素1受体（MC1R）配体的肽和功能性或连接体的修饰的MC1R肽配体，例如用于与表面或试剂共轭的功能性或接头。修饰的MC1R肽配体可以例如通过与所连接的互补点击功能的点击反应偶联，以形成MC1R靶向的试剂。药物，造影剂，聚合物，颗粒，胶束，较大结构的表面或其它部分可以靶向MC1R。本发明还涉及包含通过点胶反应产物与胶束连接的黑皮质素1受体配体的肽的MC1R肽配体 - 胶束复合物。胶束在体内是稳定的并且可以通过肽配体与MC1R或肿瘤的缔合来靶向黑素瘤肿瘤细胞，并选择性地提供可检测和/或治疗剂（例如可成像的造影剂和/或抗癌剂）到肿瘤细胞。

5. 发明申请

US20120277245A1 Method of Increasing Intratumoral pHe and Reducing Acid-Mediated Invasion 审中-公开
标题翻译：增加肿瘤内pH值并减少酸介导入侵的方法
公开(公告)号：US20120277245A1
公开(公告)日：2012-11-01
申请号：US13479638
申请日：2012-05-24
申请人： Robert J. Gillies , David L. Morse , Ariosto Siqueira Silva , Arig A. Ibrahim Hashim , Robert A. Gatenby , Gary Martinez
发明人： Robert J. Gillies , David L. Morse , Ariosto Siqueira Silva , Arig A. Ibrahim Hashim , Robert A. Gatenby , Gary Martinez
IPC分类号： A61K31/185 , A61K31/4172 , A61P35/04 , A61K31/14 , A61P35/00 , A61K31/495 , A61K31/198
CPC分类号： A61K31/4172 , A61K31/133 , A61K31/198 , A61K31/255 , A61K31/495 , A61K45/06 , A61K2300/00
摘要： A method of treating cancer or inhibiting metastasis in a subject by increasing intratumoral extracellular pH is presented. The method includes administering to the subject a therapeutically effective amount of a buffer having a pKa greater than 6.1. In an advantageous embodiment the pKa of the buffer is about 7.0. Examples of buffers for increasing extracellular pH include NaHCO3, 2-imidazole-1-yl-3-ethoxycarbonylpropionic acid (IEPA), cholamine chloride, N,N-Bis(2-hydroxyethyl)-2-aminoethanesulfonic acid (BES), N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid (TES) and 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid (HEPES). The method can further include the step of pretreating with one or more chemotherapeutic agents.
摘要翻译：提出了通过增加瘤内细胞外pH来治疗受试者的癌症或抑制转移的方法。该方法包括向受试者施用治疗有效量的pKa大于6.1的缓冲液。在有利的实施方案中，缓冲液的pKa为约7.0。用于增加细胞外pH的缓冲液的实例包括NaHCO 3，2-咪唑-1-基-3-乙氧基羰基丙酸（IEPA），氯化氯化胺，N，N-双（2-羟乙基）-2-氨基乙磺酸（BES），N- 三（羟甲基）甲基-2-氨基乙磺酸（TES）和4-（2-羟乙基）哌嗪-1-乙磺酸（HEPES）。该方法还可以包括用一种或多种化学治疗剂预处理的步骤。

6. 发明授权

US4608349A Photochromic glass compositions for lightweight lenses 失效
标题翻译：用于轻型镜片的光致变色玻璃组合物
公开(公告)号：US4608349A
公开(公告)日：1986-08-26
申请号：US797223
申请日：1985-11-28
申请人： David J. Kerko , David W. Morgan , David L. Morse
发明人： David J. Kerko , David W. Morgan , David L. Morse
IPC分类号： G02C7/10 , C03C3/093 , C03C3/11 , C03C4/06 , C09K9/00 , C03C3/118
CPC分类号： C03C3/093 , C03C4/06
摘要： Photochromic glass compositions for thin refractive-index-corrected lens elements consisting essentially of about:______________________________________ SiO.sub.2 54-58% B.sub.2 O.sub.3 18-22% Al.sub.2 O.sub.3 7-8% Li.sub.2 O 3.75-4.5% Na.sub.2 O 0-1% K.sub.2 O 5.5-7.5% TiO.sub.2 0-2% ZrO.sub.2 2-4.5% Ag 0.20-0.33% Cl 0.30-0.50% Br 0.04-0.12% CuO 0.007-0.012% PbO 0-0.08% Sb.sub.2 O.sub.3 0-0.20% ______________________________________ having a Li.sub.2 O:Na.sub.2 O molar ratio of at least 9:1 and exhibiting good darkening, fast fading, good chemical strengthenability and neutral dark-state coloration at thicknesses on the order of 1 mm, are described.
摘要翻译：用于薄折射率校正透镜元件的光致变色玻璃组合物，其基本上由以下组成：-SiO 2 54-58％-B 2 O 3 18-22％-Al 2 O 3 7-8％-Li 2 O 3.75-4.5％-Na 2 O 0-1％-K 2 O 5.5 -7.5％-TiO 2 0-2％-ZrO2 2-4.5％-Ag 0.20-0.33％-Cl 0.30-0.50％-Br 0.04-0.12％-CuO 0.007-0.012％-PbO 0-0.08％-Sb2O3 0-0.20 ％ - 具有至少9:1的Li 2 O:Na 2 O摩尔比，并且在1mm的厚度下表现出良好的变暗，快速褪色，良好的化学强化性和中性暗态着色。

