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1. 发明授权

US08585689B2 Cryotreatment devices and methods of forming conduction blocks 有权
公开(公告)号：US08585689B2
公开(公告)日：2013-11-19
申请号：US13252817
申请日：2011-10-04
申请人： Daniel M. Lafontaine
发明人： Daniel M. Lafontaine
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/0218 , A61B2018/0212 , A61B2018/0262 , A61B2018/0293
摘要： Cryotreatment devices and methods of ablating tissue within the body are disclosed. A cryotreatment device in accordance with an exemplary embodiment of the present invention includes an elongated member having one or more needle-like ablation tips configured to induce necrosis at a target site within the heart. A cooling fluid such as a cryogen may be injected through a lumen extending into the distal portion of the device. The ablation tips can be configured to pierce and ablate surrounding tissue, blocking electrical stimuli that can cause fibrillations or other arrhythmias of the heart. The device may also include means for controlling the transmural depth at which the ablation tips are inserted into the cardiac tissue. Methods of forming a contiguous line of conduction block in accordance with the present invention are also disclosed.

2. 发明授权

US08398677B2 Closure device with textured surface 有权
标题翻译：带纹理表面的封闭装置
公开(公告)号：US08398677B2
公开(公告)日：2013-03-19
申请号：US12790554
申请日：2010-05-28
申请人： Daniel M. Lafontaine , Mark T. Ungs , William J. Drasler , Sheng-Ping (Samuel) Zhong
发明人： Daniel M. Lafontaine , Mark T. Ungs , William J. Drasler , Sheng-Ping (Samuel) Zhong
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00349 , A61B2017/00637 , A61B2017/00654 , A61B2017/00659 , A61B2017/00898 , A61B2017/12004
摘要： A closure device closes an opening in a body cavity. The closure device includes a plurality of fibrous tissue engaging members coupled to a proximally extending elongate member, a closure sheath sized to receive the elongate member and slidable over the elongate member to move the fibrous tissue engaging members from an expanded position to a collapsed position, a delivery sheath sized to receive the closure sheath and having a distal end sized to engage the fibrous tissue engaging members in the expanded position, and a closure member having an aperture sized to receive the closure sheath.
摘要翻译：闭合装置关闭体腔中的开口。闭合装置包括多个与近端延伸的细长构件联接的纤维组织接合构件，封闭护套，其尺寸适于容纳细长构件，并可在细长构件上方滑动，以将纤维组织接合构件从扩张位置移动到收缩位置，传送护套的尺寸被设计成容纳封闭护套并且具有尺寸适于接合处于展开位置的纤维组织接合构件的远端，以及封闭构件，该封闭构件具有尺寸适于容纳闭合护套的孔。

3. 发明授权

US08123741B2 Treating internal body tissue 有权
标题翻译：治疗内部身体组织
公开(公告)号：US08123741B2
公开(公告)日：2012-02-28
申请号：US12428719
申请日：2009-04-23
申请人： Nassir Marrouche , Daniel M. Lafontaine
发明人： Nassir Marrouche , Daniel M. Lafontaine
IPC分类号： A61B18/02 , A61B18/04
CPC分类号： A61B18/02 , A61B18/04 , A61B2017/00243 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212
摘要： Some embodiments of the invention relate to a system for treating tissue internal to a body, such as heart tissue. For example, the system may be used to ablate tissue as a treatment for atrial fibrillation. In certain embodiments, the system is capable of causing scar tissue to form in ostial areas of the atrium rather than inside the pulmonary vein. In such embodiments, the system may include a tissue treatment member that is operable to form an annular area of ablated tissue along the outer portion of the ostium in an area known as the antrum.
摘要翻译：本发明的一些实施方案涉及用于治疗身体内部的组织例如心脏组织的系统。例如，该系统可用于消融组织作为心房颤动的治疗。在某些实施方案中，该系统能够在心房的口部区域中形成瘢痕组织，而不是在肺静脉内部。在这样的实施例中，系统可以包括组织处理构件，其可操作以沿着称为窦的区域沿着口的外部部分形成消融组织的环形区域。