7. 发明授权

US4488864A Integral optical device and method of making it 失效
标题翻译：一体化光学器件及其制作方法
公开(公告)号：US4488864A
公开(公告)日：1984-12-18
申请号：US520457
申请日：1983-08-04
申请人： Nicholas F. Borrelli , Thomas H. Elmer , David L. Morse , Paul A. Sachenik
发明人： Nicholas F. Borrelli , Thomas H. Elmer , David L. Morse , Paul A. Sachenik
IPC分类号： C03B8/00 , C03B20/00 , C03C11/00 , C03C23/00 , G02B3/00 , G03C1/68
CPC分类号： G02B3/0056 , C03C23/0095
摘要： There is disclosed an improved integral optical device of the type produced by creating optical patterns in porous glass bodies, especially patterns involving gradient refractive index distributions. The optical strength of an element, such as a lens, in such an optical pattern is increased by treatment with a polymerizable, organo functional silicone fluid while the matrix glass is sealed.
摘要翻译：公开了通过在多孔玻璃体中产生光学图案而产生的改进的一体光学器件，特别是涉及梯度折射率分布的图案。通过在将基质玻璃密封的情况下通过可聚合的有机官能的硅氧烷流体的处理来增加这种光学图案中的诸如透镜的元件的光学强度。

8. 发明申请

US20200164093A1 Molecular Imaging of Cancer Cells In Vivo 审中-公开
公开(公告)号：US20200164093A1
公开(公告)日：2020-05-28
申请号：US16565188
申请日：2019-09-09
申请人： David L. Morse , Robert J. Gillies , Amanda Huynh , Josef Vagner
发明人： David L. Morse , Robert J. Gillies , Amanda Huynh , Josef Vagner
IPC分类号： A61K49/00 , C07K7/08 , C07K7/06
摘要： Cellular targets on cancer cells have been identified that can be used with targeted molecular imaging to detect the cancer cells in vivo. Non-invasive methods for detecting cancer cells, such as metastasized cancer cells, are therefore provided. Also provided are compositions and kits for use in the disclosed methods.

9. 发明授权

US10258607B2 Method of increasing intratumoral pHe and reducing acid-mediated invasion 有权
公开(公告)号：US10258607B2
公开(公告)日：2019-04-16
申请号：US13479638
申请日：2012-05-24
申请人： Robert J. Gillies , David L. Morse , Ariosto Siqueira Silva , Arig A. Ibrahim Hashim , Robert A. Gatenby , Gary Martinez
发明人： Robert J. Gillies , David L. Morse , Ariosto Siqueira Silva , Arig A. Ibrahim Hashim , Robert A. Gatenby , Gary Martinez
IPC分类号： A61K31/4172 , A61K45/06 , A61K31/133 , A61K31/198 , A61K31/255 , A61K31/495
摘要： A method of treating cancer or inhibiting metastasis in a subject by increasing intratumoral extracellular pH is presented. The method includes administering to the subject a therapeutically effective amount of a buffer having a pKa greater than 6.1. In an advantageous embodiment the pKa of the buffer is about 7.0. Examples of buffers for increasing extracellular pH include NaHCO3, 2-imidazole-1-yl-3-ethoxycarbonylpropionic acid (IEPA), cholamine chloride, N,N-Bis(2-hydroxyethyl)-2-aminoethanesulfonic acid (BES), N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid (TES) and 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid (HEPES). The method can further include the step of pretreating with one or more chemotherapeutic agents.

10. 发明授权

US4526873A Transparent, mullite glass-ceramics containing ZnO and method 失效
标题翻译：含有ZnO的透明莫来石玻璃陶瓷及方法
公开(公告)号：US4526873A
公开(公告)日：1985-07-02
申请号：US627073
申请日：1984-07-02
申请人： George H. Beall , Nicholas F. Borrelli , David L. Morse
发明人： George H. Beall , Nicholas F. Borrelli , David L. Morse
IPC分类号： C03C3/062 , C03C3/093 , C03C3/108 , C03C10/00 , C03C10/04 , C03C3/22 , C09K11/10
CPC分类号： C03C10/0054 , Y10S501/904
摘要： There is disclosed an improved, transparent, mullite glass-ceramic doped with Cr.sub.2 O.sub.3 to fluoresce in the 650-900 nm. region of the spectrum and having an absorption peak centered at about 600 nm. The improvement is inclusion in the composition of 2-15% by weight of ZnO and sufficient MgO, if necessary, to provide at least 5% ZnO+MgO. The ZnO or ZnO--MgO components selectively shift the absorption peak centered at 600 nm. toward the lower (blue) end of the spectrum.
摘要翻译：公开了一种改进的透明的莫来石玻璃陶瓷，掺杂有Cr 2 O 3以在650-900nm中发荧光。并具有以约600nm为中心的吸收峰。如果需要，改进是包含2-15重量％的ZnO和足够的MgO，以提供至少5％的ZnO + MgO。 ZnO或ZnO-MgO组分选择性地移动以600nm为中心的吸收峰。朝向光谱的下（蓝）端。

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