4. 发明申请

US20100100173A1 VALVE APPARATUS, SYSTEM AND METHOD 有权
标题翻译：阀门装置，系统和方法
公开(公告)号：US20100100173A1
公开(公告)日：2010-04-22
申请号：US12648221
申请日：2009-12-28
申请人： Daniel M. Lafontaine
发明人： Daniel M. Lafontaine
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61M25/1011
摘要： A cardiac valve with a first anchor frame and a cover on the first anchor frame for unidirectional flow of a liquid through the valve.
摘要翻译：一种心脏瓣膜，其具有第一锚架和第一锚架上的盖子，用于单向流动液体通过该阀。

5. 发明授权

US07674256B2 Treating internal body tissue 有权
标题翻译：治疗内部身体组织
公开(公告)号：US07674256B2
公开(公告)日：2010-03-09
申请号：US11082677
申请日：2005-03-17
申请人： Nassir Marrouche , Daniel M. Lafontaine
发明人： Nassir Marrouche , Daniel M. Lafontaine
IPC分类号： A61B18/02 , A61B18/04
CPC分类号： A61B18/02 , A61B18/04 , A61B2017/00243 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212
摘要： Some embodiments of the invention relate to a system for treating tissue internal to a body, such as heart tissue. For example, the system may be used to ablate tissue as a treatment for atrial fibrillation. In certain embodiments, the system is capable of causing scar tissue to form in ostial areas of the atrium rather than inside the pulmonary vein. In such embodiments, the system may include a tissue treatment member that is operable to form an annular area of ablated tissue along the outer portion of the ostium in an area known as the antrum.
摘要翻译：本发明的一些实施方案涉及用于治疗身体内部的组织例如心脏组织的系统。例如，该系统可用于消融组织作为心房颤动的治疗。在某些实施方案中，该系统能够在心房的口部区域中形成瘢痕组织，而不是在肺静脉内部。在这样的实施例中，系统可以包括组织处理构件，其可操作以沿着称为窦的区域沿着口的外部部分形成消融组织的环形区域。

6. 发明授权

US07566343B2 Cardiac valve, system, and method 有权
标题翻译：心脏瓣膜，系统和方法
公开(公告)号：US07566343B2
公开(公告)日：2009-07-28
申请号：US10933088
申请日：2004-09-02
申请人： Mark L. Jenson , William J. Drasler , Daniel M. Lafontaine
发明人： Mark L. Jenson , William J. Drasler , Daniel M. Lafontaine
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2230/008
摘要： A cardiac valve with a support frame having a first end member and a second end member opposing the first end member in a substantially fixed distance relationship, and a cover extending over the support frame to allow for unidirectional flow of a liquid through the valve.
摘要翻译：具有支撑框架的心脏瓣膜具有第一端构件和与所述第一端构件基本上固定的距离关系相对的第二端构件，以及在所述支撑框架上延伸以允许液体通过所述瓣膜的单向流动的盖。

7. 发明授权

US07022120B2 Cryoplasty device and method 失效
公开(公告)号：US07022120B2
公开(公告)日：2006-04-04
申请号：US10659116
申请日：2003-09-10
申请人： Daniel M. Lafontaine
发明人： Daniel M. Lafontaine
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B2017/00088 , A61B2017/00292 , A61B2017/00557 , A61B2017/22002 , A61B2018/00101 , A61B2018/0022 , A61B2018/0212 , A61M25/104 , C21B13/0033 , C22B5/14 , C22B23/021
摘要： A cryoplasty catheter and method for preventing or slowing reclosure of a lesion following angioplasty. The cryoplasty catheter includes a shaft having proximal and distal ends and a dilatation balloon disposed at the distal end. An intake lumen and exhaust lumen are defined by the shaft to deliver coolant to the balloon and to exhaust or drain coolant from the balloon. The method in accordance with the present invention includes cooling a lesion to aid in remodeling the lesion through dilatation and/or freezing a portion of the lesion adjacent the dilatation balloon to kill cells within the lesion to prevent or retard restenosis.

8. 发明授权

US06656199B1 Magnetic clamp assembly for an elongated flexible medical device 失效
标题翻译：用于细长柔性医疗设备的磁性夹具组件
公开(公告)号：US06656199B1
公开(公告)日：2003-12-02
申请号：US09645222
申请日：2000-08-24
申请人： Daniel M. Lafontaine
发明人： Daniel M. Lafontaine
IPC分类号： A61B500
CPC分类号： A61M25/0127
摘要： A magnetic clamp assembly for an elongated flexible medical device. The clamp assembly includes magnetic clamp members operably coupled to clamp a portion of the flexible medical device to secure the medical device during treatment.
摘要翻译：一种用于细长柔性医疗装置的磁夹组件。夹具组件包括可操作地联接以夹紧柔性医疗装置的一部分以在治疗期间固定医疗装置的磁性夹具构件。

9. 发明授权

US06648878B2 Cryoplasty device and method 有权
公开(公告)号：US06648878B2
公开(公告)日：2003-11-18
申请号：US09916147
申请日：2001-07-25
申请人： Daniel M. Lafontaine
发明人： Daniel M. Lafontaine
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B2017/00088 , A61B2017/00292 , A61B2017/00557 , A61B2017/22002 , A61B2018/00101 , A61B2018/0022 , A61B2018/0212 , A61M25/104 , C21B13/0033 , C22B5/14 , C22B23/021
摘要： A cryoplasty catheter and method for preventing or slowing reclosure of a lesion following angioplasty. The cryoplasty catheter includes a shaft having proximal and distal ends and a dilatation balloon disposed at the distal end. An intake lumen and exhaust lumen are defined by the shaft to deliver coolant to the balloon and to exhaust or drain coolant from the balloon. The method in accordance with the present invention includes cooling a lesion to aid in remodeling the lesion through dilatation and/or freezing a portion of the lesion adjacent the dilatation balloon to kill cells within the lesion to prevent or retard restenosis.

10. 发明授权

US06497711B1 Therectomy device having a light weight drive shaft and an imaging device 失效
标题翻译：动脉粥样硬化切除装置具有重量轻的驱动轴和成像装置
公开(公告)号：US06497711B1
公开(公告)日：2002-12-24
申请号：US09639873
申请日：2000-08-16
申请人： Mark Plaia , Robert L. Barry , Daniel M. Lafontaine
发明人： Mark Plaia , Robert L. Barry , Daniel M. Lafontaine
IPC分类号： A61B1722
CPC分类号： A61B17/320758 , A61B17/221 , A61B17/320725 , A61B90/37 , A61B2017/320004 , A61B2017/320733 , A61B2090/378
摘要： An atherectomy device having the ability to create variably sized lumens in a vessel. An ablation burr rotated by a drive shaft is routed through a control shaft having a bend in its distal end. The control shaft is in turn routed through a surrounding guide catheter. By extending or retracting the bend of the control shaft into the distal end of the guide catheter, the lateral displacement of the ablation burr is varied. A lumen in a vessel is created by rotating the control shaft within the surrounding guide catheter. In addition, the atherectomy device may include an integrated imaging sensor contained within a separate lumen of the catheter surrounding the drive shaft. The imaging sensor provides images of the interior of the vessel wall to determine if an occlusion has been removed by operation of the ablation burr. The catheter may include a self-expanding stent at its distal end to force the ablation burr against a vessel wall in order to create various sized lumens in a patient's vasculature. Finally, the drive shaft that rotates the ablation burr is made of a lightweight polymeric material such as a liquid crystal polymer having fibers that are braided to provide desired torque and flexibility characteristics of the drive shaft.
摘要翻译：具有在血管中产生可变大小的腔的能力的粥样斑块切除装置。由驱动轴旋转的消融毛刺通过其远端具有弯曲部的控制轴布置。控制轴又穿过周围的引导导管。通过将控制轴的弯曲部延伸或缩回到导向导管的远端，消融毛刺的横向位移变化。通过在周围的引导导管内旋转控制轴来产生容器中的内腔。另外，粥样斑块切除装置可以包括集成的成像传感器，其包含在围绕驱动轴的导管的分开的内腔内。成像传感器提供血管壁内部的图像，以确定是否通过消融毛刺的操作去除了闭塞。导管可以在其远端包括自扩张支架，以迫使消融毛刺抵靠血管壁，以在患者的脉管系统中产生各种尺寸的腔。最后，旋转消融毛刺的驱动轴由轻质的聚合物材料制成，例如具有编织纤维的液晶聚合物，以提供驱动轴的期望的扭矩和柔性特性。

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